메뉴 건너뛰기




Volumn 4 E, Issue 2, 2012, Pages 607-619

Neuroprotective role of estrogens: Relationship with insulin/IGF-1 signaling

Author keywords

Aging; Estrogen; Insulin; Review

Indexed keywords

ESTRADIOL; ESTROGEN; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN C; NEUROPROTECTIVE AGENT;

EID: 84860855755     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (19)

References (137)
  • 1
    • 0034012731 scopus 로고    scopus 로고
    • Intracerebroventricular insulin enhances memory in a passive-avoidance task
    • C. R. Park, R. J. Seeley, S. Craft and S. C. Woods: Intracerebroventricular insulin enhances memory in a passive-avoidance task. PhysiolBehav 68, 509-514 (2000)
    • (2000) PhysiolBehav , vol.68 , pp. 509-514
    • Park, C.R.1    Seeley, R.J.2    Craft, S.3    Woods, S.C.4
  • 2
    • 0034938160 scopus 로고    scopus 로고
    • Cognitive effects of insulin in the central nervous system
    • C. R. Park: Cognitive effects of insulin in the central nervous system. Neurosci Biobehav Rev 25, 311-323 (2001)
    • (2001) Neurosci Biobehav Rev , vol.25 , pp. 311-323
    • Park, C.R.1
  • 3
    • 0031871767 scopus 로고    scopus 로고
    • Glucose treatment attenuates spatial learning and memory deficits of aged rats on tests of hippocampal function
    • G. Winocur and S. Gagnon: Glucose treatment attenuates spatial learning and memory deficits of aged rats on tests of hippocampal function. Neurobiol Aging 19, 233-241 (1998)
    • (1998) Neurobiol Aging , vol.19 , pp. 233-241
    • Winocur, G.1    Gagnon, S.2
  • 4
    • 0036838768 scopus 로고    scopus 로고
    • Protective effects of estrogen and selective estrogen receptor modulators in the brain
    • K. M. Dhandapani and D. W. Brann: Protective effects of estrogen and selective estrogen receptor modulators in the brain. Biol Reprod 67, 1379-1385 (2002)
    • (2002) Biol Reprod , vol.67 , pp. 1379-1385
    • Dhandapani, K.M.1    Brann, D.W.2
  • 8
    • 0037202286 scopus 로고    scopus 로고
    • Synergistic interaction of estradiol and insulin-like growth factor-I in the activation of PI3K/Akt signaling in the adult rat hypothalamus
    • G. P. Cardona-Gomez, P. Mendez and L. M. Garcia-Segura: Synergistic interaction of estradiol and insulin-like growth factor-I in the activation of PI3K/Akt signaling in the adult rat hypothalamus. Brain Res Mol Brain Res 107, 80-88 (2002)
    • (2002) Brain Res Mol Brain Res , vol.107 , pp. 80-88
    • Cardona-Gomez, G.P.1    Mendez, P.2    Garcia-Segura, L.M.3
  • 9
    • 34347252649 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor i signaling in neurons
    • 3194-202
    • D. Davila, J. Piriz, J. L. Trejo, A. Nunez and I. Torres- Aleman: Insulin and insulin-like growth factor I signaling in neurons. Front Biosci 12:3194-202., 3194-3202 (2007)
    • (2007) Front Biosci , vol.12 , pp. 3194-3202
    • Davila, D.1    Piriz, J.2    Trejo, J.L.3    Nunez, A.4    Torres- Aleman, I.5
  • 11
    • 23444432499 scopus 로고    scopus 로고
    • Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging
    • W. E. Sonntag, M. Ramsey and C. S. Carter: Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res Rev 4, 195-212 (2005)
    • (2005) Ageing Res Rev , vol.4 , pp. 195-212
    • Sonntag, W.E.1    Ramsey, M.2    Carter, C.S.3
  • 14
    • 0031426348 scopus 로고    scopus 로고
    • Effect of diabetes mellitus on the permeability of the blood-brain barrier to insulin
    • W. A. Banks, J. B. Jaspan and A. J. Kastin: Effect of diabetes mellitus on the permeability of the blood-brain barrier to insulin. Peptides 18, 1577-1584 (1997)
    • (1997) Peptides , vol.18 , pp. 1577-1584
    • Banks, W.A.1    Jaspan, J.B.2    Kastin, A.J.3
  • 15
    • 0033857975 scopus 로고    scopus 로고
    • Obesity induced by a highfat diet is associated with reduced brain insulin transport in dogs
    • K. J. Kaiyala, R. L. Prigeon, S. E. Kahn, S. C. Woods and M. W. Schwartz: Obesity induced by a highfat diet is associated with reduced brain insulin transport in dogs. Diabetes 49, 1525-1533 (2000)
    • (2000) Diabetes , vol.49 , pp. 1525-1533
    • Kaiyala, K.J.1    Prigeon, R.L.2    Kahn, S.E.3    Woods, S.C.4    Schwartz, M.W.5
  • 16
    • 0018090354 scopus 로고
    • Insulin receptors are widely distributed in the central nervous system of the rat
    • J. Havrankova, J. Roth and M. Brownstein: Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272, 827-829 (1978)
    • (1978) Nature , vol.272 , pp. 827-829
    • Havrankova, J.1    Roth, J.2    Brownstein, M.3
  • 17
    • 0025612094 scopus 로고
    • Localization of insulin receptor mRNA in rat brain by in situ hybridization
    • J. L. Marks, D. Porte, Jr., W. L. Stahl and D. G. Baskin: Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology 127, 3234-3236 (1990)
    • (1990) Endocrinology , vol.127 , pp. 3234-3236
    • Marks, J.L.1    Porte Jr., D.2    Stahl, W.L.3    Baskin, D.G.4
  • 18
    • 0023271871 scopus 로고
    • Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry
    • G. A. Werther, A. Hogg, B. J. Oldfield, M. J. McKinley, R. Figdor, A. M. Allen and F. A. Mendelsohn: Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. Endocrinology 121, 1562-1570 (1987)
    • (1987) Endocrinology , vol.121 , pp. 1562-1570
    • Werther, G.A.1    Hogg, A.2    Oldfield, B.J.3    McKinley, M.J.4    Figdor, R.5    Allen, A.M.6    Mendelsohn, F.A.7
  • 20
    • 33748295795 scopus 로고    scopus 로고
    • Insulin signaling in the central nervous system: Learning to survive
