Toxicity testing: Creating a revolution based on new technologies

Trends in Biotechnology

Volumn 23, Issue 6, 2005, Pages 299-307

  Bhogal, Nirmala ^a   Grindon, Christina ^a   Combes, Robert ^a   Balls, Michael ^a  

^a RUSSELL AND BURCH HOUSE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; DRUG PRODUCTS; HEALTH CARE; RISK ASSESSMENT;

DRUG DISCOVERY; TOXICOLOGICAL EVALUATION;

TOXICITY;

ENDOCRINE DISRUPTOR;

BIOTECHNOLOGY; COMPUTER AIDED DESIGN; EVALUATION; GENETIC POLYMORPHISM; HEALTH; HUMAN; KINETICS; METHODOLOGY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTECTION; PROTEOMICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; TECHNOLOGY; TOXICITY TESTING; TOXICOLOGY;

ANIMAL TESTING ALTERNATIVES; ANIMALS; DRUG TOXICITY; HUMANS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SOFTWARE; TOXICITY TESTS;

EID: 18844446770     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibtech.2005.04.006     Document Type: Review

References (43)

1. R. Combes A Scientific and Animal Welfare Assessment of the OECD Health Effects Test Guidelines for the Safety Testing of Chemicals Under the European Union REACH System Altern. Lab. Anim. 32 2004 163 208
2. R. Combes An Overall Strategy for the Testing of Chemicals for Human Hazard and Risk Assessment Under the EU REACH System Altern. Lab. Anim. 31 2003 7 19
3. E. George Comparison of Hepatocyte Cultures and Liver Slices in In Vitro Toxicity Testing Altern. Lab. Anim. 27 1999 769 781
4. S.Y. Brendler-Schwaab Cells of Different Tissues for In Vitro and In Vivo Studies in Toxicity: Compilation of Isolation Methods Toxicol. In Vitro 8 1994 1285 1302
5. R.D. Combes The Use of Human Cells in Biomedical Research and Testing Altern. Lab. Anim. 32 2004 43 49
6. R. Anderson The Establishment of Human Research Tissue Banking in the UK and Several Western European Countries Altern. Lab. Anim. 29 2001 125 134
7. S. Coecke The Use of Long-Term Hepatocyte Cultures For Detecting Induction of Drug Metabolising Enzymes: The Current Status. ECVAM Hepatocytes and Metabolically Competent Systems Task Force Report 1 Altern. Lab. Anim. 27 1999 579 638
8. R.K. Ward Human Keratinocyte Cultures in an In Vitro Approach for the Assessment of Surfactant-Induced Irritation Toxicol. In Vitro 12 2001 163 173
9. R.D. Combes The Third FRAME Toxicity Committee: Working Toward Greater Implementation of Alternatives in Toxicity Testing Altern. Lab. Anim. 32 Suppl. 1 2002 635 642
10. M. Gumbleton, and K.L. Audus Progress and Limitations in the Use of In Vitro Cell Cultures to Serve as a Permeability Screen for The Blood-Brain Barrier J. Pharm. Sci. 90 2001 1681 1698
11. R.J. Fielder BTS Working Party Report on In Vitro Toxicology Hum. Exp. Toxicol. 16 1997 S1 S40
12. E. Lavik, and R. Langer Tissue Engineering: Current State and Perspectives Appl. Microbiol. Biotechnol. 65 2004 1 8
13. R. Roquet Reconstructed Human Epidermis Equivalents. Characterization and Applications in Cutaneous Pharmacotoxicity Skin Pharmacol. Appl. Skin Physiol. 15 Suppl. 1 2002 1 3
14. M. Zorn-Kruppa Comparison of Human Corneal Cell Cultures in Cytotoxicity Testing ALTEX 21 2004 129 134
15. C.K. Atterwill, and W.M. Purcell Brain Spheroid and Other Organotypic Culture Systems in In Vitro Neurotoxicology V.W. Pentreath Neurotoxicology In vitro 1999 Taylor and Francis 213 238
16. A.C. Gray The Development of a Standardised Protocol to Measure Squamous Differentiation in Stratified Epithelia, by Using the Fluorescein Cadaverine Incorporation Technique Altern. Lab. Anim. 32 2004 91 100
17. T.E. Gray Mucociliary Differentiation of Serially Passaged Normal Human Tracheobronchial Epithelial Cells Am. J. Respir. Cell Mol. Biol. 14 1996 104 112
18. Y. Takeda Can the Life Span of Human Marrow Stromal Cells be Prolonged by bmi-1, E6, E7 and/or Telomerase without Affecting Cardiomyogenic Differentiation? J. Gene Med. 6 2004 833 845
19. P. Goberdhan The Bmi-1 Oncogene Induces Telomerase Activity and Immortalizes Human Mammary Epithelial Cells Cancer Research 62 2002 4736 4745
