DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency

Cell Cycle

Volumn 10, Issue 1, 2011, Pages 108-117

  Houlard, Martin ^a   Artus, Jérôme ^a,b   Léguillier, Teddy ^a   Vandormael Pournin, Sandrine ^a   Cohen Tannoudji, Michel ^a  

^a INSTITUT PASTEUR   (France)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Cell cycle checkpoint; Genome stability; R loop; Replication; RNA processing

Indexed keywords

ATM PROTEIN; ATR PROTEIN; MESSENGER RNA; RIBONUCLEASE H;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL VIABILITY; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA RNA HYBRIDIZATION; EMBRYO; EMBRYO CELL; FIBROBLAST; GENE; GENE DELETION; GENE FUNCTION; GENE INACTIVATION; GENE REPLICATION; GENOMIC INSTABILITY; MOUSE; MOUSE EMBRYO; NONHUMAN; OPEN READING FRAME; OVUM MUTANT CANDIDATE GENE 1; PROTEIN EXPRESSION; RNA PROCESSING;

EID: 78650849800     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.1.14379     Document Type: Article

References (34)

1. Aladjem MI. Replication in context: dynamic regulation of DNA replication patterns in metazoans. Nat Rev Genet 2007; 8:588-600.
2. Ivessa AS, Lenzmeier BA, Bessler JB, Goudsouzian LK, Schnakenberg SL, Zakian VA. The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes. Mol Cell 2003; 12:1525-36.
3. Tourriere H, Pasero P. Maintenance of fork integrity at damaged DNA and natural pause sites. DNA Repair (Amst) 2007; 6:900-13. (Pubitemid 46880471)
4. Lindahl T. Instability and decay of the primary structure of DNA. Nature 1993; 362:709-15. (Pubitemid 23125973)
5. Lopes M, Cotta-Ramusino C, Pellicioli A, Liberi G, Plevani P, Muzi-Falconi M, et al. The DNA replication checkpoint response stabilizes stalled replication forks. Nature 2001; 412:557-61. (Pubitemid 32743836)
6. Sogo JM, Lopes M, Foiani M. Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 2002; 297:599-602. (Pubitemid 34815343)
7. Tercero JA, Diffley JF. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 2001; 412:553-7.
8. Su TT. Cellular responses to DNA damage: one signal, multiple choices. Annu Rev Genet 2006; 40:187-208. (Pubitemid 44956784)
9. Aguilera A, Gomez-Gonzalez B. Genome instability: a mechanistic view of its causes and consequences. Nat Rev Genet 2008; 9:204-17. (Pubitemid 351271797)
10. Li X, Manley JL. Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell 2005; 122:365-78. (Pubitemid 41127139)
11. Li X, Manley JL. Cotranscriptional processes and their influence on genome stability. Genes Dev 2006; 20:1838-47.
12. Tuduri S, Crabbe L, Conti C, Tourriere H, Holtgreve-Grez H, Jauch A, et al. Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription. Nat Cell Biol 2009; 11:1315-24.
13. Artus J, Vandormael-Pournin S, Frodin M, Nacerddine K, Babinet C, Cohen-Tannoudji M. Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein. Mol Cell Biol 2005; 25:6289-302.
14. Hameyer D, Loonstra A, Eshkind L, Schmitt S, Antunes C, Groen A, et al. Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues. Physiol Genomics 2007; 31:32-41.
15. Loonstra A, Vooijs M, Beverloo HB, Allak BA, van Drunen E, Kanaar R, et al. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc Natl Acad Sci USA 2001; 98:9209-14.
16. Semprini S, Troup TJ, Kotelevtseva N, King K, Davis JR, Mullins LJ, et al. Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques. Nucleic Acids Res 2007; 35:1402-10.
17. Silver DP, Livingston DM. Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol Cell 2001; 8:233-43.
18. Thyagarajan B, Guimaraes MJ, Groth AC, Calos MP. Mammalian genomes contain active recombinase recognition sites. Gene 2000; 244:47-54.
19. Beck H, Nahse V, Larsen MS, Groth P, Clancy T, Lees M, et al. Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. J Cell Biol 2010; 188:629-38.
20. Binz SK, Sheehan AM, Wold MS. Replication protein A phosphorylation and the cellular response to DNA damage. DNA Repair (Amst) 2004; 3:1015-24.
21. Marques M, Kumar A, Poveda AM, Zuluaga S, Hernandez C, Jackson S, et al. Specific function of phosphoinositide 3-kinase beta in the control of DNA replication. Proc Natl Acad Sci USA 2009; 106:7525-30.
22. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, 3rd, Hurov KE, Luo J, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007; 316:1160-6.
23. Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, et al. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 1999; 59:4375-82. (Pubitemid 29418757)
24. Sinha R, Allemand E, Zhang Z, Karni R, Myers MP, Krainer AR. Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF. Mol Cell Biol 2010; 30:2762-74.
25. Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, et al. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell 2009; 35:228-39.
26. Lamond AI, Spector DL. Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol 2003; 4:605-12.
27. Saitoh N, Spahr CS, Patterson SD, Bubulya P, Neuwald AF, Spector DL. Proteomic analysis of interchromatin granule clusters. Mol Biol Cell 2004; 15:3876-90. (Pubitemid 38989721)
28. Kuraoka I, Ito S, Wada T, Hayashida M, Lee L, Saijo M, et al. Isolation of XAB2 complex involved in pre-mRNA splicing, transcription and transcription-coupled repair. J Biol Chem 2008; 283:940-50.
29. Bessonov S, Anokhina M, Will CL, Urlaub H, Luhrmann R. Isolation of an active step I spliceosome and composition of its RNP core. Nature 2008; 452:846-50. (Pubitemid 351550864)
30. Houlard M, Artus J, Cohen-Tannoudji M. Cell cycle checkpoints and DNA damage response in early mouse embryo. In: Kubiak J, Ciemerych M, Richard-Parpaillon L, Eds. Cell cycle and development in vertebrates. Trivandrum 695 023, Kerala, India: Research Signpost 2009; 244.
31. Aladjem MI, Spike BT, Rodewald LW, Hope TJ, Klemm M, Jaenisch R, et al. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol 1998; 8:145-55.
32. Hong Y, Stambrook PJ. Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. Proc Natl Acad Sci USA 2004; 101:14443-8.
33. Xu X, Yang D, Ding JH, Wang W, Chu PH, Dalton ND, et al. ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell 2005; 120:59-72.
34. Todaro GJ, Wolman SR, Green H. Rapid Transformation of Human Fibroblasts with Low Growth Potential into Established Cell Lines by Sv40. J Cell Physiol 1963; 62:257-65.