    • L. P. van der Heide, G. M. Ramakers and M. P. Smidt: Insulin signaling in the central nervous system: learning to survive. Prog Neurobiol 79, 205-221 (2006)
    • (2006) Prog Neurobiol , vol.79 , pp. 205-221
    • Van Der Heide, L.P.1    Ramakers, G.M.2    Smidt, M.P.3
  • 21
    • 1842633872 scopus 로고    scopus 로고
    • Insulin and the insulin receptor in experimental models of learning and memory
    • W. Q. Zhao, H. Chen, M. J. Quon and D. L. Alkon: Insulin and the insulin receptor in experimental models of learning and memory. Eur J Pharmacol 490, 71-81 (2004)
    • (2004) Eur J Pharmacol , vol.490 , pp. 71-81
    • Zhao, W.Q.1    Chen, H.2    Quon, M.J.3    Alkon, D.L.4
  • 22
    • 33645982255 scopus 로고    scopus 로고
    • From mice to men: Insights into the insulin resistance syndromes
    • S.B.Biddinger and C.R. Kahn. From mice to men: insights into the insulin resistance syndromes Annu Rev Physiol 68, 123-158, (2006)
    • (2006) Annu Rev Physiol , vol.68 , pp. 123-158
    • Biddinger, S.B.1    Kahn, C.R.2
  • 23
    • 0035319913 scopus 로고    scopus 로고
    • Brain glucose transporters: Relationship to local energy demand
    • R. Duelli and W. Kuschinsky: Brain glucose transporters: relationship to local energy demand. News Physiol Sci 16, 71-76 (2001)
    • (2001) News Physiol Sci , vol.16 , pp. 71-76
    • Duelli, R.1    Kuschinsky, W.2
  • 24
    • 0032487335 scopus 로고    scopus 로고
    • Immunocytochemical localization of the insulin-responsive glucose transporter 4 (Glut4) in the rat central nervous system
    • S. El Messari, C. Leloup, M. Quignon, M. J. Brisorgueil, L. Penicaud and M. Arluison: Immunocytochemical localization of the insulin-responsive glucose transporter 4 (Glut4) in the rat central nervous system. J Comp Neurol 399, 492-512 (1998)
    • (1998) J Comp Neurol , vol.399 , pp. 492-512
    • El Messari, S.1    Leloup, C.2    Quignon, M.3    Brisorgueil, M.J.4    Penicaud, L.5    Arluison, M.6
  • 25
    • 0027427381 scopus 로고
    • Transport of insulin-related peptides and glucose across the blood-brain barrier
    • W. M. Pardridge: Transport of insulin-related peptides and glucose across the blood-brain barrier. Ann N Y Acad Sci 692:126-37., 126-137 (1993)
    • (1993) Ann N y Acad Sci , vol.692 , pp. 126-137
    • Pardridge, W.M.1
  • 26
    • 33748744723 scopus 로고    scopus 로고
    • Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor i receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant
    • R. Slaaby, L. Schaffer, I. Lautrup-Larsen, A. S. Andersen, A. C. Shaw, I. S. Mathiasen and J. Brandt: Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant. J Biol Chem 281, 25869-25874 (2006)
    • (2006) J Biol Chem , vol.281 , pp. 25869-25874
    • Slaaby, R.1    Schaffer, L.2    Lautrup-Larsen, I.3    Andersen, A.S.4    Shaw, A.C.5    Mathiasen, I.S.6    Brandt, J.7
  • 27
    • 0035706134 scopus 로고    scopus 로고
    • Glucose treatment reduces memory deficits in young adult rats fed high-fat diets
    • C. E. Greenwood and G. Winocur: Glucose treatment reduces memory deficits in young adult rats fed high-fat diets. Neurobiol Learn Mem 75, 179-189 (2001)
    • (2001) Neurobiol Learn Mem , vol.75 , pp. 179-189
    • Greenwood, C.E.1    Winocur, G.2
  • 28
    • 0030787422 scopus 로고    scopus 로고
    • Effect of glucose and peripheral glucose regulation on memory in the elderly
    • C. Messier, M. Gagnon and V. Knott: Effect of glucose and peripheral glucose regulation on memory in the elderly. Neurobiol Aging 18, 297-304 (1997)
    • (1997) Neurobiol Aging , vol.18 , pp. 297-304
    • Messier, C.1    Gagnon, M.2    Knott, V.3
  • 30
    • 33748451468 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial dysfunction, and stress signaling in Alzheimer's disease
    • I. G. Onyango and S. M. Khan: Oxidative stress, mitochondrial dysfunction, and stress signaling in Alzheimer's disease. Curr Alzheimer Res 3, 339-349 (2006)
    • (2006) Curr Alzheimer Res , vol.3 , pp. 339-349
    • Onyango, I.G.1    Khan, S.M.2
  • 33
    • 0031014133 scopus 로고    scopus 로고
    • Diabetes mellitus, impaired glucose tolerance, and hyperinsulinemia in an elderly population. The Rotterdam Study
    • R. P. Stolk, H. A. Pols, S. W. Lamberts, P. T. de Jong, A. Hofman and D. E. Grobbee: Diabetes mellitus, impaired glucose tolerance, and hyperinsulinemia in an elderly population. The Rotterdam Study. Am J Epidemiol 145, 24-32 (1997)
    • (1997) Am J Epidemiol , vol.145 , pp. 24-32
    • Stolk, R.P.1    Pols, H.A.2    Lamberts, S.W.3    De Jong, P.T.4    Hofman, A.5    Grobbee, D.E.6
  • 34
    • 33748755428 scopus 로고    scopus 로고
    • Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to Alzheimer's disease
    • S. M. de la Monte, M. Tong, N. Lester-Coll, M. Plater, Jr. and J. R. Wands: Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease. J Alzheimer Dis 10, 89-109 (2006)
    • (2006) J Alzheimer Dis , vol.10 , pp. 89-109
    • De La Monte, S.M.1    Tong, M.2    Lester-Coll, N.3    Plater Jr., M.4    Wands, J.R.5
  • 35
    • 0035574487 scopus 로고    scopus 로고
    • Effects of age on elements of insulin-signaling pathway in central nervous system of rats
    • M. L. Fernandes, M. J. Saad and L. A. Velloso: Effects of age on elements of insulin-signaling pathway in central nervous system of rats. Endocrine 16, 227-234 (2001)
    • (2001) Endocrine , vol.16 , pp. 227-234
    • Fernandes, M.L.1    Saad, M.J.2    Velloso, L.A.3
  • 36
    • 1242316296 scopus 로고    scopus 로고
    • Insulin and neurodegenerative disease: Shared and specific mechanisms
