Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 43, Issue 5, 2007, Pages 1789-1795

  Guo, Ping ^a   Wang, Xiaomin ^a   Liu, Liansheng ^a   Belinsky, Martin G ^b   Kruh, Gary D ^b   Gallo, James M ^a  

^a TEMPLE UNIVERSITY   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

7 Hydroxymethotrexate (7 OH MTX); Brain tumor; Cerebrospinal fluid; Column switching; LC MS MS; Methotrexate (MTX); Microdialysis; Pharmacokinetic; Primary CNS lymphoma (PCNSL)

Indexed keywords

7 HYDROXYMETHOTREXATE; METHOTREXATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; BRAIN TUMOR; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BRAIN; BRAIN NEOPLASMS; CHROMATOGRAPHY, LIQUID; METHOTREXATE; MICE; MICE, INBRED C57BL; MICRODIALYSIS; MOLECULAR STRUCTURE; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 33947383662     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.12.034     Document Type: Article

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