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Volumn 45, Issue 4, 2008, Pages 990-1000

Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages

Author keywords

Inflammation; PP2; TNF; Tyrosine kinase

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN TYROSINE KINASE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR;

EID: 35548985405     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.07.026     Document Type: Article
Times cited : (64)

References (40)
  • 2
    • 21344449546 scopus 로고    scopus 로고
    • The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis
    • Andreakos E., Sacre S., Foxwell B.M., and Feldmann M. The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis. Front Biosci. 10 (2005) 2478-2488
    • (2005) Front Biosci. , vol.10 , pp. 2478-2488
    • Andreakos, E.1    Sacre, S.2    Foxwell, B.M.3    Feldmann, M.4
  • 3
    • 0037392942 scopus 로고    scopus 로고
    • The specificities of protein kinase inhibitors: an update
    • Bain J., McLauchlan H., Elliott M., and Cohen P. The specificities of protein kinase inhibitors: an update. Biochem. J. 371 (2003) 199-204
    • (2003) Biochem. J. , vol.371 , pp. 199-204
    • Bain, J.1    McLauchlan, H.2    Elliott, M.3    Cohen, P.4
  • 4
    • 0028364801 scopus 로고
    • Lipopolysaccharide-induced cytokine production in human monocytes: role of tyrosine phosphorylation in transmembrane signal transduction
    • Beaty C.D., Franklin T.L., Uehara Y., and Wilson C.B. Lipopolysaccharide-induced cytokine production in human monocytes: role of tyrosine phosphorylation in transmembrane signal transduction. Eur. J. Immunol. 24 (1994) 1278-1284
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1278-1284
    • Beaty, C.D.1    Franklin, T.L.2    Uehara, Y.3    Wilson, C.B.4
  • 5
    • 0026530288 scopus 로고
    • Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages
    • Boulet I., Ralph S., Stanley E., Lock P., Dunn A.R., Green S.P., and Phillips W.A. Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages. Oncogene 7 (1992) 703-710
    • (1992) Oncogene , vol.7 , pp. 703-710
    • Boulet, I.1    Ralph, S.2    Stanley, E.3    Lock, P.4    Dunn, A.R.5    Green, S.P.6    Phillips, W.A.7
  • 6
    • 4644298609 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10
    • Dahle M.K., Overland G., Myhre A.E., Stuestol J.F., Hartung T., Krohn C.D., Mathiesen O., Wang J.E., and Aasen A.O. The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10. Infect. Immun. 72 (2004) 5704-5711
    • (2004) Infect. Immun. , vol.72 , pp. 5704-5711
    • Dahle, M.K.1    Overland, G.2    Myhre, A.E.3    Stuestol, J.F.4    Hartung, T.5    Krohn, C.D.6    Mathiesen, O.7    Wang, J.E.8    Aasen, A.O.9
  • 7
    • 0037093989 scopus 로고    scopus 로고
    • Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages
    • Denys A., Udalova I.A., Smith C., Williams L.M., Ciesielski C.J., Campbell J., Andrews C., Kwaitkowski D., and Foxwell B.M. Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages. J. Immunol. 168 (2002) 4837-4845
    • (2002) J. Immunol. , vol.168 , pp. 4837-4845
    • Denys, A.1    Udalova, I.A.2    Smith, C.3    Williams, L.M.4    Ciesielski, C.J.5    Campbell, J.6    Andrews, C.7    Kwaitkowski, D.8    Foxwell, B.M.9
  • 8
    • 0038385023 scopus 로고    scopus 로고
    • Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus
    • Fan H., Teti G., Ashton S., Guyton K., Tempel G.E., Halushka P.V., and Cook J.A. Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus. Cytokine 22 (2003) 126-133
    • (2003) Cytokine , vol.22 , pp. 126-133
    • Fan, H.1    Teti, G.2    Ashton, S.3    Guyton, K.4    Tempel, G.E.5    Halushka, P.V.6    Cook, J.A.7
  • 9
    • 0036953532 scopus 로고    scopus 로고
    • Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production
