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Volumn 16, Issue 1, 2010, Pages 320-329

Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYTIDINE DEAMINASE; DEOXYCYTIDINE KINASE; DEOXYCYTIDINE PHOSPHATE DEAMINASE; GEMCITABINE; HCNT1 PROTEIN; HCNT2 PROTEIN; HCNT3 PROTEIN; HENT1 PROTEIN; NUCLEOSIDE TRANSPORTER; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE M1; UNCLASSIFIED DRUG;

EID: 74949112149     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-09-1555     Document Type: Article
Times cited : (95)

References (31)
  • 1
    • 33646550512 scopus 로고    scopus 로고
    • Molecular biomarkers: Their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer
    • Jimeno A, Hidalgo M. Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer. Mol Cancer Ther 2006;5:787-96.
    • (2006) Mol Cancer Ther , vol.5 , pp. 787-796
    • Jimeno, A.1    Hidalgo, M.2
  • 2
    • 33745686698 scopus 로고    scopus 로고
    • Mini E, Nobili S, Caciagli B, Landini I, Mazzei T. Cellular pharmacology of gemcitabine. Ann Oncol 2006;17:v7-12.
    • Mini E, Nobili S, Caciagli B, Landini I, Mazzei T. Cellular pharmacology of gemcitabine. Ann Oncol 2006;17:v7-12.
  • 3
    • 0028832342 scopus 로고
    • Gemcitabine: A modulator of intracellular nucleotide and deoxynucleotide metabolism
    • Heinemann V, Schulz L, Issels RD, Plunkett W. Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism. Semin Oncol 1995;22:11-18.
    • (1995) Semin Oncol , vol.22 , pp. 11-18
    • Heinemann, V.1    Schulz, L.2    Issels, R.D.3    Plunkett, W.4
  • 4
    • 0025737572 scopus 로고
    • 2′-Deoxy-2′- methylenecytidine and 2′-deoxy-2′,2′-difluorocytidine 5′-diphosphates: Potent mechanism-based inhibitors of ribonucleotide reductase
    • Baker CH, Banzon J, Bollinger JM, et al. 2′-Deoxy-2′- methylenecytidine and 2′-deoxy-2′,2′-difluorocytidine 5′-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase. J Med Chem 1991;34:1879-84.
    • (1991) J Med Chem , vol.34 , pp. 1879-1884
    • Baker, C.H.1    Banzon, J.2    Bollinger, J.M.3
  • 5
    • 0002831066 scopus 로고    scopus 로고
    • Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity
    • Kroep JR, Loves WJP, van der Wilt CL, et al. Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol Cancer Ther 2002;1:371-6.
    • (2002) Mol Cancer Ther , vol.1 , pp. 371-376
    • Kroep, J.R.1    Loves, W.J.P.2    van der Wilt, C.L.3
  • 6
    • 33745712217 scopus 로고    scopus 로고
    • Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells
    • Jordheim LP, Galmarini CM, Dumontet C. Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells. Cancer Chemother Pharmacol 2006;58:547-54.
    • (2006) Cancer Chemother Pharmacol , vol.58 , pp. 547-554
    • Jordheim, L.P.1    Galmarini, C.M.2    Dumontet, C.3
  • 7
    • 2642535305 scopus 로고    scopus 로고
    • Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene
    • Galmarini CM, Clarke ML, Jordheim L, et al. Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene. BMC Pharmacol 2004;4:8.
    • (2004) BMC Pharmacol , vol.4 , pp. 8
    • Galmarini, C.M.1    Clarke, M.L.2    Jordheim, L.3
  • 8
    • 9244234326 scopus 로고    scopus 로고
    • Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients
    • Shi JY, Shi ZZ, Zhang SJ, et al. Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients. Pharmacogenetics 2004;14:759-68.
    • (2004) Pharmacogenetics , vol.14 , pp. 759-768
    • Shi, J.Y.1    Shi, Z.Z.2    Zhang, S.J.3
  • 9
    • 0036462584 scopus 로고    scopus 로고
    • Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine)
    • Bergman AM, Pinedo HM, Peters GJ. Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine). Drug Resist Updat 2002;5:19-33.
    • (2002) Drug Resist Updat , vol.5 , pp. 19-33
    • Bergman, A.M.1    Pinedo, H.M.2    Peters, G.J.3
  • 10
    • 5044225419 scopus 로고    scopus 로고
    • Determinations of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer
    • Achiwa H, Oguri T, Sato S, Maeda H, Niimi T, Ueda R. Determinations of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer. Cancer Sci 2004;95:753-7.
