-
1
-
-
0032694577
-
Metabonomics': Understanding the metabolic reponses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
-
Nicholson JK, Lindon JC, Holmes E: 'Metabonomics': understanding the metabolic reponses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29(11), 1181-1189 (1999).
-
(1999)
Xenobiotica
, vol.29
, Issue.11
, pp. 1181-1189
-
-
Nicholson, J.K.1
Lindon, J.C.2
Holmes, E.3
-
2
-
-
0036007687
-
Metabolomics - the link between genotypes and phenotypes
-
Fiehn O: Metabolomics - the link between genotypes and phenotypes. Plant Mol. Bid. 48, 155-171 (2002).
-
(2002)
Plant Mol. Bid
, vol.48
, pp. 155-171
-
-
Fiehn, O.1
-
3
-
-
0035160371
-
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
-
Raamsdonk LM, Teusink B, Broadhurst D et al.: A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat. Biotech. 19(1), 45-50 (2001).
-
(2001)
Nat. Biotech
, vol.19
, Issue.1
, pp. 45-50
-
-
Raamsdonk, L.M.1
Teusink, B.2
Broadhurst, D.3
-
4
-
-
0035369191
-
1H nuclear magnetic resonance spectroscopic and pattern recognition study into dystrophic tissue
-
1H nuclear magnetic resonance spectroscopic and pattern recognition study into dystrophic tissue. Anal. Biochem. 293(1), 16-21 (2001).
-
(2001)
Anal. Biochem
, vol.293
, Issue.1
, pp. 16-21
-
-
Griffin, J.L.1
Willisms, H.J.2
Sang, E.3
Clarke, K.4
Rae, C.5
Nicholson, J.K.6
-
5
-
-
20544466649
-
Matabonomics in toxicology: A review
-
2DO5
-
Robertson DG: Matabonomics in toxicology: a review. Toxicol. Sci. 85(2), 809-822 (2DO5).
-
Toxicol. Sci
, vol.85
, Issue.2
, pp. 809-822
-
-
Robertson, D.G.1
-
6
-
-
28444480986
-
Metabonomic modeling of drug toxicity
-
Keun HC: Metabonomic modeling of drug toxicity. Pharmacol. Ther. 109(1-2), 92-106 (2006).
-
(2006)
Pharmacol. Ther
, vol.109
, Issue.1-2
, pp. 92-106
-
-
Keun, H.C.1
-
7
-
-
0036913503
-
-
1H-NMR-based metabonomics, Nat. Med. 8(12), 1439-1444(20O3).
-
1H-NMR-based metabonomics, Nat. Med. 8(12), 1439-1444(20O3).
-
-
-
-
8
-
-
33747185356
-
NMR metabolic profiling of Aspergillusnidulans to monitor drug and protein activity
-
Forgue P, Halouska S, Werth M, Xu K, Harris S, Powers R: NMR metabolic profiling of Aspergillusnidulans to monitor drug and protein activity. J. Proteome Res 5(8), 1916-1923 (2006).
-
(2006)
J. Proteome Res
, vol.5
, Issue.8
, pp. 1916-1923
-
-
Forgue, P.1
Halouska, S.2
Werth, M.3
Xu, K.4
Harris, S.5
Powers, R.6
-
9
-
-
33750383279
-
Choline phospholipid metabolism in cancer: Consequences for molecular pharmaceutical interventions Mol
-
Glunde K, Ackerstaff E, Mori N et al.: Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions Mol. Pharmaceutics 3(5), 496-506 (2006).
-
(2006)
Pharmaceutics
, vol.3
, Issue.5
, pp. 496-506
-
-
Glunde, K.1
Ackerstaff, E.2
Mori, N.3
-
10
-
-
33750435528
-
Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism
-
Glunde K, Serkova NJ: Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism. Pharmacogenomics 7(7), 1109-1123 (2006).
-
(2006)
Pharmacogenomics
, vol.7
, Issue.7
, pp. 1109-1123
-
-
Glunde, K.1
Serkova, N.J.2
-
11
-
-
33847370301
-
Tumour metabolomics in animal models of human cancer
-
Griffin JL, Kauppinen RA: Tumour metabolomics in animal models of human cancer. J. Proteome Res 6(2), 498-505 (2007).
