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Volumn 8, Issue 7, 2007, Pages 731-741

Application of metabonomics in drug development

Author keywords

Biomarkers; Drug development; Metabolic profiling; Metabolomics; Metabonomics; Personalized healthcare; Pharmacology; Toxicology; Translational research

Indexed keywords

BIOLOGICAL MARKER; PARACETAMOL; TRIMETHYLAMINE;

EID: 34548065407     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/14622416.8.7.731     Document Type: Review
Times cited : (54)

References (50)
  • 1
    • 0032694577 scopus 로고    scopus 로고
    • Metabonomics': Understanding the metabolic reponses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson JK, Lindon JC, Holmes E: 'Metabonomics': understanding the metabolic reponses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29(11), 1181-1189 (1999).
    • (1999) Xenobiotica , vol.29 , Issue.11 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 2
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics - the link between genotypes and phenotypes
    • Fiehn O: Metabolomics - the link between genotypes and phenotypes. Plant Mol. Bid. 48, 155-171 (2002).
    • (2002) Plant Mol. Bid , vol.48 , pp. 155-171
    • Fiehn, O.1
  • 3
    • 0035160371 scopus 로고    scopus 로고
    • A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
    • Raamsdonk LM, Teusink B, Broadhurst D et al.: A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat. Biotech. 19(1), 45-50 (2001).
    • (2001) Nat. Biotech , vol.19 , Issue.1 , pp. 45-50
    • Raamsdonk, L.M.1    Teusink, B.2    Broadhurst, D.3
  • 5
    • 20544466649 scopus 로고    scopus 로고
    • Matabonomics in toxicology: A review
    • 2DO5
    • Robertson DG: Matabonomics in toxicology: a review. Toxicol. Sci. 85(2), 809-822 (2DO5).
    • Toxicol. Sci , vol.85 , Issue.2 , pp. 809-822
    • Robertson, D.G.1
  • 6
    • 28444480986 scopus 로고    scopus 로고
    • Metabonomic modeling of drug toxicity
    • Keun HC: Metabonomic modeling of drug toxicity. Pharmacol. Ther. 109(1-2), 92-106 (2006).
    • (2006) Pharmacol. Ther , vol.109 , Issue.1-2 , pp. 92-106
    • Keun, H.C.1
  • 7
    • 0036913503 scopus 로고    scopus 로고
    • 1H-NMR-based metabonomics, Nat. Med. 8(12), 1439-1444(20O3).
    • 1H-NMR-based metabonomics, Nat. Med. 8(12), 1439-1444(20O3).
  • 8
    • 33747185356 scopus 로고    scopus 로고
    • NMR metabolic profiling of Aspergillusnidulans to monitor drug and protein activity
    • Forgue P, Halouska S, Werth M, Xu K, Harris S, Powers R: NMR metabolic profiling of Aspergillusnidulans to monitor drug and protein activity. J. Proteome Res 5(8), 1916-1923 (2006).
    • (2006) J. Proteome Res , vol.5 , Issue.8 , pp. 1916-1923
    • Forgue, P.1    Halouska, S.2    Werth, M.3    Xu, K.4    Harris, S.5    Powers, R.6
  • 9
    • 33750383279 scopus 로고    scopus 로고
    • Choline phospholipid metabolism in cancer: Consequences for molecular pharmaceutical interventions Mol
    • Glunde K, Ackerstaff E, Mori N et al.: Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions Mol. Pharmaceutics 3(5), 496-506 (2006).
    • (2006) Pharmaceutics , vol.3 , Issue.5 , pp. 496-506
    • Glunde, K.1    Ackerstaff, E.2    Mori, N.3
  • 10
    • 33750435528 scopus 로고    scopus 로고
    • Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism
    • Glunde K, Serkova NJ: Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism. Pharmacogenomics 7(7), 1109-1123 (2006).
    • (2006) Pharmacogenomics , vol.7 , Issue.7 , pp. 1109-1123
    • Glunde, K.1    Serkova, N.J.2
  • 11
    • 33847370301 scopus 로고    scopus 로고
    • Tumour metabolomics in animal models of human cancer
    • Griffin JL, Kauppinen RA: Tumour metabolomics in animal models of human cancer. J. Proteome Res 6(2), 498-505 (2007).