    • S. Craft and G. S. Watson: Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol 3, 169-178 (2004)
    • (2004) Lancet Neurol , vol.3 , pp. 169-178
    • Craft, S.1    Watson, G.S.2
  • 38
    • 0142026832 scopus 로고    scopus 로고
    • Potential roles of insulin and IGF-1 in Alzheimer's disease
    • L. Gasparini and H. Xu: Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends Neurosci 26, 404-406 (2003)
    • (2003) Trends Neurosci , vol.26 , pp. 404-406
    • Gasparini, L.1    Xu, H.2
  • 39
    • 0038343343 scopus 로고    scopus 로고
    • Amyloid precursor protein (APP) and the biology of proteolytic processing: Relevance to Alzheimer's disease
    • Y. Ling, K. Morgan and N. Kalsheker: Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease. Int J Biochem Cell Biol 35, 1505-1535 (2003)
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 1505-1535
    • Ling, Y.1    Morgan, K.2    Kalsheker, N.3
  • 40
    • 0037134505 scopus 로고    scopus 로고
    • Insulin-degrading enzyme rapidly removes the betaamyloid precursor protein intracellular domain (AICD)
    • D. Edbauer, M. Willem, S. Lammich, H. Steiner and C. Haass: Insulin-degrading enzyme rapidly removes the betaamyloid precursor protein intracellular domain (AICD). J Biol Chem 277, 13389-13393 (2002)
    • (2002) J Biol Chem , vol.277 , pp. 13389-13393
    • Edbauer, D.1    Willem, M.2    Lammich, S.3    Steiner, H.4    Haass, C.5
  • 42
    • 0027984086 scopus 로고
    • The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer's disease
    • J. W. Simpkins, M. Singh and J. Bishop: The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer's disease. Neurobiol Aging 15 Suppl 2, S195-S197 (1994)
    • (1994) Neurobiol Aging , vol.15 , Issue.SUPPL. 2
    • Simpkins, J.W.1    Singh, M.2    Bishop, J.3
  • 43
    • 27244447434 scopus 로고    scopus 로고
    • Metabolic depression in hibernation and major depression: An explanatory theory and an animal model of depression
    • J. A. Tsiouris: Metabolic depression in hibernation and major depression: an explanatory theory and an animal model of depression. Med Hypotheses 65, 829-840 (2005)
    • (2005) Med Hypotheses , vol.65 , pp. 829-840
    • Tsiouris, J.A.1
  • 44
    • 7944227783 scopus 로고    scopus 로고
    • 17 Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats
    • Y. C. Choi, J. H. Lee, K. W. Hong and K. S. Lee: 17 Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats. Fundam Clin Pharmacol 18, 547-557 (2004)
    • (2004) Fundam Clin Pharmacol , vol.18 , pp. 547-557
    • Choi, Y.C.1    Lee, J.H.2    Hong, K.W.3    Lee, K.S.4
  • 45
    • 0032487513 scopus 로고    scopus 로고
    • Cerebral vasodilating capacity during forebrain ischemia: Effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase
    • D. A. Pelligrino, R. Santizo, V. L. Baughman and Q. Wang: Cerebral vasodilating capacity during forebrain ischemia: effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase. Neuroreport 9, 3285-3291 (1998)
    • (1998) Neuroreport , vol.9 , pp. 3285-3291
    • Pelligrino, D.A.1    Santizo, R.2    Baughman, V.L.3    Wang, Q.4
  • 46
    • 67349239425 scopus 로고    scopus 로고
    • Chronic nicotine exposure inhibits 17beta-estradiol-mediated protection of the hippocampal CA1 region against cerebral ischemia in female rats
    • A. P. Raval, A. Bhatt and I. Saul: Chronic nicotine exposure inhibits 17beta-estradiol-mediated protection of the hippocampal CA1 region against cerebral ischemia in female rats. Neurosci Lett 458, 65-69 (2009)
    • (2009) Neurosci Lett , vol.458 , pp. 65-69
    • Raval, A.P.1    Bhatt, A.2    Saul, I.3
  • 47
    • 61849115783 scopus 로고    scopus 로고
    • 17beta-estradiol and enriched environment accelerate cognitive recovery after focal brain ischemia
    • I. Soderstrom, M. Strand, A. C. Ingridsson, S. Nasic and T. Olsson: 17beta-estradiol and enriched environment accelerate cognitive recovery after focal brain ischemia. Eur J Neurosci 29, 1215-1224 (2009)
    • (2009) Eur J Neurosci , vol.29 , pp. 1215-1224
    • Soderstrom, I.1    Strand, M.2    Ingridsson, A.C.3    Nasic, S.4    Olsson, T.5
  • 48
    • 68249086298 scopus 로고    scopus 로고
    • Dose-related neuroprotective versus neurodamaging effects of estrogens in rat cerebral ischemia: A systematic analysis
    • J. O. Strom, A. Theodorsson and E. Theodorsson: Dose-related neuroprotective versus neurodamaging effects of estrogens in rat cerebral ischemia: a systematic analysis. J Cereb Blood Flow Metab 29, 1359-1372 (2009)
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1359-1372
    • Strom, J.O.1    Theodorsson, A.2    Theodorsson, E.3
  • 49
    • 33645993568 scopus 로고    scopus 로고
    • Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation
    • C. K. Won, H. H. Ji and P. O. Koh: Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation. Neurosci Lett 398, 39-43 (2006)
    • (2006) Neurosci Lett , vol.398 , pp. 39-43
    • Won, C.K.1    Ji, H.H.2    Koh, P.O.3
  • 50
    • 33646494508 scopus 로고    scopus 로고
    • Estrogens as neuroprotectants against ischemic stroke
    • de Lecinana Alonso and J. A. Egido: Estrogens as neuroprotectants against ischemic stroke. Cerebrovasc Dis 21 Suppl 2, 48-53 (2006)
    • (2006) Cerebrovasc Dis , Issue.21 SUPPL. 2 , pp. 48-53
    • De Lecinana Alonso1    Egido, J.A.2
  • 51
    • 20444488688 scopus 로고    scopus 로고
    • From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens
    • D. Amantea, R. Russo, G. Bagetta and M. T. Corasaniti: From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens. Pharmacol Res 52, 119-132 (2005)