-
(2007)
J. Proteome Res
, vol.6
, Issue.2
, pp. 498-505
-
-
Griffin, J.L.1
Kauppinen, R.A.2
-
12
-
-
0036847446
-
31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin
-
31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin. Magn. Reson. Med. 48(5) 819-825 (2002).
-
(2002)
Magn. Reson. Med
, vol.48
, Issue.5
, pp. 819-825
-
-
Glunde, K.1
Ackerstaff, E.2
Natarajan, K.3
Artemov, D.4
Bhujwall, Z.M.5
-
13
-
-
0033010321
-
31P-NMR study using a phosphonium analog of choline
-
31P-NMR study using a phosphonium analog of choline. Cancer Lett. 140(1-2), 189-194 (1999).
-
(1999)
Cancer Lett
, vol.140
, Issue.1-2
, pp. 189-194
-
-
Adebodun, F.1
-
14
-
-
31544473808
-
Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models
-
Al-Saffar NMS, Troy H, Ramírez de Molina A et al.: Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models Cancer Res 66(1), 427-434 (2006).
-
(2006)
Cancer Res
, vol.66
, Issue.1
, pp. 427-434
-
-
Al-Saffar, N.M.S.1
Troy, H.2
Ramírez de Molina, A.3
-
15
-
-
0000981799
-
Detection of in vivo biomarkers of phosspholipidosis using NMR-based metabonomic approacheas
-
Espina JR, Shockcor JP, Herron WJ et al.: Detection of in vivo biomarkers of phosspholipidosis using NMR-based metabonomic approacheas Magn. Reson. Chem. 39(9), 559-565 (2001).
-
(2001)
Magn. Reson. Chem
, vol.39
, Issue.9
, pp. 559-565
-
-
Espina, J.R.1
Shockcor, J.P.2
Herron, W.J.3
-
16
-
-
0035029632
-
1H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue
-
1H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue. Magn. Reson. Med. 45(5), 781-790 (2001).
-
(2001)
Magn. Reson. Med
, vol.45
, Issue.5
, pp. 781-790
-
-
Garrod, S.1
Humpher, E.2
Connor, S.C.3
-
17
-
-
0027052705
-
Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions the rat induced by mercury(II) chloride and 2-bromosthanamine
-
Holmes E, Bonner FW, Sweetmen BC et al.: Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions the rat induced by mercury(II) chloride and 2-bromosthanamine Mol. Pharmacol. 42(5), 922-930 (1992).
-
(1992)
Mol. Pharmacol
, vol.42
, Issue.5
, pp. 922-930
-
-
Holmes, E.1
Bonner, F.W.2
Sweetmen, B.C.3
-
18
-
-
0031949067
-
Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins
-
Beckwith-Hall BM, Nicholson JK, Nicholls AW et al.: Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chem. Res. Toxicol. 11(4), 260-272 (1998).
-
(1998)
Chem. Res. Toxicol
, vol.11
, Issue.4
, pp. 260-272
-
-
Beckwith-Hall, B.M.1
Nicholson, J.K.2
Nicholls, A.W.3
-
19
-
-
26944489574
-
The Consortium for Metabonomic Toxicology (COMET): Aims, activities and achievements
-
Lindon JC, Keun HC, Ebbels TMD et al.: The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements. Pharmacogenomics 6(7), 691-699 (2005).
-
(2005)
Pharmacogenomics
, vol.6
, Issue.7
, pp. 691-699
-
-
Lindon, J.C.1
Keun, H.C.2
Ebbels, T.M.D.3
-
20
-
-
27744542580
-
Trying to catch troublemakers with a metabolic profile
-
Sinha G:Trying to catch troublemakers with a metabolic profile. Science 310(5750), 965-966 (2005).
-
(2005)
Science
, vol.310
, Issue.5750
, pp. 965-966
-
-
Sinha, G.1
-
21
-
-
33749012286
-
Application of metabonomics a compound ranking study in early drug development revealing drug-induced excretion of choline into urine
-
Dieterle F, Schlotterbeck G, Ross A, Niederhauser U, Sann H: Application of metabonomics a compound ranking study in early drug development revealing drug-induced excretion of choline into urine. Chem. Res Toxicol. 19(9), 1175-1181 (2006).
