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Volumn 13, Issue 6, 2012, Pages 811-828

Systemic therapies for pancreatic cancer - the role of pharmacogenetics

Author keywords

Chemotherapy; Pancreatic cancer; Pharmacogenetics

Indexed keywords

ANTINEOPLASTIC AGENT; ATM PROTEIN; CISPLATIN; CYTIDINE DEAMINASE; CYTOTOXIC AGENT; DEOXYCYTIDINE KINASE; DNA DIRECTED DNA POLYMERASE BETA; EPIDERMAL GROWTH FACTOR RECEPTOR; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; ERLOTINIB; EXONUCLEASE; FLUOROURACIL; GEMCITABINE; GEMCITABINE TRIPHOSPHATE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; IRINOTECAN; NUCLEIC ACID BINDING PROTEIN; OXALIPLATIN; PROTEIN P73; RIBONUCLEOTIDE REDUCTASE; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG; XRCC1 PROTEIN; XRCC2 PROTEIN;

EID: 84860826582     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945012800564068     Document Type: Review
Times cited : (15)

References (188)
  • 2
    • 38549113698 scopus 로고    scopus 로고
    • Chemotherapy for pancreatic cancer: From metastatic disease to adjuvant therapy
    • Wolff RA. Chemotherapy for pancreatic cancer: from metastatic disease to adjuvant therapy. Cancer J 2007; 13(3): 175-184.
    • (2007) Cancer J , vol.13 , Issue.3 , pp. 175-184
    • Wolff, R.A.1
  • 3
    • 42349093032 scopus 로고    scopus 로고
    • Meta-analysis of randomized trials: Evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer
    • Heinemann V, Boeck S, Hinke A, Labianca R, Louvet C. Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer. BMC Cancer 2008; 8: 82.
    • (2008) BMC Cancer , vol.8 , pp. 82
    • Heinemann, V.1    Boeck, S.2    Hinke, A.3    Labianca, R.4    Louvet, C.5
  • 5
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA, 3rd, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997; 15(6): 2403-2413.
    • (1997) J Clin Oncol , vol.15 , Issue.6 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3
  • 6
    • 68949114505 scopus 로고    scopus 로고
    • Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: A trial of the Eastern Cooperative Oncology Group
    • Poplin E, Feng Y, Berlin J, et al. Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol 2009; 27(23): 3778-3785.
    • (2009) J Clin Oncol , vol.27 , Issue.23 , pp. 3778-3785
    • Poplin, E.1    Feng, Y.2    Berlin, J.3
  • 7
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial
    • Louvet C, Labianca R, Hammel P, et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol 2005; 23(15): 3509-3516.
    • (2005) J Clin Oncol , vol.23 , Issue.15 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3
  • 8
    • 33748445708 scopus 로고    scopus 로고
    • Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer
    • Heinemann V, Quietzsch D, Gieseler F, et al. Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. J Clin Oncol 2006; 24(24): 3946-3952.
    • (2006) J Clin Oncol , vol.24 , Issue.24 , pp. 3946-3952
    • Heinemann, V.1    Quietzsch, D.2    Gieseler, F.3
  • 9
    • 73949135518 scopus 로고    scopus 로고
    • Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
    • Cunningham D, Chau I, Stocken DD, et al. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol 2009; 27(33): 5513-5518.
    • (2009) J Clin Oncol , vol.27 , Issue.33 , pp. 5513-5518
    • Cunningham, D.1    Chau, I.2    Stocken, D.D.3
  • 10
    • 34250180939 scopus 로고    scopus 로고
    • Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: A randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group
    • Herrmann R, Bodoky G, Ruhstaller T, et al. Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J Clin Oncol 2007; 25(16): 2212-2217.
    • (2007) J Clin Oncol , vol.25 , Issue.16 , pp. 2212-2217
    • Herrmann, R.1    Bodoky, G.2    Ruhstaller, T.3
  • 11
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
    • Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG, Benson AB, 3rd. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 2002; 20(15): 3270-3275.
    • (2002) J Clin Oncol , vol.20 , Issue.15 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3    Kugler, J.W.4    Haller, D.G.5    Benson, A.B.6
  • 12
    • 28344452125 scopus 로고    scopus 로고
    • A randomised, prospective, multicenter, phase III trial of gemcitabine, 5-fluorouracil (5-FU), folinic acid vs. gemcitabine alone in patients with advanced pancreatic cancer
    • abstract 4009
    • Riess H, Helm A, Niedergethmann M, et al. A randomised, prospective, multicenter, phase III trial of gemcitabine, 5-fluorouracil (5-FU), folinic acid vs. gemcitabine alone in patients with advanced pancreatic cancer. J Clin Oncol 2005; 23(16S): abstract 4009.
    • (2005) J Clin Oncol , vol.23 , Issue.16 S
    • Riess, H.1    Helm, A.2    Niedergethmann, M.3
  • 13
    • 4644327989 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
    • Rocha Lima CM, Green MR, Rotche R, et al. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol 2004; 22(18): 3776-3783.
    • (2004) J Clin Oncol , vol.22 , Issue.18 , pp. 3776-3783
    • Rocha Lima, C.M.1    Green, M.R.2    Rotche, R.3
  • 14
    • 33749071359 scopus 로고    scopus 로고
    • Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer
    • Abou-Alfa GK, Letourneau R, Harker G, et al. Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer. J Clin Oncol 2006; 24(27): 4441-4447.
    • (2006) J Clin Oncol , vol.24 , Issue.27 , pp. 4441-4447
    • Abou-Alfa, G.K.1    Letourneau, R.2    Harker, G.3
  • 15
    • 27144530079 scopus 로고    scopus 로고
    • A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer
    • Oettle H, Richards D, Ramanathan RK, et al. A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer. Ann Oncol 2005; 16(10): 1639-1645.
    • (2005) Ann Oncol , vol.16 , Issue.10 , pp. 1639-1645
    • Oettle, H.1    Richards, D.2    Ramanathan, R.K.3
  • 16
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011; 364(19): 1817-1825.
    • (2011) N Engl J Med , vol.364 , Issue.19 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 17
    • 0141688333 scopus 로고    scopus 로고
    • Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Hamm J, Dancey J, et al. Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2003; 21(17): 3296-3302.
    • (2003) J Clin Oncol , vol.21 , Issue.17 , pp. 3296-3302
    • Moore, M.J.1    Hamm, J.2    Dancey, J.3
  • 18
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall SR, Schulz J, Nemunaitis J, Brown PD, Baillet M, Buckels JA. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 2002; 87(2): 161-167.
    • (2002) Br J Cancer , vol.87 , Issue.2 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3    Brown, P.D.4    Baillet, M.5    Buckels, J.A.6
  • 19
    • 2342645506 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
    • Van Cutsem E, van de Velde H, Karasek P, et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 2004; 22(8): 1430-1438.
    • (2004) J Clin Oncol , vol.22 , Issue.8 , pp. 1430-1438
    • van Cutsem, E.1    van de Velde, H.2    Karasek, P.3
  • 20
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007; 25(15): 1960-1966.
    • (2007) J Clin Oncol , vol.25 , Issue.15 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 21
    • 77955914277 scopus 로고    scopus 로고
    • Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205
    • Philip PA, Benedetti J, Corless CL, et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol 2010; 28(22): 3605-3610.
    • (2010) J Clin Oncol , vol.28 , Issue.22 , pp. 3605-3610
    • Philip, P.A.1    Benedetti, J.2    Corless, C.L.3
  • 22
    • 77955887676 scopus 로고    scopus 로고
    • Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
    • Kindler HL, Niedzwiecki D, Hollis D, et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol 2010; 28(22): 3617-3622.
    • (2010) J Clin Oncol , vol.28 , Issue.22 , pp. 3617-3622
    • Kindler, H.L.1    Niedzwiecki, D.2    Hollis, D.3
  • 23
    • 65549150854 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
    • Van Cutsem E, Vervenne WL, Bennouna J, et al. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol 2009; 27(13): 2231-2237.
    • (2009) J Clin Oncol , vol.27 , Issue.13 , pp. 2231-2237
    • van Cutsem, E.1    Vervenne, W.L.2    Bennouna, J.3
  • 24
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics--drug disposition, drug targets, and side effects
    • Evans WE, McLeod HL. Pharmacogenomics--drug disposition, drug targets, and side effects. N Engl J Med 2003; 348(6): 538-549.
    • (2003) N Engl J Med , vol.348 , Issue.6 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 25
    • 0344197480 scopus 로고    scopus 로고
    • Cancer pharmacogenetics: Polymorphisms, pathways and beyond
    • Ulrich CM, Robien K, McLeod HL. Cancer pharmacogenetics: polymorphisms, pathways and beyond. Nat Rev Cancer 2003; 3(12): 912-920.
    • (2003) Nat Rev Cancer , vol.3 , Issue.12 , pp. 912-920
    • Ulrich, C.M.1    Robien, K.2    McLeod, H.L.3
  • 26
    • 1442302331 scopus 로고    scopus 로고
    • Mammalian nucleoside transporters
    • Kong W, Engel K, Wang J. Mammalian nucleoside transporters. Curr Drug Metab 2004; 5(1): 63-84.
    • (2004) Curr Drug Metab , vol.5 , Issue.1 , pp. 63-84
    • Kong, W.1    Engel, K.2    Wang, J.3
  • 27
    • 0033520708 scopus 로고    scopus 로고
    • Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters
    • Mackey JR, Yao SY, Smith KM, et al. Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. J Natl Cancer Inst 1999; 91(21): 1876-1881.
    • (1999) J Natl Cancer Inst , vol.91 , Issue.21 , pp. 1876-1881
    • Mackey, J.R.1    Yao, S.Y.2    Smith, K.M.3
  • 28
    • 0029584109 scopus 로고
    • Preclinical characteristics of gemcitabine
    • Plunkett W, Huang P, Gandhi V. Preclinical characteristics of gemcitabine. Anticancer Drugs 1995; 6(Suppl 6): 7-13.