    • (2005) Pharmacol Res , vol.52 , pp. 119-132
    • Amantea, D.1    Russo, R.2    Bagetta, G.3    Corasaniti, M.T.4
  • 52
    • 0038620494 scopus 로고    scopus 로고
    • Cellular strategies of estrogenmediated neuroprotection during brain development
    • M. Kajta and C. Beyer: Cellular strategies of estrogenmediated neuroprotection during brain development. Endocrine 21, 3-9 (2003)
    • (2003) Endocrine , vol.21 , pp. 3-9
    • Kajta, M.1    Beyer, C.2
  • 53
    • 0038268485 scopus 로고    scopus 로고
    • Estrogen and ischemic neuroprotection: An integrated view
    • L. D. McCullough and P. D. Hurn: Estrogen and ischemic neuroprotection: an integrated view. Trends Endocrinol Metab 14, 228-235 (2003)
    • (2003) Trends Endocrinol Metab , vol.14 , pp. 228-235
    • McCullough, L.D.1    Hurn, P.D.2
  • 54
    • 0035089767 scopus 로고    scopus 로고
    • Minireview: Neuroprotective effects of estrogen-new insights into mechanisms of action
    • P. M. Wise, D. B. Dubal, M. E. Wilson, S. W. Rau and M. Bottner: Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action. Endocrinology 142, 969-973 (2001)
    • (2001) Endocrinology , vol.142 , pp. 969-973
    • Wise, P.M.1    Dubal, D.B.2    Wilson, M.E.3    Rau, S.W.4    Bottner, M.5
  • 55
    • 0348109349 scopus 로고    scopus 로고
    • Estradiol attenuates programmed cell death after stroke-like injury
    • S. W. Rau, D. B. Dubal, M. Bottner, L. M. Gerhold and P. M. Wise: Estradiol attenuates programmed cell death after stroke-like injury. J Neurosci 23, 11420-11426 (2003)
    • (2003) J Neurosci , vol.23 , pp. 11420-11426
    • Rau, S.W.1    Dubal, D.B.2    Bottner, M.3    Gerhold, L.M.4    Wise, P.M.5
  • 57
    • 0033178294 scopus 로고    scopus 로고
    • Estradiol modulates bcl-2 in cerebral ischemia: A potential role for estrogen receptors
    • D. B. Dubal, P. J. Shughrue, M. E. Wilson, I. Merchenthaler and P. M. Wise: Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J Neurosci 19, 6385-6393 (1999)
    • (1999) J Neurosci , vol.19 , pp. 6385-6393
    • Dubal, D.B.1    Shughrue, P.J.2    Wilson, M.E.3    Merchenthaler, I.4    Wise, P.M.5
  • 58
    • 33645694378 scopus 로고    scopus 로고
    • Estrogen modulates Bcl-2 family proteins in ischemic brain injury
    • C. K. Won, M. O. Kim and P. O. Koh: Estrogen modulates Bcl-2 family proteins in ischemic brain injury. J Vet Med Sci 68, 277-280 (2006)
    • (2006) J Vet Med Sci , vol.68 , pp. 277-280
    • Won, C.K.1    Kim, M.O.2    Koh, P.O.3
  • 59
    • 33750027699 scopus 로고    scopus 로고
    • Bcl-2 enhances neurogenesis and inhibits apoptosis of newborn neurons in adult rat brain following a transient middle cerebral artery occlusion
    • R. Zhang, Y. Y. Xue, S. D. Lu, Y. Wang, L. M. Zhang, Y. L. Huang, A. P. Signore, J. Chen and F. Y. Sun: Bcl-2 enhances neurogenesis and inhibits apoptosis of newborn neurons in adult rat brain following a transient middle cerebral artery occlusion. Neurobiol Dis 24, 345-356 (2006)
    • (2006) Neurobiol Dis , vol.24 , pp. 345-356
    • Zhang, R.1    Xue, Y.Y.2    Lu, S.D.3    Wang, Y.4    Zhang, L.M.5    Huang, Y.L.6    Signore, A.P.7    Chen, J.8    Sun, F.Y.9
  • 60
    • 33645102888 scopus 로고    scopus 로고
    • Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice
    • M. D'Astous, P. Mendez, M. Morissette, L. M. Garcia-Segura and T. Di Paolo: Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Mol Pharmacol 69, 1492-1498 (2006)
    • (2006) Mol Pharmacol , vol.69 , pp. 1492-1498
    • D'Astous, M.1    Mendez, P.2    Morissette, M.3    Garcia-Segura, L.M.4    Di Paolo, T.5
  • 61
    • 0037430850 scopus 로고    scopus 로고
    • Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain
    • P. Mendez, I. Azcoitia and L. M. Garcia-Segura: Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain. Brain Res Mol Brain Res 112, 170-176 (2003)
    • (2003) Brain Res Mol Brain Res , vol.112 , pp. 170-176
    • Mendez, P.1    Azcoitia, I.2    Garcia-Segura, L.M.3
  • 62
    • 0037204526 scopus 로고    scopus 로고
    • Age differentially influences estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) gene expression in specific regions of the rat brain
    • M. E. Wilson, K. L. Rosewell, M. L. Kashon, P. J. Shughrue, I. Merchenthaler and P. M. Wise: Age differentially influences estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) gene expression in specific regions of the rat brain. Mech Ageing Dev 123, 593-601 (2002)
    • (2002) Mech Ageing Dev , vol.123 , pp. 593-601
    • Wilson, M.E.1    Rosewell, K.L.2    Kashon, M.L.3    Shughrue, P.J.4    Merchenthaler, I.5    Wise, P.M.6
  • 65
    • 12844268496 scopus 로고    scopus 로고
    • Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model
    • A. A. Ardelt, L. D. McCullough, K. S. Korach, M. M. Wang, D. H. Munzenmaier and P. D. Hurn: Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Stroke 36, 337-341 (2005)
    • (2005) Stroke , vol.36 , pp. 337-341
    • Ardelt, A.A.1    McCullough, L.D.2    Korach, K.S.3    Wang, M.M.4    Munzenmaier, D.H.5    Hurn, P.D.6
  • 66
    • 0032875858 scopus 로고    scopus 로고
    • A women's health issue: Alzheimer's disease and strategies for maintaining cognitive health
    • R. D. Brinton: A women's health issue: Alzheimer's disease and strategies for maintaining cognitive health. Int J Fertil Womens Med 44, 174-185 (1999)
    • (1999) Int J Fertil Womens Med , vol.44 , pp. 174-185
    • Brinton, R.D.1
  • 67
