UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan

Annals of Oncology

Volumn 9, Issue 8, 1998, Pages 845-847

  Ando, Y ^a   Saka, H ^a   Asai, G ^a   Sugiura, S ^a   Shimokata, K ^a   Kamataki, T ^b  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Genetic polymorphism; Glucuronidation; Irinotecan; Pharmacokinetics

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CARBOPLATIN; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; IRINOTECAN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG GLUCURONIDATION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LUNG CANCER; MALE; PHARMACOGENETICS; PRIORITY JOURNAL; TATA BOX;

EID: 0031661579     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008438109725     Document Type: Article

References (7)

1. Iyer L, King CD, Whitington PF et al. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of itsactive metabolite (SN-38) in human liver microsomes. J Clin Invest 1998; 101: 847-54.
2. Mackenzie PI, Owens IS, Burchell B et al. The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence. Pharmacogenetics 1997; 7: 255-69.
3. Monaghan G, Ryan M. Seddon R et al. Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome. Lancet 1996; 347: 578-81.
4. Ando Y, Chida M, Nakayama K et al. The UGT1A1* 28 allele is relatively rare in a Japanese population. Pharmacogenetics 1998 (in press).
5. Gupta E, Lestingi TM, Mick R et al. Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea. Cancer Res 1994; 54: 3723-5.
6. Krynetski EY, Tai HL, Yates CR et al. Genetic polymorphism of thiopurine S-methyltransferase: Clinical importance and molecular mechanisms. Pharamacogenetics 1996; 6: 279-90.
7. Wasserman E, Myara A, Lokiec F et al. Severe CPT-11 toxicity in patients with Gilbert's syndrome: Two case reports. Ann Oncol 1997; 8: 1049-51.