-
2
-
-
77955227695
-
-
Bethesda MD: National Cancer Institute. Updated January 7, 2009, [online database]
-
Pancreatic Cancer Treatment. Bethesda, MD: National Cancer Institute; 1996. Updated January 7, 2009, [online database].
-
(1996)
Pancreatic Cancer Treatment
-
-
-
3
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA III, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403-2413.
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris III, H.A.1
Moore, M.J.2
Andersen, J.3
-
4
-
-
27644460508
-
Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer
-
A phase III trial of the National Cancer Institute of Canada Clinical Trials Group [NCICCTG]. 2005 ASCO Annual Meeting Proceedings. Vol 23, No. 16S, Part I of II (June 1 Supplement).
-
Moore MJ GD, Hamm J, et al. Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group [NCICCTG]. J Clin Oncol. 2005;1 2005 ASCO Annual Meeting Proceedings. Vol 23, No. 16S, Part I of II (June 1 Supplement).
-
(2005)
J Clin Oncol
, vol.1
-
-
Moore, M.J.G.D.1
Hamm, J.2
-
5
-
-
67649334763
-
GEM-CAP: PHASE III radnomised comparison of gemcitabine with gemcitabine plus capecitabine in patients with advanced pancreas cancer
-
#PS11
-
Cunningham DCI, Stocken D, et al. GEM-CAP: PHASE III radnomised comparison of gemcitabine with gemcitabine plus capecitabine in patients with advanced pancreas cancer. ECCO 2005, #PS11.
-
(2005)
ECCO
-
-
Cunningham, D.C.I.1
Stocken, D.2
-
6
-
-
0026759309
-
Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation
-
Guan JL, Shalloway D. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature. 1992;358:690-692.
-
(1992)
Nature
, vol.358
, pp. 690-692
-
-
Guan, J.L.1
Shalloway, D.2
-
7
-
-
0026612521
-
Pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions
-
Schaller MD, Borgman CA, Cobb BS, et al. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci U S A. 1992;89:5192-5196.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 5192-5196
-
-
Schaller, M.D.1
Borgman, C.A.2
Cobb, B.S.3
-
8
-
-
0026674919
-
Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin
-
Hanks SK, Calalb MB, Harper MC, et al. Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci U S A. 1992;89:8487-8491.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 8487-8491
-
-
Hanks, S.K.1
Calalb, M.B.2
Harper, M.C.3
-
9
-
-
0026497659
-
Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets
-
Lipfert L, Haimovich B, Schaller MD, et al. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J Cell Biol. 1992;119:905-912.
-
(1992)
J Cell Biol
, vol.119
, pp. 905-912
-
-
Lipfert, L.1
Haimovich, B.2
Schaller, M.D.3
-
10
-
-
0026700191
-
Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate
-
Zachary I, Sinnett-Smith J, Rozengurt E. Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate. J Biol Chem. 1992;267:19031-19034.
-
(1992)
J Biol Chem
, vol.267
, pp. 19031-19034
-
-
Zachary, I.1
Sinnett-Smith, J.2
Rozengurt, E.3
-
11
-
-
0030662101
-
Focal adhesion kinase
-
Zachary I. Focal adhesion kinase. Int J Biochem Cell Biol. 1997;29:929-934.
-
(1997)
Int J Biochem Cell Biol
, vol.29
, pp. 929-934
-
-
Zachary, I.1
-
12
-
-
0028122650
-
Focal adhesion kinase and associated proteins
-
Schaller MD, Parsons JT. Focal adhesion kinase and associated proteins. Curr Opin Cell Biol. 1994;6:705-710.
-
(1994)
Curr Opin Cell Biol
, vol.6
, pp. 705-710
-
-
Schaller, M.D.1
Parsons, J.T.2
-
13
-
-
33845630384
-
Focal adhesion kinase signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells
-
Salasznyk RM, Klees RF, Williams WA, et al. Focal adhesion kinase signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells. Exp Cell Res. 2007;313:22-37.
-
(2007)
Exp Cell Res
, vol.313
, pp. 22-37
-
-
Salasznyk, R.M.1
Klees, R.F.2
Williams, W.A.3
-
14
-
-
0033555070
-
Focal adhesion kinase in integrin-mediated signaling
-
Cary LA, Guan JL. Focal adhesion kinase in integrin-mediated signaling. Front Biosci. 1999;4:D102-D113.