    • 0034968269 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: Recent insights and remaining challenges
    • R. D. Brinton: Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: recent insights and remaining challenges. Learn Mem 8, 121-133 (2001)
    • (2001) Learn Mem , vol.8 , pp. 121-133
    • Brinton, R.D.1
  • 68
    • 0034237128 scopus 로고    scopus 로고
    • Neuroprotective effects of estrogens: Potential mechanisms of action
    • P. S. Green and J. W. Simpkins: Neuroprotective effects of estrogens: potential mechanisms of action. Int J Dev Neurosci 18, 347-358 (2000)
    • (2000) Int J Dev Neurosci , vol.18 , pp. 347-358
    • Green, P.S.1    Simpkins, J.W.2
  • 69
    • 0030968187 scopus 로고    scopus 로고
    • Ovarian steroids and the brain: Implications for cognition and aging
    • B. S. McEwen, S. E. Alves, K. Bulloch and N. G. Weiland: Ovarian steroids and the brain: implications for cognition and aging. Neurology 48, S8-15 (1997)
    • (1997) Neurology , vol.48
    • McEwen, B.S.1    Alves, S.E.2    Bulloch, K.3    Weiland, N.G.4
  • 70
    • 0035180875 scopus 로고    scopus 로고
    • Invited review: Estrogens effects on the brain: Multiple sites and molecular mechanisms
    • B. S. McEwen: Invited review: Estrogens effects on the brain: multiple sites and molecular mechanisms. J Appl Physiol 91, 2785-2801 (2001)
    • (2001) J Appl Physiol , vol.91 , pp. 2785-2801
    • McEwen, B.S.1
  • 72
    • 0036141071 scopus 로고    scopus 로고
    • Impact of progestins on estrogen-induced neuroprotection: Synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate
    • J. Nilsen and R. D. Brinton: Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology 143, 205-212 (2002)
    • (2002) Endocrinology , vol.143 , pp. 205-212
    • Nilsen, J.1    Brinton, R.D.2
  • 73
    • 0037418287 scopus 로고    scopus 로고
    • Mechanism of estrogenmediated neuroprotection: Regulation of mitochondrial calcium and Bcl-2 expression
    • J. Nilsen and R.D.Brinton: Mechanism of estrogenmediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression. Proc Natl Acad Sci U S A 100, 2842-2847 (2003)
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2842-2847
    • Nilsen, J.1    Brinton, R.D.2
  • 74
    • 0028224213 scopus 로고
    • Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats
    • M. Singh, E. M. Meyer, W. J. Millard and J. W. Simpkins: Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats. Brain Res 644, 305-312 (1994)
    • (1994) Brain Res , vol.644 , pp. 305-312
    • Singh, M.1    Meyer, E.M.2    Millard, W.J.3    Simpkins, J.W.4
  • 75
    • 0033152160 scopus 로고    scopus 로고
    • Effects of estrogen in the CNS
    • C. S. Woolley: Effects of estrogen in the CNS. Curr Opin Neurobiol 9, 349-354 (1999)
    • (1999) Curr Opin Neurobiol , vol.9 , pp. 349-354
    • Woolley, C.S.1
  • 76
    • 45549084972 scopus 로고    scopus 로고
    • Aromatase in the brain: Not just for reproduction anymore
    • L.M. Garcia-Segura: Aromatase in the brain: not just for reproduction anymore. J Neuroendocrinol 20(6), 705-712, (2008)
    • (2008) J Neuroendocrinol , vol.20 , Issue.6 , pp. 705-712
    • Garcia-Segura, L.M.1
  • 77
    • 77954154151 scopus 로고    scopus 로고
    • Rapid behavioural effects of oestrogens and fast regulation of their local synthesis by brain aromatase
    • C.A.Cornil and T.D.Charlier: Rapid behavioural effects of oestrogens and fast regulation of their local synthesis by brain aromatase. J Neuroendocrinol 22(7), 664-673, (2010)
    • (2010) J Neuroendocrinol , vol.22 , Issue.7 , pp. 664-673
    • Cornil, C.A.1    Charlier, T.D.2
  • 79
    • 79952314892 scopus 로고    scopus 로고
    • Hippocampal responsiveness to 17β-estradiol and equol after long-term ovariectomy: Implication for a therapeutic window of opportunity
    • doi:10.1016/j.brainres.2011.01.029
    • R. T. Hamilton, J. R. Rettberg, Z. Mao, J. To, L. Zhao, S. E. Appt, T.C. Register, J. R. Kaplan, R. DiazBrinton: Hippocampal responsiveness to 17β-estradiol and equol after long-term ovariectomy: Implication for a therapeutic window of opportunity. Brain Research doi:10.1016/j.brainres.2011. 01.029
    • Brain Research
    • Hamilton, R.T.1    Rettberg, J.R.2    Mao, Z.3    To, J.4    Zhao, L.5    Appt, S.E.6    Register, T.C.7    Kaplan, J.R.8    Diaz Brinton, R.9
  • 80
    • 0029669930 scopus 로고    scopus 로고
    • Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiolreceptor complex in MCF-7 cells
    • A. Migliaccio, M. Di Domenico, G. Castoria, A. de Falco, P. Bontempo, E. Nola and F. Auricchio: Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiolreceptor complex in MCF-7 cells. EMBO J 15(6), 1292-300 (1996)
    • (1996) EMBO J , vol.15 , Issue.6 , pp. 1292-1300
    • Migliaccio, A.1    Di Domenico, M.2    Castoria, G.3    De Falco, A.4    Bontempo, P.5    Nola, E.6    Auricchio, F.7
  • 81
    • 0033118665 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons
    • .C.A. Singer, X.A. Figueroa-Masot, R.H. Batchelor and D.M. Dorsa: The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J Neurosci 19(7), 2455-63 (1999)
    • (1999) J Neurosci , vol.19 , Issue.7 , pp. 2455-2463
    • Singer, C.A.1    Figueroa-Masot, X.A.2    Batchelor, R.H.3    Dorsa, D.M.4
  • 83
    • 0344097487 scopus 로고    scopus 로고
    • Estrogen-induced activation of mitogenactivated protein kinase in cerebral cortical explants: Convergence of estrogen and neurotrophin signaling pathways
    • M. Singh, G. Setalo, Jr., X. Guan, M. Warren and C. D. Toran-Allerand: Estrogen-induced activation of mitogenactivated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J Neurosci 19, 1179-1188 (1999)