    • (2007) J. Proteome Res , vol.6 , Issue.2 , pp. 498-505
    • Griffin, J.L.1    Kauppinen, R.A.2
  • 12
    • 0036847446 scopus 로고    scopus 로고
    • 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin
    • 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin. Magn. Reson. Med. 48(5) 819-825 (2002).
    • (2002) Magn. Reson. Med , vol.48 , Issue.5 , pp. 819-825
    • Glunde, K.1    Ackerstaff, E.2    Natarajan, K.3    Artemov, D.4    Bhujwall, Z.M.5
  • 13
    • 0033010321 scopus 로고    scopus 로고
    • 31P-NMR study using a phosphonium analog of choline
    • 31P-NMR study using a phosphonium analog of choline. Cancer Lett. 140(1-2), 189-194 (1999).
    • (1999) Cancer Lett , vol.140 , Issue.1-2 , pp. 189-194
    • Adebodun, F.1
  • 14
    • 31544473808 scopus 로고    scopus 로고
    • Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models
    • Al-Saffar NMS, Troy H, Ramírez de Molina A et al.: Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models Cancer Res 66(1), 427-434 (2006).
    • (2006) Cancer Res , vol.66 , Issue.1 , pp. 427-434
    • Al-Saffar, N.M.S.1    Troy, H.2    Ramírez de Molina, A.3
  • 15
    • 0000981799 scopus 로고    scopus 로고
    • Detection of in vivo biomarkers of phosspholipidosis using NMR-based metabonomic approacheas
    • Espina JR, Shockcor JP, Herron WJ et al.: Detection of in vivo biomarkers of phosspholipidosis using NMR-based metabonomic approacheas Magn. Reson. Chem. 39(9), 559-565 (2001).
    • (2001) Magn. Reson. Chem , vol.39 , Issue.9 , pp. 559-565
    • Espina, J.R.1    Shockcor, J.P.2    Herron, W.J.3
  • 16
    • 0035029632 scopus 로고    scopus 로고
    • 1H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue
    • 1H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue. Magn. Reson. Med. 45(5), 781-790 (2001).
    • (2001) Magn. Reson. Med , vol.45 , Issue.5 , pp. 781-790
    • Garrod, S.1    Humpher, E.2    Connor, S.C.3
  • 17
    • 0027052705 scopus 로고
    • Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions the rat induced by mercury(II) chloride and 2-bromosthanamine
    • Holmes E, Bonner FW, Sweetmen BC et al.: Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions the rat induced by mercury(II) chloride and 2-bromosthanamine Mol. Pharmacol. 42(5), 922-930 (1992).
    • (1992) Mol. Pharmacol , vol.42 , Issue.5 , pp. 922-930
    • Holmes, E.1    Bonner, F.W.2    Sweetmen, B.C.3
  • 18
    • 0031949067 scopus 로고    scopus 로고
    • Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins
    • Beckwith-Hall BM, Nicholson JK, Nicholls AW et al.: Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chem. Res. Toxicol. 11(4), 260-272 (1998).
    • (1998) Chem. Res. Toxicol , vol.11 , Issue.4 , pp. 260-272
    • Beckwith-Hall, B.M.1    Nicholson, J.K.2    Nicholls, A.W.3
  • 19
    • 26944489574 scopus 로고    scopus 로고
    • The Consortium for Metabonomic Toxicology (COMET): Aims, activities and achievements
    • Lindon JC, Keun HC, Ebbels TMD et al.: The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements. Pharmacogenomics 6(7), 691-699 (2005).
    • (2005) Pharmacogenomics , vol.6 , Issue.7 , pp. 691-699
    • Lindon, J.C.1    Keun, H.C.2    Ebbels, T.M.D.3
  • 20
    • 27744542580 scopus 로고    scopus 로고
    • Trying to catch troublemakers with a metabolic profile
    • Sinha G:Trying to catch troublemakers with a metabolic profile. Science 310(5750), 965-966 (2005).
    • (2005) Science , vol.310 , Issue.5750 , pp. 965-966
    • Sinha, G.1
  • 21
    • 33749012286 scopus 로고    scopus 로고
    • Application of metabonomics a compound ranking study in early drug development revealing drug-induced excretion of choline into urine
    • Dieterle F, Schlotterbeck G, Ross A, Niederhauser U, Sann H: Application of metabonomics a compound ranking study in early drug development revealing drug-induced excretion of choline into urine. Chem. Res Toxicol. 19(9), 1175-1181 (2006).