-
(2006)
Chem. Res Toxicol
, vol.19
, Issue.9
, pp. 1175-1181
-
-
Dieterle, F.1
Schlotterbeck, G.2
Ross, A.3
Niederhauser, U.4
Sann, H.5
-
22
-
-
33745209659
-
Differential metabolonomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption
-
Soga T, Baran R, Suematsu M et al.: Differential metabolonomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J. Biol. Chem. 281(24), 16768-16776 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, Issue.24
, pp. 16768-16776
-
-
Soga, T.1
Baran, R.2
Suematsu, M.3
-
23
-
-
33646198860
-
Pharmaco-metabonomic phenotyping and personalized drug treatment
-
Clayton TA, Lindon JC, Cloarec O et al.: Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 440(7087), 1073-1077 (2006).
-
(2006)
Nature
, vol.440
, Issue.7087
, pp. 1073-1077
-
-
Clayton, T.A.1
Lindon, J.C.2
Cloarec, O.3
-
24
-
-
33748354488
-
Metabolic profiling of CSF: Evidence that early intervention may impact on disease progression and outcome schizophrenia
-
Holmes E, Tsang TM, Huang JT et al.: Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome schizophrenia PLoS Med. 3(8), 1420-1428 (2006).
-
(2006)
PLoS Med
, vol.3
, Issue.8
, pp. 1420-1428
-
-
Holmes, E.1
Tsang, T.M.2
Huang, J.T.3
-
25
-
-
33747618036
-
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
-
Dumas ME, Barton RH, Toye A et al.: Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc. Natl Acad. Sci. USA 103(33), 12511-12516 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, Issue.33
, pp. 12511-12516
-
-
Dumas, M.E.1
Barton, R.H.2
Toye, A.3
-
26
-
-
33750213694
-
Susceptibility of human metabolic phenotypes to dietary modulation
-
Stella C, Beckwith-Hall B, Cloarec O et al.: Susceptibility of human metabolic phenotypes to dietary modulation. J Proteome Res 5(10), 2780-2788 (2006).
-
(2006)
J Proteome Res
, vol.5
, Issue.10
, pp. 2780-2788
-
-
Stella, C.1
Beckwith-Hall, B.2
Cloarec, O.3
-
27
-
-
24044546760
-
Metabonomic identification of two distinct phenotypes in in Sprague-Dawley (Crl:CD(SD)) rats
-
Robosky LC, Wells DF Egnash LA et al.: Metabonomic identification of two distinct phenotypes in in Sprague-Dawley (Crl:CD(SD)) rats. Toxicol. Sci. 87(1), 277-284 (2005).
-
(2005)
Toxicol. Sci
, vol.87
, Issue.1
, pp. 277-284
-
-
Robosky, L.C.1
Wells, D.F.2
Egnash, L.A.3
-
28
-
-
0043069547
-
Understanding 'global' systembiology: Metabonomics and the continuum of metabolism
-
Nicholson JK, Wilson ID: Understanding 'global' systembiology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2(8), 668-676 (2003).
-
(2003)
Nat. Rev. Drug Discov
, vol.2
, Issue.8
, pp. 668-676
-
-
Nicholson, J.K.1
Wilson, I.D.2
-
29
-
-
21144435518
-
A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: Application to age, gander and diurnal variation in normal/Zucker obese rats and black, white and nude mice
-
Plumb RS, Granger JH, Stumpf CL et al.: A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gander and diurnal variation in normal/Zucker obese rats and black, white and nude mice. Analyst 130(6), 884-849 (2005).
-
(2005)
Analyst
, vol.130
, Issue.6
, pp. 884-849
-
-
Plumb, R.S.1
Granger, J.H.2
Stumpf, C.L.3
-
30
-
-
33646244255
-
Urine profiling using capillary electrophoresis-mass spectrometry and multivariate data analysis
-
Ullsten S, Danielsson R, Bäckström D, Sjöberg P, Bergquist J. Urine profiling using capillary electrophoresis-mass spectrometry and multivariate data analysis. J. Chromatogr. A 1117(1), 87-93 (2006).
