-
2
-
-
38949101952
-
Targeting mitochondria
-
A.T. Hoye, J.E. Davoren, P. Wipf, M.P. Fink, and V.E. Kagan Targeting mitochondria Acc. Chem. Res. 41 2008 87 97
-
(2008)
Acc. Chem. Res.
, vol.41
, pp. 87-97
-
-
Hoye, A.T.1
Davoren, J.E.2
Wipf, P.3
Fink, M.P.4
Kagan, V.E.5
-
3
-
-
57649233172
-
Mitochondria-targeted antioxidants in the treatment of disease
-
R.A. Smith, V.J. Adlam, F.H. Blaikie, A.R. Manas, C.M. Porteous, A.M. James, M.F. Ross, A. Logan, H.M. Cochemé, J. Trnka, T.A. Prime, I. Abakumova, B.A. Jones, A. Filipovska, and M.P. Murphy Mitochondria-targeted antioxidants in the treatment of disease Ann. N. Y. Acad. Sci. 1147 2008 105 111
-
(2008)
Ann. N. Y. Acad. Sci.
, vol.1147
, pp. 105-111
-
-
Smith, R.A.1
Adlam, V.J.2
Blaikie, F.H.3
Manas, A.R.4
Porteous, C.M.5
James, A.M.6
Ross, M.F.7
Logan, A.8
Cochemé, H.M.9
Trnka, J.10
Prime, T.A.11
Abakumova, I.12
Jones, B.A.13
Filipovska, A.14
Murphy, M.P.15
-
4
-
-
67349283471
-
An attempt to prevent senescence: A mitochondrial approach
-
V.P. Skulachev, V.N. Anisimov, Y.N. Antonenko, L.E. Bakeeva, B.V. Chernyak, V.P. Erichev, O.F. Filenko, N.I. Kalinina, V.I. Kapelko, N.G. Kolosova, B.P. Kopnin, G.A. Korshunova, M.R. Lichinitser, L.A. Obukhova, E.G. Pasyukova, O.I. Pisarenko, V.A. Roginsky, E.K. Ruuge, I.I. Senin, I.I. Severina, M.V. Skulachev, I.M. Spivak, V.N. Tashlitsky, V.A. Tkachuk, M.Y. Vyssokikh, L.S. Yaguzhinsky, and D.B. Zorov An attempt to prevent senescence: a mitochondrial approach Biochim. Biophys. Acta 1787 2009 437 461
-
(2009)
Biochim. Biophys. Acta
, vol.1787
, pp. 437-461
-
-
Skulachev, V.P.1
Anisimov, V.N.2
Antonenko, Y.N.3
Bakeeva, L.E.4
Chernyak, B.V.5
Erichev, V.P.6
Filenko, O.F.7
Kalinina, N.I.8
Kapelko, V.I.9
Kolosova, N.G.10
Kopnin, B.P.11
Korshunova, G.A.12
Lichinitser, M.R.13
Obukhova, L.A.14
Pasyukova, E.G.15
Pisarenko, O.I.16
Roginsky, V.A.17
Ruuge, E.K.18
Senin, I.I.19
Severina, I.I.20
Skulachev, M.V.21
Spivak, I.M.22
Tashlitsky, V.N.23
Tkachuk, V.A.24
Vyssokikh, M.Y.25
Yaguzhinsky, L.S.26
Zorov, D.B.27
more..
-
5
-
-
77955283395
-
Animal and human studies with the mitochondria-targeted antioxidant MitoQ
-
R.A. Smith, and M.P. Murphy Animal and human studies with the mitochondria-targeted antioxidant MitoQ Ann. N. Y. Acad. Sci. 1201 2010 96 103
-
(2010)
Ann. N. Y. Acad. Sci.
, vol.1201
, pp. 96-103
-
-
Smith, R.A.1
Murphy, M.P.2
-
6
-
-
47549092354
-
α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II
-
DOI 10.1038/onc.2008.69, PII ONC200869
-
L.F. Dong, P. Low, J.C. Dyason, X.F. Wang, L. Prochazka, P.K. Witting, R. Freeman, E. Swettenham, K. Valis, J. Liu, R. Zobalova, J. Turanek, D.R. Spitz, F.E. Domann, I.E. Scheffler, S.J. Ralph, and J. Neuzil Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II Oncogene 27 2008 4324 4335 (Pubitemid 352010000)
-
(2008)
Oncogene
, vol.27
, Issue.31
, pp. 4324-4335
-
-
Dong, L.-F.1
Low, P.2
Dyason, J.C.3
Wang, X.-F.4
Prochazka, L.5
Witting, P.K.6
Freeman, R.7
Swettenham, E.8
Valis, K.9
Liu, J.10
Zobalova, R.11
Turanek, J.12
Spitz, D.R.13
Domann, F.E.14
Scheffler, I.E.15
Ralph, S.J.16
Neuzil, J.17
-
7
-
-
63549096948
-
Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II
-
L.F. Dong, R. Freeman, J. Liu, R. Zobalova, A. Marin-Hernandez, M. Stantic, J. Rohlena, K. Valis, S. Rodriguez-Enriquez, B. Butcher, J. Goodwin, U.T. Brunk, P.K. Witting, R. Moreno-Sanchez, I.E. Scheffler, S.J. Ralph, and J. Neuzil Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II Clin. Cancer Res. 15 2009 1593 1600
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 1593-1600
-
-
Dong, L.F.1
Freeman, R.2
Liu, J.3
Zobalova, R.4
Marin-Hernandez, A.5
Stantic, M.6
Rohlena, J.7
Valis, K.8
Rodriguez-Enriquez, S.9
Butcher, B.10
Goodwin, J.11
Brunk, U.T.12
Witting, P.K.13
Moreno-Sanchez, R.14
Scheffler, I.E.15
Ralph, S.J.16
Neuzil, J.17
-
8
-
-
79952786984
-
Mitochondrial targeting of vitamin e succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II
-
L.F. Dong, V.J. Jameson, D. Tilly, J. Cerny, E. Mahdavian, A. Marín-Hernández, L. Hernández-Esquivel, S. Rodríguez-Enríquez, J. Stursa, P.K. Witting, B. Stantic, J. Rohlena, J. Truksa, K. Kluckova, J.C. Dyason, M. Ledvina, B.A. Salvatore, R. Moreno-Sánchez, M.J. Coster, S.J. Ralph, R.A. Smith, and J. Neuzil Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II J. Biol. Chem. 286 2011 3717 3728
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 3717-3728
-
-
Dong, L.F.1
Jameson, V.J.2
Tilly, D.3
Cerny, J.4
Mahdavian, E.5
Marín-Hernández, A.6
Hernández-Esquivel, L.7
Rodríguez-Enríquez, S.8
Stursa, J.9
Witting, P.K.10
Stantic, B.11
Rohlena, J.12
Truksa, J.13
Kluckova, K.14
Dyason, J.C.15
Ledvina, M.16
Salvatore, B.A.17
Moreno-Sánchez, R.18
Coster, M.J.19
Ralph, S.J.20
Smith, R.A.21
Neuzil, J.22
more..
