-
1
-
-
33646550512
-
Molecular biomarkers: Their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer
-
Jimeno A, Hidalgo M. Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer. Mol Cancer Ther 2006;5:787-96.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 787-796
-
-
Jimeno, A.1
Hidalgo, M.2
-
2
-
-
33745686698
-
-
Mini E, Nobili S, Caciagli B, Landini I, Mazzei T. Cellular pharmacology of gemcitabine. Ann Oncol 2006;17:v7-12.
-
Mini E, Nobili S, Caciagli B, Landini I, Mazzei T. Cellular pharmacology of gemcitabine. Ann Oncol 2006;17:v7-12.
-
-
-
-
3
-
-
0028832342
-
Gemcitabine: A modulator of intracellular nucleotide and deoxynucleotide metabolism
-
Heinemann V, Schulz L, Issels RD, Plunkett W. Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism. Semin Oncol 1995;22:11-18.
-
(1995)
Semin Oncol
, vol.22
, pp. 11-18
-
-
Heinemann, V.1
Schulz, L.2
Issels, R.D.3
Plunkett, W.4
-
4
-
-
0025737572
-
2′-Deoxy-2′- methylenecytidine and 2′-deoxy-2′,2′-difluorocytidine 5′-diphosphates: Potent mechanism-based inhibitors of ribonucleotide reductase
-
Baker CH, Banzon J, Bollinger JM, et al. 2′-Deoxy-2′- methylenecytidine and 2′-deoxy-2′,2′-difluorocytidine 5′-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase. J Med Chem 1991;34:1879-84.
-
(1991)
J Med Chem
, vol.34
, pp. 1879-1884
-
-
Baker, C.H.1
Banzon, J.2
Bollinger, J.M.3
-
5
-
-
0002831066
-
Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity
-
Kroep JR, Loves WJP, van der Wilt CL, et al. Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol Cancer Ther 2002;1:371-6.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 371-376
-
-
Kroep, J.R.1
Loves, W.J.P.2
van der Wilt, C.L.3
-
6
-
-
33745712217
-
Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells
-
Jordheim LP, Galmarini CM, Dumontet C. Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells. Cancer Chemother Pharmacol 2006;58:547-54.
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, pp. 547-554
-
-
Jordheim, L.P.1
Galmarini, C.M.2
Dumontet, C.3
-
7
-
-
2642535305
-
Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene
-
Galmarini CM, Clarke ML, Jordheim L, et al. Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene. BMC Pharmacol 2004;4:8.
-
(2004)
BMC Pharmacol
, vol.4
, pp. 8
-
-
Galmarini, C.M.1
Clarke, M.L.2
Jordheim, L.3
-
8
-
-
9244234326
-
Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients
-
Shi JY, Shi ZZ, Zhang SJ, et al. Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients. Pharmacogenetics 2004;14:759-68.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 759-768
-
-
Shi, J.Y.1
Shi, Z.Z.2
Zhang, S.J.3
-
9
-
-
0036462584
-
Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine)
-
Bergman AM, Pinedo HM, Peters GJ. Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine). Drug Resist Updat 2002;5:19-33.
-
(2002)
Drug Resist Updat
, vol.5
, pp. 19-33
-
-
Bergman, A.M.1
Pinedo, H.M.2
Peters, G.J.3
-
10
-
-
5044225419
-
Determinations of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer
-
Achiwa H, Oguri T, Sato S, Maeda H, Niimi T, Ueda R. Determinations of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer. Cancer Sci 2004;95:753-7.
-
(2004)
Cancer Sci
, vol.95
, pp. 753-757
-
-
Achiwa, H.1
Oguri, T.2
Sato, S.3
Maeda, H.4
Niimi, T.5
Ueda, R.6
-
11
-
-
33645731188
-
Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
-
Giovannetti E, Tacca MD, Mey V, et al. Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res 2006;66:3928-35.