-
(1999)
Front Biosci
, vol.4
-
-
Cary, L.A.1
Guan, J.L.2
-
15
-
-
0028342938
-
Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain
-
Xing Z, Chen HC, Nowlen JK, et al. Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol Biol Cell. 1994;5:413-421.
-
(1994)
Mol Biol Cell
, vol.5
, pp. 413-421
-
-
Xing, Z.1
Chen, H.C.2
Nowlen, J.K.3
-
16
-
-
0032509402
-
C-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells
-
Rahimi N, Hung W, Tremblay E, et al. c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells. J Biol Chem. 1998;273:33714-33721.
-
(1998)
J Biol Chem
, vol.273
, pp. 33714-33721
-
-
Rahimi, N.1
Hung, W.2
Tremblay, E.3
-
17
-
-
0035947714
-
The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase
-
Hauck CR, Hunter T, Schlaepfer DD. The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase. J Biol Chem. 2001;276:17653-17662.
-
(2001)
J Biol Chem
, vol.276
, pp. 17653-17662
-
-
Hauck, C.R.1
Hunter, T.2
Schlaepfer, D.D.3
-
18
-
-
0037150728
-
Src in cancer: Deregulation and consequences for cell behaviour
-
Frame MC. Src in cancer: deregulation and consequences for cell behaviour. Biochim Biophys Acta. 2002;1602:114-130.
-
(2002)
Biochim Biophys Acta
, vol.1602
, pp. 114-130
-
-
Frame, M.C.1
-
20
-
-
33748068089
-
New concepts regarding focal adhesion kinase promotion of cell migration and proliferation
-
Cox BD, Natarajan M, Stettner MR, et al. New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. J Cell Biochem. 2006;99:35-52.
-
(2006)
J Cell Biochem
, vol.99
, pp. 35-52
-
-
Cox, B.D.1
Natarajan, M.2
Stettner, M.R.3
-
21
-
-
40349100337
-
Clinical significance of FAK expression in human neoplasia. Histology and Histopathology
-
Chatzizacharias NA, Kouraklis GP, Theocharis SE. Clinical significance of FAK expression in human neoplasia. Histology and Histopathology. Histol Histopathol. 2008;23:629-650.
-
(2008)
Histol Histopathol
, vol.23
, pp. 629-650
-
-
Chatzizacharias, N.A.1
Kouraklis, G.P.2
Theocharis, S.E.3
-
22
-
-
0038386613
-
Src Family kinases in tumor progression and metastasis
-
Summy JM, Gallick GE. Src Family kinases in tumor progression and metastasis. Cancer Metastasis Rev. 2003;22:337-358.
-
(2003)
Cancer Metastasis Rev
, vol.22
, pp. 337-358
-
-
Summy, J.M.1
Gallick, G.E.2
-
24
-
-
33745063122
-
Src inhibitors as potential therapeutic agents for human cancers
-
Trevino JG, Summy JM, Gallick GE. Src inhibitors as potential therapeutic agents for human cancers. Mini Rev Med Chem. 2006;6:681-687.
-
(2006)
Mini Rev Med Chem
, vol.6
, pp. 681-687
-
-
Trevino, J.G.1
Summy, J.M.2
Gallick, G.E.3
-
25
-
-
35349017845
-
Phase 1 study of a focal adhesion kinase (FAK) inhibitor PF-00562271 in patients with advanced solid tumors
-
2007 ASCO Annual Meeting Proceedings
-
Siu LL, Burris HA, Mileshkin L, et al. Phase 1 study of a focal adhesion kinase (FAK) inhibitor PF-00562271 in patients with advanced solid tumors. J Clin Oncol. 2007;25:3527 2007 ASCO Annual Meeting Proceedings.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3527
-
-
Siu, L.L.1
Burris, H.A.2
Mileshkin, L.3
-
27
-
-
77955227195
-
-
June 17, Updated June 26, 2009. Available at: Accessed July 1, 2009
-
Randomized, Double-Blinded, Placebo-Controlled, Multi-Institutional, Phase II.5 Study of AZDO53O, a Selective Src Kinase Inhibitor, in Patients With Recurrent Osteosarcoma Localized to the Lung. [Clinical Trials Web site]. June 17, 2009. Updated June 26, 2009. Available at: http://clinicaltrials.gov/ct2/ show/ NCT00923286?term=src&rank=1. Accessed July 1, 2009.
