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Volumn 59, Issue 17, 1999, Pages 4204-4207

Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line

Author keywords

[No Author keywords available]

Indexed keywords

GEMCITABINE; MESSENGER RNA; RIBONUCLEOTIDE REDUCTASE;

EID: 0033198464     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (211)

References (20)
  • 1
    • 0029902591 scopus 로고
    • Clinical, toxicological and pharmacological aspects of gemcitabine
    • Guchelaar, H. J., Richel, D. J., and van Knapen, A. Clinical, toxicological and pharmacological aspects of gemcitabine. Cancer Treat. Rev., 22: 15-31, 1983.
    • (1983) Cancer Treat. Rev. , vol.22 , pp. 15-31
    • Guchelaar, H.J.1    Richel, D.J.2    Van Knapen, A.3
  • 2
    • 0028799108 scopus 로고
    • Gemcitabine: Metabolism, mechanisms of action, and self-potentiation
    • Plunkett, W., Huang, P., Xu, Y. Z., Heinemann, V., Grunewald, R., and Gandhi, V. Gemcitabine: metabolism, mechanisms of action, and self-potentiation. Semin. Oncol., 22 (Suppl. 11): 3-10, 1995.
    • (1995) Semin. Oncol. , vol.22 , Issue.SUPPL. 11 , pp. 3-10
    • Plunkett, W.1    Huang, P.2    Xu, Y.Z.3    Heinemann, V.4    Grunewald, R.5    Gandhi, V.6
  • 3
    • 0023783698 scopus 로고
    • Comparison of the cellular pharmacokinetics and toxicity of 2,2-difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine
    • Heinemann, V., Hertel, L. W., Grindey, G. B., and Plunkett, W. Comparison of the cellular pharmacokinetics and toxicity of 2,2-difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine. Cancer Res., 48: 4024-4031, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 4024-4031
    • Heinemann, V.1    Hertel, L.W.2    Grindey, G.B.3    Plunkett, W.4
  • 4
    • 10344266073 scopus 로고
    • Regulation of ribonucleotide reductase activity in mammalian cells
    • Cory, J. G., and Sato, A. Regulation of ribonucleotide reductase activity in mammalian cells. Mol. Cell. Biochem., 53: 257-266, 1983.
    • (1983) Mol. Cell. Biochem. , vol.53 , pp. 257-266
    • Cory, J.G.1    Sato, A.2
  • 5
    • 0022799261 scopus 로고
    • Isolation and characterization of expressible cDNA clones encoding the M1 and M2 subunits of mouse ribonucleotide reductase
    • Thelander, L., and Berg, P. Isolation and characterization of expressible cDNA clones encoding the M1 and M2 subunits of mouse ribonucleotide reductase. Mol. Cell. Biol., 6: 3433-3422, 1986.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 3433-13422
    • Thelander, L.1    Berg, P.2
  • 6
    • 0031938457 scopus 로고    scopus 로고
    • Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhance their invasion potential
    • Zhou, B. S., Tsai, P., Ker, R., Tsai, J., Ho, R., Yu, J., Shih, J., and Yen, Y. Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhance their invasion potential. Clin. Exp. Metastasis, 16: 43-49, 1998.
    • (1998) Clin. Exp. Metastasis , vol.16 , pp. 43-49
    • Zhou, B.S.1    Tsai, P.2    Ker, R.3    Tsai, J.4    Ho, R.5    Yu, J.6    Shih, J.7    Yen, Y.8
  • 7
    • 0030450403 scopus 로고    scopus 로고
    • Ribonucleotide reductase R2 component is a novel malignancy determination that cooperates with activated oncogenes to determine transformation and malignant potential
    • Fan H., Villegas, C., and Wright, J. A. Ribonucleotide reductase R2 component is a novel malignancy determination that cooperates with activated oncogenes to determine transformation and malignant potential. Proc. Natl. Acad. Sci. USA, 93: 14036-14040, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14036-14040
    • Fan, H.1    Villegas, C.2    Wright, J.A.3
  • 9
    • 0025977171 scopus 로고
    • Preclinical in vivo activity of 2,2-difluorodeoxycytidine (gemcitabine) against human head and neck cancer
    • Braakhuis, B. J. M., Van Dongen, G. A. M. S., Vermorken, J. B., and Snow, G. B. Preclinical in vivo activity of 2,2-difluorodeoxycytidine (gemcitabine) against human head and neck cancer. Cancer Res., 51: 211-214, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 211-214
    • Braakhuis, B.J.M.1    Van Dongen, G.A.M.S.2    Vermorken, J.B.3    Snow, G.B.4