-
9
-
-
74149087396
-
Consequences of long-term oral administration of the mitochondria- targeted antioxidant MitoQ to wild-type mice
-
S. Rodriguez-Cuenca, H.M. Cochemé, A. Logan, I. Abakumova, T.A. Prime, C. Rose, A. Vidal-Puig, A.C. Smith, D.C. Rubinsztein, I.M. Fearnley, B.A. Jones, S. Pope, S.J. Heales, B.Y. Lam, S.G. Neogi, I. McFarlane, A.M. James, R.A. Smith, and M.P. Murphy Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice Free Radic. Biol. Med. 48 2010 161 172
-
(2010)
Free Radic. Biol. Med.
, vol.48
, pp. 161-172
-
-
Rodriguez-Cuenca, S.1
Cochemé, H.M.2
Logan, A.3
Abakumova, I.4
Prime, T.A.5
Rose, C.6
Vidal-Puig, A.7
Smith, A.C.8
Rubinsztein, D.C.9
Fearnley, I.M.10
Jones, B.A.11
Pope, S.12
Heales, S.J.13
Lam, B.Y.14
Neogi, S.G.15
McFarlane, I.16
James, A.M.17
Smith, R.A.18
Murphy, M.P.19
-
10
-
-
35448968884
-
Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis
-
DOI 10.1089/ars.2007.1693
-
A.K. Doughn, and S.I. Dikalov Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis Antiox. Redox Signal. 9 2007 1825 1836 (Pubitemid 47622346)
-
(2007)
Antioxidants and Redox Signaling
, vol.9
, Issue.11
, pp. 1825-1836
-
-
Doughan, A.K.1
Dikalov, S.I.2
-
11
-
-
59449097051
-
A mitochondriotropic derivative of quercetin: A strategy to increase the effectiveness of polyphenols
-
A. Mattarei, L. Biasutto, E. Marotta, U. De Marchi, N. Sassi, S. Garbisa, M. Zoratti, and C. Paradisi A mitochondriotropic derivative of quercetin: a strategy to increase the effectiveness of polyphenols ChemBioChem 9 2008 2633 2642
-
(2008)
ChemBioChem
, vol.9
, pp. 2633-2642
-
-
Mattarei, A.1
Biasutto, L.2
Marotta, E.3
De Marchi, U.4
Sassi, N.5
Garbisa, S.6
Zoratti, M.7
Paradisi, C.8
-
12
-
-
80053198141
-
Redox properties and cytotoxicity of synthetic isomeric mitochondriotropic derivatives of the natural polyphenol quercetin
-
A. Mattarei, N. Sassi, C. Durante, L. Biasutto, G. Sandonà, E. Marotta, S. Garbisa, A. Gennaro, C. Paradisi, and M. Zoratti Redox properties and cytotoxicity of synthetic isomeric mitochondriotropic derivatives of the natural polyphenol quercetin Eur. J. Org. Chem. 2011 2011 5577 5586
-
(2011)
Eur. J. Org. Chem.
