Effects of estrogen in the CNS

Current Opinion in Neurobiology

Volumn 9, Issue 3, 1999, Pages 349-354

  Woolley, Catherine S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ESTROGEN; ESTROGEN RECEPTOR;

CENTRAL NERVOUS SYSTEM; DENDRITIC SPINE; HIPPOCAMPUS; HORMONAL REGULATION; NEUROPROTECTION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE;

EID: 0033152160     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(99)80051-8     Document Type: Article

References (44)

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36. Murphy DD, Segal M: Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein. Proc Natl Acad Sci USA 1997, 94:1482-1487. This study links estradiol induction of dendritic spines in cultured hippocampal neurons to activation of CREB and CBP. Estradiol produces an increase in CBP and phosphorylated CREB that precedes the increase in dendritic spine density. Similar to the effect on spines, blockade of NMDA receptors also inhibits the increase in CBP and phosphorylation of CREB. Two further pieces of evidence from this study corroborate a cAMP-dependent effect on spine density. First, inhibition of cAMP-dependent protein kinase A with H89 blocks both the estradiol-induced increase in spine density and the effects on CBP and CREB. Second, treatment of cultures with a cAMP analog at least partially mimics the effect of estradiol on spines.
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