-
1
-
-
78650934360
-
Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts
-
Danks L,Workman S,Webster D, Horwood NJ. Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts. J BoneMiner Res. 2011;26(1):182-192.
-
(2011)
J BoneMiner Res.
, vol.26
, Issue.1
, pp. 182-192
-
-
Danks, L.1
Workman, S.2
Webster, D.3
Horwood, N.J.4
-
2
-
-
37549021148
-
Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase
-
Doyle SL, Jefferies CA, Feighery C, O'Neill LA. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007;282(51):36953-36960.
-
(2007)
J Biol Chem.
, vol.282
, Issue.51
, pp. 36953-36960
-
-
Doyle, S.L.1
Jefferies, C.A.2
Feighery, C.3
O'Neill, L.A.4
-
3
-
-
0038544296
-
Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor α production
-
DOI 10.1084/jem.20021845
-
HorwoodNJ,Mahon T,McDaid JP, et al. Bruton's tyrosine kinase is required for lipopolysaccharideinduced tumor necrosis factor alpha production. J ExpMed. 2003;197(12):1603-1611. (Pubitemid 36745336)
-
(2003)
Journal of Experimental Medicine
, vol.197
, Issue.12
, pp. 1603-1611
-
-
Horwood, N.J.1
Mahon, T.2
McDaid, J.P.3
Campbell, J.4
Mano, H.5
Brennan, F.M.6
Webster, D.7
Foxwell, B.M.J.8
-
4
-
-
33644844972
-
Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production
-
Horwood NJ, Page TH, McDaid JP, et al. Bruton's tyrosine kinase is required for TLR2 and TLR4- induced TNF, but not IL-6, production. J Immunol. 2006;176(6):3635-3641. (Pubitemid 43364011)
-
(2006)
Journal of Immunology
, vol.176
, Issue.6
, pp. 3635-3641
-
-
Horwood, N.J.1
Page, T.H.2
McDaid, J.P.3
Palmer, C.D.4
Campbell, J.5
Mahon, T.6
Brennan, F.M.7
Webster, D.8
Foxwell, B.M.J.9
-
5
-
-
1842814062
-
Bruton's tyrosine kinase (Btk) - The critical tyrosine kinase in LPS signalling?
-
DOI 10.1016/j.imlet.2003.11.017, PII S0165247803002955
-
Jefferies CA, O'Neill LA. Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signallingč Immunol Lett. 2004;92(1-2):15-22. (Pubitemid 38470045)
-
(2004)
Immunology Letters
, vol.92
, Issue.1-2
, pp. 15-22
-
-
Jefferies, C.A.1
O'Neill, L.A.J.2
-
6
-
-
43049096082
-
Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts
-
Palmer CD, Mutch BE, Page TH, Horwood NJ, Foxwell BM. Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts. Biochem Biophys Res Commun. 2008;370(4):599-602.
-
(2008)
Biochem Biophys Res Commun.
, vol.370
, Issue.4
, pp. 599-602
-
-
Palmer, C.D.1
Mutch, B.E.2
Page, T.H.3
Horwood, N.J.4
Foxwell, B.M.5
-
7
-
-
41349109980
-
Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFκB activity
-
DOI 10.1182/blood-2007-07-102343
-
Palmer CD,MutchBE,Workman S,McDaid JP,HorwoodNJ, FoxwellBM. Bmx tyrosine kinase regulates TLR4-induced IL-6 production in humanmacrophages independently of p38 MAPK andNFkappaB activity. Blood. 2008;111(4):1781-1788. (Pubitemid 351451482)
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 1781-1788
-
-
Palmer, C.D.1
Mutch, B.E.2
Workman, S.3
McDaid, J.P.4
Horwood, N.J.5
Foxwell, B.M.J.6
-
8
-
-
17644379578
-
B cell signaling and tumorigenesis
-
DOI 10.1146/annurev.immunol.23.021704.115606
-
Jumaa H, Hendriks RW, Reth M. B cell signaling and tumorigenesis. Annu Rev Immunol. 2005;23:415-445. (Pubitemid 40563176)
-
(2005)
Annual Review of Immunology
, vol.23
, pp. 415-445
-
-
Jumaa, H.1
Hendriks, R.W.2
Reth, M.3
-
9
-
-
69149095639
-
The role of Tec family kinases in mononuclear phagocytes
-
Koprulu AD, Ellmeier W. The role of Tec family kinases in mononuclear phagocytes. Crit Rev Immunol. 2009;29(4):317-333.
-
(2009)
Crit Rev Immunol.
, vol.29
, Issue.4
, pp. 317-333
-
-
Koprulu, A.D.1
Ellmeier, W.2
-
10
-
-
61849110214
-
Tec kinases regulate Tlymphocyte development and function: New insights into the roles of Itk and Rlk/Txk
-
Readinger JA, Mueller KL, Venegas AM, Horai R, Schwartzberg PL. Tec kinases regulate Tlymphocyte development and function: new insights into the roles of Itk and Rlk/Txk. Immunol Rev 2009;228(1):93-114.
-
(2009)
Immunol Rev
, vol.228
, Issue.1
, pp. 93-114
-
-
Readinger, J.A.1
Mueller, K.L.2
Venegas, A.M.3
Horai, R.4
Schwartzberg, P.L.5
-
11
-
-
47249153519
-
Role of cytokines in rheumatoid arthritis: An education in pathophysiology and therapeutics
-
DOI 10.1111/j.1600-065X.2008.00626.x
-
Feldmann M,Maini SR. Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics. Immunol Rev. 2008;223:7-19. (Pubitemid 351986171)
-
(2008)
Immunological Reviews
, vol.223
, Issue.1
, pp. 7-19
-
-
Feldmann, M.1
Maini, S.R.N.2
-
13
-
-
79952424457
-
B cells andmacrophages in cancer: Yin and yang
-
Mantovani A. B cells andmacrophages in cancer: yin and yang. NatMed. 2011;17(3):285-286.
-
(2011)
NatMed.
, vol.17
, Issue.3
, pp. 285-286
-
-
Mantovani, A.1
-
14
-
-
34548656855
-
Signaling pathways downstream of pattern-recognition receptors and their cross talk
-
Lee MS, Kim YJ. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem. 2007;76:447-480.
-
(2007)
Annu Rev Biochem.
, vol.76
, pp. 447-480
-
-
Lee, M.S.1
Kim, Y.J.2
-
15
-
-
0028364801
-
Lipopolysaccharide-induced cytokine production in human monocytes: Role of tyrosine phosphorylation in transmembrane signal transduction
-
DOI 10.1002/eji.1830240606
-
Beaty CD, Franklin TL, Uehara Y, Wilson CB. Lipopolysaccharide-induced cytokine production in human monocytes: role of tyrosine phosphorylation in transmembrane signal transduction. Eur J Immunol. 1994;24(6):1278-1284. (Pubitemid 24169507)
-
(1994)
European Journal of Immunology
, vol.24
, Issue.6
, pp. 1278-1284
-
-
Beaty, C.D.1
Franklin, T.L.2
Uehara, Y.3
Wilson, C.B.4
-
17
-
-
0029164795
-
Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen-activated protein kinases p 44, p42, and p 41 in vascular endothelial cells in a soluble CD14-dependent manner: Role of protein tyrosine phosphorylation in lipopolysaccharide-induced stimulation of endothelial cells
-
Arditi M, Zhou J, Torres M, Durden DL, Stins M, Kim KS. Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen-activated protein kinases p 44, p 42, and p 41 in vascular endothelial cells in a soluble CD14-dependent manner: role of protein tyrosine phosphorylation in lipopolysaccharide-induced stimulation of endothelial cells. J Immunol. 1995;155(8):3994-4003.
-
(1995)
J Immunol.
, vol.155
, Issue.8
, pp. 3994-4003
-
-
Arditi, M.1
Zhou, J.2
Torres, M.3
Durden, D.L.4
Stins, M.5
Kim, K.S.6
-
18
-
-
0027325770
-
Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide- nonresponsive murine macrophages
-
Dong Z, Qi X, Xie K, Fidler IJ. Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide- responsive and lipopolysaccharide-nonresponsivemurine macrophages. J Immunol. 1993;151(5):2717-2724. (Pubitemid 23264523)
-
(1993)
Journal of Immunology
, vol.151
, Issue.5
, pp. 2717-2724
-
-
Dong, Z.1
Qi, X.2
Xie, K.3
Fidler, I.J.4
-
19
-
-
0031421345
-
Differential effects on TNFα production by pharmacological agents with varying molecular sites of action
-
DOI 10.1016/S0192-0561(97)00088-X, PII S019205619700088X
-
Mander T, Hill S, Hughes A, et al. Differential effects on TNF alpha production by pharmacological agents with varyingmolecular sites of action. Int J Immunopharmacol. 1997;19(8):451-462. (Pubitemid 28161131)
-
(1997)
International Journal of Immunopharmacology
, vol.19
, Issue.8
, pp. 451-462
-
-
Mander, T.1
Hill, S.2
Hughes, A.3
Rawlins, P.4
Clark, C.5
Gammon, G.6
Foxwell, B.7
Moore, M.8
-
20
-
-
38449099025
-
Src tyrosine kinases mediate activations of NF-kappaB and integrin signal during lipopolysaccharide-induced acute lung injury
-
Lee HS, Moon C, Lee HW, Park EM, Cho MS, Kang JL. Src tyrosine kinases mediate activations of NF-kappaB and integrin signal during lipopolysaccharide- induced acute lung injury. J Immunol. 2007;179(10):7001-7011.