    • (1995) Anticancer Drugs , vol.6 , Issue.SUPPL. 6 , pp. 7-13
    • Plunkett, W.1    Huang, P.2    Gandhi, V.3
  • 29
    • 0023783698 scopus 로고
    • Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine
    • Heinemann V, Hertel LW, Grindey GB, Plunkett W. Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine. Cancer Res 1988; 48(14): 4024-4031.
    • (1988) Cancer Res , vol.48 , Issue.14 , pp. 4024-4031
    • Heinemann, V.1    Hertel, L.W.2    Grindey, G.B.3    Plunkett, W.4
  • 30
    • 0025049372 scopus 로고
    • Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine
    • Heinemann V, Xu YZ, Chubb S, et al. Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine. Mol Pharmacol 1990; 38(4): 567-572.
    • (1990) Mol Pharmacol , vol.38 , Issue.4 , pp. 567-572
    • Heinemann, V.1    Xu, Y.Z.2    Chubb, S.3
  • 31
    • 0026571795 scopus 로고
    • Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: A mechanism of self-potentiation
    • Heinemann V, Xu YZ, Chubb S, et al. Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation. Cancer Res 1992; 52(3): 533-539.
    • (1992) Cancer Res , vol.52 , Issue.3 , pp. 533-539
    • Heinemann, V.1    Xu, Y.Z.2    Chubb, S.3
  • 32
    • 0031808788 scopus 로고    scopus 로고
    • Cross-resistance of the gemcitabine resistant human ovarian cancer cell line AG6000 to standard and investigational drugs
    • Bergman AM, Pinedo HM, Ruiz van Haperen VW, Veerman G, Kuiper CM, Peters GJ. Cross-resistance of the gemcitabine resistant human ovarian cancer cell line AG6000 to standard and investigational drugs. Adv Exp Med Biol 1998; 431: 587-590.
    • (1998) Adv Exp Med Biol , vol.431 , pp. 587-590
    • Bergman, A.M.1    Pinedo, H.M.2    van Haperen, V.W.R.3    Veerman, G.4    Kuiper, C.M.5    Peters, G.J.6
  • 33
    • 0142219312 scopus 로고    scopus 로고
    • Nucleoside transporter profiles in human pancreatic cancer cells: Role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity
    • Garcia-Manteiga J, Molina-Arcas M, Casado FJ, Mazo A, Pastor-Anglada M. Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity. Clin Cancer Res 2003; 9(13): 5000-5008.
    • (2003) Clin Cancer Res , vol.9 , Issue.13 , pp. 5000-5008
    • Garcia-Manteiga, J.1    Molina-Arcas, M.2    Casado, F.J.3    Mazo, A.4    Pastor-Anglada, M.5
  • 34
    • 6044267987 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
    • Spratlin J, Sangha R, Glubrecht D, et al. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 2004; 10(20): 6956-6961.
    • (2004) Clin Cancer Res , vol.10 , Issue.20 , pp. 6956-6961
    • Spratlin, J.1    Sangha, R.2    Glubrecht, D.3
  • 35
    • 33645731188 scopus 로고    scopus 로고
    • Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
    • Giovannetti E, Del Tacca M, Mey V, et al. Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res 2006; 66(7): 3928-3935.
    • (2006) Cancer Res , vol.66 , Issue.7 , pp. 3928-3935
    • Giovannetti, E.1    Del Tacca, M.2    Mey, V.3
  • 36
    • 59849115856 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer
    • Farrell JJ, Elsaleh H, Garcia M, et al. Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer. Gastroenterology 2009; 136(1): 187-195.
    • (2009) Gastroenterology , vol.136 , Issue.1 , pp. 187-195
    • Farrell, J.J.1    Elsaleh, H.2    Garcia, M.3
  • 37
    • 65349163336 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma
    • Marechal R, Mackey JR, Lai R, et al. Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma. Clin Cancer Res 2009; 15(8): 2913-2919.
    • (2009) Clin Cancer Res , vol.15 , Issue.8 , pp. 2913-2919
    • Marechal, R.1    Mackey, J.R.2    Lai, R.3
  • 38
    • 84860795210 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 expression is a strong independent prognostic factor in UICC T3-T4 pancreatic cancer patients treated with preoperative gemcitabine-based chemoradiotherapy
    • in press
    • Murata Y, Hamada T, Kishiwada M, et al. Human equilibrative nucleoside transporter 1 expression is a strong independent prognostic factor in UICC T3-T4 pancreatic cancer patients treated with preoperative gemcitabine-based chemoradiotherapy. J Hepatobiliary Pancreat Sci 2011; in press.
    • (2011) J Hepatobiliary Pancreat Sci
    • Murata, Y.1    Hamada, T.2    Kishiwada, M.3
  • 39
    • 84865044045 scopus 로고    scopus 로고
    • Immunohistochemical analysis of human equilibrative nucleoside transporter-1 (hENT1) predicts survival in resected pancreatic cancer patients treated with adjuvant gemcitabine monotherapy
    • in press
    • Morinaga S, Nakamura Y, Watanabe T, et al. Immunohistochemical analysis of human equilibrative nucleoside transporter-1 (hENT1) predicts survival in resected pancreatic cancer patients treated with adjuvant gemcitabine monotherapy. Ann Surg Oncol 2011; in press.
    • (2011) Ann Surg Oncol
    • Morinaga, S.1    Nakamura, Y.2    Watanabe, T.3
  • 40
    • 2442451440 scopus 로고    scopus 로고
    • Synergistic cytotoxicity and pharmacogenetics of gemcitabine and pemetrexed combination in pancreatic cancer cell lines
    • Giovannetti E, Mey V, Danesi R, Mosca I, del Tacca M. Synergistic cytotoxicity and pharmacogenetics of gemcitabine and pemetrexed combination in pancreatic cancer cell lines. Clin Cancer Res 2004; 10(9): 2936-2943.
    • (2004) Clin Cancer Res , vol.10 , Issue.9 , pp. 2936-2943
    • Giovannetti, E.1    Mey, V.2    Danesi, R.3    Mosca, I.4    Del Tacca, M.5
  • 41
    • 0002831066 scopus 로고    scopus 로고
    • Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity
    • Kroep JR, Loves WJ, van der Wilt CL, et al. Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol Cancer Ther 2002; 1(6): 371-376.
    • (2002) Mol Cancer Ther , vol.1 , Issue.6 , pp. 371-376
    • Kroep, J.R.1    Loves, W.J.2    van der Wilt, C.L.3
  • 42
    • 33646407273 scopus 로고    scopus 로고
    • Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: Relationship to molecular mechanisms of gemcitabine resistance and survival
    • Sebastiani V, Ricci F, Rubio-Viqueira B, et al. Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival. Clin Cancer Res 2006; 12(8): 2492-2497.
    • (2006) Clin Cancer Res , vol.12 , Issue.8 , pp. 2492-2497
    • Sebastiani, V.1    Ricci, F.2    Rubio-Viqueira, B.3
  • 43
    • 78449295201 scopus 로고    scopus 로고
    • Deoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma
    • Marechal R, Mackey JR, Lai R, et al. Deoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma. Cancer 2010; 116(22): 5200-5206.
    • (2010) Cancer , vol.116 , Issue.22 , pp. 5200-5206
    • Marechal, R.1    Mackey, J.R.2    Lai, R.3
  • 44
    • 0034994444 scopus 로고    scopus 로고
    • Nucleoside analogues: Mechanisms of drug resistance and reversal strategies
    • Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 2001; 15(6): 875-890.
    • (2001) Leukemia , vol.15 , Issue.6 , pp. 875-890
    • Galmarini, C.M.1    Mackey, J.R.2    Dumontet, C.3
  • 45
    • 23044435447 scopus 로고    scopus 로고
    • Prolonged fixed dose rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma
    • Bengala C, Guarneri V, Giovannetti E, et al. Prolonged fixed dose rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma. Br J Cancer 2005; 93(1): 35-40.
    • (2005) Br J Cancer , vol.93 , Issue.1 , pp. 35-40
    • Bengala, C.1    Guarneri, V.2    Giovannetti, E.3
  • 46
    • 20244364241 scopus 로고    scopus 로고
    • Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin
    • Yonemori K, Ueno H, Okusaka T, et al. Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin. Clin Cancer Res 2005; 11(7): 2620-2624.
    • (2005) Clin Cancer Res , vol.11 , Issue.7 , pp. 2620-2624
    • Yonemori, K.1    Ueno, H.2    Okusaka, T.3
  • 47
    • 62549146215 scopus 로고    scopus 로고
    • Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients
    • Ueno H, Kaniwa N, Okusaka T, et al. Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients. Br J Cancer 2009; 100(6): 870-873.
    • (2009) Br J Cancer , vol.100 , Issue.6 , pp. 870-873
    • Ueno, H.1    Kaniwa, N.2    Okusaka, T.3
  • 48
    • 34447303456 scopus 로고    scopus 로고
    • Pharmacokinetics of gemcitabine in Japanese cancer patients: The impact of a cytidine deaminase polymorphism
    • Sugiyama E, Kaniwa N, Kim SR, et al. Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. J Clin Oncol 2007; 25(1): 32-42.
    • (2007) J Clin Oncol , vol.25 , Issue.1 , pp. 32-42
    • Sugiyama, E.1    Kaniwa, N.2    Kim, S.R.3
  • 49
    • 79960282941 scopus 로고    scopus 로고
    • Effect of cytidine deaminase (CDA)-related biomarkers on overall survival in patients with advanced pancreatic cancer receiving gemcitabine (GEM) monotherapy
    • Ueno H, Kaniwa N, Sugiyama E, et al. Effect of cytidine deaminase (CDA)-related biomarkers on overall survival in patients with advanced pancreatic cancer receiving gemcitabine (GEM) monotherapy. J Clin Oncol 2011; 29: abstr e14645.
    • (2011) J Clin Oncol , vol.29
    • Ueno, H.1    Kaniwa, N.2    Sugiyama, E.3
  • 50
    • 84866728813 scopus 로고    scopus 로고
    • Cytidine deaminase single-nucleotide polymorphism is predictive of toxicity from gemcitabine in patients with pancreatic cancer: RTOG 9704
    • in press
    • Farrell JJ, Bae K, Wong J, Guha C, Dicker AP, Elsaleh H. Cytidine deaminase single-nucleotide polymorphism is predictive of toxicity from gemcitabine in patients with pancreatic cancer: RTOG 9704. Pharmacogenomics J 2011; in press.