, vol.2011
, pp. 5577-5586
-
-
Mattarei, A.1
Sassi, N.2
Durante, C.3
Biasutto, L.4
Sandonà, G.5
Marotta, E.6
Garbisa, S.7
Gennaro, A.8
Paradisi, C.9
Zoratti, M.10
-
13
-
-
53449086865
-
Development of mitochondria-targeted derivatives of resveratrol
-
L. Biasutto, A. Mattarei, E. Marotta, A. Bradaschia, N. Sassi, S. Garbisa, M. Zoratti, and C. Paradisi Development of mitochondria-targeted derivatives of resveratrol Bioorg. Med. Chem. Lett. 18 2008 5594 5597
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 5594-5597
-
-
Biasutto, L.1
Mattarei, A.2
Marotta, E.3
Bradaschia, A.4
Sassi, N.5
Garbisa, S.6
Zoratti, M.7
Paradisi, C.8
-
14
-
-
73249137593
-
Impact of mitochondriotropic quercetin derivatives on mitochondria
-
L. Biasutto, N. Sassi, A. Mattarei, E. Marotta, P. Cattelan, A. Toninello, S. Garbisa, M. Zoratti, and C. Paradisi Impact of mitochondriotropic quercetin derivatives on mitochondria Biochim. Biophys. Acta 1797 2010 189 196
-
(2010)
Biochim. Biophys. Acta
, vol.1797
, pp. 189-196
-
-
Biasutto, L.1
Sassi, N.2
Mattarei, A.3
Marotta, E.4
Cattelan, P.5
Toninello, A.6
Garbisa, S.7
Zoratti, M.8
Paradisi, C.9
-
15
-
-
0031020195
-
Antioxidant and prooxidant behavior of flavonoids: Structure-activity relationships
-
DOI 10.1016/S0891-5849(96)00351-6, PII S0891584996003516
-
G. Cao, E. Sofic, and R.L. Prior Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships Free Radic. Biol. Med. 22 1997 749 760 (Pubitemid 27058337)
-
(1997)
Free Radical Biology and Medicine
, vol.22
, Issue.5
, pp. 749-760
-
-
Cao, G.1
Sofic, E.2
Prior, R.L.3
-
16
-
-
0033052299
-
Glutathione-dependent generation of reactive oxygen species by the peroxidase-catalyzed redox cycling of flavonoids
-
DOI 10.1021/tx980271b
-
G. Galati, T. Chan, B. Wu, and P.J. O'Brien Glutathione-dependent generation of reactive oxygen species by the peroxidase-catalyzed redox cycling of flavonoids Chem. Res. Toxicol. 12 1999 521 525 (Pubitemid 29282923)
-
(1999)
Chemical Research in Toxicology
, vol.12
, Issue.6
, pp. 521-525
-
-
Galati, G.1
Chan, T.2
Wu, B.3
O'Brien, P.J.4
-
17
-
-
48349140474
-
Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?
-
B. Halliwell Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch. Biochem. Biophys. 476 2008 107 112
-
(2008)
Arch. Biochem. Biophys.
, vol.476
, pp. 107-112
-
-
Halliwell, B.1
-
18
-
-
69249214137
-
Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols
-
U. De Marchi, L. Biasutto, S. Garbisa, A. Toninello, and M. Zoratti Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: a demonstration of the ambivalent redox character of polyphenols Biochim. Biophys. Acta 1787 2009 1425 1432
-
(2009)
Biochim. Biophys. Acta
, vol.1787
, pp. 1425-1432
-
-
De Marchi, U.1
Biasutto, L.2
Garbisa, S.3
Toninello, A.4
Zoratti, M.5
-
19
-
-
0037246317
-
Anti- and pro-oxidant activity of rutin and quercetin derivatives
-
DOI 10.1211/002235702559
-
M. Kessler, G. Ubeaud, and L. Jung Anti- and pro-oxidant activity of rutin and quercetin derivatives J. Pharm. Pharmacol. 55 2003 131 142 (Pubitemid 36142091)
-
(2003)
Journal of Pharmacy and Pharmacology
, vol.55
, Issue.1
, pp. 131-142
-
-
Kessler, M.1
Ubeaud, G.2
Jung, L.3
-
20
-
-
77949908145
-
Hormesis is central to toxicology, pharmacology and risk assessment
-
E.J. Calabrese Hormesis is central to toxicology, pharmacology and risk assessment Hum. Exp. Toxicol. 29 2010 249 261
-
(2010)
Hum. Exp. Toxicol.
, vol.29
, pp. 249-261
-
-
Calabrese, E.J.1
-
21
-
-
77950268110
-
The hormetic role of dietary antioxidants in free radical-related diseases
-
V. Calabrese, C. Cornelius, A. Trovato, M. Cavallaro, C. Mancuso, L. Di Rienzo, D. Condorelli, A. De Lorenzo, and E.J. Calabrese The hormetic role of dietary antioxidants in free radical-related diseases Curr. Pharm. Des. 16 2010 877 883
-
(2010)
Curr. Pharm. Des.
, vol.16
, pp. 877-883
-
-
Calabrese, V.1
Cornelius, C.2
Trovato, A.3
Cavallaro, M.4
Mancuso, C.5
Di Rienzo, L.6
Condorelli, D.7
De Lorenzo, A.8
Calabrese, E.J.9
-
22
-
-
77954978354
-
Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative
-
A. Mattarei, L. Biasutto, F. Rastrelli, S. Garbisa, E. Marotta, M. Zoratti, and C. Paradisi Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative Molecules 15 2010 4722 4736
-
(2010)
Molecules
, vol.15
, pp. 4722-4736
-
-
Mattarei, A.1
Biasutto, L.2
Rastrelli, F.3
Garbisa, S.4
Marotta, E.5
Zoratti, M.6
Paradisi, C.7
-
23
-
-
79957652846
-
Fluorescence properties of quercetin in human leukemia Jurkat T-cells
-
I. Baran, C. Ganea, I. Ursu, V. Baran, O. Calinescu, A. Iftime, R. Ungureanu, and I.T. Tofolean Fluorescence properties of quercetin in human leukemia Jurkat T-cells Rom. J. Phys. 56 2011 388 398
-
(2011)
Rom. J. Phys.
, vol.56
, pp. 388-398
-
-
Baran, I.1
Ganea, C.2
Ursu, I.3
Baran, V.4
Calinescu, O.5
Iftime, A.6
Ungureanu, R.7
Tofolean, I.T.8
-
27
-
-
77952576788
-
Cell death mechanisms: Cross-talk and role in disease
-
B. Zhivotovsky, and S. Orrenius Cell death mechanisms: cross-talk and role in disease Exp. Cell Res. 316 2010 1374 1383
-
(2010)
Exp. Cell Res.