    • Ferlito M., Romanenko O.G., Guyton K., Ashton S., Squadrito F., Halushka P.V., and Cook J.A. Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production. J. Endotoxin Res. 8 (2002) 427-435
    • (2002) J. Endotoxin Res. , vol.8 , pp. 427-435
    • Ferlito, M.1    Romanenko, O.G.2    Guyton, K.3    Ashton, S.4    Squadrito, F.5    Halushka, P.V.6    Cook, J.A.7
  • 10
    • 0032493278 scopus 로고    scopus 로고
    • Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent
    • Foxwell B., Browne K., Bondeson J., Clarke C., de Martin R., Brennan F., and Feldmann M. Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 8211-8215
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 8211-8215
    • Foxwell, B.1    Browne, K.2    Bondeson, J.3    Clarke, C.4    de Martin, R.5    Brennan, F.6    Feldmann, M.7
  • 12
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • Guha M., and Mackman N. LPS induction of gene expression in human monocytes. Cell Signal. 13 (2001) 85-94
    • (2001) Cell Signal. , vol.13 , pp. 85-94
    • Guha, M.1    Mackman, N.2
  • 14
    • 33846685017 scopus 로고    scopus 로고
    • NF-kappaB activation in development and progression of cancer
    • Inoue J., Gohda J., Akiyama T., and Semba K. NF-kappaB activation in development and progression of cancer. Cancer Sci. 98 (2007) 268-274
    • (2007) Cancer Sci. , vol.98 , pp. 268-274
    • Inoue, J.1    Gohda, J.2    Akiyama, T.3    Semba, K.4
  • 15
    • 33646147362 scopus 로고    scopus 로고
    • Toll-like receptor function and signaling
    • quiz 988
    • Kaisho T., and Akira S. Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 117 (2006) 979-987 quiz 988
    • (2006) J. Allergy Clin. Immunol. , vol.117 , pp. 979-987
    • Kaisho, T.1    Akira, S.2
  • 16
    • 0346850850 scopus 로고    scopus 로고
    • Oxidative stress reprograms lipopolysaccharide signaling via Src kinase-dependent pathway in RAW 264.7 macrophage cell line
    • Khadaroo R.G., Kapus A., Powers K.A., Cybulsky M.I., Marshall J.C., and Rotstein O.D. Oxidative stress reprograms lipopolysaccharide signaling via Src kinase-dependent pathway in RAW 264.7 macrophage cell line. J. Biol. Chem. 278 (2003) 47834-47841
    • (2003) J. Biol. Chem. , vol.278 , pp. 47834-47841
    • Khadaroo, R.G.1    Kapus, A.2    Powers, K.A.3    Cybulsky, M.I.4    Marshall, J.C.5    Rotstein, O.D.6
  • 17
    • 0041326624 scopus 로고    scopus 로고
    • Oxidant-induced priming of the macrophage involves activation of p38 mitogen-activated protein kinase through an Src-dependent pathway
    • Khadaroo R.G., Parodo J., Powers K.A., Papia G., Marshall J.C., Kapus A., and Rotstein O.D. Oxidant-induced priming of the macrophage involves activation of p38 mitogen-activated protein kinase through an Src-dependent pathway. Surgery 134 (2003) 242-246
    • (2003) Surgery , vol.134 , pp. 242-246
    • Khadaroo, R.G.1    Parodo, J.2    Powers, K.A.3    Papia, G.4    Marshall, J.C.5    Kapus, A.6    Rotstein, O.D.7
  • 18
    • 0027278222 scopus 로고
    • Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction
    • Kobayashi N., Kono T., Hatakeyama M., Minami Y., Miyazaki T., Perlmutter R.M., and Taniguchi T. Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 4201-4205
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 4201-4205
    • Kobayashi, N.1    Kono, T.2    Hatakeyama, M.3    Minami, Y.4    Miyazaki, T.5    Perlmutter, R.M.6    Taniguchi, T.7
  • 19
    • 33846524474 scopus 로고    scopus 로고
    • Haplotype-independent costimulation of IL-10 secretion by SDF-1/CXCL12 proceeds via AP-1 binding to the human IL-10 promoter
    • Kremer K.N., Kumar A., and Hedin K.E. Haplotype-independent costimulation of IL-10 secretion by SDF-1/CXCL12 proceeds via AP-1 binding to the human IL-10 promoter. J. Immunol. 178 (2007) 1581-1588
    • (2007) J. Immunol. , vol.178 , pp. 1581-1588
    • Kremer, K.N.1    Kumar, A.2    Hedin, K.E.3
  • 20
    • 0035380992 scopus 로고    scopus 로고