-
(2007)
J Immunol.
, vol.179
, Issue.10
, pp. 7001-7011
-
-
Lee, H.S.1
Moon, C.2
Lee, H.W.3
Park, E.M.4
Cho, M.S.5
Kang, J.L.6
-
21
-
-
0030912071
-
Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn
-
DOI 10.1084/jem.185.9.1661
-
Meng F, LowellCA. Lipopolysaccharide (LPS)-inducedmacrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J ExpMed. 1997;185(9):1661-1670. (Pubitemid 27203262)
-
(1997)
Journal of Experimental Medicine
, vol.185
, Issue.9
, pp. 1661-1670
-
-
Meng, F.1
Lowell, C.A.2
-
22
-
-
35548985405
-
Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages
-
DOI 10.1016/j.molimm.2007.07.026, PII S0161589007006578
-
Smolinska MJ, Horwood NJ, Page TH, Smallie T, Foxwell BM. Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages. Mol Immunol. 2008;45(4):990-1000. (Pubitemid 350017845)
-
(2008)
Molecular Immunology
, vol.45
, Issue.4
, pp. 990-1000
-
-
Smolinska, M.J.1
Horwood, N.J.2
Page, T.H.3
Smallie, T.4
Foxwell, B.M.J.5
-
23
-
-
82755187669
-
Hck tyrosine kinase regulates TLR4- induced TNF and IL-6 production via AP-1
-
SmolinskaMJ, Page TH,Urbaniak AM,Mutch BE,Horwood NJ.Hck tyrosine kinase regulates TLR4- induced TNF and IL-6 production via AP-1. J Immunol. 2011;187(11):6043-6051.
-
(2011)
J Immunol.
, vol.187
, Issue.11
, pp. 6043-6051
-
-
Smolinska, M.J.1
Page, T.H.2
Urbaniak, A.M.3
Mutch, B.E.4
Horwood, N.J.5
-
24
-
-
33645867986
-
A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes
-
Cha HS, Boyle DL, Inoue T, et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol ExpTher. 2006;317(2):571-578.
-
(2006)
J Pharmacol ExpTher.
, vol.317
, Issue.2
, pp. 571-578
-
-
Cha, H.S.1
Boyle, D.L.2
Inoue, T.3
-
25
-
-
11144355389
-
The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase
-
DOI 10.1073/pnas.0401602101
-
Mocsai A, Humphrey MB, Van Ziffle JA, et al.Theimmunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcR gamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Nat Acad Sci USA. 2004;101(16):6158-6163. (Pubitemid 38520544)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.16
, pp. 6158-6163
-
-
Mocsai, A.1
Humphrey, M.B.2
Van Ziffle, J.A.G.3
Hu, Y.4
Burghardt, A.5
Spusta, S.C.6
Majumdar, S.7
Lanier, L.L.8
Lowell, C.A.9
Nakamura, M.C.10
-
26
-
-
0022611188
-
X-linkedimmune deficiency (xid) of CBA/Nmice
-
Wicker LS, Scher I. X-linkedimmune deficiency (xid) of CBA/Nmice. Curr TopMicrobiolImmunol. 1986;124:87-101.
-
(1986)
Curr TopMicrobiolImmunol.
, vol.124
, pp. 87-101
-
-
Wicker, L.S.1
Scher, I.2
-
27
-
-
0028183398
-
Bruton's tyrosine kinase is a key regulator in B-cell development
-
Rawlings DJ, Witte ON. Bruton's tyrosine kinase is a key regulator in B-cell development. Immunol Rev. 1994;138:105-119. (Pubitemid 24147418)
-
(1994)
Immunological Reviews
, Issue.138
, pp. 105-119
-
-
Rawlings, D.J.1
Witte, O.N.2
-
28
-
-
0027441332
-
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases
-
DOI 10.1038/361226a0
-
Vetrie D, Vorechovsky I, Sideras P, et al.The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature. 1993;361(6409):226-233. (Pubitemid 23034471)
-
(1993)
Nature
, vol.361
, Issue.6409
, pp. 226-233
-
-
Vetrie, D.1
Vorechovsky, I.2
Sideras, P.3
Holland, J.4
Davies, A.5
Flinter, F.6
Hammarstrom, L.7
Kinnon, C.8
Levinsky, R.9
Bobrow, M.10
Smith, C.I.E.11
Bentley, D.R.12
-
29
-
-
0030890949
-
Initiation and processing of signals from the B cell antigen receptor
-
DOI 10.1146/annurev.immunol.15.1.453
-
Reth M, Wienands J. Initiation and processing of signals fromthe B cell antigen receptor. Annu Rev Immunol. 1997;15:453-479. (Pubitemid 27169289)
-
(1997)
Annual Review of Immunology
, vol.15
, pp. 453-479
-
-
Reth, M.1
Wienands, J.2
-
30
-
-
79956307046
-
Regulation of BCR signaling
-
Kurosaki T. Regulation of BCR signaling.Mol Immunol. 2011;48(11):1287- 1291.
-
(2011)
Mol Immunol.
, vol.48
, Issue.11
, pp. 1287-1291
-
-
Kurosaki, T.1
-
31
-
-
0032055476
-
2+ following B-cell receptor activation
-
DOI 10.1093/emboj/17.7.1973
-
Fluckiger AC, Li Z, Kato RM, et al. Btk/Tec kinases regulate sustained increases in intracellularCa2+ following B-cell receptor activation. EMBO J. 1998;17(7):1973-1985. (Pubitemid 28154527)
-
(1998)
EMBO Journal
, vol.17
, Issue.7
, pp. 1973-1985
-
-
Fluckiger, A.-C.1
Li, Z.2
Kato, R.M.3
Wahl, M.I.4
Ochs, H.D.5
Longnecker, R.6
Kinet, J.-P.7
Witte, O.N.8
Scharenberg, A.M.9
Rawlings, D.J.10
-
32
-
-
61849183478
-
Bruton's tyrosine kinase (Btk): Function, regulation, and transformation with special emphasis on the PH domain
-
Mohamed AJ, Yu L, Backesjo CM, et al. Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev. 2009;228(1):58-73.
-
(2009)
Immunol Rev.
, vol.228
, Issue.1
, pp. 58-73
-
-
Mohamed, A.J.1
Yu, L.2
Backesjo, C.M.3
-
33
-
-
0033056366
-
BLNK required for coupling syk to PLCγ2 and rac1-JNK in B cells
-
DOI 10.1016/S1074-7613(00)80012-6
-
Ishiai M, Kurosaki M, Pappu R, et al. BLNKrequired for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells. Immunity. 1999;10(1):117-125. (Pubitemid 29077389)
-
(1999)
Immunity
, vol.10
, Issue.1
, pp. 117-125
-
-
Ishiai, M.1
Kurosaki, M.2
Pappu, R.3
Okawa, K.4
Ronko, I.5
Chong, F.6
Shibata, M.7
Iwamatsu, A.8
Chan, A.C.9
Kurosaki, T.10
-
34
-
-
0033566733
-
Cutting edge: Association of phospholipase C-γ2 Src homology 2 domains with BLNK is critical for B cell antigen receptor signaling
-
IshiaiM,Sugawara H,KurosakiM,Kurosaki T.Cutting edge: association ofphospholipaseC-gamma 2 Src homology 2 domains with BLNK is critical for B cell antigen receptor signaling. J Immunol. 1999;163(4):1746-1749. (Pubitemid 29382170)
-
(1999)
Journal of Immunology
, vol.163
, Issue.4
, pp. 1746-1749
-
-
Ishiai, M.1
Sugawara, H.2
Kurosaki, M.3
Kurosaki, T.4
-
35
-
-
0031053360
-
Akt signaling: Linking membrane events to life and death decisions
-
DOI 10.1126/science.275.5300.628
-
Hemmings BA. Akt signaling: linking membrane events to life and death decisions. Science. 1997;275(5300):628-630. (Pubitemid 27061321)
-
(1997)
Science
, vol.275
, Issue.5300
, pp. 628-630
-
-
Hemmings, B.A.1
-
36
-
-
0034507903
-
BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
-
DOI 10.1016/S1074-7613(00)00079-0
-
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity. 2000;13(6):817-827. (Pubitemid 32041804)
-
(2000)
Immunity
, vol.13
, Issue.6
, pp. 817-827
-
-
Okada, T.1
Maeda, A.2
Iwamatsu, A.3
Gotoh, K.4
Kurosaki, T.5
-
37
-
-
0033934512
-
Reduced formation of phosphatidic acid upon B-cell receptor triggering of mouse B-lymphocytes lacking Bruton's tyrosine kinase
-
DOI 10.1046/j.1365-3083.2000.00747.x
-
Forssell J, Nilsson A, Sideras P. Reduced formation of phosphatidic acid upon B-cell receptor triggering of mouse B-lymphocytes lacking Bruton's tyrosine kinase. Scand J Immunol. 2000;52(1):30-38. (Pubitemid 30435982)
-
(2000)
Scandinavian Journal of Immunology
, vol.52
, Issue.1
, pp. 30-38
-
-
Forssell, J.1
Nilsson, A.2
Sideras, P.3
-
38
-
-
0037341617
-
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction
-
DOI 10.1038/ni890
-
Suzuki H,Matsuda S, Terauchi Y, et al. PI3K and Btk differentially regulate B cell antigen receptormediated signal transduction. Nat Immunol. 2003;4(3):280-286. (Pubitemid 36322139)
-
(2003)
Nature Immunology
, vol.4
, Issue.3
, pp. 280-286
-
-
Suzuki, H.1
Matsuda, S.2
Terauchi, Y.3
Fujiwara, M.4
Ohteki, T.5
Asano, T.6
Behrens, T.W.7
Kouro, T.8
Takatsu, K.9
Kadowaki, T.10
Koyasu, S.11
-
39
-
-
0029824848
-
Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity
-
DOI 10.1074/jbc.271.48.30303
-
Fukuda M, Kojima T, Kabayama H, Mikoshiba K. Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity. J Biol Chem. 1996;271(48):30303-30306. (Pubitemid 26404025)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.48
, pp. 30303-30306
-
-
Fukuda, M.1
Kojima, T.2
Kabayama, H.3
Mikoshiba, K.4
-
40
-
-
0033812082
-
Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase C gamma pathway
-
Marshall AJ, Niiro H, Yun TJ, Clark EA. Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase C gamma pathway. Immunol Rev. 2000;176:30-46.