20. A. Butte Use and Analysis of Microarray Data Nat. Rev. Drug Discov. 1 2004 951 960
21. A.E. Carpenter, and D.M. Sabatini Systematic Genome-Wide Screens of Gene Function Nat. Rev. Genet. 5 2004 11 22
22. M.P. Washburn Large-Scale Analysis of the Yeast Proteome by Multidimensional Protein Identification Technology Nat. Biotechnol. 19 2001 242 247
23. T. Kislinger PRISM, a Generic Large Scale Proteomic Investigation Strategy for Mammals Mol. Cell. Proteomics 2 2003 96 106
24. T.W. Schultz The Present Status of QSAR in Toxicology J. Mol. Struct. 622 2003 23 38
25. R.D. Combes, and R. Rodford The Use of Expert Systems for Toxicity Prediction - Illustrated With Reference to the DEREK Program M.T.D. Cronin D.J. Livingstone Predicting Toxicity and Fate 2004 CRC Press 193 204
26. M. Barratt, and J. Langowski Validation and Development of the DEREK Skin Sensitisation Rulebase by Anaylsis of the BgVV List of Contact Allergens M. Balls Progress in the Reduction Refinement and Replacement of Animal Experimentation 2000 Elsevier 493 512
27. S. Zinke Evaluation of a Rule Base for Identifying Contact Allergens by Using a Regulatory Database: Comparison of Data on Chemicals Notified in the European Union With 'Structural Alerts' Used in the DEREK Expert System Altern. Lab. Anim. 30 2002 285 298
28. J.C. Dearden The Development and Validation of Expert Systems for Predicting Toxicity Altern. Lab. Anim. 25 1997 223 252
29. G. Klopman ESP: A Method to Predict Toxicity and Pharmacological Properties of Chemicals Using Multiple MCASE Databases J. Chem. Inf. Comput. Sci. 44 2004 704 715
30. B.J. Blaauboer The Integration of Data on Physico-Chemical Properties, In Vitro-Derived Toxicity Data and Physiologically Based Kinetic and Dynamics Modelling as a Tool in Hazard and Risk Assessment. A Commentary Toxicol. Lett. 138 2003 161 171
31. S. Coecke The Use of Genetically Engineered Cells for Assessing CYP2D6-Related Polymorphic Effects Toxicol. In Vitro 15 2001 553 556
32. M.P. Payne Computer-Based Methods for the Prediction of Chemical Metabolism and Biotransformation Within Biological Organisms M.T.D. Cronin D.J. Livingstone Predicting Toxicity and Fate 2004 CRC Press 205 227
33. N. Krebsfaenger V79 Chinese Hamster Cells Genetically Engineered for Polymorphic Cytochrome P450 2D6 and Their Predictive Value for Humans ALTEX 20 2003 143 154
34. J.I. Macgregor, and V.C. Jordan Basic Guide to the Mechanisms of Antiestrogen Action Pharmacol. Rev. 50 1998 151 196
35. S.E. George A High-Throughput Glow-Type Aequorin Assay for Measuring Receptor-Mediated Changes in Intracellular Calcium Levels Anal. Biochem. 286 2000 231 237
36. W.D. Pennie Differential Activation by Xenoestrogens of ER Alpha and ER Beta When Linked to Different Response Elements J. Endocrinol. 158 1998 R11 R14
37. S. Terasaka Using a Customised DNA Microarray for Expression Profiling of the Estrogen-Responsive Genes to Evaluate Estrogen Activity Among Natural Estrogens and Industrial Chemicals Environ. Health Perspect. 113 2004 773 781
38. N. Canova Evaluation of a Flat Membrane Hepatocyte Bioreactor for Pharmacotoxicological Applications: Evidence that Inhibition of Spontaneously Produced Nitric Oxide Improves Cell Functionality Altern. Lab. Anim. 32 2004 25 35
39. U. Marx Monoclonal Antibody Production. The Report and Recommendations of ECVAM Workshop 23 Altern. Lab. Anim. 25 1997 121 137
40. W. Pfaller Novel Advanced In Vitro Methods for Longterm Toxicity Testing: The Report and Recommendations of ECVAM Workshop 45 Altern. Lab. Anim. 29 2001 393 426
41. P. Pazos Long-Term In Vitro Toxicity Models: Comparisons between Flow-Cell Bioreactor, a Static-Cell Bioreactor and Static Cell Cultures Altern. Lab. Anim. 30 2002 515 523
42. J.R. Sanchez-Ramos Expression of Neural Markers in Human Umbilical Cord Blood Exp. Neurol. 171 2001 109 115
43. L. Bujanska Human Cord Blood-Derived Cells Attain Neuronal and Glial Features In Vitro J. Cell Sci. 115 2002 2131 2138