    • Structural characterisation of the distal 5′ flanking region of the human interleukin-10 gene
    • Kube D., Rieth H., Eskdale J., Kremsner P.G., and Gallagher G. Structural characterisation of the distal 5′ flanking region of the human interleukin-10 gene. Genes Immun. 2 (2001) 181-190
    • (2001) Genes Immun. , vol.2 , pp. 181-190
    • Kube, D.1    Rieth, H.2    Eskdale, J.3    Kremsner, P.G.4    Gallagher, G.5
  • 21
    • 34548656855 scopus 로고    scopus 로고
    • Signaling pathways downstream of pattern-recognition receptors and their cross talk
    • Lee M.S., and Kim Y.J. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu. Rev. Biochem. 76 (2007) 447-480
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 447-480
    • Lee, M.S.1    Kim, Y.J.2
  • 22
    • 24944549093 scopus 로고    scopus 로고
    • The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4
    • Lee J.Y., Lowell C.A., Lemay D.G., Youn H.S., Rhee S.H., Sohn K.H., Jang B., Ye J., Chung J.H., and Hwang D.H. The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem. Pharmacol. 70 (2005) 1231-1240
    • (2005) Biochem. Pharmacol. , vol.70 , pp. 1231-1240
    • Lee, J.Y.1    Lowell, C.A.2    Lemay, D.G.3    Youn, H.S.4    Rhee, S.H.5    Sohn, K.H.6    Jang, B.7    Ye, J.8    Chung, J.H.9    Hwang, D.H.10
  • 23
    • 27944487579 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages
    • Leu T.H., Charoenfuprasert S., Yen C.K., Fan C.W., and Maa M.C. Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages. Mol. Immunol. 43 (2006) 308-316
    • (2006) Mol. Immunol. , vol.43 , pp. 308-316
    • Leu, T.H.1    Charoenfuprasert, S.2    Yen, C.K.3    Fan, C.W.4    Maa, M.C.5
  • 25
    • 0025820850 scopus 로고
    • Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization
    • Lock P., Ralph S., Stanley E., Boulet I., Ramsay R., and Dunn A.R. Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization. Mol. Cell Biol. 11 (1991) 4363-4370
    • (1991) Mol. Cell Biol. , vol.11 , pp. 4363-4370
    • Lock, P.1    Ralph, S.2    Stanley, E.3    Boulet, I.4    Ramsay, R.5    Dunn, A.R.6
  • 26
    • 0035209941 scopus 로고    scopus 로고
    • Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion
    • Majeed M., Caveggion E., Lowell C.A., and Berton G. Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion. J. Leukocyte Biol. 70 (2001) 801-811
    • (2001) J. Leukocyte Biol. , vol.70 , pp. 801-811
    • Majeed, M.1    Caveggion, E.2    Lowell, C.A.3    Berton, G.4
  • 27
    • 0030912071 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn
    • Meng F., and Lowell C.A. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J. Exp. Med. 185 (1997) 1661-1670
    • (1997) J. Exp. Med. , vol.185 , pp. 1661-1670
    • Meng, F.1    Lowell, C.A.2
  • 28
    • 0242335086 scopus 로고    scopus 로고
    • Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation
    • Napolitani G., Bortoletto N., Racioppi L., Lanzavecchia A., and D'Oro U. Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation. Eur. J. Immunol. 33 (2003) 2832-2841
    • (2003) Eur. J. Immunol. , vol.33 , pp. 2832-2841
    • Napolitani, G.1    Bortoletto, N.2    Racioppi, L.3    Lanzavecchia, A.4    D'Oro, U.5
  • 30
    • 0033228567 scopus 로고    scopus 로고
    • The src family selective tyrosine kinase inhibitor PP1 blocks LPS and IFN-gamma-mediated TNF and iNOS production in murine macrophages
    • Orlicek S.L., Hanke J.H., and English B.K. The src family selective tyrosine kinase inhibitor PP1 blocks LPS and IFN-gamma-mediated TNF and iNOS production in murine macrophages. Shock 12 (1999) 350-354
    • (1999) Shock , vol.12 , pp. 350-354
    • Orlicek, S.L.1    Hanke, J.H.2    English, B.K.3
  • 31
    • 0038757753 scopus 로고    scopus 로고
    • TLR4-dependent lipopolysaccharide-induced shedding of tumor necrosis factor receptors in mouse bone marrow granulocytes