, vol.316
, pp. 1374-1383
-
-
Zhivotovsky, B.1
Orrenius, S.2
-
28
-
-
78650175369
-
ZVAD-induced necrosis in L929 cells depends on autocrine production of TNFalpha mediated by the PKC-MAPK-AP-1 pathway
-
Y.T. Wu, H.L. Tan, Q. Huang, X.J. Sun, and H.M. Shen zVAD-induced necrosis in L929 cells depends on autocrine production of TNFalpha mediated by the PKC-MAPK-AP-1 pathway Cell Death Differ. 18 2011 26 37
-
(2011)
Cell Death Differ.
, vol.18
, pp. 26-37
-
-
Wu, Y.T.1
Tan, H.L.2
Huang, Q.3
Sun, X.J.4
Shen, H.M.5
-
29
-
-
0030900980
-
Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
-
DOI 10.1084/jem.185.8.1481
-
M. Leist, B. Single, A.F. Castoldi, S. Kühnle, and P. Nicotera Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis J. Exp. Med. 185 1997 1481 1486 (Pubitemid 27187604)
-
(1997)
Journal of Experimental Medicine
, vol.185
, Issue.8
, pp. 1481-1486
-
-
Leist, M.1
Single, B.2
Castoldi, A.F.3
Kuhnle, S.4
Nicotera, P.5
-
30
-
-
79960917666
-
Autophagy as a mediator of chemotherapy-induced cell death in cancer
-
A. Notte, L. Leclere, and C. Michiels Autophagy as a mediator of chemotherapy-induced cell death in cancer Biochem. Pharmacol. 82 2011 427 434
-
(2011)
Biochem. Pharmacol.
, vol.82
, pp. 427-434
-
-
Notte, A.1
Leclere, L.2
Michiels, C.3
-
32
-
-
75749122303
-
Methods in mammalian autophagy research
-
N. Mizushima, T. Yoshimori, and B. Levine Methods in mammalian autophagy research Cell 140 2010 313 326
-
(2010)
Cell
, vol.140
, pp. 313-326
-
-
Mizushima, N.1
Yoshimori, T.2
Levine, B.3
-
33
-
-
0345120940
-
Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives
-
R.C. Scaduto Jr., and L.W. Grotyohann Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives Biophys. J. 76 1999 469 477 (Pubitemid 29202474)
-
(1999)
Biophysical Journal
, vol.76
, Issue.1
, pp. 469-477
-
-
Scaduto Jr., R.C.1
Grotyohann, L.W.2
-
34
-
-
58249093939
-
How mitochondria produce reactive oxygen species
-
M.P. Murphy How mitochondria produce reactive oxygen species Biochem. J. 417 2009 1 13
-
(2009)
Biochem. J.
, vol.417
, pp. 1-13
-
-
Murphy, M.P.1
-
35
-
-
78650436415
-
Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signalling
-
M. Müller, K.H. Cheung, and J.K. Foskett Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signalling Antioxid. Redox Signal. 14 2011 1225 1235
-
(2011)
Antioxid. Redox Signal.
, vol.14
, pp. 1225-1235
-
-
Müller, M.1
Cheung, K.H.2
Foskett, J.K.3
-
37
-
-
80052621140
-
Calcium and cell death mechanisms: A perspective from the cell death community
-
B. Zhivotovsky, and S. Orrenius Calcium and cell death mechanisms: a perspective from the cell death community Cell Calcium 50 2011 211 221
-
(2011)
Cell Calcium
, vol.50
, pp. 211-221
-
-
Zhivotovsky, B.1
Orrenius, S.2
-
38
-
-
34250777194
-
The quercetin paradox
-
DOI 10.1016/j.taap.2007.04.004, PII S0041008X0700169X
-
A.W. Boots, H. Li, R.P. Schins, R. Duffin, J.W. Heemskerk, A. Bast, and G.R. Haenen The quercetin paradox Toxicol. Appl. Pharmacol. 222 2007 89 96 (Pubitemid 46962659)
-
(2007)
Toxicology and Applied Pharmacology
, vol.222
, Issue.1
, pp. 89-96
-
-
Boots, A.W.1
Li, H.2
Schins, R.P.F.3
Duffin, R.4
Heemskerk, J.W.M.5
Bast, A.6
Haenen, G.R.M.M.7
-
39
-
-
0036679876
-
Plant phenolic antioxidant and prooxidant activities: Phenolics-induced oxidative damage mediated by metals in plants
-
DOI 10.1016/S0300-483X(02)00196-8, PII S0300483X02001968
-
Y. Sakihama, M.F. Cohen, S.C. Grace, and H. Yamasaki Plant phenolic antioxidant and prooxidant activities: phenolics-induced oxidative damage mediated by metals in plants Toxicology 177 2002 67 80 (Pubitemid 34786245)
-
(2002)
Toxicology
, vol.177
, Issue.1
, pp. 67-80
-
-
Sakihama, Y.1
Cohen, M.F.2
Grace, S.C.3
Yamasaki, H.4
-
40
-
-
0345148810
-
Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product
-
DOI 10.1016/S0891-5849(98)00167-1, PII S0891584998001671
-
D. Metodiewa, A.K. Jaiswal, N. Cenas, E. Dickancaité, and J. Segura-Aguilar Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product Free Radic. Biol. Med. 26 1999 107 116 (Pubitemid 29001498)
-
(1998)
Free Radical Biology and Medicine
, vol.26
, Issue.1-2
, pp. 107-116
-
-
Metodiewa, D.1
Jaiswal, A.K.2
Cenas, N.3
Dickancaite, E.4
Segura-Aguilar, J.5
-
41
-
-
73449124480
-
Mitochondrial glutathione, a key survival antioxidant
-
M. Marí, A. Morales, A. Colell, C. García-Ruiz, and J.C. Fernández-Checa Mitochondrial glutathione, a key survival antioxidant Antiox. Redox Signal. 11 2009 2685 2700
-
(2009)
Antiox. Redox Signal.