    • (2011) Pharmacogenomics J
    • Farrell, J.J.1    Bae, K.2    Wong, J.3    Guha, C.4    Dicker, A.P.5    Elsaleh, H.6
  • 51
    • 0033198464 scopus 로고    scopus 로고
    • Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line
    • Goan YG, Zhou B, Hu E, Mi S, Yen Y. Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line. Cancer Res 1999; 59(17): 4204-4207.
    • (1999) Cancer Res , vol.59 , Issue.17 , pp. 4204-4207
    • Goan, Y.G.1    Zhou, B.2    Hu, E.3    Mi, S.4    Yen, Y.5
  • 52
    • 33846958737 scopus 로고    scopus 로고
    • Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer
    • Nakahira S, Nakamori S, Tsujie M, et al. Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer. Int J Cancer 2007; 120(6): 1355-1363.
    • (2007) Int J Cancer , vol.120 , Issue.6 , pp. 1355-1363
    • Nakahira, S.1    Nakamori, S.2    Tsujie, M.3
  • 53
    • 1542742114 scopus 로고    scopus 로고
    • RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine
    • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine. Oncogene 2004; 23(8): 1539-1548.
    • (2004) Oncogene , vol.23 , Issue.8 , pp. 1539-1548
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 54
    • 33846296549 scopus 로고    scopus 로고
    • RRM2 induces NF-kappaB-dependent MMP-9 activation and enhances cellular invasiveness
    • Duxbury MS, Whang EE. RRM2 induces NF-kappaB-dependent MMP-9 activation and enhances cellular invasiveness. Biochem Biophys Res Commun 2007; 354(1): 190-196.
    • (2007) Biochem Biophys Res Commun , vol.354 , Issue.1 , pp. 190-196
    • Duxbury, M.S.1    Whang, E.E.2
  • 55
    • 33846816556 scopus 로고    scopus 로고
    • Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
    • Nakano Y, Tanno S, Koizumi K, et al. Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells. Br J Cancer 2007; 96(3): 457-463.
    • (2007) Br J Cancer , vol.96 , Issue.3 , pp. 457-463
    • Nakano, Y.1    Tanno, S.2    Koizumi, K.3
  • 56
    • 77957814960 scopus 로고    scopus 로고
    • Gene expression levels as predictive markers of outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy
    • Fujita H, Ohuchida K, Mizumoto K, et al. Gene expression levels as predictive markers of outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy. Neoplasia 2010; 12(10): 807-817.
    • (2010) Neoplasia , vol.12 , Issue.10 , pp. 807-817
    • Fujita, H.1    Ohuchida, K.2    Mizumoto, K.3
  • 57
    • 74949112149 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity
    • Okazaki T, Javle M, Tanaka M, Abbruzzese JL, Li D. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. Clin Cancer Res. 2010 Jan 1; 16(1): 320-329.
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 320-329
    • Okazaki, T.1    Javle, M.2    Tanaka, M.3    Abbruzzese, J.L.4    Li, D.5
  • 58
    • 78449305536 scopus 로고    scopus 로고
    • Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer
    • Tanaka M, Javle M, Dong X, Eng C, Abbruzzese JL, Li D. Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer. Cancer 2010; 116(22): 5325-5335.
    • (2010) Cancer , vol.116 , Issue.22 , pp. 5325-5335
    • Tanaka, M.1    Javle, M.2    Dong, X.3    Eng, C.4    Abbruzzese, J.L.5    Li, D.6
  • 59
    • 33947156771 scopus 로고    scopus 로고
    • Effects of base excision repair gene polymorphisms on pancreatic cancer survival
    • Li D, Li Y, Jiao L, et al. Effects of base excision repair gene polymorphisms on pancreatic cancer survival. Int J Cancer 2007; 120(8): 1748-1754.
    • (2007) Int J Cancer , vol.120 , Issue.8 , pp. 1748-1754
    • Li, D.1    Li, Y.2    Jiao, L.3
  • 61
    • 33645514237 scopus 로고    scopus 로고
    • Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival
    • Li D, Liu H, Jiao L, et al. Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. Cancer Res 2006; 66(6): 3323-3330.
    • (2006) Cancer Res , vol.66 , Issue.6 , pp. 3323-3330
    • Li, D.1    Liu, H.2    Jiao, L.3
  • 62
    • 33645814832 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer
    • Li D, Frazier M, Evans DB, et al. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. J Clin Oncol 2006; 24(11): 1720-1728.
    • (2006) J Clin Oncol , vol.24 , Issue.11 , pp. 1720-1728
    • Li, D.1    Frazier, M.2    Evans, D.B.3
  • 63
    • 63749130819 scopus 로고    scopus 로고
    • Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer
    • Dong X, Jiao L, Li Y, et al. Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer. J Clin Oncol 2009; 27(10): 1592-1599.
    • (2009) J Clin Oncol , vol.27 , Issue.10 , pp. 1592-1599
    • Dong, X.1    Jiao, L.2    Li, Y.3
  • 64
    • 82255193117 scopus 로고    scopus 로고
    • Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy
    • Giovannetti E, Pacetti P, Reni M, et al. Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy. Pharmacogenomics 2011; 12(12): 1641-1652.
    • (2011) Pharmacogenomics , vol.12 , Issue.12 , pp. 1641-1652
    • Giovannetti, E.1    Pacetti, P.2    Reni, M.3
  • 65
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • Elledge SJ. Cell cycle checkpoints: preventing an identity crisis. Science 1996; 274(5293): 1664-1672.
    • (1996) Science , vol.274 , Issue.5293 , pp. 1664-1672
    • Elledge, S.J.1
  • 66
    • 0035802112 scopus 로고    scopus 로고
    • Activation of mammalian Chk1 during DNA replication arrest: A role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
    • Feijoo C, Hall-Jackson C, Wu R, et al. Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J Cell Biol 2001; 154(5): 913-923.
    • (2001) J Cell Biol , vol.154 , Issue.5 , pp. 913-923
    • Feijoo, C.1    Hall-Jackson, C.2    Wu, R.3
  • 67
    • 42249105871 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer
    • Okazaki T, Jiao L, Chang P, Evans DB, Abbruzzese JL, Li D. Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer. Clin Cancer Res 2008; 14(7): 2042-2048.
    • (2008) Clin Cancer Res , vol.14 , Issue.7 , pp. 2042-2048
    • Okazaki, T.1    Jiao, L.2    Chang, P.3    Evans, D.B.4    Abbruzzese, J.L.5    Li, D.6
  • 68
    • 59449096031 scopus 로고    scopus 로고
    • Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation
    • Chen J, Li D, Killary AM, et al. Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. Ann Surg Oncol 2009; 16(2): 431-439.
    • (2009) Ann Surg Oncol , vol.16 , Issue.2 , pp. 431-439
    • Chen, J.1    Li, D.2    Killary, A.M.3
  • 69
    • 0041338049 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
    • Bondar VM, Sweeney-Gotsch B, Andreeff M, Mills GB, McConkey DJ. Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol Cancer Ther 2002; 1(12): 989-997.
    • (2002) Mol Cancer Ther , vol.1 , Issue.12 , pp. 989-997
    • Bondar, V.M.1    Sweeney-Gotsch, B.2    Andreeff, M.3    Mills, G.B.4    McConkey, D.J.5
  • 70
    • 0038621384 scopus 로고    scopus 로고
    • Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
    • Arlt A, Gehrz A, Muerkoster S, et al. Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 2003; 22(21): 3243-3251.
    • (2003) Oncogene , vol.22 , Issue.21 , pp. 3243-3251
    • Arlt, A.1    Gehrz, A.2    Muerkoster, S.3
  • 71
    • 11144354317 scopus 로고    scopus 로고
    • Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma
    • Yamamoto S, Tomita Y, Hoshida Y, et al. Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma. Clin Cancer Res 2004; 10(8): 2846-2850.
    • (2004) Clin Cancer Res , vol.10 , Issue.8 , pp. 2846-2850
    • Yamamoto, S.1    Tomita, Y.2    Hoshida, Y.3
  • 72
    • 34248573808 scopus 로고    scopus 로고
    • Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products
    • Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res 2007; 67(8): 3853-3861.
    • (2007) Cancer Res , vol.67 , Issue.8 , pp. 3853-3861
    • Kunnumakkara, A.B.1    Guha, S.2    Krishnan, S.3    Diagaradjane, P.4    Gelovani, J.5    Aggarwal, B.B.6
  • 73
    • 0032600214 scopus 로고    scopus 로고
    • Bak expression and cell death occur in peritumorous tissue but not in pancreatic cancer cells
    • discussion 1
    • Graber HU, Friess H, Zimmermann A, et al. Bak expression and cell death occur in peritumorous tissue but not in pancreatic cancer cells. J Gastrointest Surg 1999; 3(1): 74-80; discussion 1.
    • (1999) J Gastrointest Surg , vol.3 , Issue.1 , pp. 74-80
    • Graber, H.U.1    Friess, H.2    Zimmermann, A.3
  • 74
    • 0031715838 scopus 로고    scopus 로고
    • Bax, but not bcl-2, influences the prognosis of human pancreatic cancer
    • Friess H, Lu Z, Graber HU, et al. Bax, but not bcl-2, influences the prognosis of human pancreatic cancer. Gut 1998; 43(3): 414-421.
    • (1998) Gut , vol.43 , Issue.3 , pp. 414-421
    • Friess, H.1    Lu, Z.2    Graber, H.U.3
  • 75
    • 0036092840 scopus 로고    scopus 로고
    • Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents
    • Xu ZW, Friess H, Buchler MW, Solioz M. Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents. Cancer Chemother Pharmacol 2002; 49(6): 504-510.
    • (2002) Cancer Chemother Pharmacol , vol.49 , Issue.6 , pp. 504-510
    • Xu, Z.W.1    Friess, H.2    Buchler, M.W.3    Solioz, M.4
  • 76
    • 17144390205 scopus 로고    scopus 로고
    • Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer
    • Akada M, Crnogorac-Jurcevic T, Lattimore S, et al. Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer. Clin Cancer Res 2005; 11(8): 3094-3101.