    • (2006) Chem. Res Toxicol , vol.19 , Issue.9 , pp. 1175-1181
    • Dieterle, F.1    Schlotterbeck, G.2    Ross, A.3    Niederhauser, U.4    Sann, H.5
  • 22
    • 33745209659 scopus 로고    scopus 로고
    • Differential metabolonomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption
    • Soga T, Baran R, Suematsu M et al.: Differential metabolonomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J. Biol. Chem. 281(24), 16768-16776 (2006).
    • (2006) J. Biol. Chem , vol.281 , Issue.24 , pp. 16768-16776
    • Soga, T.1    Baran, R.2    Suematsu, M.3
  • 23
    • 33646198860 scopus 로고    scopus 로고
    • Pharmaco-metabonomic phenotyping and personalized drug treatment
    • Clayton TA, Lindon JC, Cloarec O et al.: Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 440(7087), 1073-1077 (2006).
    • (2006) Nature , vol.440 , Issue.7087 , pp. 1073-1077
    • Clayton, T.A.1    Lindon, J.C.2    Cloarec, O.3
  • 24
    • 33748354488 scopus 로고    scopus 로고
    • Metabolic profiling of CSF: Evidence that early intervention may impact on disease progression and outcome schizophrenia
    • Holmes E, Tsang TM, Huang JT et al.: Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome schizophrenia PLoS Med. 3(8), 1420-1428 (2006).
    • (2006) PLoS Med , vol.3 , Issue.8 , pp. 1420-1428
    • Holmes, E.1    Tsang, T.M.2    Huang, J.T.3
  • 25
    • 33747618036 scopus 로고    scopus 로고
    • Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
    • Dumas ME, Barton RH, Toye A et al.: Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc. Natl Acad. Sci. USA 103(33), 12511-12516 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.33 , pp. 12511-12516
    • Dumas, M.E.1    Barton, R.H.2    Toye, A.3
  • 26
    • 33750213694 scopus 로고    scopus 로고
    • Susceptibility of human metabolic phenotypes to dietary modulation
    • Stella C, Beckwith-Hall B, Cloarec O et al.: Susceptibility of human metabolic phenotypes to dietary modulation. J Proteome Res 5(10), 2780-2788 (2006).
    • (2006) J Proteome Res , vol.5 , Issue.10 , pp. 2780-2788
    • Stella, C.1    Beckwith-Hall, B.2    Cloarec, O.3
  • 27
    • 24044546760 scopus 로고    scopus 로고
    • Metabonomic identification of two distinct phenotypes in in Sprague-Dawley (Crl:CD(SD)) rats
    • Robosky LC, Wells DF Egnash LA et al.: Metabonomic identification of two distinct phenotypes in in Sprague-Dawley (Crl:CD(SD)) rats. Toxicol. Sci. 87(1), 277-284 (2005).
    • (2005) Toxicol. Sci , vol.87 , Issue.1 , pp. 277-284
    • Robosky, L.C.1    Wells, D.F.2    Egnash, L.A.3
  • 28
    • 0043069547 scopus 로고    scopus 로고
    • Understanding 'global' systembiology: Metabonomics and the continuum of metabolism
    • Nicholson JK, Wilson ID: Understanding 'global' systembiology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2(8), 668-676 (2003).
    • (2003) Nat. Rev. Drug Discov , vol.2 , Issue.8 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 29
    • 21144435518 scopus 로고    scopus 로고
    • A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: Application to age, gander and diurnal variation in normal/Zucker obese rats and black, white and nude mice
    • Plumb RS, Granger JH, Stumpf CL et al.: A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gander and diurnal variation in normal/Zucker obese rats and black, white and nude mice. Analyst 130(6), 884-849 (2005).
    • (2005) Analyst , vol.130 , Issue.6 , pp. 884-849
    • Plumb, R.S.1    Granger, J.H.2    Stumpf, C.L.3
  • 30
    • 33646244255 scopus 로고    scopus 로고
    • Urine profiling using capillary electrophoresis-mass spectrometry and multivariate data analysis
    • Ullsten S, Danielsson R, Bäckström D, Sjöberg P, Bergquist J. Urine profiling using capillary electrophoresis-mass spectrometry and multivariate data analysis. J. Chromatogr. A 1117(1), 87-93 (2006).