, vol.11
, pp. 2685-2700
-
-
Marí, M.1
Morales, A.2
Colell, A.3
García-Ruiz, C.4
Fernández-Checa, J.C.5
-
42
-
-
70349172938
-
Apoptosis and glutathione: Beyond an antioxidant
-
R. Franco, and J.A. Cidlowski Apoptosis and glutathione: beyond an antioxidant Cell Death Differ. 16 2009 1303 1314
-
(2009)
Cell Death Differ.
, vol.16
, pp. 1303-1314
-
-
Franco, R.1
Cidlowski, J.A.2
-
43
-
-
76049083966
-
Reactive oxygen species, cellular redox systems, and apoptosis
-
M.L. Circu, and T.Y. Aw Reactive oxygen species, cellular redox systems, and apoptosis Free Radic. Biol. Med. 48 2010 749 762
-
(2010)
Free Radic. Biol. Med.
, vol.48
, pp. 749-762
-
-
Circu, M.L.1
Aw, T.Y.2
-
44
-
-
0026495979
-
Effects of phenol compounds, glutathione analogues and a diuretic drug on glutathione S-transferase, glutathione reductase and glutathione peroxidase from canine erythrocytes
-
M. Kurata, M. Suzuki, and K. Takeda Effects of phenol compounds, glutathione analogues and a diuretic drug on glutathione S-transferase, glutathione reductase and glutathione peroxidase from canine erythrocytes Comp. Biochem. Physiol. B 103 1992 863 867
-
(1992)
Comp. Biochem. Physiol. B
, vol.103
, pp. 863-867
-
-
Kurata, M.1
Suzuki, M.2
Takeda, K.3
-
45
-
-
0026744221
-
Inhibition of glutathione reductase by flavonoids: A structure-activity study
-
A.J. Elliott, S.A. Scheiber, C. Thomas, and R.S. Pardini Inhibition of glutathione reductase by flavonoids: a structure-activity study Biochem. Pharmacol. 44 1992 1603 1608
-
(1992)
Biochem. Pharmacol.
, vol.44
, pp. 1603-1608
-
-
Elliott, A.J.1
Scheiber, S.A.2
Thomas, C.3
Pardini, R.S.4
-
46
-
-
0030722172
-
Inhibition of glutathione reductase by plant polyphenols
-
DOI 10.1016/S0006-2952(97)00315-8, PII S0006295297003158
-
K. Zhang, E.B. Yang, W.Y. Tang, K.P. Wong, and P. Mack Inhibition of glutathione reductase by plant polyphenols Biochem. Pharmacol. 54 1997 1047 1053 (Pubitemid 27475244)
-
(1997)
Biochemical Pharmacology
, vol.54
, Issue.9
, pp. 1047-1053
-
-
Zhang, K.1
Yang, E.-B.2
Tang, W.-Y.3
Wong, K.P.4
Mack, P.5
-
47
-
-
15244352965
-
Long-term combined administration of quercetin and daidzein inhibits quercetin-induced suppression of glutathione antioxidant defenses
-
DOI 10.1016/j.fct.2004.12.012
-
E.J. Choi, B.H. Lee, K. Lee, and K.M. Chee Long-term combined administration of quercetin and daidzein inhibits quercetin-induced suppression of glutathione antioxidant defenses Food Chem. Toxicol. 43 2005 793 798 (Pubitemid 40385120)
-
(2005)
Food and Chemical Toxicology
, vol.43
, Issue.5
, pp. 793-798
-
-
Choi, E.J.1
Lee, B.H.2
Lee, K.3
Chee, K.-M.4
-
48
-
-
0037422461
-
Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin
-
DOI 10.1016/S0009-2797(02)00250-8
-
J.J. van Zanden, O. Ben Hamman, M.L. van Iersel, S. Boeren, N.H. Cnubben, M. Lo Bello, J. Vervoort, P.J. van Bladeren, and I.M. Rietjens Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin Chem. Biol. Interact. 145 2003 139 148 (Pubitemid 36398427)
-
(2003)
Chemico-Biological Interactions
, vol.145
, Issue.2
, pp. 139-148
-
-
Van Zanden, J.J.1
Hamman, O.B.2
Van Iersel, M.L.P.S.3
Boeren, S.4
Cnubben, N.H.P.5
Lo Bello, M.6
Vervoort, J.7
Van Bladeren, P.J.8
Rietjens, I.M.C.M.9
-
49
-
-
33646233781
-
Inhibition of mammalian thioredoxin reductase by some flavonoids: Implications for myricetin and quercetin anticancer activity
-
J. Lu, L.V. Papp, J. Fang, S. Rodriguez-Nieto, B. Zhivotovsky, and A. Holmgren Inhibition of mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity Cancer Res. 66 2006 4410 4418
-
(2006)
Cancer Res.