    • (2005) Clin Cancer Res , vol.11 , Issue.8 , pp. 3094-3101
    • Akada, M.1    Crnogorac-Jurcevic, T.2    Lattimore, S.3
  • 77
    • 53849124668 scopus 로고    scopus 로고
    • Diverse molecular functions of Hu proteins
    • Hinman MN, Lou H. Diverse molecular functions of Hu proteins. Cell Mol Life Sci 2008; 65(20): 3168-3181.
    • (2008) Cell Mol Life Sci , vol.65 , Issue.20 , pp. 3168-3181
    • Hinman, M.N.1    Lou, H.2
  • 78
    • 66349114705 scopus 로고    scopus 로고
    • The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase
    • Costantino CL, Witkiewicz AK, Kuwano Y, et al. The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. Cancer Res 2009; 69(11): 4567-4572.
    • (2009) Cancer Res , vol.69 , Issue.11 , pp. 4567-4572
    • Costantino, C.L.1    Witkiewicz, A.K.2    Kuwano, Y.3
  • 79
    • 77956222392 scopus 로고    scopus 로고
    • HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients
    • discussion-6
    • Richards NG, Rittenhouse DW, Freydin B, et al. HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients. Ann Surg 2010; 252(3): 499-505; discussion-6.
    • (2010) Ann Surg , vol.252 , Issue.3 , pp. 499-505
    • Richards, N.G.1    Rittenhouse, D.W.2    Freydin, B.3
  • 80
    • 79551690986 scopus 로고    scopus 로고
    • Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome
    • Tanaka M, Okazaki T, Suzuki H, Abbruzzese JL, Li D. Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome. Cancer 2011; 117(4): 744-751.
    • (2011) Cancer , vol.117 , Issue.4 , pp. 744-751
    • Tanaka, M.1    Okazaki, T.2    Suzuki, H.3    Abbruzzese, J.L.4    Li, D.5
  • 81
    • 1642551021 scopus 로고    scopus 로고
    • Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells
    • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. Clin Cancer Res 2004; 10(7): 2307-2318.
    • (2004) Clin Cancer Res , vol.10 , Issue.7 , pp. 2307-2318
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 82
    • 74549213069 scopus 로고    scopus 로고
    • Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines
    • Huanwen W, Zhiyong L, Xiaohua S, Xinyu R, Kai W, Tonghua L. Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines. Mol Cancer 2009; 8: 125.
    • (2009) Mol Cancer , vol.8 , pp. 125
    • Huanwen, W.1    Zhiyong, L.2    Xiaohua, S.3    Xinyu, R.4    Kai, W.5    Tonghua, L.6
  • 83
    • 77955230400 scopus 로고    scopus 로고
    • Evaluation of the clinical significance of focal adhesion kinase and SRC expression in human pancreatic ductal adenocarcinoma
    • Chatzizacharias NA, Giaginis C, Zizi-Serbetzoglou D, Kouraklis GP, Karatzas G, Theocharis SE. Evaluation of the clinical significance of focal adhesion kinase and SRC expression in human pancreatic ductal adenocarcinoma. Pancreas 2010; 39(6): 930-936.
    • (2010) Pancreas , vol.39 , Issue.6 , pp. 930-936
    • Chatzizacharias, N.A.1    Giaginis, C.2    Zizi-Serbetzoglou, D.3    Kouraklis, G.P.4    Karatzas, G.5    Theocharis, S.E.6
  • 84
    • 40949087142 scopus 로고    scopus 로고
    • HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma
    • Liau SS, Whang E. HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma. Clin Cancer Res 2008; 14(5): 1470-1477.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1470-1477
    • Liau, S.S.1    Whang, E.2
  • 85
    • 78650194206 scopus 로고    scopus 로고
    • CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: A novel target for therapy
    • Singh S, Srivastava SK, Bhardwaj A, Owen LB, Singh AP. CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy. Br J Cancer 2010; 103(11): 1671-1679.
    • (2010) Br J Cancer , vol.103 , Issue.11 , pp. 1671-1679
    • Singh, S.1    Srivastava, S.K.2    Bhardwaj, A.3    Owen, L.B.4    Singh, A.P.5
  • 86
    • 73349125465 scopus 로고    scopus 로고
    • MicroRNAs in cancer: Small molecules with a huge impact
    • Iorio MV, Croce CM. MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol 2009; 27(34): 5848-5856.
    • (2009) J Clin Oncol , vol.27 , Issue.34 , pp. 5848-5856
    • Iorio, M.V.1    Croce, C.M.2
  • 87
    • 77953169001 scopus 로고    scopus 로고
    • MicroRNA-21 in pancreatic cancer: Correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity
    • Giovannetti E, Funel N, Peters GJ, et al. MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity. Cancer Res. 2010 Jun 1; 70(11): 4528-4538.
    • (2010) Cancer Res , vol.70 , Issue.11 , pp. 4528-4538
    • Giovannetti, E.1    Funel, N.2    Peters, G.J.3
  • 88
    • 12144287320 scopus 로고    scopus 로고
    • A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    • Neoptolemos JP, Stocken DD, Friess H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med. 2004 Mar 18; 350(12): 1200-1210.
    • (2004) N Engl J Med , vol.350 , Issue.12 , pp. 1200-1210
    • Neoptolemos, J.P.1    Stocken, D.D.2    Friess, H.3
  • 89
    • 40449113435 scopus 로고    scopus 로고
    • Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: A randomized controlled trial
    • Regine WF, Winter KA, Abrams RA, et al. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial. JAMA 2008; 299(9): 1019-1026.
    • (2008) JAMA , vol.299 , Issue.9 , pp. 1019-1026
    • Regine, W.F.1    Winter, K.A.2    Abrams, R.A.3
  • 90
    • 77956416112 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: A randomized controlled trial
    • Neoptolemos JP, Stocken DD, Bassi C, et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 2010; 304(10): 1073-1081.
    • (2010) JAMA , vol.304 , Issue.10 , pp. 1073-1081
    • Neoptolemos, J.P.1    Stocken, D.D.2    Bassi, C.3
  • 92
    • 66149104739 scopus 로고    scopus 로고
    • Cardiotoxicity of 5-fluorouracil and capecitabine in a pancreatic cancer patient with a novel mutation in the dihydropyrimidine dehydrogenase gene
    • Shahrokni A, Rajebi MR, Harold L, Saif MW. Cardiotoxicity of 5-fluorouracil and capecitabine in a pancreatic cancer patient with a novel mutation in the dihydropyrimidine dehydrogenase gene. JOP 2009; 10(2): 215-220.
    • (2009) JOP , vol.10 , Issue.2 , pp. 215-220
    • Shahrokni, A.1    Rajebi, M.R.2    Harold, L.3    Saif, M.W.4
  • 93
    • 29344443013 scopus 로고    scopus 로고
    • Methylation of the DPYD promoter: An alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients
    • Ezzeldin HH, Lee AM, Mattison LK, Diasio RB. Methylation of the DPYD promoter: an alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients. Clin Cancer Res 2005; 11(24 Pt 1): 8699-8705.
    • (2005) Clin Cancer Res , vol.11 , Issue.24 Pt 1 , pp. 8699-8705
    • Ezzeldin, H.H.1    Lee, A.M.2    Mattison, L.K.3    Diasio, R.B.4
  • 94
    • 0033930019 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase activity in human pancreatic tumor tissues
    • Nagakawa T, Kayahara M, Ohta T, et al. Dihydropyrimidine dehydrogenase activity in human pancreatic tumor tissues. Cancer Invest 2000; 18(6): 516-520.
    • (2000) Cancer Invest , vol.18 , Issue.6 , pp. 516-520
    • Nagakawa, T.1    Kayahara, M.2    Ohta, T.3
  • 95
    • 0012365921 scopus 로고    scopus 로고
    • Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues
    • Mori K, Hasegawa M, Nishida M, et al. Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues. Int J Oncol 2000; 17(1): 33-38.
    • (2000) Int J Oncol , vol.17 , Issue.1 , pp. 33-38
    • Mori, K.1    Hasegawa, M.2    Nishida, M.3
  • 96
    • 7044247819 scopus 로고    scopus 로고
    • Clinical significance of dihydropyrimidine dehydrogenase in adjuvant 5-fluorouracil liver perfusion chemotherapy for pancreatic cancer
    • Nakayama S, Takeda S, Kawase Y, Inoue S, Kaneko T, Nakao A. Clinical significance of dihydropyrimidine dehydrogenase in adjuvant 5-fluorouracil liver perfusion chemotherapy for pancreatic cancer. Ann Surg 2004; 240(5): 840-844.
    • (2004) Ann Surg , vol.240 , Issue.5 , pp. 840-844
    • Nakayama, S.1    Takeda, S.2    Kawase, Y.3    Inoue, S.4    Kaneko, T.5    Nakao, A.6
  • 97
    • 53149090560 scopus 로고    scopus 로고
    • High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1
    • Kuramochi H, Hayashi K, Uchida K, et al. High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1. Cancer Chemother Pharmacol 2008; 63(1): 85-89.
    • (2008) Cancer Chemother Pharmacol , vol.63 , Issue.1 , pp. 85-89
    • Kuramochi, H.1    Hayashi, K.2    Uchida, K.3
  • 98
    • 33746872914 scopus 로고    scopus 로고
    • The role of pharmacogenetics in cancer therapeutics
    • Yong WP, Innocenti F, Ratain MJ. The role of pharmacogenetics in cancer therapeutics. Br J Clin Pharmacol 2006; 62(1): 35-46.
    • (2006) Br J Clin Pharmacol , vol.62 , Issue.1 , pp. 35-46
    • Yong, W.P.1    Innocenti, F.2    Ratain, M.J.3
  • 99
    • 0036355046 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer
    • Park DJ, Stoehlmacher J, Zhang W, Tsao-Wei D, Groshen S, Lenz HJ. Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer. Int J Colorectal Dis 2002; 17(1): 46-49.
