Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: Involvement of cytochrome P450 CYP2E1

Phytomedicine

Volumn 16, Issue 8, 2009, Pages 751-760

  Hau, Desmond Kwok Po ^a   Gambari, Roberto ^b   Wong, Raymond Siu Ming ^c   Yuen, Marcus Chun Wah ^d   Cheng, Gregory Yin Ming ^c   Tong, Cindy Sze Wai ^c   Zhu, Guo Yuan ^a   Leung, Alexander Kai Man ^a   Lai, Paul Bo San ^c   Lau, Fung Yi ^c   Chan, Andrew Kit Wah ^c   Wong, Wai Yeung ^a   Kok, Stanton Hon Lung ^d   Cheng, Chor Hing ^d   Kan, Chi Wai ^d   Chan, Albert Sun Chi ^d   Chui, Chung Hin ^c   Tang, Johnny Cheuk On ^d   Fong, David Wang Fun ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b UNIVERSITY OF FERRARA   (Italy)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Acetaminophen; Cytochrome 450 CYP2E1; Hepatoprotection; Hepatotoxicity; Phyllanthus urinaria

Indexed keywords

ARSENIC; CADMIUM; CORILAGIN; CYTOCHROME P450 2E1; ENZYME ANTIBODY; GALLIC ACID; HERBICIDE; LEAD; MERCURY; PARACETAMOL; PHYLLANTHUS URINARIA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LETHAL DOSE; LIVER; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MOUSE; NONHUMAN; PHYLLANTHUS; PHYLLANTHUS URINARIA; PRIORITY JOURNAL; TOXICITY TESTING;

ACETAMINOPHEN; ANIMALS; CYTOCHROME P-450 CYP2E1; GALLIC ACID; GLUCOSIDES; HEPATITIS, TOXIC; HEPATOCYTES; LIVER; METALS, HEAVY; MICE; MICE, INBRED C57BL; NECROSIS; PHYLLANTHUS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL;

MUS; PHYLLANTHUS URINARIA;

EID: 67349162779     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.01.008     Document Type: Article

References (24)

1. Asha V.V., Akhila S., Wills P.J., and Subramoniam A. Further studies on the antihepatotoxicity activity of Phyllanthus maderaspatensis. Linn. J. Ethnopharmacol. 92 (2004) 67-70
2. Bhattacharjee R., and Sil P.C. The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytother. Res. 20 (2006) 595-601
3. Bianchi, N., Zuccato, C., Lampronti, I., Borgatti, M., Gambari, R., 2008. Fetal hemoglobin inducers from the natural world: a novel approach for identification of drugs for the treatment of β-thalassemia and sickle cell anemia. Evidence-based Complementary Alternative Med., eCAM 2007, in press, doi:10.1093/ecam/nem139.
4. Bonkovsky H.L., Kane R.E., Jones D.P., Galinsky R.E., and Banner B. Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency. Hepatology 19 (1994) 1141-1148
5. Chui C.H., Lau F.Y., Chan A.S.C., Cheng G.Y.M., Wong R.S.M., Lai K.B., Kok S.H.L., Yeung T.T.L., Teo I.T.N., Yau M.Y.C., Cheung F., Cheng C.H., and Tang J.C.O. Gleditsia sinensis fruit extract-induced apoptosis involves changes of reactive oxygen species level, mitochondrial membrane depolarization and caspase 3 activation. Int. J. Mol. Med. 15 (2005) 539-543
6. Curry Jr. R.W., Robinson J.D., and Sughrue M.J. Acute renal failure after acetaminophen ingestion. J. Am. Med. Assoc. 247 (1982) 1012-1014
7. Dahlin D.C., Miwa G.T., Lu A.Y., and Nelson S.D. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc. Natl. Acad. Sci. USA 81 (1984) 1327-1331
8. Huang S.T., Yang R.C., Yang L.J., Lee P.N., and Pang J.H.S. Phyllanthus urinaria triggers the apoptosis and Bcl-2 down-regulation in Lewis lung carcinoma cells. Life Sci. 72 (2003) 1705-1716
9. Huang S.T., Yang R.C., and Pang J.H.S. Aqueous extract of Phyllanthus urinaria induces apoptosis in human cancer cells. Am. J. Chin. Med. 32 (2004) 175-183
10. Huang S.T., Yang R.C., Chan M.Y., and Pang J.HS. Phyllanthus urinaria induces the Fas receptor/ligand expression and cermide-medicated apoptosis in HL-60 cells. Life Sci. 75 (2004) 339-351
11. Huang S.T., Yang R.C., Lee P.N., Yang S.H., Liao S.K., Chan T.Y., and Pang J.H.S. Anti-tumor and anti-angiogenic effects of Phyllanthus urinaria mice bearing Lewis lung carcinoma. Int. Immunopharmacol. 6 (2006) 870-879
12. Keaton M.R. Acute renal failure in an alcoholic during therapeutic acetaminophen ingestion. South. Med. J. 81 (1988) 1163-1166
13. Khan M.T., Ather A., Thompson K.D., and Gambari R. Extracts and molecules from medicinal plants against herpes simplex viruses. Antiviral. Res. 67 (2005) 107-119
14. Kiemer A.K., Hartung T., Huber C., and Vollmar A.M. Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-κB pathway. J. Hepatol. 38 (2003) 289-297
15. Krajka-Kuzniak V., and Baer-Dubowska W. The effects of tannic acid on cytochrome P450 and phase II enzymes in mouse liver and kidney. Toxicol. Lett. 143 (2003) 209-216
16. Lampronti I., Martello D., Bianchi N., Borgatti M., Lambertini E., Piva R., Jabbar S., Choudhuri M.S., Khan M.T., and Gambari R. In vitro antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Aegle marmelos Correa. Phytomedicine 10 (2003) 300-308
17. Lee C.Y., Peng W.H., Cheng H.Y., Chen F.N., Lai M.T., and Chiu T.H. Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride. Am. J. Chin. Med. 34 (2006) 471-482
18. Mitchell J.R., Jollow D.J., Potter W.Z., Gillette J.R., and Brodie B.B. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J. Pharmacol. Exp. Ther. 187 (1973) 211-217
19. Park J.C., Han W.D., Park J.R., Choi S.H., and Choi J.W. Changes in hepatic drug metabolizing enzymes and lipid peroxidation by methanol extract and major compound of Orostachys japonicus. J. Ethnopharmacol. 102 (2005) 313-318
20. Simpson K., Hogaboam C.M., Kunkel S.L., Harrison D.J., Bone-Larson C., and Lukacs N.W. Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury. Lab. Invest. 83 (2003) 199-206
21. Tang W.K., Chui C.H., Fatima S., Kok S.H.L., Pak K.C., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S., Tsao S.W., Lam K.Y., Beh P.S., Srivastava G., Ho K.P., Chan A.S., and Tang J.C.O. Inhibitory effects of Gleditsia sinensis fruit extract on telomerase activity and oncogenic expression in human esophageal squamous cell carcinoma. Int. J. Mol. Med. 19 (2007) 953-960
22. Vermeulen N.P., Bessems J.G., and Van-de-Straat R. Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention. Drug Metab. Rev. 24 (1992) 367-407
23. Whitcomb D.C. Acetaminophen poisoning and liver function. N. Engl. J. Med. 331 (1994) 1311-1312
24. Yang Y.S., Ahn T.H., Leem J.C., Moon C.J., Kim S.H., Jun W., Park S.S., Kim H.C., and Kim J.C. Protective effects of Pycnogenol on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats. Food. Chem. Toxicol. 46 (2008) 380-387