, vol.66
, pp. 4410-4418
-
-
Lu, J.1
Papp, L.V.2
Fang, J.3
Rodriguez-Nieto, S.4
Zhivotovsky, B.5
Holmgren, A.6
-
50
-
-
0032094557
-
Effect of antioxidants (digoxin, quercetin, and ascorbic acid) on catalytic properties of horseradish peroxidase
-
V.V. Rogozhin, and V.V. Verkhoturov Effect of antioxidants (digoxin, quercetin, and ascorbic acid) on catalytic properties of horseradish peroxidise Biochemistry (Mosc) 63 1998 657 661 (Pubitemid 128588074)
-
(1998)
Biochemistry (Moscow)
, vol.63
, Issue.6
, pp. 657-661
-
-
Rogozhin, V.V.1
Verkhoturov, V.V.2
-
51
-
-
0022259872
-
Inactivation of glutathione peroxidase by superoxide radical
-
DOI 10.1016/0003-9861(85)90056-6
-
J. Blum, and I. Fridovich Inactivation of glutathione peroxidase by superoxide radical Arch. Biochem. Biophys. 240 1985 500 508 (Pubitemid 15250062)
-
(1985)
Archives of Biochemistry and Biophysics
, vol.240
, Issue.2
, pp. 500-508
-
-
Blum, J.1
Fridovich, I.2
-
52
-
-
84856431622
-
The end of autophagic cell death?
-
Shen, O. Kepp, and G. Kroemer The end of autophagic cell death? Autophagy 8 2012 1 3
-
(2012)
Autophagy
, vol.8
, pp. 1-3
-
-
Shen1
Kepp, O.2
Kroemer, G.3
-
53
-
-
0037094386
-
Autoschizis: A novel cell death
-
DOI 10.1016/S0006-2952(02)00904-8, PII S0006295202009048
-
J.M. Jamison, J. Gilloteaux, H.S. Taper, P.B. Calderon, and J.L. Summers Autoschizis: a novel cell death Biochem. Pharmacol. 63 2002 1773 1783 (Pubitemid 34603442)
-
(2002)
Biochemical Pharmacology
, vol.63
, Issue.10
, pp. 1773-1783
-
-
Jamison, J.M.1
Gilloteaux, J.2
Taper, H.S.3
Calderon, P.B.4
Summers, J.L.5
-
54
-
-
70349680622
-
Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells
-
S.Y. Chien, Y.C. Wu, J.G. Chung, J.S. Yang, H.F. Lu, M.F. Tsou, W.G. Wood, S.J. Kuo, and D.R. Chen Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells Hum. Exp. Toxicol. 28 2009 493 503
-
(2009)
Hum. Exp. Toxicol.
, vol.28
, pp. 493-503
-
-
Chien, S.Y.1
Wu, Y.C.2
Chung, J.G.3
Yang, J.S.4
Lu, H.F.5
Tsou, M.F.6
Wood, W.G.7
Kuo, S.J.8
Chen, D.R.9
-
55
-
-
77955773776
-
Cytoprotective effects of silymarin on epithelial cells against arsenic-induced apoptosis in contrast with quercetin cytotoxicity
-
E.A. Soria, A.R. Eynard, and G.A. Bongiovanni Cytoprotective effects of silymarin on epithelial cells against arsenic-induced apoptosis in contrast with quercetin cytotoxicity Life Sci. 87 2010 309 315
-
(2010)
Life Sci.
, vol.87
, pp. 309-315
-
-
Soria, E.A.1
Eynard, A.R.2
Bongiovanni, G.A.3
-
56
-
-
78049294193
-
The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-kB inhibition
-
R.V. Priyadarsini, R.S. Murugan, S. Maitreyi, K. Ramalingam, D. Karunagaran, and S. Nagini The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-kB inhibition Eur. J. Pharmacol. 649 2010 84 91
-
(2010)
Eur. J. Pharmacol.
, vol.649
, pp. 84-91
-
-
Priyadarsini, R.V.1
Murugan, R.S.2
Maitreyi, S.3
Ramalingam, K.4
Karunagaran, D.5
Nagini, S.6
-
57
-
-
77957319672
-
Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells
-
C.C. Chou, J.S. Yang, H.F. Lu, S.W. Ip, C.C. Wu, J.P. Lin, N.Y. Tang, J.G. Chung, M.J. Chou, Y.H. Teng, and D.R. Cehn Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells Arch. Pharm. Res. 33 2010 1181 1191
-
(2010)
Arch. Pharm. Res.
, vol.33
, pp. 1181-1191
-
-
Chou, C.C.1
Yang, J.S.2
Lu, H.F.3
Ip, S.W.4
Wu, C.C.5
Lin, J.P.6
Tang, N.Y.7
Chung, J.G.8
Chou, M.J.9
Teng, Y.H.10
Cehn, D.R.11
-
58
-
-
79960894101
-
Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells
-
H. Seibert, E. Maser, K. Schweda, S. Seibert, and M. Gülden Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells Food Chem. Toxicol. 49 2011 2398 2407
-
(2011)
Food Chem. Toxicol.
, vol.49
, pp. 2398-2407
-
-
Seibert, H.1
Maser, E.2
Schweda, K.3
Seibert, S.4
Gülden, M.5
-
59
-
-
34447530779
-
Induction of apoptosis by quercetin: Different response of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells
-
F. Brisdelli, C. Coccia, B. Cinque, M.G. Cifone, and A. Bozzi Induction of apoptosis by quercetin: different response of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells Mol. Cell. Biochem. 296 2007 137 149
-
(2007)
Mol. Cell. Biochem.