    • (2006) J. Chromatogr. A , vol.1117 , Issue.1 , pp. 87-93
    • Ullsten, S.1    Danielsson, R.2    Bäckström, D.3    Sjöberg, P.4    Bergquist, J.5
  • 31
    • 10944242220 scopus 로고    scopus 로고
    • Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients a pilot study for achieving their normalization
    • Casado B, Zanone C, Annovazzi L, Iadarola P, Whalen G, Baraniuk JN: Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients a pilot study for achieving their normalization. J. Chromatogr. B Analyst Technol. Biomed. Life Sci. 814(1), 43-51 (2005).
    • (2005) J. Chromatogr. B Analyst Technol. Biomed. Life Sci , vol.814 , Issue.1 , pp. 43-51
    • Casado, B.1    Zanone, C.2    Annovazzi, L.3    Iadarola, P.4    Whalen, G.5    Baraniuk, J.N.6
  • 32
    • 33845742504 scopus 로고    scopus 로고
    • Increasing conclusiveness of metabonomic studies by cheminformatic preprocessing of capillary electrophoretic data on urinary nucleoside profiles
    • Szymañska E, Markuszewski MJ, Capron X et al.: Increasing conclusiveness of metabonomic studies by cheminformatic preprocessing of capillary electrophoretic data on urinary nucleoside profiles. J. Pharm. Biomed. Anal. 43(2), 413-420 (2007).
    • (2007) J. Pharm. Biomed. Anal , vol.43 , Issue.2 , pp. 413-420
    • Szymañska, E.1    Markuszewski, M.J.2    Capron, X.3
  • 33
    • 33746449986 scopus 로고    scopus 로고
    • Metabolic fingerprinting in disease diagnosis biomedical applications of infrared and Raman spectroscopy
    • Ellis DI, Goodacre R: Metabolic fingerprinting in disease diagnosis biomedical applications of infrared and Raman spectroscopy. Analyst 131, 875-885 (2006).
    • (2006) Analyst , vol.131 , pp. 875-885
    • Ellis, D.I.1    Goodacre, R.2
  • 35
    • 33645663178 scopus 로고    scopus 로고
    • Scaling and normalization effects in NMR spectroscopic metabonomic data sets
    • Craig A, Cloarec O, Holmes E, Nicholson JK, Lindon JC: Scaling and normalization effects in NMR spectroscopic metabonomic data sets Anal. Chem. 78(7) 2262-2267 (2006).
    • (2006) Anal. Chem , vol.78 , Issue.7 , pp. 2262-2267
    • Craig, A.1    Cloarec, O.2    Holmes, E.3    Nicholson, J.K.4    Lindon, J.C.5
  • 36
    • 28844433017 scopus 로고    scopus 로고
    • Negative impact of noise on the principal component analysis of NMR data
    • Halouska S, Powers R: Negative impact of noise on the principal component analysis of NMR data. J. Magn. Reson. 178(1) 88-95 (2006).
    • (2006) J. Magn. Reson , vol.178 , Issue.1 , pp. 88-95
    • Halouska, S.1    Powers, R.2
  • 37
    • 0142102568 scopus 로고    scopus 로고
    • Improved analysis of multivariate data by variable stability scaling application to NMR-based metabolic profiling
    • Keun HC, Ebbels TMD, Antti H et al.: Improved analysis of multivariate data by variable stability scaling application to NMR-based metabolic profiling. Anal. Chim. Acta 490(1-2) 265-276 (2003).
    • (2003) Anal. Chim. Acta , vol.490 , Issue.1-2 , pp. 265-276
    • Keun, H.C.1    Ebbels, T.M.D.2    Antti, H.3
  • 39
    • 30744443014 scopus 로고    scopus 로고
    • Stistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets application in metabonomic toxicology studies
    • Crockford DJ, Holmes E, Lindon JC et al.: Stistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets application in metabonomic toxicology studies. Anal. Chem. 78(2), 363-371 (2006).
    • (2006) Anal. Chem , vol.78 , Issue.2 , pp. 363-371
    • Crockford, D.J.1    Holmes, E.2    Lindon, J.C.3
  • 40
    • 33846064843 scopus 로고    scopus 로고
    • Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism
    • Pan Z, Gu H, Talaty N et al.: Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism. Anal. Bioanal. Chem. 387, 539-549 (2007).