    • (2002) Int J Colorectal Dis , vol.17 , Issue.1 , pp. 46-49
    • Park, D.J.1    Stoehlmacher, J.2    Zhang, W.3    Tsao-Wei, D.4    Groshen, S.5    Lenz, H.J.6
  • 100
    • 84856072698 scopus 로고    scopus 로고
    • Thymidylate synthase (TYMS) enhancer region genotype-directed phase II trial of oral capecitabine for 2nd line treatment of advanced pancreatic cancer
    • Weekes CD, Nallapareddy S, Rudek MA, et al. Thymidylate synthase (TYMS) enhancer region genotype-directed phase II trial of oral capecitabine for 2nd line treatment of advanced pancreatic cancer. Invest New Drugs 2010; 29(5): 1057-1065.
    • (2010) Invest New Drugs , vol.29 , Issue.5 , pp. 1057-1065
    • Weekes, C.D.1    Nallapareddy, S.2    Rudek, M.A.3
  • 101
    • 0036183722 scopus 로고    scopus 로고
    • Implication of thymidylate synthase in the outcome of patients with invasive ductal carcinoma of the pancreas and efficacy of adjuvant chemotherapy using 5-fluorouracil or its derivatives
    • Takamura M, Nio Y, Yamasawa K, Dong M, Yamaguchi K, Itakura M. Implication of thymidylate synthase in the outcome of patients with invasive ductal carcinoma of the pancreas and efficacy of adjuvant chemotherapy using 5-fluorouracil or its derivatives. Anticancer Drugs 2002; 13(1): 75-85.
    • (2002) Anticancer Drugs , vol.13 , Issue.1 , pp. 75-85
    • Takamura, M.1    Nio, Y.2    Yamasawa, K.3    Dong, M.4    Yamaguchi, K.5    Itakura, M.6
  • 102
    • 67651089739 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydropyrimidine dehydrogenase are upregulated in pancreatic and biliary tract cancers
    • Shimoda M, Sawada T, Kubota K. Thymidylate synthase and dihydropyrimidine dehydrogenase are upregulated in pancreatic and biliary tract cancers. Pathobiology 2009; 76(4): 193-198.
    • (2009) Pathobiology , vol.76 , Issue.4 , pp. 193-198
    • Shimoda, M.1    Sawada, T.2    Kubota, K.3
  • 103
    • 0141678071 scopus 로고    scopus 로고
    • Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer
    • Hu YC, Komorowski RA, Graewin S, et al. Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer. Clin Cancer Res 2003; 9(11): 4165-4171.
    • (2003) Clin Cancer Res , vol.9 , Issue.11 , pp. 4165-4171
    • Hu, Y.C.1    Komorowski, R.A.2    Graewin, S.3
  • 104
    • 33244485826 scopus 로고    scopus 로고
    • Phase I study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: Expression analysis of genes related to outcome
    • Saif MW, Eloubeidi MA, Russo S, et al. Phase I study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: expression analysis of genes related to outcome. J Clin Oncol 2005; 23(34): 8679-8687.
    • (2005) J Clin Oncol , vol.23 , Issue.34 , pp. 8679-8687
    • Saif, M.W.1    Eloubeidi, M.A.2    Russo, S.3
  • 105
    • 35748929435 scopus 로고    scopus 로고
    • Phase II study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: Up-regulation of thymidine phosphorylase
    • Saif MW, Black G, Roy S, et al. Phase II study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: up-regulation of thymidine phosphorylase. Cancer J 2007; 13(4): 247-256.
    • (2007) Cancer J , vol.13 , Issue.4 , pp. 247-256
    • Saif, M.W.1    Black, G.2    Roy, S.3
  • 106
    • 77950510166 scopus 로고    scopus 로고
    • Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: Results from RTOG 9704
    • Manuyakorn A, Paulus R, Farrell J, et al. Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. J Clin Oncol 2010; 28(8): 1358-1365.
    • (2010) J Clin Oncol , vol.28 , Issue.8 , pp. 1358-1365
    • Manuyakorn, A.1    Paulus, R.2    Farrell, J.3
  • 107
    • 33846404174 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance and toxicity associated with platinating agents
    • Rabik CA, Dolan ME. Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat Rev 2007; 33(1): 9-23.
    • (2007) Cancer Treat Rev , vol.33 , Issue.1 , pp. 9-23
    • Rabik, C.A.1    Dolan, M.E.2
  • 108
    • 0031791029 scopus 로고    scopus 로고
    • Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy
    • Reed E. Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy. Cancer Treat Rev 1998; 24(5): 331-344.
    • (1998) Cancer Treat Rev , vol.24 , Issue.5 , pp. 331-344
    • Reed, E.1
  • 109
    • 24344456401 scopus 로고    scopus 로고
    • ERCC1 and clinical resistance to platinum-based therapy
    • Reed E. ERCC1 and clinical resistance to platinum-based therapy. Clin Cancer Res 2005; 11(17): 6100-6102.
    • (2005) Clin Cancer Res , vol.11 , Issue.17 , pp. 6100-6102
    • Reed, E.1
  • 110
    • 78650245775 scopus 로고    scopus 로고
    • Clinical and molecular determinants of survival in pancreatic cancer patients treated with second-line chemotherapy: Results of an Italian/Swiss multicenter survey
    • Mancuso A, Sacchetta S, Saletti PC, et al. Clinical and molecular determinants of survival in pancreatic cancer patients treated with second-line chemotherapy: results of an Italian/Swiss multicenter survey. Anticancer Res 2010; 30(10): 4289-4295.
    • (2010) Anticancer Res , vol.30 , Issue.10 , pp. 4289-4295
    • Mancuso, A.1    Sacchetta, S.2    Saletti, P.C.3
  • 111
    • 4143051317 scopus 로고    scopus 로고
    • Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy
    • Zhou W, Gurubhagavatula S, Liu G, et al. Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy. Clin Cancer Res 2004; 10(15): 4939-4943.
    • (2004) Clin Cancer Res , vol.10 , Issue.15 , pp. 4939-4943
    • Zhou, W.1    Gurubhagavatula, S.2    Liu, G.3
  • 112
    • 24344479165 scopus 로고    scopus 로고
    • ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer
    • Viguier J, Boige V, Miquel C, et al. ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer. Clin Cancer Res 2005; 11(17): 6212-6217.
    • (2005) Clin Cancer Res , vol.11 , Issue.17 , pp. 6212-6217
    • Viguier, J.1    Boige, V.2    Miquel, C.3
  • 113
    • 68849129048 scopus 로고    scopus 로고
    • Cisplatin pharmacogenetics, DNA repair polymorphisms, and esophageal cancer outcomes
    • Bradbury PA, Kulke MH, Heist RS, et al. Cisplatin pharmacogenetics, DNA repair polymorphisms, and esophageal cancer outcomes. Pharmacogenet Genomics 2009; 19(8): 613-625.
    • (2009) Pharmacogenet Genomics , vol.19 , Issue.8 , pp. 613-625
    • Bradbury, P.A.1    Kulke, M.H.2    Heist, R.S.3
  • 114
    • 4143107582 scopus 로고    scopus 로고
    • ERCC1 gene polymorphism as a predictor for clinical outcome in advanced colorectal cancer patients treated with platinum-based chemotherapy
    • Park DJ, Zhang W, Stoehlmacher J, et al. ERCC1 gene polymorphism as a predictor for clinical outcome in advanced colorectal cancer patients treated with platinum-based chemotherapy. Clin Adv Hematol Oncol 2003; 1(3): 162-166.
    • (2003) Clin Adv Hematol Oncol , vol.1 , Issue.3 , pp. 162-166
    • Park, D.J.1    Zhang, W.2    Stoehlmacher, J.3
  • 115
    • 45849142592 scopus 로고    scopus 로고
    • ERCC1 codon 118 polymorphism is a useful prognostic marker in patients with pancreatic cancer treated with platinum-based chemotherapy
    • Kamikozuru H, Kuramochi H, Hayashi K, Nakajima G, Yamamoto M. ERCC1 codon 118 polymorphism is a useful prognostic marker in patients with pancreatic cancer treated with platinum-based chemotherapy. Int J Oncol 2008; 32(5): 1091-1096.
    • (2008) Int J Oncol , vol.32 , Issue.5 , pp. 1091-1096
    • Kamikozuru, H.1    Kuramochi, H.2    Hayashi, K.3    Nakajima, G.4    Yamamoto, M.5
  • 116
    • 0028839053 scopus 로고
    • Phase II trial of CPT-11 in patients with advanced pancreatic cancer, an EORTC early clinical trials group study
    • Wagener DJ, Verdonk HE, Dirix LY, et al. Phase II trial of CPT-11 in patients with advanced pancreatic cancer, an EORTC early clinical trials group study. Ann Oncol 1995; 6(2): 129-132.
    • (1995) Ann Oncol , vol.6 , Issue.2 , pp. 129-132
    • Wagener, D.J.1    Verdonk, H.E.2    Dirix, L.Y.3
  • 117
    • 33748297529 scopus 로고    scopus 로고
    • A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer
    • Stathopoulos GP, Syrigos K, Aravantinos G, et al. A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer. Br J Cancer 2006; 95(5): 587-592.
    • (2006) Br J Cancer , vol.95 , Issue.5 , pp. 587-592
    • Stathopoulos, G.P.1    Syrigos, K.2    Aravantinos, G.3
  • 118
    • 0034162687 scopus 로고    scopus 로고
    • Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2
    • Humerickhouse R, Lohrbach K, Li L, Bosron WF, Dolan ME. Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2. Cancer Res 2000; 60(5): 1189-1192.
    • (2000) Cancer Res , vol.60 , Issue.5 , pp. 1189-1192
    • Humerickhouse, R.1    Lohrbach, K.2    Li, L.3    Bosron, W.F.4    Dolan, M.E.5
  • 119
    • 53849098896 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of irinotecan in metastatic colorectal cancer patients
    • Rouits E, Charasson V, Petain A, et al. Pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of irinotecan in metastatic colorectal cancer patients. Br J Cancer 2008; 99(8): 1239-1245.