, vol.296
, pp. 137-149
-
-
Brisdelli, F.1
Coccia, C.2
Cinque, B.3
Cifone, M.G.4
Bozzi, A.5
-
61
-
-
78650334862
-
Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax
-
S. Cheng, N. Gao, Z. Zhang, G. Chen, A. Budhraja, Z. Ke, Y. Son, X. Wang, J. Luo, and X. Shi Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax Clin. Cancer Res. 16 2010 5679 5691
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 5679-5691
-
-
Cheng, S.1
Gao, N.2
Zhang, Z.3
Chen, G.4
Budhraja, A.5
Ke, Z.6
Son, Y.7
Wang, X.8
Luo, J.9
Shi, X.10
-
62
-
-
27244453562
-
Quantitative structure-activity relationships in prooxidant cytotoxicity of polyphenols: Role of potential of phenoxyl radical/phenol redox couple
-
DOI 10.1016/j.abb.2005.07.002
-
A. Nemeikaite-Ceniene, A. Imbrasaite, E. Sergediene, and N. Cenas Quantitative structure-activity relationships in prooxidant cytotoxicity of polyphenols: role of potential of phenoxyl radical/phenol redox couple Arch. Biochem. Biophys. 441 2005 182 190 (Pubitemid 41557695)
-
(2005)
Archives of Biochemistry and Biophysics
, vol.441
, Issue.2
, pp. 182-190
-
-
Nemeikaite-Ceniene, A.1
Imbrasaite, A.2
Sergediene, E.3
Cenas, N.4
-
63
-
-
69149085268
-
Protective mechanism of quercetin and rutin using glutathione metabolism on HO-induced oxidative stress in HepG2 cells
-
G.N. Kim, and H.D. Jang Protective mechanism of quercetin and rutin using glutathione metabolism on HO-induced oxidative stress in HepG2 cells Ann. N. Y. Acad. Sci. 1171 2009 530 537
-
(2009)
Ann. N. Y. Acad. Sci.
, vol.1171
, pp. 530-537
-
-
Kim, G.N.1
Jang, H.D.2
-
64
-
-
77956634425
-
Hormesis and synergy: Pathways and mechanisms of quercetin in cancer prevention and management
-
A.J. Vargas, and R. Burd Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management Nutr. Rev. 68 2010 418 428
-
(2010)
Nutr. Rev.
, vol.68
, pp. 418-428
-
-
Vargas, A.J.1
Burd, R.2
-
65
-
-
0034660208
-
Peroxidase-catalyzed formation of quercetin quinone methide-glutathione adducts
-
DOI 10.1006/abbi.2000.1832
-
H.M. Awad, M.G. Boersma, J. Vervoort, and I.M. Rietjens Peroxidase-catalyzed formation of quercetin quinone methide-glutathione adducts Arch. Biochem. Biophys. 378 2000 224 233 (Pubitemid 30397623)
-
(2000)
Archives of Biochemistry and Biophysics
, vol.378
, Issue.2
, pp. 224-233
-
-
Awad, H.M.1
Boersma, M.G.2
Vervoort, J.3
Rietjens, I.M.C.M.4
-
66
-
-
29644439608
-
Formation of transient covalent protein and DNA adducts by quercetin in cells with and without oxidative enzyme activity
-
DOI 10.1021/tx050201m
-
H. van der Woude, G.M. Alink, B.E. van Rossum, K. Walle, H. van Steeg, T. Walle, and I.M. Rietjens Formation of transient covalent protein and DNA adducts by quercetin in cells with and without oxidative enzyme activity Chem. Res. Toxicol. 18 2005 1907 1916 (Pubitemid 43023049)
-
(2005)
Chemical Research in Toxicology
, vol.18
, Issue.12
, pp. 1907-1916
-
-
Van Der Woude, H.1
Alink, G.M.2
Van Rossum, B.E.J.3
Walle, K.4
Van Steeg, H.5
Walle, T.6
Rietjens, I.M.C.M.7
-
67
-
-
42649083649
-
Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines
-
A.M. Ramos, and P. Aller Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines Biochem. Pharmacol. 75 2008 1912 1923
-
(2008)
Biochem. Pharmacol.
, vol.75
, pp. 1912-1923
-
-
Ramos, A.M.1
Aller, P.2
-
68
-
-
61349146539
-
Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: Importance of the glutamate cysteine ligase modifier subunit
-
S. Lavoie, Y. Chen, T.P. Dalton, R. Gysin, M. Cuénod, P. Steullet, and K.Q. Do Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit J. Neurochem. 108 2009 1410 1422
-
(2009)
J. Neurochem.
, vol.108
, pp. 1410-1422
-
-
Lavoie, S.1
Chen, Y.2
Dalton, T.P.3
Gysin, R.4
Cuénod, M.5
Steullet, P.6
Do, K.Q.7
-
69
-
-
77955097118
-
After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult
-
F. Arredondo, C. Echeverry, J.A. Abin-Carriquiry, F. Blasina, K. Antúnez, D.P. Jones, Y.M. Go, Y.L. Liang, and F. Dajas After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult Free Radic. Biol. Med. 49 2010 738 747
-
(2010)
Free Radic. Biol. Med.