    • Pedron T., Girard R., and Chaby R. TLR4-dependent lipopolysaccharide-induced shedding of tumor necrosis factor receptors in mouse bone marrow granulocytes. J. Biol. Chem. 278 (2003) 20555-20564
    • (2003) J. Biol. Chem. , vol.278 , pp. 20555-20564
    • Pedron, T.1    Girard, R.2    Chaby, R.3
  • 32
    • 1242276189 scopus 로고    scopus 로고
    • D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a
    • Rena G., Bain J., Elliott M., and Cohen P. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 5 (2004) 60-65
    • (2004) EMBO Rep. , vol.5 , pp. 60-65
    • Rena, G.1    Bain, J.2    Elliott, M.3    Cohen, P.4
  • 33
    • 0035908126 scopus 로고    scopus 로고
    • Two waves of nuclear factor kappaB recruitment to target promoters
    • Saccani S., Pantano S., and Natoli G. Two waves of nuclear factor kappaB recruitment to target promoters. J. Exp. Med. 193 (2001) 1351-1359
    • (2001) J. Exp. Med. , vol.193 , pp. 1351-1359
    • Saccani, S.1    Pantano, S.2    Natoli, G.3
  • 34
    • 0034881367 scopus 로고    scopus 로고
    • The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart
    • Scholz G.M., Hartson S.D., Cartledge K., Volk L., Matts R.L., and Dunn A.R. The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart. Cell Growth Differ. 12 (2001) 409-417
    • (2001) Cell Growth Differ. , vol.12 , pp. 409-417
    • Scholz, G.M.1    Hartson, S.D.2    Cartledge, K.3    Volk, L.4    Matts, R.L.5    Dunn, A.R.6
  • 36
    • 0027434028 scopus 로고
    • Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn
    • Stefanova I., Corcoran M.L., Horak E.M., Wahl L.M., Bolen J.B., and Horak I.D. Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn. J. Biol. Chem. 268 (1993) 20725-20728
    • (1993) J. Biol. Chem. , vol.268 , pp. 20725-20728
    • Stefanova, I.1    Corcoran, M.L.2    Horak, E.M.3    Wahl, L.M.4    Bolen, J.B.5    Horak, I.D.6
  • 37
    • 0033490109 scopus 로고    scopus 로고
    • Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages
    • Suen P.W., Ilic D., Caveggion E., Berton G., Damsky C.H., and Lowell C.A. Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J. Cell Sci. 112 Pt 22 (1999) 4067-4078
    • (1999) J. Cell Sci. , vol.112 , Issue.PART 22 , pp. 4067-4078
    • Suen, P.W.1    Ilic, D.2    Caveggion, E.3    Berton, G.4    Damsky, C.H.5    Lowell, C.A.6
  • 38
    • 9844235351 scopus 로고    scopus 로고
    • Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3.4-d]pyrimidines
    • Traxler P., Bold G., Frei J., Lang M., Lydon N., Mett H., Buchdunger E., Meyer T., Mueller M., and Furet P. Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3.4-d]pyrimidines. J. Med. Chem. 40 (1997) 3601-3616
    • (1997) J. Med. Chem. , vol.40 , pp. 3601-3616
    • Traxler, P.1    Bold, G.2    Frei, J.3    Lang, M.4    Lydon, N.5    Mett, H.6    Buchdunger, E.7    Meyer, T.8    Mueller, M.9    Furet, P.10
  • 39
    • 0027291238 scopus 로고
    • Heat-shock protein hsp90 governs the activity of pp60v-src kinase
    • Xu Y., and Lindquist S. Heat-shock protein hsp90 governs the activity of pp60v-src kinase. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 7074-7078
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 7074-7078
    • Xu, Y.1    Lindquist, S.2
  • 40
    • 0036070526 scopus 로고    scopus 로고
    • Lipopolysaccharide-binding protein- and CD14-dependent activation of mitogen-activated protein kinase p38 by lipopolysaccharide in human neutrophils is associated with priming of respiratory burst
    • Yan S.R., Al-Hertani W., Byers D., and Bortolussi R. Lipopolysaccharide-binding protein- and CD14-dependent activation of mitogen-activated protein kinase p38 by lipopolysaccharide in human neutrophils is associated with priming of respiratory burst. Infect. Immun. 70 (2002) 4068-4074
    • (2002) Infect. Immun. , vol.70 , pp. 4068-4074
    • Yan, S.R.1    Al-Hertani, W.2    Byers, D.3    Bortolussi, R.4


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