Light and electron microscopic analysis of liver biopsy samples from rheumatoid arthritis patients receiving long-term methotrexate therapy

Scandinavian Journal of Rheumatology

Volumn 31, Issue 6, 2002, Pages 330-336

  Ros, Sergio ^a   Juanola, X ^a   Condom, E ^b   Canas C ^c   Riera, J ^d   Guardiola, J ^e   Del Blanco, J ^f   Rebasa, P ^g   Valverde, J ^a   Roig Escofet, D ^a  

^a Rheumatology ^*  (Spain)

^b Cell Biology Services   (Spain)

^c Radiodiagnosis Service   (Spain)

^d HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^e G U Hospital Comarcal Baix Penedes   (Spain)

^f Rheum U Hosp Sant Jaume Calella   (Spain)

^g Gen Surg Serv Hosp Sant Celoni   (Spain)

Author keywords

Hepatotoxicity; Methotrexate; Rheumatoid arthritis

Indexed keywords

ALBUMIN; ANTIMALARIAL AGENT; FOLINIC ACID; GAMMA GLUTAMYLTRANSFERASE; GOLD; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PENICILLAMINE; SALAZOSULFAPYRIDINE;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; BIOCHEMISTRY; CLINICAL ARTICLE; COLLAGEN METABOLISM; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DOSE RESPONSE; DOSE TIME EFFECT RELATION; EDEMA; ELECTRON MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; JOINT INJURY; LIVER BIOPSY; LIVER FIBROSIS; LIVER INJURY; LIVER SINUSOID; LONG TERM EXPOSURE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RISK FACTOR;

ADULT; AGED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; BIOPSY; FEMALE; HUMANS; LIVER; LIVER DISEASES; MALE; METHOTREXATE; MICROSCOPY, ELECTRON; MIDDLE AGED; REFERENCE VALUES;

EID: 18744398391     PISSN: 03009742     EISSN: None     Source Type: Journal    
DOI: 10.1080/030097402320817040     Document Type: Article

References (32)