  • 11
    • 0021719254 scopus 로고
    • Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-β-D-arabinofuranosylcytosine
    • Bhalla, K., Nayak, R., and Grant, S. Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-β-D-arabinofuranosylcytosine. Cancer Res., 44: 5029-5037, 1984.
    • (1984) Cancer Res. , vol.44 , pp. 5029-5037
    • Bhalla, K.1    Nayak, R.2    Grant, S.3
  • 12
    • 0020072941 scopus 로고
    • 1-β-D-arabinofuranosylcytosine influx and nucleoside transport sites in acute leukemia
    • Wiley, J. S., Jones, S. P., Sawyer, W. H., and Paterson, A. R. P. 1-β-D-arabinofuranosylcytosine influx and nucleoside transport sites in acute leukemia. J. Clin. Invest., 69: 479-489, 1982.
    • (1982) J. Clin. Invest. , vol.69 , pp. 479-489
    • Wiley, J.S.1    Jones, S.P.2    Sawyer, W.H.3    Paterson, A.R.P.4
  • 13
    • 0024397460 scopus 로고
    • Augmentation of 1-β-D-arabinofuranosylcytosine cytotoxicity in human tumor cells by inhibiting drug efflux
    • Chan, T. C. K., Augmentation of 1-β-D-arabinofuranosylcytosine cytotoxicity in human tumor cells by inhibiting drug efflux. Cancer Res., 49: 2656-2660, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 2656-2660
    • Chan, T.C.K.1
  • 14
    • 0028107848 scopus 로고
    • Characterization of a hydroxyurea-resistant human KB cell line with supersensitivity to 6-thioguanine
    • Yen, Y., Grill, S. P., Dutschman, G. E., Chang, C. N., Zhou, B. S., and Cheng, Y. C. Characterization of a hydroxyurea-resistant human KB cell line with supersensitivity to 6-thioguanine. Cancer Res., 54: 3686-3691, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 3686-3691
    • Yen, Y.1    Grill, S.P.2    Dutschman, G.E.3    Chang, C.N.4    Zhou, B.S.5    Cheng, Y.C.6
  • 15
    • 0028928261 scopus 로고
    • Overexpression of ribonucleotide reductase in transfected human KB cells increases their resistance to hydroxyurea: M2 but not M1 is sufficient to increase resistance to hydroxyurea in transfected cells
    • Zhou, B. S., Hsu, N. Y., Pan, B. C., Doroshow, J. H., and Yen, Y. Overexpression of ribonucleotide reductase in transfected human KB cells increases their resistance to hydroxyurea: M2 but not M1 is sufficient to increase resistance to hydroxyurea in transfected cells. Cancer Res., 55: 1328-1333, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 1328-1333
    • Zhou, B.S.1    Hsu, N.Y.2    Pan, B.C.3    Doroshow, J.H.4    Yen, Y.5
  • 16
    • 0032524942 scopus 로고    scopus 로고
    • Determination of deoxyribonucleoside triphosphate pool size in ribonucleotide reductase cDNA transfected human KB cells
    • Zhou, B. S., Ker, R., Ho, R., Yu J., Zhao, Y. R., Shih, J., and Yen, Y. Determination of deoxyribonucleoside triphosphate pool size in ribonucleotide reductase cDNA transfected human KB cells. Biochem. Pharmacol., 55: 1657-1665, 1998.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1657-1665
    • Zhou, B.S.1    Ker, R.2    Ho, R.3    Yu, J.4    Zhao, Y.R.5    Shih, J.6    Yen, Y.7
  • 17
    • 0014759788 scopus 로고
    • A rapid assay for CDP reductase activity in mammalian cell extracts
    • Steeper, J. P., and Stuart, C. D. A rapid assay for CDP reductase activity in mammalian cell extracts. Anal. Biochem., 34: 123-130, 1970.
    • (1970) Anal. Biochem. , vol.34 , pp. 123-130
    • Steeper, J.P.1    Stuart, C.D.2
  • 18
    • 0014663461 scopus 로고
    • Rapid determination of nucleoside kinase and nucleotidase activities with tritium-labeled substrates
    • Ivies, D. H., Durhan, J. P., and Tucker, V. S. Rapid determination of nucleoside kinase and nucleotidase activities with tritium-labeled substrates. Anal. Biochem., 28: 192-205, 1968.
    • (1968) Anal. Biochem. , vol.28 , pp. 192-205
    • Ivies, D.H.1    Durhan, J.P.2    Tucker, V.S.3
  • 19
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the qualification of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. A. A rapid and sensitive method for the qualification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254, 1976.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.