-
(2000)
Immunol Rev.
, vol.176
, pp. 30-46
-
-
Marshall, A.J.1
Niiro, H.2
Yun, T.J.3
Clark, E.A.4
-
41
-
-
0032147181
-
Btk function in B cell development and responsee
-
DOI 10.1006/smim.1998.0123
-
Satterthwaite AB, Li Z, WitteON. Btk function in B cell development and response. SeminImmunol. 1998;10(4):309-316. (Pubitemid 28375306)
-
(1998)
Seminars in Immunology
, vol.10
, Issue.4
, pp. 309-316
-
-
Satterthwaite, A.B.1
Li, Z.2
Witte, O.N.3
-
42
-
-
0030031886
-
Augmented humoral and anaphylactic responses in FcγRII-deficient mice
-
DOI 10.1038/379346a0
-
Takai T,Ono M,Hikida M,Ohmori H, Ravetch JV. Augmented humoral and anaphylactic responses in Fc gamma RII-deficientmice. Nature. 1996;379(6563):346-349. (Pubitemid 26033077)
-
(1996)
Nature
, vol.379
, Issue.6563
, pp. 346-349
-
-
Takai, T.1
Ono, M.2
Hikida, M.3
Ohmori, H.4
Ravetch, J.V.5
-
43
-
-
0029835940
-
Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB
-
DOI 10.1038/383263a0
-
OnoM, Bolland S, Tempst P, Ravetch JV. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature. 1996;383(6597):263-266. (Pubitemid 26317676)
-
(1996)
Nature
, vol.383
, Issue.6597
, pp. 263-266
-
-
Ono, M.1
Bolland, S.2
Tempst, P.3
Ravetch, J.V.4
-
44
-
-
0032055485
-
SHIP modulates immune receptor responses by regulating membrane association of Btk
-
DOI 10.1016/S1074-7613(00)80555-5
-
Bolland S, Pearse RN, Kurosaki T, Ravetch JV. SHIPmodulates immune receptor responses by regulatingmembrane association of Btk. Immunity. 1998;8(4):509-516. (Pubitemid 28196804)
-
(1998)
Immunity
, vol.8
, Issue.4
, pp. 509-516
-
-
Bolland, S.1
Pearse, R.N.2
Kurosaki, T.3
Ravetch, J.V.4
-
45
-
-
26944456633
-
Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus
-
DOI 10.1007/s00439-005-1302-3
-
Blank MC, Stefanescu RN, Masuda E, et al. Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus. HumGenet. 2005;117(2-3):220-227. (Pubitemid 43136798)
-
(2005)
Human Genetics
, vol.117
, Issue.2-3
, pp. 220-227
-
-
Blank, M.C.1
Stefanescu, R.N.2
Masuda, E.3
Marti, F.4
King, P.D.5
Redecha, P.B.6
Wurzburger, R.J.7
Peterson, M.G.E.8
Tanaka, S.9
Pricop, L.10
-
46
-
-
77950803212
-
B cells from rheumatoid arthritis patients showimportant alterations inthe expression ofCD86and Fc gammaRIIb,which aremodulated by anti-tumornecrosis factor therapy
-
CatalanD, Aravena O, Sabugo F, et al. B cells from rheumatoid arthritis patients showimportant alterations inthe expression ofCD86and Fc gammaRIIb,which aremodulated by anti-tumornecrosis factor therapy. Arthritis ResTher. 2010;12(2):R68.
-
(2010)
Arthritis ResTher.
, vol.12
, Issue.2
-
-
Cataland Aravena, O.1
Sabugo, F.2
-
47
-
-
37549036732
-
Fcgamma receptors as regulators of immune responses
-
Nimmerjahn F, Ravetch JV. Fcgamma receptors as regulators of immune responses. Nat Rev Immunol. 2008;8(1):34-47.
-
(2008)
Nat Rev Immunol.
, vol.8
, Issue.1
, pp. 34-47
-
-
Nimmerjahn, F.1
Ravetch, J.V.2
-
48
-
-
0033151596
-
SHIP recruitment attenuates FcγRIIB-induced B cell apoptosis
-
DOI 10.1016/S1074-7613(00)80074-6
-
Pearse RN,Kawabe T,Bolland S,GuinamardR,Kurosaki T,Ravetch JV. SHIP recruitment attenuates Fc gamma RIIB-induced B cell apoptosis. Immunity. 1999;10(6):753-760. (Pubitemid 29302928)
-
(1999)
Immunity
, vol.10
, Issue.6
, pp. 753-760
-
-
Pearse, R.N.1
Kawabe, T.2
Bolland, S.3
Guinamard, R.4
Kurosaki, T.5
Ravetch, J.V.6
-
49
-
-
0026772133
-
A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells
-
Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Nat Acad Sci USA. 1992;89(14):6550-6554.
-
(1992)
Proc Nat Acad Sci USA.
, vol.89
, Issue.14
, pp. 6550-6554
-
-
Noelle, R.J.1
Roy, M.2
Shepherd, D.M.3
Stamenkovic, I.4
Ledbetter, J.A.5
Aruffo, A.6
-
50
-
-
0037443519
-
Cutting edge: CD40 engagement eliminates the need for Bruton's tyrosine kinase in B cell receptor signaling for NF-κB
-
Mizuno T, Rothstein TL. Cutting edge: CD40 engagement eliminates the need for Bruton's tyrosine kinase in B cell receptor signaling for NF-kappa B. J Immunol. 2003;170(6):2806-2810. (Pubitemid 36302149)
-
(2003)
Journal of Immunology
, vol.170
, Issue.6
, pp. 2806-2810
-
-
Mizuno, T.1
Rothstein, T.L.2
-
51
-
-
0035996806
-
2-terminal kinase (JNK) 1 upon CD40 stimulation in B cells of patients with X-linked agammaglobulinemia
-
DOI 10.1023/A:1016097010274
-
Brunner C, Kreth HW, Ochs HD, Schuster V. Unimpaired activation of c-Jun NH2-terminal kinase (JNK) 1 upon CD40 stimulation in B cells of patients with X-linked agammaglobulinemia. J Clin Immunol. 2002;22(4):244-251. (Pubitemid 34774988)
-
(2002)
Journal of Clinical Immunology
, vol.22
, Issue.4
, pp. 244-251
-
-
Brunner, C.1
Kreth, H.W.2
Ochs, H.D.3
Schuster, V.4
-
52
-
-
79953282681
-
Syk mediates BCR- and CD40-signaling integration during B cell activation
-
Ying H, Li Z, Yang L, Zhang J. Syk mediates BCR- and CD40-signaling integration during B cell activation. Immunobiology. 2011;216(5):566-570.
-
(2011)
Immunobiology.
, vol.216
, Issue.5
, pp. 566-570
-
-
Ying, H.1
Li, Z.2
Yang, L.3
Zhang, J.4
-
53
-
-
0027944227
-
BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2
-
Tamagnone L, Lahtinen I,Mustonen T, et al. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. Oncogene. 1994;9(12):3683-3688.
-
(1994)
Oncogene.
