A metabonomic characterization of CCl4-induced acute liver failure using partial least square regression based on the GC/MS metabolic profiles of plasma in mice

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 870, Issue 2, 2008, Pages 178-185

  Huang, Xin ^a   Shao, Li ^a   Gong, Yifei ^a   Mao, Yong ^a   Liu, Changxiao ^b   Qu, Haibin ^a   Cheng, Yiyu ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Acute liver failure; Carbon tetrachloride; GC MS; Metabonomics; PLS RA; Reactive oxygen species

Indexed keywords

AMINO ACIDS; CARBON TETRACHLORIDE; CHLORINE COMPOUNDS; GAS CHROMATOGRAPHY; MAMMALS; METABOLISM; METABOLITES; OLEIC ACID; PHOSPHOLIPIDS; REGRESSION ANALYSIS; SATURATED FATTY ACIDS;

ACUTE LIVER FAILURE; CHEMICAL DERIVATIZATION; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; GC/MS; METABONOMICS; PARTIAL LEAST SQUARE REGRESSION; PARTIAL LEAST SQUARE REGRESSION ANALYSIS; REACTIVE OXYGEN SPECIES;

PALMITIC ACID;

CARBON TETRACHLORIDE; CITRIC ACID; DOCOSAHEXAENOIC ACID; GLUTAMIC ACID; GLYCEROPHOSPHATE; OLEIC ACID; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; SERINE; THREONINE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMICS; CONTROLLED STUDY; DERIVATIZATION; GAS CHROMATOGRAPHY; INTOXICATION; LIVER FAILURE; LIVER TOXICITY; MALE; MASS SPECTROMETRY; METABOLIC REGULATION; METABOLITE; METABONOMICS; MOUSE; NONHUMAN; PARTIAL LEAST SQUARES REGRESSION; PRIORITY JOURNAL; STATISTICAL MODEL; ACUTE LIVER FAILURE; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; MASS FRAGMENTOGRAPHY; METABOLISM; METHODOLOGY; PATHOLOGY; PRINCIPAL COMPONENT ANALYSIS; REGRESSION ANALYSIS;

MUS;

ANIMALS; CARBON TETRACHLORIDE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LEAST-SQUARES ANALYSIS; LIVER FAILURE, ACUTE; MALE; MICE; PRINCIPAL COMPONENT ANALYSIS; REACTIVE OXYGEN SPECIES;

EID: 47349119387     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.05.049     Document Type: Article

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