    • (2004) Cancer Sci , vol.95 , pp. 753-757
    • Achiwa, H.1    Oguri, T.2    Sato, S.3    Maeda, H.4    Niimi, T.5    Ueda, R.6
  • 11
    • 33645731188 scopus 로고    scopus 로고
    • Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
    • Giovannetti E, Tacca MD, Mey V, et al. Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res 2006;66:3928-35.
    • (2006) Cancer Res , vol.66 , pp. 3928-3935
    • Giovannetti, E.1    Tacca, M.D.2    Mey, V.3
  • 12
    • 6044267987 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
    • Spratlin J, Sangha R, Glubrecht D, et al. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 2004;10:6956-61.
    • (2004) Clin Cancer Res , vol.10 , pp. 6956-6961
    • Spratlin, J.1    Sangha, R.2    Glubrecht, D.3
  • 13
    • 33846816556 scopus 로고    scopus 로고
    • Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
    • Nakano Y, Tanno S, Koizumi K, et al. Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells. Br J Cancer 2007;96:457-63.
    • (2007) Br J Cancer , vol.96 , pp. 457-463
    • Nakano, Y.1    Tanno, S.2    Koizumi, K.3
  • 14
    • 5044242910 scopus 로고    scopus 로고
    • Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway
    • Fukunaga AK, Marsh S, Murry DJ, Hurley TD, McLeod HL. Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway. Pharmacogenomics 2004;4:307-14.
    • (2004) Pharmacogenomics , vol.4 , pp. 307-314
    • Fukunaga, A.K.1    Marsh, S.2    Murry, D.J.3    Hurley, T.D.4    McLeod, H.L.5
  • 15
    • 34447329337 scopus 로고    scopus 로고
    • Pharmacogenomics of gemcitabine: Can genetic studies lead to tailor-made therapy?
    • Ueno H, Kiyosawa K, Kaniwa N. Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy? Br J Cancer 2007;97:145-51.
    • (2007) Br J Cancer , vol.97 , pp. 145-151
    • Ueno, H.1    Kiyosawa, K.2    Kaniwa, N.3
  • 16
    • 20244364241 scopus 로고    scopus 로고
    • Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin
    • Yonemori K, Ueno H, Okusaka T, et al. Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin. Clin Cancer Res 2005;11:2620-4.
    • (2005) Clin Cancer Res , vol.11 , pp. 2620-2624
    • Yonemori, K.1    Ueno, H.2    Okusaka, T.3
  • 17
    • 34447303456 scopus 로고    scopus 로고
    • Pharmacokinetics of gemcitabine in Japanese cancer patients: The impact of a cytidine deaminase polymorphism
    • Sugiyama E, Kaniwa N, Kim SR, et al. Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. J Clin Oncol 2007;25:32-42.
    • (2007) J Clin Oncol , vol.25 , pp. 32-42
    • Sugiyama, E.1    Kaniwa, N.2    Kim, S.R.3
  • 18
    • 49049102131 scopus 로고    scopus 로고
    • Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head
    • Varadhachary GR, Wolff RA, Crane CH, et al. Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head. J Clin Oncol 2008;26:3487-95.
    • (2008) J Clin Oncol , vol.26 , pp. 3487-3495
    • Varadhachary, G.R.1    Wolff, R.A.2    Crane, C.H.3
  • 19
    • 49049101358 scopus 로고    scopus 로고
    • Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head
    • Evans DB, Varadhachary GR, Crane CH, et al. Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head. J Clin Oncol 2008;26:3496-502.
    • (2008) J Clin Oncol , vol.26 , pp. 3496-3502
    • Evans, D.B.1    Varadhachary, G.R.2    Crane, C.H.3
  • 20
    • 0026454511 scopus 로고
    • Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas
    • Evans DB, Rich TA, Byrd DR, et al. Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas. Arch Surg 1992;127:1335-9.
    • (1992) Arch Surg , vol.127 , pp. 1335-1339
    • Evans, D.B.1    Rich, T.A.2    Byrd, D.R.3
  • 21
    • 1642295096 scopus 로고    scopus 로고
    • Assessing the probability that a positive report is false: An approach for molecular epidemiology studies
    • Wacholder S, Chanock S, Garcia-Closas M, El ghormli L, Rothman N. Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst 2004;96:434-42.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 434-442
    • Wacholder, S.1    Chanock, S.2    Garcia-Closas, M.3    El ghormli, L.4    Rothman, N.5
  • 22
    • 63749130819 scopus 로고    scopus 로고
    • Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer
    • Dong X, Jiao L, Li Y, et al. Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer. J Clin Oncol 2009;27:1592-9.