, vol.9
, Issue.12
, pp. 3683-3688
-
-
Tamagnone, L.1
Lahtinen, I.2
Mustonen, T.3
-
54
-
-
0030697510
-
The Bmx tyrosine kinase induces activation of the stat signaling pathway, which is specifically inhibited by protein kinase Cδ
-
Saharinen P, Ekman N, Sarvas K, Parker P, Alitalo K, Silvennoinen O. The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase C delta. Blood. 1997;90(11):4341-4353. (Pubitemid 27508440)
-
(1997)
Blood
, vol.90
, Issue.11
, pp. 4341-4353
-
-
Saharinen, P.1
Ekman, N.2
Sarvas, K.3
Parker, P.4
Alitalo, K.5
Silvennoinen, O.6
-
55
-
-
0033532146
-
Reconstitution ofBtk signaling by the atypical tec family tyrosine kinases Bmx and Txk
-
TomlinsonMG,Kurosaki T, Berson AE, Fujii GH, Johnston JA, Bolen JB. Reconstitution ofBtk signaling by the atypical tec family tyrosine kinases Bmx and Txk. J Biol Chem. 1999;274(19):13577-13585.
-
(1999)
J Biol Chem.
, vol.274
, Issue.19
, pp. 13577-13585
-
-
Tomlinson, M.G.1
Kurosaki, T.2
Berson, A.E.3
Fujii, G.H.4
Johnston, J.A.5
Bolen, J.B.6
-
56
-
-
0034954684
-
Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium
-
DOI 10.1128/MCB.21.14.4647-4655.2001
-
Rajantie I, Ekman N, Iljin K, et al. Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. Mol Cell Biol. 2001;21(14):4647-4655. (Pubitemid 32588247)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.14
, pp. 4647-4655
-
-
Rajantie, I.1
Ekman, N.2
Iljin, K.3
Arighi, E.4
Gunji, Y.5
Kaukonen, J.6
Palotie, A.7
Dewerchin, M.8
Carmeliet, P.9
Alitalo, K.10
-
57
-
-
0034606219
-
Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk
-
Ellmeier W, Jung S, Sunshine MJ, et al. Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk. J ExpMed. 2000;192(11):1611-1624.
-
(2000)
J ExpMed.
, vol.192
, Issue.11
, pp. 1611-1624
-
-
Ellmeier, W.1
Jung, S.2
Sunshine, M.J.3
-
58
-
-
0032006789
-
Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells
-
Kitanaka A,Mano H, Conley ME,Campana D. Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells. Blood. 1998;91(3):940-948. (Pubitemid 28078297)
-
(1998)
Blood
, vol.91
, Issue.3
, pp. 940-948
-
-
Kitanaka, A.1
Mano, H.2
Conley, M.E.3
Campana, D.4
-
59
-
-
39749180445
-
Tyrosine kinases btk and tec regulate osteoclast differentiation by linking rank and itam signals
-
DOI 10.1016/j.cell.2007.12.037, PII S0092867408000585
-
ShinoharaM, Koga T, Okamoto K, et al. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell. 2008;132(5):794-806. (Pubitemid 351312796)
-
(2008)
Cell
, vol.132
, Issue.5
, pp. 794-806
-
-
Shinohara, M.1
Koga, T.2
Okamoto, K.3
Sakaguchi, S.4
Arai, K.5
Yasuda, H.6
Takai, T.7
Kodama, T.8
Morio, T.9
Geha, R.S.10
Kitamura, D.11
Kurosaki, T.12
Ellmeier, W.13
Takayanagi, H.14
-
60
-
-
28544447532
-
B cells and osteoblast and osteoclast development
-
Horowitz MC, Bothwell AL, Hesslein DG, Pflugh DL, Schatz DG. B cells and osteoblast and osteoclast development. Immunol Rev. 2005;208:141-153. (Pubitemid 41746390)
-
(2005)
Immunological Reviews
, vol.208
, pp. 141-153
-
-
Horowitz, M.C.1
Bothwell, A.L.M.2
Hesslein, D.G.T.3
Pflugh, D.L.4
Schatz, D.G.5
-
61
-
-
77955851132
-
Lorenzo JA.HowB cells influence bone biology in health and disease
-
Horowitz MC, Fretz JA, Lorenzo JA.HowB cells influence bone biology in health and disease. Bone. 2010;47(3):472-479.
-
(2010)
Bone.
, vol.47
, Issue.3
, pp. 472-479
-
-
Horowitz, M.C.1
Fretz, J.A.2
-
62
-
-
45149127782
-
Osteoimmunology: Interactions of the bone and immune system
-
DOI 10.1210/er.2007-0038
-
Lorenzo J, Horowitz M, Choi Y. Osteoimmunology: interactions of the bone and immune system. Endocr Rev. 2008;29(4):403-440. (Pubitemid 351831507)
-
(2008)
Endocrine Reviews
, vol.29
, Issue.4
, pp. 403-440
-
-
Lorenzo, J.1
Horowitz, M.2
Choi, Y.3
-
63
-
-
0032400933
-
OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40
-
Yun TJ, Chaudhary PM, Shu GL, et al. OPG/FDCR-1, a TNF receptor familymember, is expressed in lymphoid cells and is up-regulated by ligating CD40. J Immunol. 1998;161(11):6113-6121. (Pubitemid 28535982)
-
(1998)
Journal of Immunology
, vol.161
, Issue.11
, pp. 6113-6121
-
-
Yun, T.J.1
Chaudhary, P.M.2
Shu, G.L.3
Kimble Frazer, J.4
Ewings, M.K.5
Schwartz, S.M.6
Pascual, V.7
Hood, L.E.8
Clark, E.A.9
-
64
-
-
84856587339
-
Development and function of murine B cells lacking RANK
-
Perlot T, Penninger JM. Development and function of murine B cells lacking RANK. J Immunol. 2012;188(3):1201-1205.
-
(2012)
J Immunol.
, vol.188
, Issue.3
, pp. 1201-1205
-
-
Perlot, T.1
Penninger, J.M.2
-
65
-
-
11144354330
-
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
-
DOI 10.1038/nature02444
-
Koga T, Inui M, Inoue K, et al. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature. 2004;428(6984):758-763. (Pubitemid 38508286)
-
(2004)
Nature
, vol.428
, Issue.6984
, pp. 758-763
-
-
Koga, T.1
Inui, M.2
Inoue, K.3
Kim, S.4
Suematsu, A.5
Kobayashi, E.6
Iwata, T.7
Ohnishi, H.8
Matozaki, T.9
Kodama, T.10
Taniguchi, T.11
Takayanagi, H.12
Takai, T.13
-
66
-
-
45549099188
-
The tec family tyrosine kinase Btk regulates RANKL-induced osteoclastmaturation
-
Lee SH, Kim T, Jeong D, KimN, Choi Y.The tec family tyrosine kinase Btk regulates RANKL-induced osteoclastmaturation. J Biol Chem. 2008;283(17):11526- 11534.
-
(2008)
J Biol Chem.
, vol.283
, Issue.17
, pp. 11526-11534
-
-
Lee, S.H.1
Kim, T.2
Jeong, D.3
Kim, N.4
Choi, Y.5
-
67
-
-
80052388933
-
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice
-
Barrow AD, Raynal N, Andersen TL, et al. OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J Clin Invest. 2011;121(9):3505-3516.
-
(2011)
J Clin Invest.
, vol.121
, Issue.9
, pp. 3505-3516
-
-
Barrow, A.D.1
Raynal, N.2
Andersen, T.L.3
-
68
-
-
36249032544
-
Themacrophage: Past, present and future
-
Gordon S. Themacrophage: past, present and future. Eur J Immunol. 2007;37(Suppl. 1):S9-S17.
-
(2007)
Eur J Immunol.
, vol.37
, Issue.SUPPL. 1
-
-
Gordon, S.1
-
69
-
-
33750813483
-
Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression
-
Martinez FO, Gordon S, Locati M,Mantovani A. Transcriptional profiling of the humanmonocyteto- macrophage differentiation and polarization: newmolecules and patterns of gene expression. J Immunol. 2006;177(10):7303-7311. (Pubitemid 44715100)
-
(2006)
Journal of Immunology
, vol.177
, Issue.10
, pp. 7303-7311
-
-
Martinez, F.O.1
Gordon, S.2
Locati, M.3
Mantovani, A.4
-
70
-
-
58749083404
-
Macrophages as APC and the dendritic cellmyth
-
Hume DA.Macrophages as APC and the dendritic cellmyth. J Immunol. 2008;181(9):5829-5835.
-
(2008)
J Immunol.
, vol.181
, Issue.9
, pp. 5829-5835
-
-
Hume, D.A.1
-
71
-
-
84855813364
-
Critical roles of the WASP N-terminal domain and Btk in LPS-induced inflammatory response inmacrophages
-
Sakuma C, Sato M, Takenouchi T, Chiba J, Kitani H. Critical roles of the WASP N-terminal domain and Btk in LPS-induced inflammatory response inmacrophages. PLoS One. 2012;7(1):e30351.
-
(2012)
PLoS One.