    • (2008) Br J Cancer , vol.99 , Issue.8 , pp. 1239-1245
    • Rouits, E.1    Charasson, V.2    Petain, A.3
  • 120
    • 0031661579 scopus 로고    scopus 로고
    • UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan
    • Ando Y, Saka H, Asai G, Sugiura S, Shimokata K, Kamataki T. UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan. Ann Oncol 1998; 9: 845-847.
    • (1998) Ann Oncol , vol.9 , pp. 845-847
    • Ando, Y.1    Saka, H.2    Asai, G.3    Sugiura, S.4    Shimokata, K.5    Kamataki, T.6
  • 121
    • 0036025450 scopus 로고    scopus 로고
    • UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity
    • Iyer L, Das S, Janisch L, et al. UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J 2002; 2: 43-47.
    • (2002) Pharmacogenomics J , vol.2 , pp. 43-47
    • Iyer, L.1    Das, S.2    Janisch, L.3
  • 122
    • 2342459714 scopus 로고    scopus 로고
    • Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
    • Innocenti F, Undevia SD, Iyer L, et al. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 2004; 22: 1382-1388.
    • (2004) J Clin Oncol , vol.22 , pp. 1382-1388
    • Innocenti, F.1    Undevia, S.D.2    Iyer, L.3
  • 123
    • 66349133649 scopus 로고    scopus 로고
    • Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan
    • Cecchin E, Innocenti F, D'Andrea M, et al. Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. J Clin Oncol 2009; 27(15): 2457-2465.
    • (2009) J Clin Oncol , vol.27 , Issue.15 , pp. 2457-2465
    • Cecchin, E.1    Innocenti, F.2    D'Andrea, M.3
  • 124
    • 66349102227 scopus 로고    scopus 로고
    • Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: Clinical and pharmacogenomic results from SWOG S0124
    • Lara PN, Jr., Natale R, Crowley J, et al. Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: clinical and pharmacogenomic results from SWOG S0124. J Clin Oncol 2009; 27(15): 2530-2535.
    • (2009) J Clin Oncol , vol.27 , Issue.15 , pp. 2530-2535
    • Lara Jr., P.N.1    Natale, R.2    Crowley, J.3
  • 125
    • 77955511761 scopus 로고    scopus 로고
    • UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy
    • Martinez-Balibrea E, Abad A, Martinez-Cardus A, et al. UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy. Br J Cancer 2010; 103(4): 581-589.
    • (2010) Br J Cancer , vol.103 , Issue.4 , pp. 581-589
    • Martinez-Balibrea, E.1    Abad, A.2    Martinez-Cardus, A.3
  • 126
    • 79151469394 scopus 로고    scopus 로고
    • Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer
    • Glimelius B, Garmo H, Berglund A, et al. Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. Pharmacogenomics J 2011; 11(1): 61-71.
    • (2011) Pharmacogenomics J , vol.11 , Issue.1 , pp. 61-71
    • Glimelius, B.1    Garmo, H.2    Berglund, A.3
  • 127
    • 4344632633 scopus 로고    scopus 로고
    • UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer
    • Marcuello E, Altes A, Menoyo A, Del Rio E, Gomez-Pardo M, Baiget M. UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer. Br J Cancer 2004; 91(4): 678-682.
    • (2004) Br J Cancer , vol.91 , Issue.4 , pp. 678-682
    • Marcuello, E.1    Altes, A.2    Menoyo, A.3    Del Rio, E.4    Gomez-Pardo, M.5    Baiget, M.6
  • 128
    • 4143101374 scopus 로고    scopus 로고
    • Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: A molecular and clinical study of 75 patients
    • Rouits E, Boisdron-Celle M, Dumont A, Guerin O, Morel A, Gamelin E. Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients. Clin Cancer Res 2004; 10(15): 5151-5159.
    • (2004) Clin Cancer Res , vol.10 , Issue.15 , pp. 5151-5159
    • Rouits, E.1    Boisdron-Celle, M.2    Dumont, A.3    Guerin, O.4    Morel, A.5    Gamelin, E.6
  • 130
    • 77649210559 scopus 로고    scopus 로고
    • Genotype-driven phase I study of irinotecan administered in combination with fluorouracil/leucovorin in patients with metastatic colorectal cancer
    • Toffoli G, Cecchin E, Gasparini G, et al. Genotype-driven phase I study of irinotecan administered in combination with fluorouracil/leucovorin in patients with metastatic colorectal cancer. J Clin Oncol 2010; 28(5): 866-871.
    • (2010) J Clin Oncol , vol.28 , Issue.5 , pp. 866-871
    • Toffoli, G.1    Cecchin, E.2    Gasparini, G.3
  • 131
    • 0031719562 scopus 로고    scopus 로고
    • Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: A common missense mutation among Japanese, Koreans and Chinese
    • Akaba K, Kimura T, Sasaki A, et al. Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese. Biochem Mol Biol Int 1998; 46: 21-26.
    • (1998) Biochem Mol Biol Int , vol.46 , pp. 21-26
    • Akaba, K.1    Kimura, T.2    Sasaki, A.3
  • 132
    • 0033816138 scopus 로고    scopus 로고
    • Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy Taiwanese
    • Huang CS, Luo GA, Huang ML, Yu SC, Yang SS. Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy Taiwanese. Pharmacogenetics 2000; 10: 539-544.
    • (2000) Pharmacogenetics , vol.10 , pp. 539-544
    • Huang, C.S.1    Luo, G.A.2    Huang, M.L.3    Yu, S.C.4    Yang, S.S.5
  • 133
    • 2942527225 scopus 로고    scopus 로고
    • UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer
    • Sai K, Saeki M, Saito Y, et al. UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer. Clin Pharmacol Ther 2004; 75: 501-515.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 501-515
    • Sai, K.1    Saeki, M.2    Saito, Y.3
  • 134
    • 34748857912 scopus 로고    scopus 로고
    • Intra-ethnic differences in genetic variants of the UGT-glucuronosyltransferase 1A1 gene in Chinese populations
    • Zhang A, Xing Q, Qin S, et al. Intra-ethnic differences in genetic variants of the UGT-glucuronosyltransferase 1A1 gene in Chinese populations. Pharmacogenomics J 2007; 7(5): 333-338.
    • (2007) Pharmacogenomics J , vol.7 , Issue.5 , pp. 333-338
    • Zhang, A.1    Xing, Q.2    Qin, S.3
  • 135
    • 33744804311 scopus 로고    scopus 로고
    • Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin
    • Han JY, Lim HS, Shin ES, et al. Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. J Clin Oncol 2006; 24(15): 2237-2244.
    • (2006) J Clin Oncol , vol.24 , Issue.15 , pp. 2237-2244
    • Han, J.Y.1    Lim, H.S.2    Shin, E.S.3
  • 136
    • 2942527225 scopus 로고    scopus 로고
    • UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer
    • Sai K, Saeki M, Saito Y, et al. UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer. Clin Pharmacol Ther 2004; 75(6): 501-515.
    • (2004) Clin Pharmacol Ther , vol.75 , Issue.6 , pp. 501-515
    • Sai, K.1    Saeki, M.2    Saito, Y.3
  • 137
    • 34250202527 scopus 로고    scopus 로고
    • Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: Roles of UGT1A1*6 and *28
    • Minami H, Sai K, Saeki M, et al. Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28. Pharmacogenet Genomics 2007; 17(7): 497-504.
    • (2007) Pharmacogenet Genomics , vol.17 , Issue.7 , pp. 497-504
    • Minami, H.1    Sai, K.2    Saeki, M.3
  • 138
    • 7944233687 scopus 로고    scopus 로고
    • Prediction of irinotecan pharmacokinetics by use of cytochrome P450 3A4 phenotyping probes
    • Mathijssen RH, de Jong FA, van Schaik RH, et al. Prediction of irinotecan pharmacokinetics by use of cytochrome P450 3A4 phenotyping probes. J Natl Cancer Inst 2004; 96(21): 1585-1592.
    • (2004) J Natl Cancer Inst , vol.96 , Issue.21 , pp. 1585-1592
    • Mathijssen, R.H.1    de Jong, F.A.2    van Schaik, R.H.3
  • 139
    • 74549205743 scopus 로고    scopus 로고
    • A CYP3A4 phenotype-based dosing algorithm for individualized treatment of irinotecan
    • van der Bol JM, Mathijssen RH, Creemers GJ, et al. A CYP3A4 phenotype-based dosing algorithm for individualized treatment of irinotecan. Clin Cancer Res 2010; 16(2): 736-742.
    • (2010) Clin Cancer Res , vol.16 , Issue.2 , pp. 736-742
    • van der Bol, J.M.1    Mathijssen, R.H.2    Creemers, G.J.3
  • 140
    • 37549028363 scopus 로고    scopus 로고
    • Influence of the organic anion-transporting polypeptide 1B1 (OATP1B1) polymorphisms on irinotecan-pharmacokinetics and clinical outcome of patients with advanced non-small cell lung cancer
    • Han JY, Lim HS, Shin ES, et al. Influence of the organic anion-transporting polypeptide 1B1 (OATP1B1) polymorphisms on irinotecan-pharmacokinetics and clinical outcome of patients with advanced non-small cell lung cancer. Lung Cancer 2008; 59(1): 69-75.
    • (2008) Lung Cancer , vol.59 , Issue.1 , pp. 69-75
    • Han, J.Y.1    Lim, H.S.2    Shin, E.S.3
  • 141
    • 34250825286 scopus 로고    scopus 로고
    • Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer
    • Han JY, Lim HS, Yoo YK, et al. Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer. Cancer 2007; 110(1): 138-147.
    • (2007) Cancer , vol.110 , Issue.1 , pp. 138-147
    • Han, J.Y.1    Lim, H.S.2    Yoo, Y.K.3
  • 142
    • 33846012498 scopus 로고    scopus 로고
    • Irinotecan-induced diarrhea: Functional significance of the polymorphic ABCC2 transporter protein
    • de Jong FA, Scott-Horton TJ, Kroetz DL, et al. Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein. Clin Pharmacol Ther 2007; 81(1): 42-49.