    • (2007) Anal. Bioanal. Chem , vol.387 , pp. 539-549
    • Pan, Z.1    Gu, H.2    Talaty, N.3
  • 41
    • 33750093232 scopus 로고    scopus 로고
    • Statistically integrated metabonomio-proteomic studies on a human prostate cancer xenograft model in mice
    • Rantalainen M, Cloarec O, Beckonert O et al.: Statistically integrated metabonomio-proteomic studies on a human prostate cancer xenograft model in mice. J. Proteome Res. 5(10), 2642-2655 (2006).
    • (2006) J. Proteome Res , vol.5 , Issue.10 , pp. 2642-2655
    • Rantalainen, M.1    Cloarec, O.2    Beckonert, O.3
  • 42
    • 0037381260 scopus 로고    scopus 로고
    • Correlation of Ki-67 ad gelsolin expression to clinical outcome in renal clear cell carcinoma
    • Visapaa H, Bui M, Huang Y et al.: Correlation of Ki-67 ad gelsolin expression to clinical outcome in renal clear cell carcinoma. Urology 61(4), 845-850 (2003).
    • (2003) Urology , vol.61 , Issue.4 , pp. 845-850
    • Visapaa, H.1    Bui, M.2    Huang, Y.3
  • 43
    • 0034892806 scopus 로고    scopus 로고
    • Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancers
    • Thor AD, Edgerton SM, Liu S, Moore DH, Kwiatkowski DJ: Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancers Clin. Cancer Res. 7(8), 2415-2424 (2001).
    • (2001) Clin. Cancer Res , vol.7 , Issue.8 , pp. 2415-2424
    • Thor, A.D.1    Edgerton, S.M.2    Liu, S.3    Moore, D.H.4    Kwiatkowski, D.J.5
  • 44
    • 0032893518 scopus 로고    scopus 로고
    • Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma the role of gelsolin expression
    • Shieh DB, Godleski J, Hemdon JE et al.: Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma the role of gelsolin expression. Cancer 85(1) 47-67 (1999).
    • (1999) Cancer , vol.85 , Issue.1 , pp. 47-67
    • Shieh, D.B.1    Godleski, J.2    Hemdon, J.E.3
  • 45
    • 4444285866 scopus 로고    scopus 로고
    • Prognostic significance of gelsolin expression level and variability in non-small cell lung cancer
    • Yang J, Tan D, Asch HL et al.: Prognostic significance of gelsolin expression level and variability in non-small cell lung cancer. Lung Cancer 46(1), 29-42 (2004).
    • (2004) Lung Cancer , vol.46 , Issue.1 , pp. 29-42
    • Yang, J.1    Tan, D.2    Asch, H.L.3
  • 46
    • 33745823913 scopus 로고    scopus 로고
    • Systems toxicology: Intagrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat
    • Craig A, Sidaway J, Holmes E et al.: Systems toxicology: intagrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J. Proteome Res. 5(7), 1586-1601 (2006).
    • (2006) J. Proteome Res , vol.5 , Issue.7 , pp. 1586-1601
    • Craig, A.1    Sidaway, J.2    Holmes, E.3
  • 47
    • 0033016717 scopus 로고    scopus 로고
    • Correlation between protein and mRNA abundance in yeast
    • Gygi SP, Rochon Y, Franza BR, Aebersold R: Correlation between protein and mRNA abundance in yeast. Mol. Cell. Biol. 19(3), 1720-1730 (1999).
    • (1999) Mol. Cell. Biol , vol.19 , Issue.3 , pp. 1720-1730
    • Gygi, S.P.1    Rochon, Y.2    Franza, B.R.3    Aebersold, R.4
  • 50
    • 24944444149 scopus 로고    scopus 로고
    • Summary recommendations for standardization and reporting of metabolic analyses
    • Lindon C, Nicholson JK, Holmes E et al.: Summary recommendations for standardization and reporting of metabolic analyses. Nat. Biotechnol. 23(10), 833-838 (2005).
    • (2005) Nat. Biotechnol , vol.23 , Issue.10 , pp. 833-838
    • Lindon, C.1    Nicholson, J.K.2    Holmes, E.3


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