, vol.7
, Issue.1
-
-
Sakuma, C.1
Sato, M.2
Takenouchi, T.3
Chiba, J.4
Kitani, H.5
-
72
-
-
0037492123
-
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor κB activation by toll-like receptor 4
-
DOI 10.1074/jbc.M301484200
-
Jefferies CA, Doyle S, Brunner C, et al. Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. J Biol Chem. 2003;278(28):26258-26264. (Pubitemid 36835395)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.28
, pp. 26258-26264
-
-
Jefferies, C.A.1
Doyle, S.2
Brunner, C.3
Dunne, A.4
Brin, E.5
Wietek, C.6
Walch, E.7
Wirth, T.8
O'Neill, L.A.J.9
-
73
-
-
33744543517
-
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
-
DOI 10.1074/jbc.M508892200
-
Gray P, Dunne A, Brikos C, Jefferies CA, Doyle SL, O'Neill LA. MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem. 2006;281(15):10489-10495. (Pubitemid 43864588)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.15
, pp. 10489-10495
-
-
Gray, P.1
Dunne, A.2
Brikos, C.3
Jefferies, C.A.4
Doyle, S.L.5
O'Neill, L.A.J.6
-
74
-
-
31344467156
-
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
-
DOI 10.1038/ni1299, PII N1299
-
Mansell A, Smith R, Doyle SL, et al. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling bymediatingMal degradation. Nat Immunol. 2006;7(2):148-155. (Pubitemid 43135880)
-
(2006)
Nature Immunology
, vol.7
, Issue.2
, pp. 148-155
-
-
Mansell, A.1
Smith, R.2
Doyle, S.L.3
Gray, P.4
Fenner, J.E.5
Crack, P.J.6
Nicholson, S.E.7
Hilton, D.J.8
O'Neill, L.A.J.9
Luke, A.J.10
Hertzog, P.J.11
-
75
-
-
41249084567
-
Tyrosine phosphorylation ofMyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance
-
Piao W, Song C, Chen H, et al. Tyrosine phosphorylation ofMyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance. J Biol Chem. 2008;283(6):3109-3119.
-
(2008)
J Biol Chem.
, vol.283
, Issue.6
, pp. 3109-3119
-
-
Piao, W.1
Song, C.2
Chen, H.3
-
76
-
-
79954997147
-
Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk
-
Liu X, Zhan Z, Li D, et al. Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol. 2011;12(5):416-424.
-
(2011)
Nat Immunol.
, vol.12
, Issue.5
, pp. 416-424
-
-
Liu, X.1
Zhan, Z.2
Li, D.3
-
77
-
-
21244503601
-
Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-κB activation by lipopolysaccharide
-
DOI 10.1074/jbc.C500053200
-
Doyle SL, Jefferies CA,O'Neill LA. Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappaB activation by lipopolysaccharide. J Biol Chem. 2005;280(25):23496- 23501. (Pubitemid 40884827)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.25
, pp. 23496-23501
-
-
Doyle, S.L.1
Jefferies, C.A.2
O'Neill, L.A.3
-
78
-
-
33846246989
-
Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages
-
DOI 10.1016/j.cellsig.2006.08.013, PII S0898656806002075
-
Liljeroos M, Vuolteenaho R,Morath S,Hartung T,Hallman M,OjaniemiM. Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses inmacrophages. Cell Signal. 2007;19(3):625-633. (Pubitemid 46107814)
-
(2007)
Cellular Signalling
, vol.19
, Issue.3
, pp. 625-633
-
-
Liljeroos, M.1
Vuolteenaho, R.2
Morath, S.3
Hartung, T.4
Hallman, M.5
Ojaniemi, M.6
-
79
-
-
0141703513
-
Tumor necrosis factor-α-induced IKK phosphorylation of NF-κB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway
-
DOI 10.1074/jbc.M301598200
-
Sakurai H, Suzuki S, Kawasaki N, et al. Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J Biol Chem. 2003;278(38):36916-36923. (Pubitemid 37140026)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.38
, pp. 36916-36923
-
-
Sakurai, H.1
Suzuki, S.2
Kawasaki, N.3
Nakano, H.4
Okazaki, T.5
Chino, A.6
Doi, T.7
Saiki, I.8
-
80
-
-
24344468250
-
NF-κB RelA phosphorylation regulates RelA acetylation
-
DOI 10.1128/MCB.25.18.7966-7975.2005
-
Chen LF,Williams SA,Mu Y, et al.NF-kappaB RelA phosphorylation regulates RelA acetylation.Mol Cell Biol. 2005;25(18):7966-7975. (Pubitemid 41262991)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.18
, pp. 7966-7975
-
-
Chen, L.-F.1
Williams, S.A.2
Mu, Y.3
Nakano, H.4
Duerr, J.M.5
Buckbinder, L.6
Greene, W.C.7
-
81
-
-
0347087492
-
Bruton's Tyrosine Kinase Phosphorylates cAMP-responsive Element-binding Protein at Serine 133 during Neuronal Differentiation in Immortalized Hippocampal Progenitor Cells
-
DOI 10.1074/jbc.M308722200
-
Yang EJ, Yoon JH, Chung KC. Bruton's tyrosine kinase phosphorylates cAMP-responsive elementbinding protein at serine 133 during neuronal differentiation in immortalized hippocampal progenitor cells. J Biol Chem. 2004;279(3):1827-1837. (Pubitemid 38084450)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.3
, pp. 1827-1837
-
-
Yang, E.J.1
Yoon, J.-H.2
Chung, K.C.3
-
82
-
-
33750840753
-
Bruton's tyrosine kinase is required for TLR-induced IL-10 production
-
Schmidt NW, Thieu VT, Mann BA, Ahyi AN, Kaplan MH. Bruton's tyrosine kinase is required for TLR-induced IL-10 production. J Immunol. 2006;177(10):7203-7210. (Pubitemid 44715089)
-
(2006)
Journal of Immunology
, vol.177
, Issue.10
, pp. 7203-7210
-
-
Schmidt, N.W.1
Thieu, V.T.2
Mann, B.A.3
Ahyi, A.-N.4
Kaplan, M.H.5
-
83
-
-
33745125425
-
Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus inmacrophages
-
(Lond).
-
Olsson S, Sundler R. Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus inmacrophages. J Inflamm (Lond). 2006;3:8.
-
(2006)
J Inflamm
, vol.3
, pp. 8
-
-
Olsson, S.1
Sundler, R.2
-
84
-
-
84862777535
-
Defects in acute responses to TLR4 in Btk-deficient mice result in impaired dendritic cell-induced IFN-gamma production by natural killer cells
-
Ni Gabhann J, Spence S, Wynne C, et al. Defects in acute responses to TLR4 in Btk-deficient mice result in impaired dendritic cell-induced IFN-gamma production by natural killer cells. Clin Immunol. 2011;142(3):373-382.
-
(2011)
Clin Immunol.
, vol.142
, Issue.3
, pp. 373-382
-
-
Ni Gabhann, J.1
Spence, S.2
Wynne, C.3
-
85
-
-
0033567049
-
Bruton's tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of IL-12 induction
-
Mukhopadhyay S, George A, Bal V, Ravindran B, Rath S. Bruton's tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of IL-12 induction. J Immunol. 1999;163(4):1786-1792. (Pubitemid 29382176)
-
(1999)
Journal of Immunology
, vol.163
, Issue.4
, pp. 1786-1792
-
-
Mukhopadhyay, S.1
George, A.2
Bal, V.3
Ravindran, B.4
Rath, S.5
-
86
-
-
0037087438
-
Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial than the cytokine balance of T cell responses for microfilarial clearance
-
Mukhopadhyay S, Mohanty M, Mangla A, et al. Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial than the cytokine balance of T cell responses for microfilarial clearance. J Immunol. 2002;168(6):2914-2921. (Pubitemid 34211671)
-
(2002)
Journal of Immunology
, vol.168
, Issue.6
, pp. 2914-2921
-
-
Mukhopadhyay, S.1
Mohanty, M.2
Mangla, A.3
George, A.4
Bal, V.5
Rath, S.6
Ravindran, B.7
-
87
-
-
0033565721
-
Delayed clearance of filarial infection and enhanced Th1 immunity due to modulation of macrophage APC functions in xid mice
-
Mukhopadhyay S, Sahoo PK, George A, Bal V, Rath S, Ravindran B. Delayed clearance of filarial infection and enhancedTh1 immunity due to modulation ofmacrophageAPCfunctions in xidmice. J Immunol. 1999;163(2):875-883. (Pubitemid 29328097)
-
(1999)
Journal of Immunology
, vol.163
, Issue.2
, pp. 875-883
-
-
Mukhopadhyay, S.1
Sahoo, P.K.2
George, A.3
Bal, V.4
Rath, S.5
Ravindran, B.6
-
88
-
-
79960514103
-
Bruton's tyrosine kinase is required for TLR-dependent heme oxygenase-1 gene activation via Nrf2 inmacrophages
-
Vijayan V, Baumgart-Vogt E, Naidu S, Qian G, Immenschuh S. Bruton's tyrosine kinase is required for TLR-dependent heme oxygenase-1 gene activation via Nrf2 inmacrophages. J Immunol. 2011;187(2):817-827.
