An integrated decision-tree testing strategy for eye irritation with respect to the requirements of the EU REACH legislation

Alternatives to Laboratory Animals

Volumn 36, Issue 1, 2008, Pages 81-92

  Grindon, Christina ^a   Combes, Robert ^a   Cronin, Mark T D ^b   Roberts, David W ^b   Garrod, John F ^c  

^a RUSSELL AND BURCH HOUSE   (United Kingdom)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c DEFRA   (United Kingdom)

Author keywords

Animal testing; Decision trees; Defra; Eye irritation; In silico models; In vitro testing; Integrated testing strategies; REACH; Risk assessment; Three Rs

Indexed keywords

AGAROSE; FLUORESCEIN; NEUTRAL RED; SILICON; TRYPAN BLUE;

AGAROSE OVERLAY ASSAY; ANALYTIC METHOD; ANIMAL TESTING ALTERNATIVE; BOVINE CORNEAL OPACITY AND PERMEABILITY TEST; CHORIOALLANTOIC MEMBRANE TRYPAN BLUE STAINING ASSAY; COMPUTER MODEL; DECISION MAKING; EYE IRRITATION; FLUORESCEIN LEAKAGE ASSAY; HEN EGG CHORIOALLANTOIC MEMBRANE TEST; IN VITRO STUDY; IN VIVO STUDY; IRRITECTION ASSAY SYSTEM; ISOLATED CHICKEN EYE TEST; ISOLATED RABBIT EYE TEST; LAW; NEUTRAL RED RELEASE ASSAY; NEUTRAL RED UPTAKE ASSAY; NONHUMAN; NOTE; POLLEN TUBE GROWTH TEST; PREDICTION; PRIORITY JOURNAL; RED BLOOD CELL ASSAY; RISK ASSESSMENT; SAFETY; SILICON MICROPHYSIOMETER TEST; TOXICITY; UNIVERSITY; EYE TOXICITY; HAZARD ASSESSMENT; HUMAN; MEDICAL RESEARCH; TOXICITY TESTING;

ANIMALIA;

EID: 41149150239     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290803600109     Document Type: Note

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