-
(2006)
J. Chromatogr. A
, vol.1117
, Issue.1
, pp. 87-93
-
-
Ullsten, S.1
Danielsson, R.2
Bäckström, D.3
Sjöberg, P.4
Bergquist, J.5
-
31
-
-
10944242220
-
Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients a pilot study for achieving their normalization
-
Casado B, Zanone C, Annovazzi L, Iadarola P, Whalen G, Baraniuk JN: Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients a pilot study for achieving their normalization. J. Chromatogr. B Analyst Technol. Biomed. Life Sci. 814(1), 43-51 (2005).
-
(2005)
J. Chromatogr. B Analyst Technol. Biomed. Life Sci
, vol.814
, Issue.1
, pp. 43-51
-
-
Casado, B.1
Zanone, C.2
Annovazzi, L.3
Iadarola, P.4
Whalen, G.5
Baraniuk, J.N.6
-
32
-
-
33845742504
-
Increasing conclusiveness of metabonomic studies by cheminformatic preprocessing of capillary electrophoretic data on urinary nucleoside profiles
-
Szymañska E, Markuszewski MJ, Capron X et al.: Increasing conclusiveness of metabonomic studies by cheminformatic preprocessing of capillary electrophoretic data on urinary nucleoside profiles. J. Pharm. Biomed. Anal. 43(2), 413-420 (2007).
-
(2007)
J. Pharm. Biomed. Anal
, vol.43
, Issue.2
, pp. 413-420
-
-
Szymañska, E.1
Markuszewski, M.J.2
Capron, X.3
-
33
-
-
33746449986
-
Metabolic fingerprinting in disease diagnosis biomedical applications of infrared and Raman spectroscopy
-
Ellis DI, Goodacre R: Metabolic fingerprinting in disease diagnosis biomedical applications of infrared and Raman spectroscopy. Analyst 131, 875-885 (2006).
-
(2006)
Analyst
, vol.131
, pp. 875-885
-
-
Ellis, D.I.1
Goodacre, R.2
-
35
-
-
33645663178
-
Scaling and normalization effects in NMR spectroscopic metabonomic data sets
-
Craig A, Cloarec O, Holmes E, Nicholson JK, Lindon JC: Scaling and normalization effects in NMR spectroscopic metabonomic data sets Anal. Chem. 78(7) 2262-2267 (2006).
-
(2006)
Anal. Chem
, vol.78
, Issue.7
, pp. 2262-2267
-
-
Craig, A.1
Cloarec, O.2
Holmes, E.3
Nicholson, J.K.4
Lindon, J.C.5
-
36
-
-
28844433017
-
Negative impact of noise on the principal component analysis of NMR data
-
Halouska S, Powers R: Negative impact of noise on the principal component analysis of NMR data. J. Magn. Reson. 178(1) 88-95 (2006).
-
(2006)
J. Magn. Reson
, vol.178
, Issue.1
, pp. 88-95
-
-
Halouska, S.1
Powers, R.2
-
37
-
-
0142102568
-
Improved analysis of multivariate data by variable stability scaling application to NMR-based metabolic profiling
-
Keun HC, Ebbels TMD, Antti H et al.: Improved analysis of multivariate data by variable stability scaling application to NMR-based metabolic profiling. Anal. Chim. Acta 490(1-2) 265-276 (2003).
-
(2003)
Anal. Chim. Acta
, vol.490
, Issue.1-2
, pp. 265-276
-
-
Keun, H.C.1
Ebbels, T.M.D.2
Antti, H.3
-
39
-
-
30744443014
-
Stistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets application in metabonomic toxicology studies
-
Crockford DJ, Holmes E, Lindon JC et al.: Stistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets application in metabonomic toxicology studies. Anal. Chem. 78(2), 363-371 (2006).
-
(2006)
Anal. Chem
, vol.78
, Issue.2
, pp. 363-371
-
-
Crockford, D.J.1
Holmes, E.2
Lindon, J.C.3
-
40
-
-
33846064843
-
Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism
-
Pan Z, Gu H, Talaty N et al.: Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism. Anal. Bioanal. Chem. 387, 539-549 (2007).