-
(2011)
J Immunol.
, vol.187
, Issue.2
, pp. 817-827
-
-
Vijayan, V.1
Baumgart-Vogt, E.2
Naidu, S.3
Qian, G.4
Immenschuh, S.5
-
89
-
-
56949102188
-
Bruton's tyrosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells
-
Zorn CN, Keck S, Hendriks RW, Leitges M, Freudenberg MA, Huber M. Bruton's tyrosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells. Cell Signal. 2009;21(1):79-86.
-
(2009)
Cell Signal.
, vol.21
, Issue.1
, pp. 79-86
-
-
Zorn, C.N.1
Keck, S.2
Hendriks, R.W.3
Leitges, M.4
Freudenberg, M.A.5
Huber, M.6
-
90
-
-
77956616895
-
TLR signaling and effector functions are intact in XLA neutrophils
-
Marron TU, Rohr K, Martinez-Gallo M, Yu J, Cunningham-Rundles C. TLR signaling and effector functions are intact in XLA neutrophils. Clin Immunol. 2010;137(1):74-80.
-
(2010)
Clin Immunol.
, vol.137
, Issue.1
, pp. 74-80
-
-
Marron, T.U.1
Rohr, K.2
Martinez-Gallo, M.3
Yu, J.4
Cunningham-Rundles, C.5
-
91
-
-
33746286879
-
X-linked agammaglobulinemia: Report on a United States registry of 201 patients
-
DOI 10.1097/01.md.0000229482.27398.ad, PII 0000579220060700000001
-
Winkelstein JA, Marino MC, Lederman HM, et al. X-linked agammaglobulinemia: report on a United States registry of 201 patients.Medicine (Baltimore). 2006;85(4):193-202. (Pubitemid 44107177)
-
(2006)
Medicine
, vol.85
, Issue.4
, pp. 193-202
-
-
Winkelstein, J.A.1
Marino, M.C.2
Lederman, H.M.3
Jones, S.M.4
Sullivan, K.5
Burks, A.W.6
Conley, M.E.7
Cunningham-Rundles, C.8
Ochs, H.D.9
-
92
-
-
2442644014
-
Fatal disseminated mouse adenovirus type 1 infection in mice lacking B cells or Bruton's tyrosine kinase
-
DOI 10.1128/JVI.78.11.5584-5590.2004
-
Moore ML, McKissic EL, Brown CC, Wilkinson JE, Spindler KR. Fatal disseminated mouse adenovirus type 1 infection in mice lacking B cells or Bruton's tyrosine kinase. J Virol. 2004;78(11):5584-5590. (Pubitemid 38661645)
-
(2004)
Journal of Virology
, vol.78
, Issue.11
, pp. 5584-5590
-
-
Moore, M.L.1
McKissic, E.L.2
Brown, C.C.3
Wilkinson, J.E.4
Spindler, K.R.5
-
93
-
-
33947210222
-
Impaired toll-like receptor 8-mediated IL-6 and TNF-α production in antigen-presenting cells from patients with X-linked agammaglobulinemia
-
DOI 10.1182/blood-2006-07-037960
-
Sochorova K, Horvath R, Rozkova D, et al. Impaired Toll-like receptor 8-mediated IL-6 and TNFalpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia. Blood. 2007;109(6):2553-2556. (Pubitemid 46425901)
-
(2007)
Blood
, vol.109
, Issue.6
, pp. 2553-2556
-
-
Sochorova, K.1
Horvath, R.2
Rozkova, D.3
Litzman, J.4
Bartunkova, J.5
Sediva, A.6
Spisek, R.7
-
94
-
-
37849005315
-
Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia
-
Taneichi H, Kanegane H, Sira MM, et al. Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia. Clin Immunol. 2008;126(2):148-154.
-
(2008)
Clin Immunol.
, vol.126
, Issue.2
, pp. 148-154
-
-
Taneichi, H.1
Kanegane, H.2
Sira, M.M.3
-
95
-
-
19944434293
-
Bruton's tyrosine kinase: Cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling
-
DOI 10.1111/j.0105-2896.2005.00225.x
-
Lindvall JM, Blomberg KE, Valiaho J, et al. Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling. Immunol Rev. 2005;203:200-215. (Pubitemid 40185385)
-
(2005)
Immunological Reviews
, vol.203
, pp. 200-215
-
-
Lindvall, J.M.1
Blomberg, K.E.M.2
Valiaho, J.3
Vargas, L.4
Heinonen, J.E.5
Berglof, A.6
Mohamed, A.J.7
Nore, B.F.8
Vihinen, M.9
Smith, C.I.E.10
-
96
-
-
77649303336
-
MHCclass II molecules enhance Toll-like receptor mediated innate immune responses
-
Frei R, Steinle J, Birchler T, et al.MHCclass II molecules enhance Toll-like receptor mediated innate immune responses. PLoS ONE. 2010;5(1):e8808.
-
(2010)
PLoS ONE.
, vol.5
, Issue.1
-
-
Frei, R.1
Steinle, J.2
Birchler, T.3
-
97
-
-
79251611112
-
ActivationofMyD88signalingupon staphylococcal enterotoxin binding to MHC class II molecules
-
KissnerTL, RuthelG,AlamS,UlrichRG,FernandezS, SaikhKU. ActivationofMyD88signalingupon staphylococcal enterotoxin binding to MHC class II molecules. PLoS One. 2011;6(1):e15985.
-
(2011)
PLoS One.
, vol.6
, Issue.1
-
-
Kissner, T.L.1
Ruthel, G.2
Alam, S.3
Ulrich, R.G.4
Fernandez, S.5
Saikh, K.U.6
-
98
-
-
79960974011
-
Btk is a positive regulator in the TREM-1/DAP12 signaling pathway
-
Ormsby T, Schlecker E, Ferdin J, et al. Btk is a positive regulator in the TREM-1/DAP12 signaling pathway. Blood. 2011;118(4):936-945.
-
(2011)
Blood.
, vol.118
, Issue.4
, pp. 936-945
-
-
Ormsby, T.1
Schlecker, E.2
Ferdin, J.3
-
99
-
-
50949092685
-
Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival
-
MelcherM, Unger B, Schmidt U, Rajantie IA, Alitalo K, Ellmeier W. Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. J Immunol. 2008;180(12):8048-8056.
-
(2008)
J Immunol.
, vol.180
, Issue.12
, pp. 8048-8056
-
-
Melcher, M.1
Unger, B.2
Schmidt, U.3
Rajantie, I.A.4
Alitalo, K.5
Ellmeier, W.6
-
100
-
-
0030756590
-
Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries
-
Ekman N, Lymboussaki A, Vastrik I, Sarvas K, Kaipainen A, Alitalo K. Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries. Circulation. 1997;96(6):1729-1732. (Pubitemid 27400725)
-
(1997)
Circulation
, vol.96
, Issue.6
, pp. 1729-1732
-
-
Ekman, N.1
Lymboussaki, A.2
Vastrik, I.3
Sarvas, K.4
Kaipainen, A.5
Alitalo, K.6
-
101
-
-
43049140184
-
Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways
-
Semaan N, Alsaleh G, Gottenberg JE, Wachsmann D, Sibilia J. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. J Immunol. 2008;180(5):3485-3491.
-
(2008)
J Immunol.
, vol.180
, Issue.5
, pp. 3485-3491
-
-
Semaan, N.1
Alsaleh, G.2
Gottenberg, J.E.3
Wachsmann, D.4
Sibilia, J.5
-
102
-
-
79956223769
-
The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independentmanner
-
Gottar-Guillier M, Dodeller F, Huesken D, et al. The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase- independentmanner. J Immunol. 2011;186(10):6014-6023.
-
(2011)
J Immunol.
, vol.186
, Issue.10
, pp. 6014-6023
-
-
Gottar-Guillier, M.1
Dodeller, F.2
Huesken, D.3
-
103
-
-
70349961778
-
Treatment of rheumatoid arthritis: State of the art 2009
-
van Vollenhoven RF. Treatment of rheumatoid arthritis: state of the art 2009. Nat Rev Rheumatol. 2009;5(10):531-541.
-
(2009)
Nat Rev Rheumatol.
, vol.5
, Issue.10
, pp. 531-541
-
-
Van Vollenhoven, R.F.1
-
104
-
-
70350531479
-
Prospective new biological therapies for rheumatoid arthritis
-
Senolt L, Vencovsky J, Pavelka K, Ospelt C, Gay S. Prospective new biological therapies for rheumatoid arthritis. Autoimmun Rev. 2009;9(2):102-107.
-
(2009)
Autoimmun Rev.
