Metabolomics study with gas chromatography-mass spectrometry for predicting valproic acid-induced hepatotoxicity and discovery of novel biomarkers in rat urine

International Journal of Toxicology

Volumn 28, Issue 5, 2009, Pages 392-404

  Lee, Min Sun ^a   Jung, Byung Hwa ^a   Chung, Bong Chul ^a   Cho, Sung Hee ^a   Kim, Ki Young ^a,b   Kwon, Oh Seoung ^a   Nugraha, Boya ^a   Lee, Young Joo ^b  

^a Korea Institute of Science and Technology   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

Gas chromatography mass spectrometry; Hepatotoxicity; Metabolic profiling; Metabolomics; Valproic acid

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; CARNITINE DERIVATIVE; GLUTATHIONE TRANSFERASE ALPHA; OCTANOYLCARNITINE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG DOSE COMPARISON; ENZYME BLOOD LEVEL; FEASIBILITY STUDY; LIVER TOXICITY; MALE; MASS FRAGMENTOGRAPHY; METABOLOMICS; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; URINE; URINE VOLUME; VALIDATION PROCESS;

ADMINISTRATION, ORAL; ANIMALS; ANTICONVULSANTS; BIOLOGICAL MARKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE TRANSFERASE; LEAST-SQUARES ANALYSIS; MALE; METABOLOMICS; MOLECULAR STRUCTURE; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; RATS; RATS, SPRAGUE-DAWLEY; VALPROIC ACID;

RATTUS;

EID: 73149108642     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581809340329     Document Type: Article

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