-
(2007)
Anal. Bioanal. Chem
, vol.387
, pp. 539-549
-
-
Pan, Z.1
Gu, H.2
Talaty, N.3
-
41
-
-
33750093232
-
Statistically integrated metabonomio-proteomic studies on a human prostate cancer xenograft model in mice
-
Rantalainen M, Cloarec O, Beckonert O et al.: Statistically integrated metabonomio-proteomic studies on a human prostate cancer xenograft model in mice. J. Proteome Res. 5(10), 2642-2655 (2006).
-
(2006)
J. Proteome Res
, vol.5
, Issue.10
, pp. 2642-2655
-
-
Rantalainen, M.1
Cloarec, O.2
Beckonert, O.3
-
42
-
-
0037381260
-
Correlation of Ki-67 ad gelsolin expression to clinical outcome in renal clear cell carcinoma
-
Visapaa H, Bui M, Huang Y et al.: Correlation of Ki-67 ad gelsolin expression to clinical outcome in renal clear cell carcinoma. Urology 61(4), 845-850 (2003).
-
(2003)
Urology
, vol.61
, Issue.4
, pp. 845-850
-
-
Visapaa, H.1
Bui, M.2
Huang, Y.3
-
43
-
-
0034892806
-
Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancers
-
Thor AD, Edgerton SM, Liu S, Moore DH, Kwiatkowski DJ: Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancers Clin. Cancer Res. 7(8), 2415-2424 (2001).
-
(2001)
Clin. Cancer Res
, vol.7
, Issue.8
, pp. 2415-2424
-
-
Thor, A.D.1
Edgerton, S.M.2
Liu, S.3
Moore, D.H.4
Kwiatkowski, D.J.5
-
44
-
-
0032893518
-
Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma the role of gelsolin expression
-
Shieh DB, Godleski J, Hemdon JE et al.: Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma the role of gelsolin expression. Cancer 85(1) 47-67 (1999).
-
(1999)
Cancer
, vol.85
, Issue.1
, pp. 47-67
-
-
Shieh, D.B.1
Godleski, J.2
Hemdon, J.E.3
-
45
-
-
4444285866
-
Prognostic significance of gelsolin expression level and variability in non-small cell lung cancer
-
Yang J, Tan D, Asch HL et al.: Prognostic significance of gelsolin expression level and variability in non-small cell lung cancer. Lung Cancer 46(1), 29-42 (2004).
-
(2004)
Lung Cancer
, vol.46
, Issue.1
, pp. 29-42
-
-
Yang, J.1
Tan, D.2
Asch, H.L.3
-
46
-
-
33745823913
-
Systems toxicology: Intagrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat
-
Craig A, Sidaway J, Holmes E et al.: Systems toxicology: intagrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J. Proteome Res. 5(7), 1586-1601 (2006).
-
(2006)
J. Proteome Res
, vol.5
, Issue.7
, pp. 1586-1601
-
-
Craig, A.1
Sidaway, J.2
Holmes, E.3
-
47
-
-
0033016717
-
Correlation between protein and mRNA abundance in yeast
-
Gygi SP, Rochon Y, Franza BR, Aebersold R: Correlation between protein and mRNA abundance in yeast. Mol. Cell. Biol. 19(3), 1720-1730 (1999).
-
(1999)
Mol. Cell. Biol
, vol.19
, Issue.3
, pp. 1720-1730
-
-
Gygi, S.P.1
Rochon, Y.2
Franza, B.R.3
Aebersold, R.4
-
50
-
-
24944444149
-
Summary recommendations for standardization and reporting of metabolic analyses
-
Lindon C, Nicholson JK, Holmes E et al.: Summary recommendations for standardization and reporting of metabolic analyses. Nat. Biotechnol. 23(10), 833-838 (2005).
-
(2005)
Nat. Biotechnol
, vol.23
, Issue.10
, pp. 833-838
-
-
Lindon, C.1
Nicholson, J.K.2
Holmes, E.3
|