, vol.9
, Issue.2
, pp. 102-107
-
-
Senolt, L.1
Vencovsky, J.2
Pavelka, K.3
Ospelt, C.4
Gay, S.5
-
105
-
-
0141788311
-
Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653
-
DOI 10.1002/art.11227
-
Nishikawa M, Myoui A, Tomita T, Takahi K, Nampei A, Yoshikawa H. Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653. Arthritis Rheum. 2003;48(9):2670-2681. (Pubitemid 37129445)
-
(2003)
Arthritis and Rheumatism
, vol.48
, Issue.9
, pp. 2670-2681
-
-
Nishikawa, M.1
Myoui, A.2
Tomita, T.3
Takahi, K.4
Nampei, A.5
Yoshikawa, H.6
-
106
-
-
32444438052
-
Activation of p38 MAPK is a key step in tumor necrosis factor-mediated inflammatory bone destruction
-
DOI 10.1002/art.21626
-
Zwerina J, Hayer S, Redlich K, et al. Activation of p38 MAPK is a key step in tumor necrosis factormediated inflammatory bone destruction. Arthritis Rheum. 2006;54(2):463-472. (Pubitemid 43228620)
-
(2006)
Arthritis and Rheumatism
, vol.54
, Issue.2
, pp. 463-472
-
-
Zwerina, J.1
Hayer, S.2
Redlich, K.3
Bobacz, K.4
Kollias, G.5
Smolen, J.S.6
Schett, G.7
-
107
-
-
75749115980
-
Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stablemethotrexate therapy
-
Alten RE, Zerbini C, Jeka S, et al. Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stablemethotrexate therapy. Ann Rheum Dis. 2010;69(2):364-367.
-
(2010)
Ann Rheum Dis.
, vol.69
, Issue.2
, pp. 364-367
-
-
Alten, R.E.1
Zerbini, C.2
Jeka, S.3
-
108
-
-
59649114148
-
Evaluation of the efficacy and safety of pamapimod, a p38MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis
-
Cohen SB, Cheng TT, Chindalore V, et al. Evaluation of the efficacy and safety of pamapimod, a p38MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis. Arthritis Rheum. 2009;60(2):335-344.
-
(2009)
Arthritis Rheum.
, vol.60
, Issue.2
, pp. 335-344
-
-
Cohen, S.B.1
Cheng, T.T.2
Chindalore, V.3
-
109
-
-
66049086274
-
Efficacy, pharmacodynamics, and safety of VX- 702, a novel p38MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies
-
Damjanov N, Kauffman RS, Spencer-Green GT. Efficacy, pharmacodynamics, and safety of VX- 702, a novel p38MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 2009;60(5):1232-1241.
-
(2009)
Arthritis Rheum.
, vol.60
, Issue.5
, pp. 1232-1241
-
-
Damjanov, N.1
Kauffman, R.S.2
Spencer-Green, G.T.3
-
110
-
-
79955563297
-
A24-week randomized double-blind placebo-controlled parallel group study of the efficacy of oral SCIO-469 a p38 mitogen-activated protein kinase inhibitor in patients with active rheumatoid arthritis
-
GenoveseMC,Cohen SB,WofsyD, et al.A24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis. J Rheumatol. 2011;38(5):846-854.
-
(2011)
J Rheumatol.
, vol.38
, Issue.5
, pp. 846-854
-
-
Genovese, M.C.1
Cohen, S.B.2
Wofsy, D.3
-
111
-
-
75749092187
-
"Go upstream, young man": Lessons learned from the p38 saga
-
Hammaker D, Firestein GS. "Go upstream, young man": lessons learned from the p38 saga. Ann Rheum Dis. 2010;69(Suppl. 1):i77-i82.
-
(2010)
Ann Rheum Dis.
, vol.69
, Issue.SUPPL. 1
-
-
Hammaker, D.1
Firestein, G.S.2
-
112
-
-
34547849752
-
Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor
-
DOI 10.1016/j.clim.2007.03.543, PII S1521661607000617
-
Pine PR, Chang B, Schoettler N, et al. Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clin Immunol. 2007;124(3):244-257. (Pubitemid 47247604)
-
(2007)
Clinical Immunology
, vol.124
, Issue.3
, pp. 244-257
-
-
Pine, P.R.1
Chang, B.2
Schoettler, N.3
Banquerigo, M.L.4
Wang, S.5
Lau, A.6
Zhao, F.7
Grossbard, E.B.8
Payan, D.G.9
Brahn, E.10
-
113
-
-
77952887408
-
Genetic deficiency of Syk protects mice from autoantibodyinduced arthritis
-
Jakus Z, Simon E, Balazs B, Mocsai A. Genetic deficiency of Syk protects mice from autoantibodyinduced arthritis. Arthritis Rheum. 2010;62(7):1899-1910.
-
(2010)
Arthritis Rheum.
, vol.62
, Issue.7
, pp. 1899-1910
-
-
Jakus, Z.1
Simon, E.2
Balazs, B.3
Mocsai, A.4
-
114
-
-
55849114400
-
Treatment of rheumatoid arthritis with a Syk kinase inhibitor: A twelve-week, randomized, placebo-controlled trial
-
Weinblatt ME, Kavanaugh A, Burgos-Vargas R, et al. Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial. Arthritis Rheum. 2008;58(11):3309-3318.
-
(2008)
Arthritis Rheum.
, vol.58
, Issue.11
, pp. 3309-3318
-
-
Weinblatt, M.E.1
Kavanaugh, A.2
Burgos-Vargas, R.3
-
115
-
-
78650294662
-
An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents
-
Genovese MC, Kavanaugh A, Weinblatt ME, et al. An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents. Arthritis Rheum. 2011;63(2):337-345.
-
(2011)
Arthritis Rheum.
, vol.63
, Issue.2
, pp. 337-345
-
-
Genovese, M.C.1
Kavanaugh, A.2
Weinblatt, M.E.3
-
116
-
-
77957333252
-
An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis
-
Weinblatt ME, Kavanaugh A, Genovese MC, Musser TK, Grossbard EB, Magilavy DB. An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis. N Engl J Med. 2010;363(14):1303-1312.
-
(2010)
N Engl J Med.
, vol.363
, Issue.14
, pp. 1303-1312
-
-
Weinblatt, M.E.1
Kavanaugh, A.2
Genovese, M.C.3
Musser, T.K.4
Grossbard, E.B.5
Magilavy, D.B.6
-
117
-
-
84861827087
-
A JAK inhibitor tofacitinib regulates synovitis through inhibition of IFN-gamma and IL-17 production by human CD4(+) T cells
-
doi: 10.1002/art.34329[Epub ahead of print]
-
Maeshima K, Yamaoka K, Kubo S, et al. A JAK inhibitor tofacitinib regulates synovitis through inhibition of IFN-gamma and IL-17 production by human CD4(+) T cells. Arthritis Rheum. 2011 doi: 10.1002/art.34329[Epub ahead of print].
-
(2011)
Arthritis Rheum.
-
-
Maeshima, K.1
Yamaoka, K.2
Kubo, S.3
-
118
-
-
84857239335
-
The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: Autocrine role of type i interferon
-
doi:10.1136/ard.2011.150284 [Epub ahead of print]
-
Rosengren S, Corr M, Firestein GS, Boyle DL. The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon. Ann Rheum Dis. 2011 doi:10.1136/ard.2011.150284 [Epub ahead of print].
-
(2011)
Ann Rheum Dis.
-
-
Rosengren, S.1
Corr, M.2
Firestein, G.S.3
Boyle, D.L.4
-
119
-
-
79960245571
-
Pfizer's JAK inhibitor sails through phase 3 in rheumatoid arthritis
-
Garber K. Pfizer's JAK inhibitor sails through phase 3 in rheumatoid arthritis. Nat Biotechnol. 2011;29(6):467-468.
-
(2011)
Nat Biotechnol.
, vol.29
, Issue.6
, pp. 467-468
-
-
Garber, K.1
-
120
-
-
77956165442
-
Inhibition of JAK kinases in patients with rheumatoid arthritis: Scientific rationale and clinical outcomes
-
Riese RJ, Krishnaswami S, Kremer J. Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes. Best Pract Res Clin Rheumatol. 2010;24(4):513-526.
-
(2010)
Best Pract Res Clin Rheumatol.
, vol.24
, Issue.4
, pp. 513-526
-
-
Riese, R.J.1
Krishnaswami, S.2
Kremer, J.3
-
121
-
-
80051948193
-
New drugs beyond biologics in rheumatoid arthritis: The kinase inhibitors
-
(Oxford).
-
Bonilla-HernanMG,Miranda-CarusME,Martin-Mola E. New drugs beyond biologics in rheumatoid arthritis: the kinase inhibitors. Rheumatology (Oxford). 2011;50(9):1542-1550.
-
(2011)
Rheumatology
, vol.50
, Issue.9
, pp. 1542-1550
-
-
Bonilla-Hernan, M.G.1
Miranda-Carus, M.E.2
Martin-Mola, E.3
-
122
-
-
80052493233
-
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
-
Balachandran VP, CavnarMJ, Zeng S, et al. Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido. NatMed. 2011;17(9):1094-1100.
-
(2011)
NatMed.
, vol.17
, Issue.9
, pp. 1094-1100
-
-
Balachandran, V.P.1
Cavnarmj Zeng, S.2
-
123
-
-
70450193142
-
Imatinib and beyond-exploring the full potential of targeted therapy for CML
-
Quintas-Cardama A, Kantarjian H, Cortes J. Imatinib and beyond-exploring the full potential of targeted therapy for CML. Nat Rev Clin Oncol. 2009;6(9):535-543.