    • (2007) Clin Pharmacol Ther , vol.81 , Issue.1 , pp. 42-49
    • de Jong, F.A.1    Scott-Horton, T.J.2    Kroetz, D.L.3
  • 143
    • 33747096563 scopus 로고    scopus 로고
    • Pharmacogenetics of SLCO1B1 gene and the impact of *1b and *15 haplotypes on irinotecan disposition in Asian cancer patients
    • Xiang X, Jada SR, Li HH, et al. Pharmacogenetics of SLCO1B1 gene and the impact of *1b and *15 haplotypes on irinotecan disposition in Asian cancer patients. Pharmacogenet Genomics 2006; 16(9): 683-691.
    • (2006) Pharmacogenet Genomics , vol.16 , Issue.9 , pp. 683-691
    • Xiang, X.1    Jada, S.R.2    Li, H.H.3
  • 144
    • 12144286615 scopus 로고    scopus 로고
    • Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan
    • Sai K, Kaniwa N, Itoda M, et al. Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan. Pharmacogenetics 2003; 13(12): 741-757.
    • (2003) Pharmacogenetics , vol.13 , Issue.12 , pp. 741-757
    • Sai, K.1    Kaniwa, N.2    Itoda, M.3
  • 145
    • 0042196122 scopus 로고    scopus 로고
    • Irinotecan pathway genotype analysis to predict pharmacokinetics
    • Mathijssen RH, Marsh S, Karlsson MO, et al. Irinotecan pathway genotype analysis to predict pharmacokinetics. Clin Cancer Res 2003; 9(9): 3246-3253.
    • (2003) Clin Cancer Res , vol.9 , Issue.9 , pp. 3246-3253
    • Mathijssen, R.H.1    Marsh, S.2    Karlsson, M.O.3
  • 146
    • 66849111193 scopus 로고    scopus 로고
    • Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
    • Innocenti F, Kroetz DL, Schuetz E, et al. Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. J Clin Oncol 2009; 27(16): 2604-2614.
    • (2009) J Clin Oncol , vol.27 , Issue.16 , pp. 2604-2614
    • Innocenti, F.1    Kroetz, D.L.2    Schuetz, E.3
  • 147
    • 0035929574 scopus 로고    scopus 로고
    • Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans
    • Tirona RG, Leake BF, Merino G, Kim RB. Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. J Biol Chem 2001; 276(38): 35669-35675.
    • (2001) J Biol Chem , vol.276 , Issue.38 , pp. 35669-35675
    • Tirona, R.G.1    Leake, B.F.2    Merino, G.3    Kim, R.B.4
  • 148
    • 6044241807 scopus 로고    scopus 로고
    • The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma
    • Ueda S, Ogata S, Tsuda H, et al. The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas 2004; 29(1): e1-e8.
    • (2004) Pancreas , vol.29 , Issue.1
    • Ueda, S.1    Ogata, S.2    Tsuda, H.3
  • 149
    • 34447129570 scopus 로고    scopus 로고
    • Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies
    • Wacker B, Nagrani T, Weinberg J, Witt K, Clark G, Cagnoni PJ. Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies. Clin Cancer Res 2007; 13(13): 3913-3921.
    • (2007) Clin Cancer Res , vol.13 , Issue.13 , pp. 3913-3921
    • Wacker, B.1    Nagrani, T.2    Weinberg, J.3    Witt, K.4    Clark, G.5    Cagnoni, P.J.6
  • 150
    • 41949140593 scopus 로고    scopus 로고
    • Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity
    • Rudin CM, Liu W, Desai A, et al. Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity. J Clin Oncol 2008; 26(7): 1119-1127.
    • (2008) J Clin Oncol , vol.26 , Issue.7 , pp. 1119-1127
    • Rudin, C.M.1    Liu, W.2    Desai, A.3
  • 152
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005; 97(5): 339-346.
    • (2005) J Natl Cancer Inst , vol.97 , Issue.5 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 153
    • 27244451321 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    • Takano T, Ohe Y, Sakamoto H, et al. Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005; 23(28): 6829-6837.
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 6829-6837
    • Takano, T.1    Ohe, Y.2    Sakamoto, H.3
  • 154
    • 33947322389 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancer
    • Tzeng CW, Frolov A, Frolova N, et al. Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancer. Surgery 2007; 141(4): 464-469.
    • (2007) Surgery , vol.141 , Issue.4 , pp. 464-469
    • Tzeng, C.W.1    Frolov, A.2    Frolova, N.3
  • 155
    • 34247149803 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma
    • Lee J, Jang KT, Ki CS, et al. Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma. Cancer 2007; 109(8): 1561-1569.
    • (2007) Cancer , vol.109 , Issue.8 , pp. 1561-1569
    • Lee, J.1    Jang, K.T.2    Ki, C.S.3
  • 156
    • 33846220461 scopus 로고    scopus 로고
    • Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas
    • Kwak EL, Jankowski J, Thayer SP, et al. Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas. Clin Cancer Res 2006; 12(14 Pt 1): 4283-4287.
    • (2006) Clin Cancer Res , vol.12 , Issue.14 Pt 1 , pp. 4283-4287
    • Kwak, E.L.1    Jankowski, J.2    Thayer, S.P.3
  • 157
    • 35248866321 scopus 로고    scopus 로고
    • EGFR genomic gain and aberrant pathway signaling in pancreatic cancer patients
    • Tzeng CW, Frolov A, Frolova N, et al. EGFR genomic gain and aberrant pathway signaling in pancreatic cancer patients. J Surg Res 2007; 143(1): 20-26.
    • (2007) J Surg Res , vol.143 , Issue.1 , pp. 20-26
    • Tzeng, C.W.1    Frolov, A.2    Frolova, N.3
  • 158
    • 78650095716 scopus 로고    scopus 로고
    • Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3
    • da Cunha Santos G, Dhani N, Tu D, et al. Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3. Cancer 2010; 116(24): 5599-5607.
    • (2010) Cancer , vol.116 , Issue.24 , pp. 5599-5607
    • da Cunha Santos, G.1    Dhani, N.2    Tu, D.3
  • 159
    • 34548251394 scopus 로고    scopus 로고
    • ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinib
    • Frolov A, Schuller K, Tzeng CW, et al. ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinib. Cancer Biol Ther 2007; 6(4): 548-554.
    • (2007) Cancer Biol Ther , vol.6 , Issue.4 , pp. 548-554
    • Frolov, A.1    Schuller, K.2    Tzeng, C.W.3
  • 160
    • 33748361817 scopus 로고    scopus 로고
    • Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity
    • Buck E, Eyzaguirre A, Haley JD, Gibson NW, Cagnoni P, Iwata KK. Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity. Mol Cancer Ther 2006; 5(8): 2051-2059.
    • (2006) Mol Cancer Ther , vol.5 , Issue.8 , pp. 2051-2059
    • Buck, E.1    Eyzaguirre, A.2    Haley, J.D.3    Gibson, N.W.4    Cagnoni, P.5    Iwata, K.K.6
  • 161
    • 0026864473 scopus 로고
    • Two chromosome 7 dinucleotide repeat polymorphisms at gene loci epidermal growth factor receptor (EGFR) and pro alpha 2 (I) collagen (COL1A2)
    • Chi DD, Hing AV, Helms C, Steinbrueck T, Mishra SK, Donis-Keller H. Two chromosome 7 dinucleotide repeat polymorphisms at gene loci epidermal growth factor receptor (EGFR) and pro alpha 2 (I) collagen (COL1A2). Hum Mol Genet 1992; 1(2): 135.
    • (1992) Hum Mol Genet , vol.1 , Issue.2 , pp. 135
    • Chi, D.D.1    Hing, A.V.2    Helms, C.3    Steinbrueck, T.4    Mishra, S.K.5    Donis-Keller, H.6
  • 162
    • 0040886242 scopus 로고    scopus 로고
    • Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1
    • Gebhardt F, Zanker KS, Brandt B. Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1. J Biol Chem 1999; 274(19): 13176-13180.
    • (1999) J Biol Chem , vol.274 , Issue.19 , pp. 13176-13180
    • Gebhardt, F.1    Zanker, K.S.2    Brandt, B.3
  • 163
    • 33644841038 scopus 로고    scopus 로고
    • Gene polymorphisms of epidermal growth factor receptor and its downstream effector, interleukin-8, predict oxaliplatin efficacy in patients with advanced colorectal cancer
    • Zhang W, Stoehlmacher J, Park DJ, et al. Gene polymorphisms of epidermal growth factor receptor and its downstream effector, interleukin-8, predict oxaliplatin efficacy in patients with advanced colorectal cancer. Clin Colorectal Cancer 2005; 5(2): 124-131.
    • (2005) Clin Colorectal Cancer , vol.5 , Issue.2 , pp. 124-131
    • Zhang, W.1    Stoehlmacher, J.2    Park, D.J.3
  • 164
    • 19944428532 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene polymorphisms predict pelvic recurrence in patients with rectal cancer treated with chemoradiation
    • Zhang W, Park DJ, Lu B, et al. Epidermal growth factor receptor gene polymorphisms predict pelvic recurrence in patients with rectal cancer treated with chemoradiation. Clin Cancer Res 2005; 11(2 Pt 1): 600-605.
    • (2005) Clin Cancer Res , vol.11 , Issue.2 Pt 1 , pp. 600-605
    • Zhang, W.1    Park, D.J.2    Lu, B.3
  • 165
    • 10844264628 scopus 로고    scopus 로고
    • An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors
    • Amador ML, Oppenheimer D, Perea S, et al. An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors. Cancer Res 2004; 64(24): 9139-9143.
    • (2004) Cancer Res , vol.64 , Issue.24 , pp. 9139-9143
    • Amador, M.L.1    Oppenheimer, D.2    Perea, S.3
  • 166
    • 21344468378 scopus 로고    scopus 로고
    • Analysis of the dinucleotide repeat polymorphism in the epidermal growth factor receptor (EGFR) gene in head and neck cancer patients
    • Etienne-Grimaldi MC, Pereira S, Magne N, et al. Analysis of the dinucleotide repeat polymorphism in the epidermal growth factor receptor (EGFR) gene in head and neck cancer patients. Ann Oncol 2005; 16(6): 934-941.