1. Spooner RJ, Smith DH, Bedford D, Beck PR. Serum gamma-glutamyltransferase and alkaline phosphatase in rheumatoid arthritis. J Clin Pathol 1982;35: 638-41.
2. Martin A, Lore P, Chales G, Meadeb J, Frocrain L, Pawlotsky Y. Foie et polyarthrite rhumatoide. Rev Rhum Mal Osteoartic 1987;54: 589-94.
3. Laffon A, Moreno A, Gutierrez-Bucero A, Ossorio C, Sabando P, Moreno-Otero R. Hepatic sinusoidal dilatation in rheumatoid arthritis. J Clin Gastroenterol 1989;11: 653-7.
4. Dietrichson O, From A, Christofferson P, Juhl E. Morphological changes in liver biopsies from patients with rheumatoid arthritis. Scand J Rheumatol 1976;5: 65-9.
5. Ruderman EM, Crawford JM, Maier A, Liu JJ, Gravallese EM, Weinblatt ME. Histologic liver abnormalities in an autopsy series of patients with rheumatoid arthritis. Br J Rheumatol 1997;36: 210-3.
6. Mills PR, Mc Sween RNM, Dick WC, More IA, Watkinson G. Liver disease in rheumatoid arthritis. Scott Med J 1980;25: 18-22.
7. Espinoza LR, Zakraoui L, Espinoza CG, et al. Psoriatic arthritis: Clinical response and side effects to methotrexate therapy. J Rheumatol 1992;19: 872-7.
8. Dahl MGC, Gregory MM, Scheuer PJ. Liver damage due to methotrexate in patients with psoriasis. Br Med J 1971;1: 625-30.
9. Gilbert SC, Klintamalm G, Menter A, Silverman A. Methotrexate induced cirrhosis requiring liver transplantation in three patients with psoriasis. Arch Intern Med 1990; 150: 889-91.
10. Kremer JM, Galivan J, Streckfuss A, Kamen B. Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Arthritis Rheum 1986;29: 832-5.
11. Phillips CA, Cera PJ, Mangan TF, Newman ED. Clinical liver disease in patients with rheumatoid arthritis taking methotrexate. J Rheumatol 1992;19: 229-33.
12. Brick JE, Moreland LW, AL-Kawas F, Chang WW, Layne RD, Di Bartolomeo AG. Prospective analysis of liver biopsies before and after methotrexate therapy in rheumatoid arthritis. Semin Arthritis Rheum 1989;19: 31-44.
13. Whiting-O'Keefe QE, Fye KH, Sack KD. Methotrexate and histologic hepatic abnormalities: A meta-analysis. Am J Med 1991;90: 711-6.
14. Kremer JM, Lee RG, Tolman KG. Liver histology in rheumatoid arthritis patients receiving long-term methotrexate therapy. A prospective study with baseline and sequential biopsy samples. Arthritis Rheum 1989;32: 121-7.
15. Willkens RF, Leonard PA, Clegg DO, et al. Liver histology in patients receiving low dose pulse methotrexate for the treatment of rheumatoid arthritis. Ann Rheum Dis 1990; 49: 591-3.
16. Szanto E, Sandstedt B, Kollberg B. Hepatotoxicity associated with low-dose, long-term methotrexate treatment of rheumatoid arthritis. Scand J Rheumatol 1987;16: 229-34.
17. Kremer JM, Furst DE, Weinblatt ME, Blotner SD. Significants changes in serum AST across hepatic histological biopsy grades: Prospective analysis of 3 cohorts receiving methotrexate therapy for rheumatoid arthritis. J Rheumatol 1996;23: 459-61.
18. Arnett FC, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31: 315.
19. Kremer JM, Alarcon GS, Lightfoot RW Jr, et al. Methotrexate for rheumatoid arthritis. Suggested guidelines for monitoring liver toxicity. American College of Rheumatology. Arthritis Rheum 1994;37: 316-28.
20. Roenigk HH, Auerbach R, Maibach HI, et al. Methotrexate in psoriasis: Revised guidelines. J Am Acad Dermatol 1988;19: 145.
21. Kremer JM, Kaye GI. Electron microscopic analysis of sequential liver biopsy samples from patients with rheumatoid arthritis. Correlation with light microscopic findings. Arthritis Rheum 1989;32: 1202-13.
22. Steinbroker O, Traeger CH, Batterman RC. Therapeutic criteria in rheumatoid arthritis. JAMA 1949;140: 659-62.
23. Kremer JM, Kaye GI, Kaye NW, Ishak KG, Axiotis CA. Light and electron microscopic analysis of sequential liver biopsy samples from rheumatoid arthritis patients receiving long-term methotrexate therapy. Arthritis Rheum 1995;38: 1194-203.
24. Bjorkmann DJ, Hammond EH, Lee RG, Clegg DO, Tolman KG. Hepatic ultrastructure after methotrexate therapy for rheumatoid arthritis. Arthritis Rheum 1988;31: 1465-72.
25. Bjorkman DJ, Boschert M, Tolman KG, Clegg DO, Ward JR. The effect of long-term methotrexate therapy on hepatic fibrosis in rheumatoid arthritis. Arthritis Rheum 1993;36: 1697-701.
26. Weinblatt ME, Maier AL, Fraser PA, Coblyn JS. Longterm prospective study of methotrexate in rheumatoid arthritis: Conclusion after 132 months of therapy. J Rheumatol 1998; 25: 238-42.
27. Erickson AR, Reddy V, Vogelgesang SA, West SG. Usefulness of the ACR recommendations for liver biopsy in methotrexate-treated rheumatoid arthritis patients. Arthritis Rheum 1995;38: 1115-9.
28. Bergquist SR, Felson DT, Prashker MJ, Freedberg KA. The cost-effectiveness of liver biopsy in rheumatoid arthritis patients treated with methotrexate. Arthritis Rheum 1995;38: 326-33.
29. Risteli J, Sogaard, Oikarinen A, Risteli L, Karvonen J, Zachariae H. Aminoterminal propeptide of type III procollagen in methotrexate-induced liver fibrosis and cirrosis. Br J Dermatol 1988;119: 321-5.
30. Boffa MJ, Smith A, Chalmers RJ, et al. Serum type III procollagen aminopeptide for assessing liver damage in methotrexate-treated psoriatic patients. Br J Dermatol 1996;135: 538-44.
31. Furst DE, Kremer JM. Methotrexate in rheumatoid arthritis. Arthritis Rheum 1988;31: 305-14.
32. van Dooren-Greebe RJ, Kuijpers AL, Buijs WC, et al. The value of dynamic hepatic scintigraphy and serum aminoterminal propeptide of type III procollagen for early detection of methotrexate-induced hepatic damage in psoriasis patients. Br J Dermatol 1996;134: 481-7.