-
(2009)
Nat Rev Clin Oncol.
, vol.6
, Issue.9
, pp. 535-543
-
-
Quintas-Cardama, A.1
Kantarjian, H.2
Cortes, J.3
-
124
-
-
70350029224
-
Imatinib mesylate inhibited rat adjuvant arthritis and PDGFdependent growth of synovial fibroblast via interference with the Akt signaling pathway
-
Terabe F, Kitano M, Kawai M, et al. Imatinib mesylate inhibited rat adjuvant arthritis and PDGFdependent growth of synovial fibroblast via interference with the Akt signaling pathway. Mod Rheumatol. 2009;19(5):522-529.
-
(2009)
Mod Rheumatol.
, vol.19
, Issue.5
, pp. 522-529
-
-
Terabe, F.1
Kitano, M.2
Kawai, M.3
-
125
-
-
34547951348
-
Imatinib mesylate both prevents and treats the arthritis induced by type II collagen antibody in mice
-
DOI 10.1007/s10165-007-0592-9
-
Koyama K, Hatsushika K, Ando T, et al. Imatinib mesylate both prevents and treats the arthritis induced by type II collagen antibody in mice.Mod Rheumatol. 2007;17(4):306-310. (Pubitemid 47263822)
-
(2007)
Modern Rheumatology
, vol.17
, Issue.4
, pp. 306-310
-
-
Koyama, K.1
Hatsushika, K.2
Ando, T.3
Sakuma, M.4
Wako, M.5
Kato, R.6
Haro, H.7
Sugiyama, H.8
Hamada, Y.9
Ogawa, H.10
Nakao, A.11
-
126
-
-
84857048686
-
Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mousemodel ofmultiple sclerosis
-
Crespo O, Kang SC, Daneman R, et al. Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mousemodel ofmultiple sclerosis. J Clin Immunol. 2011;31(6):1010-1020.
-
(2011)
J Clin Immunol.
, vol.31
, Issue.6
, pp. 1010-1020
-
-
Crespo, O.1
Kang, S.C.2
Daneman, R.3
-
127
-
-
80053373081
-
Inhibition of fms-like tyrosine kinase 3 alleviates experimental arthritis by reducing formation of dendritic cells and antigen presentation
-
Dehlin M, Andersson S, Erlandsson M, Brisslert M, Bokarewa M. Inhibition of fms-like tyrosine kinase 3 alleviates experimental arthritis by reducing formation of dendritic cells and antigen presentation. J Leukoc Biol. 2011;90(4):811-817.
-
(2011)
J Leukoc Biol.
, vol.90
, Issue.4
, pp. 811-817
-
-
Dehlin, M.1
Andersson, S.2
Erlandsson, M.3
Brisslert, M.4
Bokarewa, M.5
-
128
-
-
57749094961
-
Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabeticmice
-
Louvet C, Szot GL, Lang J, et al. Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabeticmice. Proc Nat Acad Sci USA. 2008;105(48):18895-18900.
-
(2008)
Proc Nat Acad Sci USA.
, vol.105
, Issue.48
, pp. 18895-18900
-
-
Louvet, C.1
Szot, G.L.2
Lang, J.3
-
129
-
-
42249088418
-
Profound inhibition of antigen-specific T-cell effector functions by dasatinib
-
DOI 10.1158/1078-0432.CCR-07-4393
-
Weichsel R, Dix C,Wooldridge L, et al. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clin Cancer Res. 2008;14(8):2484-2491. (Pubitemid 351551084)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.8
, pp. 2484-2491
-
-
Weichsel, R.1
Dix, C.2
Wooldridge, L.3
Clement, M.4
Fenton-May, A.5
Sewell, A.K.6
Zezula, J.7
Greiner, E.8
Gostick, E.9
Price, D.A.10
Einsele, H.11
Seggewiss, R.12
-
130
-
-
33750989362
-
2-Aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6- [4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-1, 3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor
-
DOI 10.1021/jm060727j
-
Das J, Chen P, Norris D, et al. 2-aminothiazole as a novel kinase inhibitor template. Structureactivity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2- hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. JMed Chem. 2006;49(23):6819-6832. (Pubitemid 44749749)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.23
, pp. 6819-6832
-
-
Das, J.1
Chen, P.2
Norris, D.3
Padmanabha, R.4
Lin, J.5
Moquin, R.V.6
Shen, Z.7
Cook, L.S.8
Doweyko, A.M.9
Pitt, S.10
Pang, S.11
Shen, D.R.12
Fang, Q.13
De Fex, H.F.14
McIntyre, K.W.15
Shuster, D.J.16
Gillooly, K.M.17
Behnia, K.18
Schieven, G.L.19
Wityak, J.20
Barrish, J.C.21
more..
-
131
-
-
34548097263
-
The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib
-
DOI 10.1073/pnas.0702654104
-
HantschelO, Rix U, SchmidtU, et al.TheBtk tyrosine kinase is amajor target of the Bcr-Abl inhibitor dasatinib. Proc Nat Acad Sci USA. 2007;104(33):13283-13288. (Pubitemid 47293937)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.33
, pp. 13283-13288
-
-
Hantschel, O.1
Rix, U.2
Schmidt, U.3
Burckstummer, T.4
Kneidinger, M.5
Schutze, G.6
Colinge, J.7
Bennett, K.L.8
Ellmeier, W.9
Valent, P.10
Superti-Furga, G.11
-
132
-
-
62549089748
-
Dasatinib is a potent inhibitor of tumour-associatedmacrophages, osteoclasts and the FMS receptor
-
Brownlow N, Mol C, Hayford C, Ghaem-Maghami S, Dibb NJ. Dasatinib is a potent inhibitor of tumour-associatedmacrophages, osteoclasts and the FMS receptor. Leukemia. 2009;23(3):590-594.
-
(2009)
Leukemia.
, vol.23
, Issue.3
, pp. 590-594
-
-
Brownlow, N.1
Mol, C.2
Hayford, C.3
Ghaem-Maghami, S.4
Dibb, N.J.5
-
133
-
-
78650433517
-
Specific Btk inhibition suppresses B cell- and myeloid cellmediated arthritis
-
Di Paolo JA, Huang T, Balazs M, et al. Specific Btk inhibition suppresses B cell- and myeloid cellmediated arthritis. Nat Chem Biol. 2011;7(1):41-50.
-
(2011)
Nat Chem Biol.
, vol.7
, Issue.1
, pp. 41-50
-
-
Di Paolo, J.A.1
Huang, T.2
Balazs, M.3
-
134
-
-
0033515450
-
Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N- (2, 5-dibromophenyl)propenamide]
-
Mahajan S,Ghosh S, Sudbeck EA, et al. Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide]. J Biol Chem. 1999;274(14):9587-9599.
-
(1999)
J Biol Chem.
, vol.274
, Issue.14
, pp. 9587-9599
-
-
Mahajan, S.1
Ghosh, S.2
Sudbeck, E.A.3
-
135
-
-
38049084406
-
Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
-
Pan Z, Scheerens H, Li SJ, et al. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. ChemMed Chem. 2007;2(1):58-61.
-
(2007)
ChemMed Chem.
, vol.2
, Issue.1
, pp. 58-61
-
-
Pan, Z.1
Scheerens, H.2
Li, S.J.3
-
136
-
-
77955625479
-
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
-
Honigberg LA, Smith AM, Sirisawad M, et al.The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Nat Acad Sci USA. 2010;107(29):13075-13080.
-
(2010)
Proc Nat Acad Sci USA.
, vol.107
, Issue.29
, pp. 13075-13080
-
-
Honigberg, L.A.1
Smith, A.M.2
Sirisawad, M.3
-
137
-
-
79959522607
-
Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/ pharmacodynamicmodeling: Relationships between inhibition of BTK phosphorylation and efficacy
-
Liu L, Di Paolo J, Barbosa J, Rong H, Reif K, Wong H. Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/ pharmacodynamicmodeling: relationships between inhibition of BTK phosphorylation and efficacy. J Pharmacol ExpTher. 2011;338(1):154-163.
-
(2011)
J Pharmacol ExpTher.
, vol.338
, Issue.1
, pp. 154-163
-
-
Liu, L.1
Di Paolo, J.2
Barbosa, J.3
Rong, H.4
Reif, K.5
Wong, H.6
-
138
-
-
79960133279
-
The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells
-
Chang BY, Huang MM, Francesco M, et al. The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells. Arthritis Res Ther. 2011;13(4):R115.
-
(2011)
Arthritis Res Ther.
, vol.13
, Issue.4
-
-
Chang, B.Y.1
Huang, M.M.2
Francesco, M.3
-
139
-
-
77956416903
-
Toll-like receptor signaling: A potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis
-
Huang Q, Pope RM. Toll-like receptor signaling: a potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis. J Leukoc Biol. 2010;88(2):253-262.
-
(2010)
J Leukoc Biol.
, vol.88
, Issue.2
, pp. 253-262
-
-
Huang, Q.1
Pope, R.M.2
|