    • (2005) Ann Oncol , vol.16 , Issue.6 , pp. 934-941
    • Etienne-Grimaldi, M.C.1    Pereira, S.2    Magne, N.3
  • 167
    • 0034652578 scopus 로고    scopus 로고
    • Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression
    • Buerger H, Gebhardt F, Schmidt H, et al. Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression. Cancer Res 2000; 60(4): 854-857.
    • (2000) Cancer Res , vol.60 , Issue.4 , pp. 854-857
    • Buerger, H.1    Gebhardt, F.2    Schmidt, H.3
  • 168
    • 34250828460 scopus 로고    scopus 로고
    • Pancreatic cancer epidermal growth factor receptor (EGFR) intron 1 polymorphism influences postoperative patient survival and in vitro erlotinib response
    • Tzeng CW, Frolov A, Frolova N, et al. Pancreatic cancer epidermal growth factor receptor (EGFR) intron 1 polymorphism influences postoperative patient survival and in vitro erlotinib response. Ann Surg Oncol 2007; 14(7): 2150-2158.
    • (2007) Ann Surg Oncol , vol.14 , Issue.7 , pp. 2150-2158
    • Tzeng, C.W.1    Frolov, A.2    Frolova, N.3
  • 169
    • 84860830887 scopus 로고    scopus 로고
    • Molecular markers of the EGFR pathway in erlotinib-treated patients with advanced pancreatic cancer (APC): Translational analyses of a randomized, cross-over AIO phase III trial
    • abstr 4047
    • Boeck SH, Jung A, Laubende RP, et al. Molecular markers of the EGFR pathway in erlotinib-treated patients with advanced pancreatic cancer (APC): Translational analyses of a randomized, cross-over AIO phase III trial. J Clin Oncol 2011; 29(suppl): abstr 4047).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Boeck, S.H.1    Jung, A.2    Laubende, R.P.3
  • 170
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
    • Seo Y, Baba H, Fukuda T, Takashima M, Sugimachi K. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 2000; 88(10): 2239-2245.
    • (2000) Cancer , vol.88 , Issue.10 , pp. 2239-2245
    • Seo, Y.1    Baba, H.2    Fukuda, T.3    Takashima, M.4    Sugimachi, K.5
  • 171
    • 0036311535 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas
    • Niedergethmann M, Hildenbrand R, Wostbrock B, et al. High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas. Pancreas 2002; 25(2): 122-129.
    • (2002) Pancreas , vol.25 , Issue.2 , pp. 122-129
    • Niedergethmann, M.1    Hildenbrand, R.2    Wostbrock, B.3
  • 172
    • 32944478346 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
    • Kindler HL, Friberg G, Singh DA, et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 2005; 23(31): 8033-8040.
    • (2005) J Clin Oncol , vol.23 , Issue.31 , pp. 8033-8040
    • Kindler, H.L.1    Friberg, G.2    Singh, D.A.3
  • 173
    • 50249087586 scopus 로고    scopus 로고
    • A phase II study evaluating bevacizumab in combination with fixed-dose rate gemcitabine and low-dose cisplatin for metastatic pancreatic cancer: Is an anti-VEGF strategy still applicable?
    • Ko AH, Dito E, Schillinger B, et al. A phase II study evaluating bevacizumab in combination with fixed-dose rate gemcitabine and low-dose cisplatin for metastatic pancreatic cancer: is an anti-VEGF strategy still applicable? Invest New Drugs 2008; 26(5): 463-471.
    • (2008) Invest New Drugs , vol.26 , Issue.5 , pp. 463-471
    • Ko, A.H.1    Dito, E.2    Schillinger, B.3
  • 174
    • 67349250514 scopus 로고    scopus 로고
    • Bevacizumab combined with gemcitabine and capecitabine for advanced pancreatic cancer: A phase II study
    • Javle M, Yu J, Garrett C, et al. Bevacizumab combined with gemcitabine and capecitabine for advanced pancreatic cancer: a phase II study. Br J Cancer 2009; 100(12): 1842-1825.
    • (2009) Br J Cancer , vol.100 , Issue.12 , pp. 1825-1842
    • Javle, M.1    Yu, J.2    Garrett, C.3
  • 175
    • 53749093040 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
    • Schneider BP, Wang M, Radovich M, et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 2008; 26(28): 4672-4678.
    • (2008) J Clin Oncol , vol.26 , Issue.28 , pp. 4672-4678
    • Schneider, B.P.1    Wang, M.2    Radovich, M.3
  • 176
    • 79955851306 scopus 로고    scopus 로고
    • Prospective analysis of the impact of VEGF-A gene polymorphisms on the pharmacodynamics of bevacizumab-based therapy in metastatic breast cancer patients
    • Etienne-Grimaldi MC, Formento P, Degeorges A, et al. Prospective analysis of the impact of VEGF-A gene polymorphisms on the pharmacodynamics of bevacizumab-based therapy in metastatic breast cancer patients. Br J Clin Pharmacol 2011; 71(6): 921-928.
    • (2011) Br J Clin Pharmacol , vol.71 , Issue.6 , pp. 921-928
    • Etienne-Grimaldi, M.C.1    Formento, P.2    Degeorges, A.3
  • 177
    • 79955508461 scopus 로고    scopus 로고
    • Pharmacogenetic interaction analysis for the efficacy of systemic treatment in metastatic colorectal cancer
    • Pander J, Wessels JA, Gelderblom H, van der Straaten T, Punt CJ, Guchelaar HJ. Pharmacogenetic interaction analysis for the efficacy of systemic treatment in metastatic colorectal cancer. Ann Oncol 2011; 22(5): 1147-1153.
    • (2011) Ann Oncol , vol.22 , Issue.5 , pp. 1147-1153
    • Pander, J.1    Wessels, J.A.2    Gelderblom, H.3    van der Straaten, T.4    Punt, C.J.5    Guchelaar, H.J.6
  • 178
    • 77954243581 scopus 로고    scopus 로고
    • The predictive value of serum VEGF in multiresistant ovarian cancer patients treated with bevacizumab
    • Smerdel MP, Steffensen KD, Waldstrom M, Brandslund I, Jakobsen A. The predictive value of serum VEGF in multiresistant ovarian cancer patients treated with bevacizumab. Gynecol Oncol 2010; 118(2): 167-171.
    • (2010) Gynecol Oncol , vol.118 , Issue.2 , pp. 167-171
    • Smerdel, M.P.1    Steffensen, K.D.2    Waldstrom, M.3    Brandslund, I.4    Jakobsen, A.5
  • 179
    • 79954451405 scopus 로고    scopus 로고
    • Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer
    • Loupakis F, Cremolini C, Fioravanti A, et al. Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer. Br J Cancer 2011; 104(8): 1262-1269.
    • (2011) Br J Cancer , vol.104 , Issue.8 , pp. 1262-1269
    • Loupakis, F.1    Cremolini, C.2    Fioravanti, A.3
  • 180
    • 58149346076 scopus 로고    scopus 로고
    • Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab
    • Schultheis AM, Lurje G, Rhodes KE, et al. Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab. Clin Cancer Res 2008; 14(22): 7554-7563.
    • (2008) Clin Cancer Res , vol.14 , Issue.22 , pp. 7554-7563
    • Schultheis, A.M.1    Lurje, G.2    Rhodes, K.E.3
  • 181
    • 0033666337 scopus 로고    scopus 로고
    • Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families
    • Hull J, Thomson A, Kwiatkowski D. Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax 2000; 55(12): 1023-1027.
    • (2000) Thorax , vol.55 , Issue.12 , pp. 1023-1027
    • Hull, J.1    Thomson, A.2    Kwiatkowski, D.3
  • 183
    • 0037301007 scopus 로고    scopus 로고
    • Variations of human adrenomedullin gene and its relation to cardiovascular diseases
    • Ishimitsu T, Tsukada K, Minami J, Ono H, Matsuoka H. Variations of human adrenomedullin gene and its relation to cardiovascular diseases. Hypertens Res 2003; 26(Suppl): S129-S134.
    • (2003) Hypertens Res , vol.26 , Issue.SUPPL.
    • Ishimitsu, T.1    Tsukada, K.2    Minami, J.3    Ono, H.4    Matsuoka, H.5
  • 184
    • 84862908671 scopus 로고    scopus 로고
    • A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303
    • Innocenti F, Owzar K, Cox NL, et al. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clin Cancer Res 2011; 18(2): 577-584.
    • (2011) Clin Cancer Res , vol.18 , Issue.2 , pp. 577-584
    • Innocenti, F.1    Owzar, K.2    Cox, N.L.3
  • 185
    • 33646060990 scopus 로고    scopus 로고
    • IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity
    • Kawaguchi M, Takahashi D, Hizawa N, et al. IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. J Allergy Clin Immunol 2006; 117(4): 795-801.
    • (2006) J Allergy Clin Immunol , vol.117 , Issue.4 , pp. 795-801
    • Kawaguchi, M.1    Takahashi, D.2    Hizawa, N.3
  • 186
    • 64849092309 scopus 로고    scopus 로고
    • Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
    • Jones S, Hruban RH, Kamiyama M, et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 2009; 324(5924): 217.
    • (2009) Science , vol.324 , Issue.5924 , pp. 217
    • Jones, S.1    Hruban, R.H.2    Kamiyama, M.3
  • 187
    • 70450197805 scopus 로고    scopus 로고
    • Translating the cancer genome into clinically useful tools and strategies
    • Innocenti F, Schilsky RL. Translating the cancer genome into clinically useful tools and strategies. Dis Model Mech 2009; 2(9-10): 426-429.
    • (2009) Dis Model Mech , vol.2 , Issue.9-10 , pp. 426-429
    • Innocenti, F.1    Schilsky, R.L.2
  • 188
    • 73949107880 scopus 로고    scopus 로고
    • Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment
    • Philip PA, Mooney M, Jaffe D, et al. Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment. J Clin Oncol 2009; 27(33): 5660-5669.
    • (2009) J Clin Oncol , vol.27 , Issue.33 , pp. 5660-5669
    • Philip, P.A.1    Mooney, M.2    Jaffe, D.3


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