    • (2009) J Clin Oncol , vol.27 , pp. 1592-1599
    • Dong, X.1    Jiao, L.2    Li, Y.3
  • 23
    • 0037245970 scopus 로고    scopus 로고
    • A functional single-nucleotide polymorphism in the human cyticine deaminase gene contributing to ara-C sensitivity
    • Yue L, Saikawa Y, Ota K, et al. A functional single-nucleotide polymorphism in the human cyticine deaminase gene contributing to ara-C sensitivity. Parmacogenetics 2003;13:29-38.
    • (2003) Parmacogenetics , vol.13 , pp. 29-38
    • Yue, L.1    Saikawa, Y.2    Ota, K.3
  • 24
    • 0345628622 scopus 로고    scopus 로고
    • Structural and functional analysis of the cytidine deaminase gene in patients with acute myeloid leukaemia
    • Schröder JK, Kirch C, Seeber S, Schütte J. Structural and functional analysis of the cytidine deaminase gene in patients with acute myeloid leukaemia. Br J Haematol 1998;103:1096-103.
    • (1998) Br J Haematol , vol.103 , pp. 1096-1103
    • Schröder, J.K.1    Kirch, C.2    Seeber, S.3    Schütte, J.4
  • 25
    • 33645692656 scopus 로고    scopus 로고
    • Gemcitabine pharmacogenomics: Cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics
    • Gilbert JA, Salavaggione OE, Ji Y, et al. Gemcitabine pharmacogenomics: cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics. Clin Cancer Res 2006;12:1794-803.
    • (2006) Clin Cancer Res , vol.12 , pp. 1794-1803
    • Gilbert, J.A.1    Salavaggione, O.E.2    Ji, Y.3
  • 26
    • 33644996013 scopus 로고    scopus 로고
    • Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter
    • Fitzgerald SM, Goyal RK, Osborne WRA, Roy JD, Wilson JW, Ferrell RE. Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter. Hum Genet 2006;119:276-83.
    • (2006) Hum Genet , vol.119 , pp. 276-283
    • Fitzgerald, S.M.1    Goyal, R.K.2    Osborne, W.R.A.3    Roy, J.D.4    Wilson, J.W.5    Ferrell, R.E.6
  • 27
    • 33645917374 scopus 로고    scopus 로고
    • Myers SN, Goyal RK, Roy JD, Fairfull LD, Wilson JW, Ferrell RE. Functional single nucleotide polymorphism haplotypes in the human equilibrative nucleotide transporter1. Pharmacogenet Genomics 2006;16:315-20.
    • Myers SN, Goyal RK, Roy JD, Fairfull LD, Wilson JW, Ferrell RE. Functional single nucleotide polymorphism haplotypes in the human equilibrative nucleotide transporter1. Pharmacogenet Genomics 2006;16:315-20.
  • 28
    • 33748999014 scopus 로고    scopus 로고
    • Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleotide transporter 1(hENT1)
    • Kim SR, Saito Y, Maekawa K, et al. Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleotide transporter 1(hENT1). Drug Metab Pharmacokinet 2006;21:248-56.
    • (2006) Drug Metab Pharmacokinet , vol.21 , pp. 248-256
    • Kim, S.R.1    Saito, Y.2    Maekawa, K.3
  • 29
    • 0037565518 scopus 로고    scopus 로고
    • Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1
    • Osato DH, Huang CC, Kawamoto M, et al. Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1. Pharmacogenetics 2003;13:297-301.
    • (2003) Pharmacogenetics , vol.13 , pp. 297-301
    • Osato, D.H.1    Huang, C.C.2    Kawamoto, M.3
  • 30
    • 59849115856 scopus 로고    scopus 로고
    • Human equilibrium nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer
    • Farrel JJ, Elsaleh H, Garcia M, et al. Human equilibrium nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer. Gastroenterology 2008;136:187-95.
    • (2008) Gastroenterology , vol.136 , pp. 187-195
    • Farrel, J.J.1    Elsaleh, H.2    Garcia, M.3
  • 31
    • 33846504706 scopus 로고    scopus 로고
    • A "silent" polymorphism in the MDR1 gene changes substrate specificity
    • Kimchi-Sarfaty C, Oh JM, Kim IW, et al. A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science 2007;315:525-8.
    • (2007) Science , vol.315 , pp. 525-528
    • Kimchi-Sarfaty, C.1    Oh, J.M.2    Kim, I.W.3


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