-
(2009)
Randomized Double-Blinded, Placebo-Controlled Multi-Institutional Phase II.5 Study of AZDO53O A Selective Src Kinase Inhibitor in Patients with Recurrent Osteosarcoma Localized to the Lung
-
-
-
28
-
-
77955230776
-
-
November 6, Updated February 25, 2009. Available at: Accessed July 1, 2009
-
Phase II Study of Dasatinib in Previously Treated Patients With Advanced NSCLC (TOP0801). [Clinical Trials Web site]. November 6, 2008. Updated February 25, 2009. Available at: http://clinicaltrials.gov/ ct2/show/NCT00787267?term= src&rank=8. Accessed July 1, 2009.
-
(2008)
Phase II Study of Dasatinib in Previously Treated Patients with Advanced NSCLC (TOP0801)
-
-
-
29
-
-
77955231162
-
-
January 8, Updated April 20, 2009. Available at: Accessed July 1, 2009
-
A Phase I/II Study of Dasatinib and Dacarbazine. [Clinical Trials Web site]. January 8, 2008. Updated April 20, 2009. Available at: http://clinicaltrials.gov/ct2/show/ NCT00597038?term=src+inhibitor&rank=3. Accessed July 1, 2009.
-
(2008)
A Phase I/II Study of Dasatinib and Dacarbazine
-
-
-
30
-
-
77955229390
-
-
March 5, Updated January 30, 2009. Available at: Accessed July 1, 2009
-
Phase I Dasatinib/Erlotinib in Recurrent NSCLC. [Clinical Trials Web site]. March 5, 2007. Updated January 30, 2009. Available at: http://clinicaltrials.gov/ct2/show/ NCT00444015?term=src+inhibitor&rank=5. Accessed July 1, 2009.
-
(2007)
Phase i Dasatinib/Erlotinib in Recurrent NSCLC
-
-
-
31
-
-
31544436916
-
Clinical significance of focal adhesion kinase in resectable pancreatic cancer
-
Furuyama K, Doi R, Mori T, et al. Clinical significance of focal adhesion kinase in resectable pancreatic cancer. World J Surg. 2006;30:219-226.
-
(2006)
World J Surg
, vol.30
, pp. 219-226
-
-
Furuyama, K.1
Doi, R.2
Mori, T.3
-
32
-
-
0345195986
-
Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma
-
Lutz M, Eber IBC, Flossmann-Kast BBM, et al. Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma. Biochem Biophys Res Com. 1998;243:503-508.
-
(1998)
Biochem Biophys Res Com
, vol.243
, pp. 503-508
-
-
Lutz, M.1
Eber, I.B.C.2
Flossmann-Kast, B.B.M.3
-
36
-
-
43049122454
-
Clinical significance of tumor-associated antigen RCAS1 expression in human pancreatic ductal adenocarcinoma
-
Giaginis C, Davides D, Zarros A, et al. Clinical significance of tumor-associated antigen RCAS1 expression in human pancreatic ductal adenocarcinoma. Dig Dis Sci. 2008;53:1728-1734.
-
(2008)
Dig Dis Sci
, vol.53
, pp. 1728-1734
-
-
Giaginis, C.1
Davides, D.2
Zarros, A.3
-
37
-
-
34548158429
-
Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer
-
Ischenko I, Guba M, Yezhelyev M, et al. Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer. Angiogenesis. 2007;10:167-182.
-
(2007)
Angiogenesis
, vol.10
, pp. 167-182
-
-
Ischenko, I.1
Guba, M.2
Yezhelyev, M.3
-
38
-
-
57349147100
-
Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: An involvement of epidermal growth factor receptor signalling
-
Ischenko I, Camaj P, Seeliger H, et al. Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signalling. Oncogene. 2008;27:7212-7222.
-
(2008)
Oncogene
, vol.27
, pp. 7212-7222
-
-
Ischenko, I.1
Camaj, P.2
Seeliger, H.3
|