-
(2006)
Cancer Res
, vol.66
, pp. 3928-3935
-
-
Giovannetti, E.1
Tacca, M.D.2
Mey, V.3
-
12
-
-
6044267987
-
The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
-
Spratlin J, Sangha R, Glubrecht D, et al. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 2004;10:6956-61.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6956-6961
-
-
Spratlin, J.1
Sangha, R.2
Glubrecht, D.3
-
13
-
-
33846816556
-
Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
-
Nakano Y, Tanno S, Koizumi K, et al. Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells. Br J Cancer 2007;96:457-63.
-
(2007)
Br J Cancer
, vol.96
, pp. 457-463
-
-
Nakano, Y.1
Tanno, S.2
Koizumi, K.3
-
14
-
-
5044242910
-
Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway
-
Fukunaga AK, Marsh S, Murry DJ, Hurley TD, McLeod HL. Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway. Pharmacogenomics 2004;4:307-14.
-
(2004)
Pharmacogenomics
, vol.4
, pp. 307-314
-
-
Fukunaga, A.K.1
Marsh, S.2
Murry, D.J.3
Hurley, T.D.4
McLeod, H.L.5
-
15
-
-
34447329337
-
Pharmacogenomics of gemcitabine: Can genetic studies lead to tailor-made therapy?
-
Ueno H, Kiyosawa K, Kaniwa N. Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy? Br J Cancer 2007;97:145-51.
-
(2007)
Br J Cancer
, vol.97
, pp. 145-151
-
-
Ueno, H.1
Kiyosawa, K.2
Kaniwa, N.3
-
16
-
-
20244364241
-
Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin
-
Yonemori K, Ueno H, Okusaka T, et al. Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin. Clin Cancer Res 2005;11:2620-4.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2620-2624
-
-
Yonemori, K.1
Ueno, H.2
Okusaka, T.3
-
17
-
-
34447303456
-
Pharmacokinetics of gemcitabine in Japanese cancer patients: The impact of a cytidine deaminase polymorphism
-
Sugiyama E, Kaniwa N, Kim SR, et al. Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. J Clin Oncol 2007;25:32-42.
-
(2007)
J Clin Oncol
, vol.25
, pp. 32-42
-
-
Sugiyama, E.1
Kaniwa, N.2
Kim, S.R.3
-
18
-
-
49049102131
-
Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head
-
Varadhachary GR, Wolff RA, Crane CH, et al. Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head. J Clin Oncol 2008;26:3487-95.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3487-3495
-
-
Varadhachary, G.R.1
Wolff, R.A.2
Crane, C.H.3
-
19
-
-
49049101358
-
Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head
-
Evans DB, Varadhachary GR, Crane CH, et al. Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head. J Clin Oncol 2008;26:3496-502.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3496-3502
-
-
Evans, D.B.1
Varadhachary, G.R.2
Crane, C.H.3
-
20
-
-
0026454511
-
Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas
-
Evans DB, Rich TA, Byrd DR, et al. Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas. Arch Surg 1992;127:1335-9.
-
(1992)
Arch Surg
, vol.127
, pp. 1335-1339
-
-
Evans, D.B.1
Rich, T.A.2
Byrd, D.R.3
-
21
-
-
1642295096
-
Assessing the probability that a positive report is false: An approach for molecular epidemiology studies
-
Wacholder S, Chanock S, Garcia-Closas M, El ghormli L, Rothman N. Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst 2004;96:434-42.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 434-442
-
-
Wacholder, S.1
Chanock, S.2
Garcia-Closas, M.3
El ghormli, L.4
Rothman, N.5
-
22
-
-
63749130819
-
Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer
-
Dong X, Jiao L, Li Y, et al. Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer. J Clin Oncol 2009;27:1592-9.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1592-1599
-
-
Dong, X.1
Jiao, L.2
Li, Y.3
-
23
-
-
0037245970
-
A functional single-nucleotide polymorphism in the human cyticine deaminase gene contributing to ara-C sensitivity
-
Yue L, Saikawa Y, Ota K, et al. A functional single-nucleotide polymorphism in the human cyticine deaminase gene contributing to ara-C sensitivity. Parmacogenetics 2003;13:29-38.