    • (1999) J Neurosci , vol.19 , pp. 1179-1188
    • Singh, M.1    Setalo Jr., G.2    Guan, X.3    Warren, M.4    Toran-Allerand, C.D.5
  • 84
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signalregulated kinase activation
    • C. J. Marshall: Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signalregulated kinase activation. Cell 80, 179-185 (1995)
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 85
    • 24744449748 scopus 로고    scopus 로고
    • Estrogen activates classical and alternative mechanisms to orchestrate neuroprotection
    • R. Marin, B. Guerra, R. Alonso, C.M. Ramírez, M. Díaz: Estrogen activates classical and alternative mechanisms to orchestrate neuroprotection. Curr Neurovasc Res 2(4), 287-301, (2005)
    • (2005) Curr Neurovasc Res , vol.2 , Issue.4 , pp. 287-301
    • Marin, R.1    Guerra, B.2    Alonso, R.3    Ramírez, C.M.4    Díaz, M.5
  • 86
    • 18844395104 scopus 로고    scopus 로고
    • 17-β estradiol rapidly enhances extracellular signal-regulated kinase 2 phosphorylation in the rat brain
    • D. N. Bryant, A. Bosch, K. Rønnekleiv and D. M. Dorsaa: 17-β estradiol rapidly enhances extracellular signal-regulated kinase 2 phosphorylation in the rat brain. Neuroscience 133, 343-352 (2005)
    • (2005) Neuroscience , vol.133 , pp. 343-352
    • Bryant, D.N.1    Bosch, A.2    Rønnekleiv, K.3    Dorsaa, D.M.4
  • 87
    • 44649182975 scopus 로고    scopus 로고
    • Modulation of Abeta-induced neurotoxicity by estrogen receptor alpha and other associated proteins in lipid rafts
    • R. Marin, C. Ramírez, A. Morales, M. González, R. Alonso and M. Díaz: Modulation of Abeta-induced neurotoxicity by estrogen receptor alpha and other associated proteins in lipid rafts. Steroids 73(9-10), 992-6 (2008)
    • (2008) Steroids , vol.73 , Issue.9-10 , pp. 992-996
    • Marin, R.1    Ramírez, C.2    Morales, A.3    González, M.4    Alonso, R.5    Díaz, M.6
  • 89
    • 0028040775 scopus 로고
    • The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C
    • Z. L. Tang, P. E. Scherer and M. P. Lisanti: The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C. Gene 147, 299-300 (1994)
    • (1994) Gene , vol.147 , pp. 299-300
    • Tang, Z.L.1    Scherer, P.E.2    Lisanti, M.P.3
  • 90
    • 0030890762 scopus 로고    scopus 로고
    • Physical association with ras enhances activation of membrane-bound raf (RafCAAX)
    • C. Mineo, R. G. Anderson and M. A. White: Physical association with ras enhances activation of membrane-bound raf (RafCAAX). J Biol Chem 272, 10345-10348 (1997)
    • (1997) J Biol Chem , vol.272 , pp. 10345-10348
    • Mineo, C.1    Anderson, R.G.2    White, M.A.3
  • 91
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • S. R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh and M. E. Greenberg: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997)
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 93
    • 4544253891 scopus 로고    scopus 로고
    • Mitochondria as therapeutic targets of estrogen action in the central nervous system
    • J. Nilsen and R. D. Brinton: Mitochondria as therapeutic targets of estrogen action in the central nervous system. Curr Drug Targets CNS Neurol Disord 3, 297-313 (2004)
    • (2004) Curr Drug Targets CNS Neurol Disord , vol.3 , pp. 297-313
    • Nilsen, J.1    Brinton, R.D.2
  • 94
    • 33751226555 scopus 로고    scopus 로고
    • Regulation of estrogen receptor alpha by estradiol in pregnant and estradiol treated rats
    • A. Alonso, R. Fernandez, P. Ordonez, M. Moreno, A. M. Patterson and C. Gonzalez: Regulation of estrogen receptor alpha by estradiol in pregnant and estradiol treated rats. Steroids 71, 1052-1061 (2006)
    • (2006) Steroids , vol.71 , pp. 1052-1061
    • Alonso, A.1    Fernandez, R.2    Ordonez, P.3    Moreno, M.4    Patterson, A.M.5    Gonzalez, C.6
  • 95
    • 0034283016 scopus 로고    scopus 로고
    • Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1
    • G. Flouriot, H. Brand, S. Denger, R. Metivier, M. Kos, G. Reid, V. Sonntag-Buck and F. Gannon: Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1. EMBO J 19, 4688-4700 (2000)
    • (2000) EMBO J , vol.19 , pp. 4688-4700
    • Flouriot, G.1    Brand, H.2    Denger, S.3    Metivier, R.4    Kos, M.5    Reid, G.6    Sonntag-Buck, V.7    Gannon, F.8
  • 96
    • 0038579793 scopus 로고    scopus 로고
    • An oestrogen membrane receptor participates in estradiol actions for the prevention of amyloid-beta peptide1-40-induced toxicity in septal-derived cholinergic SN56 cells
    • R. Marin, B. Guerra, A. Morales, M. Diaz and R. Alonso: An oestrogen membrane receptor participates in estradiol actions for the prevention of amyloid-beta peptide1-40-induced toxicity in septal-derived cholinergic SN56 cells. J Neurochem 85, 1180-1189 (2003)
    • (2003) J Neurochem , vol.85 , pp. 1180-1189
    • Marin, R.1    Guerra, B.2    Morales, A.3    Diaz, M.4    Alonso, R.5
  • 97
    • 0033985036 scopus 로고    scopus 로고
    • Antibodies to the estrogen receptor-alpha modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptors
    • A. M. Norfleet, C. H. Clarke, B. Gametchu and C. S. Watson: Antibodies to the estrogen receptor-alpha modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptors. FASEB J 14, 157-165 (2000)
    • (2000) FASEB J , vol.14 , pp. 157-165
    • Norfleet, A.M.1    Clarke, C.H.2    Gametchu, B.3    Watson, C.S.4
  • 98
    • 0035921138 scopus 로고    scopus 로고