, vol.49
, pp. 738-747
-
-
Arredondo, F.1
Echeverry, C.2
Abin-Carriquiry, J.A.3
Blasina, F.4
Antúnez, K.5
Jones, D.P.6
Go, Y.M.7
Liang, Y.L.8
Dajas, F.9
-
70
-
-
35348865444
-
1-ATPase by resveratrol and related polyphenols
-
DOI 10.1073/pnas.0706290104
-
J.R. Gledhill, M.G. Montgomery, A.G. Leslie, and J.E. Walker Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols Proc. Natl. Acad. Sci. U. S. A. 104 2007 13632 13637 (Pubitemid 350003372)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.34
, pp. 13632-13637
-
-
Gledhill, J.R.1
Montgomery, M.G.2
Leslie, A.G.W.3
Walker, J.E.4
-
71
-
-
0033922250
-
Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals
-
J. Zheng, and V.D. Ramirez Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals Br. J. Pharmacol. 130 2000 1115 1123 (Pubitemid 30453547)
-
(2000)
British Journal of Pharmacology
, vol.130
, Issue.5
, pp. 1115-1123
-
-
Zheng, J.1
Ramirez, V.D.2
-
72
-
-
79952033433
-
Quercetin inhibits a large panel of kinases implicated in cancer cell biology
-
R. Boly, T. Gras, T. Lamkami, P. Guissou, D. Serteyn, R. Kiss, and J. Dubois Quercetin inhibits a large panel of kinases implicated in cancer cell biology Int. J. Oncol. 38 2011 833 842
-
(2011)
Int. J. Oncol.
, vol.38
, pp. 833-842
-
-
Boly, R.1
Gras, T.2
Lamkami, T.3
Guissou, P.4
Serteyn, D.5
Kiss, R.6
Dubois, J.7
-
73
-
-
47649086229
-
Pyrogallol as a glutathione depletor induces apoptosis in HeLa cells
-
Y.H. Han, S.Z. Kim, S.H. Kim, and W.H. Park Pyrogallol as a glutathione depletor induces apoptosis in HeLa cells Int. J. Mol. Med. 21 2008 721 730
-
(2008)
Int. J. Mol. Med.
, vol.21
, pp. 721-730
-
-
Han, Y.H.1
Kim, S.Z.2
Kim, S.H.3
Park, W.H.4
-
74
-
-
78650173771
-
Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis
-
G. Loor, J. Kondapalli, J.M. Schriewer, N.S. Chandel, T.L. Vanden Hoek, and P.T. Schimaker Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis Free Radic. Biol. Med. 49 2010 1925 1936
-
(2010)
Free Radic. Biol. Med.
, vol.49
, pp. 1925-1936
-
-
Loor, G.1
Kondapalli, J.2
Schriewer, J.M.3
Chandel, N.S.4
Vanden Hoek, T.L.5
Schimaker, P.T.6
-
75
-
-
77955839687
-
Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism
-
J. Strathmann, K. Klimo, S.W. Sauer, J.G. Okun, J.H. Prehn, and C. Gerhäuser Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism FASEB J. 24 2010 2938 2950
-
(2010)
FASEB J.
, vol.24
, pp. 2938-2950
-
-
Strathmann, J.1
Klimo, K.2
Sauer, S.W.3
Okun, J.G.4
Prehn, J.H.5
Gerhäuser, C.6
-
76
-
-
78149359547
-
Mitochondrially targeted anti-cancer agents
-
Erratum in: Mitochondrion 11(2011) 996
-
L. Biasutto, L.F. Dong, M. Zoratti, and J. Neuzil Mitochondrially targeted anti-cancer agents Mitochondrion 10 2010 670 681 Erratum in: Mitochondrion 11(2011) 996
-
(2010)
Mitochondrion
, vol.10
, pp. 670-681
-
-
Biasutto, L.1
Dong, L.F.2
Zoratti, M.3
Neuzil, J.4
-
77
-
-
81155128482
-
Complex i and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria
-
R. Lagoa, I. Graziani, C. Lopez-Sanchez, V. Garcia-Martinez, and C. Gutierrez-Merino Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria Biochim. Biophys. Acta 1807 2011 1562 1572
-
(2011)
Biochim. Biophys. Acta
, vol.1807
, pp. 1562-1572
-
-
Lagoa, R.1
Graziani, I.2
Lopez-Sanchez, C.3
Garcia-Martinez, V.4
Gutierrez-Merino, C.5
-
78
-
-
0025050374
-
Flavonoids as superoxide scavengers and antioxidants
-
Y.T. Chen, R.L. Zheng, Z.J. Jia, and Y. Ju Flavonoids as superoxide scavengers and antioxidants Free Radic. Biol. Med. 9 1990 19 21 (Pubitemid 120036876)
-
(1990)
Free Radical Biology and Medicine
, vol.9
, Issue.1
, pp. 19-21
-
-
Chen, Y.1
Zheng, R.2
Jia, Z.3
Ju, Y.4
-
79
-
-
53449101213
-
Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2
-
A.L. Eggler, K.A. Gay, and A.D. Mesecar Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2 Mol. Nutr. Food Res. 52 Suppl. 1 2008 S84 S94
-
(2008)
Mol. Nutr. Food Res.
, vol.52
, Issue.SUPPL. 1
-
-
Eggler, A.L.1
Gay, K.A.2
Mesecar, A.D.3
-
80
-
-
79953285175
-
Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway
-
N. Miyamoto, H. Izumi, R. Miyamoto, H. Kondo, A. Tawara, Y. Sasaguri, and K. Kohno Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway Invest. Ophtalmol. Vis. Sci. 52 2011 1055 1063
-
(2011)
Invest. Ophtalmol. Vis. Sci.
, vol.52
, pp. 1055-1063
-
-
Miyamoto, N.1
Izumi, H.2
Miyamoto, R.3
Kondo, H.4
Tawara, A.5
Sasaguri, Y.6
Kohno, K.7
|