-
(2003)
Parmacogenetics
, vol.13
, pp. 29-38
-
-
Yue, L.1
Saikawa, Y.2
Ota, K.3
-
24
-
-
0345628622
-
Structural and functional analysis of the cytidine deaminase gene in patients with acute myeloid leukaemia
-
Schröder JK, Kirch C, Seeber S, Schütte J. Structural and functional analysis of the cytidine deaminase gene in patients with acute myeloid leukaemia. Br J Haematol 1998;103:1096-103.
-
(1998)
Br J Haematol
, vol.103
, pp. 1096-1103
-
-
Schröder, J.K.1
Kirch, C.2
Seeber, S.3
Schütte, J.4
-
25
-
-
33645692656
-
Gemcitabine pharmacogenomics: Cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics
-
Gilbert JA, Salavaggione OE, Ji Y, et al. Gemcitabine pharmacogenomics: cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics. Clin Cancer Res 2006;12:1794-803.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1794-1803
-
-
Gilbert, J.A.1
Salavaggione, O.E.2
Ji, Y.3
-
26
-
-
33644996013
-
Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter
-
Fitzgerald SM, Goyal RK, Osborne WRA, Roy JD, Wilson JW, Ferrell RE. Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter. Hum Genet 2006;119:276-83.
-
(2006)
Hum Genet
, vol.119
, pp. 276-283
-
-
Fitzgerald, S.M.1
Goyal, R.K.2
Osborne, W.R.A.3
Roy, J.D.4
Wilson, J.W.5
Ferrell, R.E.6
-
27
-
-
33645917374
-
-
Myers SN, Goyal RK, Roy JD, Fairfull LD, Wilson JW, Ferrell RE. Functional single nucleotide polymorphism haplotypes in the human equilibrative nucleotide transporter1. Pharmacogenet Genomics 2006;16:315-20.
-
Myers SN, Goyal RK, Roy JD, Fairfull LD, Wilson JW, Ferrell RE. Functional single nucleotide polymorphism haplotypes in the human equilibrative nucleotide transporter1. Pharmacogenet Genomics 2006;16:315-20.
-
-
-
-
28
-
-
33748999014
-
Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleotide transporter 1(hENT1)
-
Kim SR, Saito Y, Maekawa K, et al. Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleotide transporter 1(hENT1). Drug Metab Pharmacokinet 2006;21:248-56.
-
(2006)
Drug Metab Pharmacokinet
, vol.21
, pp. 248-256
-
-
Kim, S.R.1
Saito, Y.2
Maekawa, K.3
-
29
-
-
0037565518
-
Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1
-
Osato DH, Huang CC, Kawamoto M, et al. Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1. Pharmacogenetics 2003;13:297-301.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 297-301
-
-
Osato, D.H.1
Huang, C.C.2
Kawamoto, M.3
-
30
-
-
59849115856
-
Human equilibrium nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer
-
Farrel JJ, Elsaleh H, Garcia M, et al. Human equilibrium nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer. Gastroenterology 2008;136:187-95.
-
(2008)
Gastroenterology
, vol.136
, pp. 187-195
-
-
Farrel, J.J.1
Elsaleh, H.2
Garcia, M.3
-
31
-
-
33846504706
-
A "silent" polymorphism in the MDR1 gene changes substrate specificity
-
Kimchi-Sarfaty C, Oh JM, Kim IW, et al. A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science 2007;315:525-8.
-
(2007)
Science
, vol.315
, pp. 525-528
-
-
Kimchi-Sarfaty, C.1
Oh, J.M.2
Kim, I.W.3
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