    • Demonstration of estrogen receptor subtypes alpha and beta in human adipose tissue: Influences of adipose cell differentiation and fat depot localization
    • S. B. Pedersen, J. M. Bruun, F. Hube, K. Kristensen, H. Hauner and B. Richelsen: Demonstration of estrogen receptor subtypes alpha and beta in human adipose tissue: influences of adipose cell differentiation and fat depot localization. Mol Cell Endocrinol 182, 27-37 (2001)
    • (2001) Mol Cell Endocrinol , vol.182 , pp. 27-37
    • Pedersen, S.B.1    Bruun, J.M.2    Hube, F.3    Kristensen, K.4    Hauner, H.5    Richelsen, B.6
  • 99
    • 1642375658 scopus 로고    scopus 로고
    • Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and betacatenin in the hippocampus
    • P. Cardona-Gomez, M. Perez, J. Avila, L. M. Garcia-Segura and F. Wandosell: Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and betacatenin in the hippocampus. Mol Cell Neurosci 25, 363-373 (2004)
    • (2004) Mol Cell Neurosci , vol.25 , pp. 363-373
    • Cardona-Gomez, P.1    Perez, M.2    Avila, J.3    Garcia-Segura, L.M.4    Wandosell, F.5
  • 100
    • 0037444650 scopus 로고    scopus 로고
    • Estrogen levels regulate the subcellular distribution of phosphorylated Akt in hippocampal CA1 dendrites
    • V. Znamensky, K. T. Akama, B. S. McEwen and T. A. Milner: Estrogen levels regulate the subcellular distribution of phosphorylated Akt in hippocampal CA1 dendrites. J Neurosci 23, 2340-2347 (2003)
    • (2003) J Neurosci , vol.23 , pp. 2340-2347
    • Znamensky, V.1    Akama, K.T.2    McEwen, B.S.3    Milner, T.A.4
  • 101
    • 1442355804 scopus 로고    scopus 로고
    • Insulin resistance, affective disorders, and Alzheimer's disease: Review and hypothesis
    • N. Rasgon and L. Jarvik: Insulin resistance, affective disorders, and Alzheimer's disease: review and hypothesis. J Gerontol A Biol Sci Med Sci 59, 178-183 (2004)
    • (2004) J Gerontol A Biol Sci Med Sci , vol.59 , pp. 178-183
    • Rasgon, N.1    Jarvik, L.2
  • 102
    • 0032483062 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 ameliorates age-related behavioral deficits
    • A. L. Markowska, M. Mooney and W. E. Sonntag: Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience 87, 559-569 (1998)
    • (1998) Neuroscience , vol.87 , pp. 559-569
    • Markowska, A.L.1    Mooney, M.2    Sonntag, W.E.3
  • 103
    • 0035117627 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals
    • C. D. Lynch, D. Lyons, A. Khan, S. A. Bennett and W. E. Sonntag: Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals. Endocrinology 142, 506-509 (2001)
    • (2001) Endocrinology , vol.142 , pp. 506-509
    • Lynch, C.D.1    Lyons, D.2    Khan, A.3    Bennett, S.A.4    Sonntag, W.E.5
  • 104
    • 0028343330 scopus 로고
    • Gonadal hormone regulation of insulin-like growth factor-I-like immunoreactivity in hypothalamic astroglia of developing and adult rats
    • M. Duenas, S. Luquin, J. A. Chowen, I. Torres-Aleman, F. Naftolin and L. M. Garcia-Segura: Gonadal hormone regulation of insulin-like growth factor-I-like immunoreactivity in hypothalamic astroglia of developing and adult rats. Neuroendocrinology 59, 528-538 (1994)
    • (1994) Neuroendocrinology , vol.59 , pp. 528-538
    • Duenas, M.1    Luquin, S.2    Chowen, J.A.3    Torres-Aleman, I.4    Naftolin, F.5    Garcia-Segura, L.M.6
  • 105
    • 4444243078 scopus 로고    scopus 로고
    • Ovariectomy and gonadal hormone treatment: Effects on insulin-like growth factor-1 receptors in the rat brain
    • N. K. El Bakri, A. Islam, I. Suliman, U. Lindgren, B. Winblad and A. Adem: Ovariectomy and gonadal hormone treatment: effects on insulin-like growth factor-1 receptors in the rat brain. Growth Horm IGF Res 14, 388-393 (2004)
    • (2004) Growth Horm IGF Res , vol.14 , pp. 388-393
    • El Bakri, N.K.1    Islam, A.2    Suliman, I.3    Lindgren, U.4    Winblad, B.5    Adem, A.6
  • 106
    • 0034608374 scopus 로고    scopus 로고
    • Estrogen receptors and insulinlike growth factor-I receptors mediate estrogen-dependent synaptic plasticity
    • G. P. Cardona-Gomez, J. L. Trejo, A. M. Fernandez and L. M. Garcia-Segura: Estrogen receptors and insulinlike growth factor-I receptors mediate estrogen-dependent synaptic plasticity. Neuroreport 11, 1735-1738 (2000)
    • (2000) Neuroreport , vol.11 , pp. 1735-1738
    • Cardona-Gomez, G.P.1    Trejo, J.L.2    Fernandez, A.M.3    Garcia-Segura, L.M.4
  • 110
    • 33847014888 scopus 로고    scopus 로고
    • Phosphoinositide-3-kinase/Akt survival signal pathways are implicated in neuronal survival after stroke
    • H. Zhao, R. M. Sapolsky and G. K. Steinberg: Phosphoinositide-3-kinase/ Akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol 34, 249-270 (2006)
    • (2006) Mol Neurobiol , vol.34 , pp. 249-270
    • Zhao, H.1    Sapolsky, R.M.2    Steinberg, G.K.3
  • 111
    • 0034044227 scopus 로고    scopus 로고
    • Neurotrophin signal transduction in the nervous system
    • D. R. Kaplan and F. D. Miller: Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 10, 381-391 (2000)
    • (2000) Curr Opin Neurobiol , vol.10 , pp. 381-391
    • Kaplan, D.R.1    Miller, F.D.2
  • 113
    • 0032846284 scopus 로고    scopus 로고
    • Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factormediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y
    • M. Encinas, M. Iglesias, N. Llecha and J. X. Comella: Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factormediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y. J Neurochem 73, 1409-1421 (1999)
    • (1999) J Neurochem , vol.73 , pp. 1409-1421
    • Encinas, M.1    Iglesias, M.2    Llecha, N.3    Comella, J.X.4
  • 114
    • 67349094570 scopus 로고    scopus 로고
    • Neuroprotection by NGF and BDNF against neurotoxinexerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways
    • N. Nguyen, S. B. Lee, Y. S. Lee, K. H. Lee and J. Y. Ahn: Neuroprotection by NGF and BDNF against neurotoxinexerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways. Neurochem Res 34, 942-951 (2009)
    • (2009) Neurochem Res , vol.34 , pp. 942-951
    • Nguyen, N.1    Lee, S.B.2    Lee, Y.S.3    Lee, K.H.4    Ahn, J.Y.5
  • 115
    • 0343825861 scopus 로고    scopus 로고
    • Insulin-like growth factor i receptors and estrogen receptors colocalize in female rat brain
    • G. P. Cardona-Gomez, L. DonCarlos and L. M. Garcia-Segura: Insulin-like growth factor I receptors and estrogen receptors colocalize in female rat brain. Neuroscience 99, 751-760 (2000)
    • (2000) Neuroscience , vol.99 , pp. 751-760
    • Cardona-Gomez, G.P.1    Doncarlos, L.2    Garcia-Segura, L.M.3
  • 116
    • 0034484498 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptors and estrogen receptors interact in the promotion of neuronal survival and neuroprotection
    • L. M. Garcia-Segura, G. P. Cardona-Gomez, J. A. Chowen and I. Azcoitia: Insulin-like growth factor-I receptors and estrogen receptors interact in the promotion of neuronal survival and neuroprotection. J Neurocytol 29, 425-437 (2000)
    • (2000) J Neurocytol , vol.29 , pp. 425-437
    • Garcia-Segura, L.M.1    Cardona-Gomez, G.P.2    Chowen, J.A.3    Azcoitia, I.4
  • 118
    • 0032907868 scopus 로고    scopus 로고
    • Novel mechanisms of estrogen action in the brain: New players in an old story
    • C. D. Toran-Allerand, M. Singh and G. Setalo, Jr.: Novel mechanisms of estrogen action in the brain: new players in an old story. Front Neuroendocrinol 20, 97-121 (1999)
    • (1999) Front Neuroendocrinol , vol.20 , pp. 97-121
    • Toran-Allerand, C.D.1    Singh, M.2    Setalo Jr., G.3
  • 119
    • 17844399257 scopus 로고    scopus 로고
    • Interdependence of oestrogen and insulin-like growth factor-I in the brain: Potential for analyzing neuroprotective mechanisms
    • P. Mendez, I. Azcoitia and L. M. Garcia-Segura: Interdependence of oestrogen and insulin-like growth factor-I in the brain: potential for analyzing neuroprotective mechanisms. J Endocrinol 185, 11-17 (2005)
    • (2005) J Endocrinol , vol.185 , pp. 11-17
    • Mendez, P.1    Azcoitia, I.2    Garcia-Segura, L.M.3
  • 120
    • 0028675873 scopus 로고
    • Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
    • S. Lovestone, C. H. Reynolds, D. Latimer, D. R. Davis, B. H. Anderton, J. M. Gallo, D. Hanger, S. Mulot, B. Marquardt, and S. Stabel: Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr Biol 4, 1077-1086 (1994)
    • (1994) Curr Biol , vol.4 , pp. 1077-1086
    • Lovestone, S.1    Reynolds, C.H.2    Latimer, D.3    Davis, D.R.4    Anderton, B.H.5    Gallo, J.M.6    Hanger, D.7    Mulot, S.8    Marquardt, B.9    Stabel, S.10
  • 121
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • D. A. Cross, D. R. Alessi, P. Cohen, M. Andjelkovich and B. A. Hemmings: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789 (1995)
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 124
    • 0039425278 scopus 로고    scopus 로고
    • Negative regulation of the forkhead transcription factor FKHR by Akt
    • E. D. Tang, G. Nunez, F. G. Barr and K. L. Guan: Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem 274, 16741-16746 (1999)
    • (1999) J Biol Chem , vol.274 , pp. 16741-16746
    • Tang, E.D.1    Nunez, G.2    Barr, F.G.3    Guan, K.L.4
  • 125
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • L.del Peso, M. Gonzalez-Garcia, C. Page, R. Herrera and G. Nunez: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278, 687-689 (1997)
    • (1997) Science , vol.278 , pp. 687-689
    • Del Peso, L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 127
    • 0042886919 scopus 로고    scopus 로고
    • Are gonadal steroid hormones involved in disorders of brain aging?
    • I. Azcoitia, L.L. DonCarlos and L.M. Garcia-Segura: Are gonadal steroid hormones involved in disorders of brain aging? Aging Cell 2(1), 31-7 (2003)
    • (2003) Aging Cell , vol.2 , Issue.1 , pp. 31-37
    • Azcoitia, I.1    Doncarlos, L.L.2    Garcia-Segura, L.M.3
  • 128
    • 23444432499 scopus 로고    scopus 로고
    • Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging
    • W.E. Sonntag, M. Ramsey and C.S. Carter: Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res Rev 4(2), 195-212 (2005)
    • (2005) Ageing Res Rev , vol.4 , Issue.2 , pp. 195-212
    • Sonntag, W.E.1    Ramsey, M.2    Carter, C.S.3
  • 132
    • 70949097002 scopus 로고    scopus 로고
    • Oestradiol and IGF1 reduce cell loss after global ischemia in middle-aged female rats
    • M. L. Traub, M. De Butte-Smith, P, R. S. Zukin, and A. M. Etgen:Oestradiol and IGF1 reduce cell loss after global ischemia in middle-aged female rats. J Neuroendocrinol 21(12), 1038-1044 (2009)
    • (2009) J Neuroendocrinol , vol.21 , Issue.12 , pp. 1038-1044
    • Traub, M.L.1    De Butte-Smith, M.P.2    Zukin, R.S.3    Etgen, A.M.4
  • 136
    • 57649134261 scopus 로고    scopus 로고
    • Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
    • L.R. Hanson and W.H. Frey: Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease. BMC Neurosci S5, (2008)
    • (2008) BMC Neurosci , vol.S5
    • Hanson, L.R.1    Frey, W.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.