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Volumn 235, Issue 1, 2012, Pages 62-69

Gene therapy approaches to enhancing plasticity and regeneration after spinal cord injury

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ADENOVIRUS VECTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CILIARY NEUROTROPHIC FACTOR; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HERPESVIRUS VECTOR; INTERLEUKIN 6; LENTIVIRUS VECTOR; LEUKEMIA INHIBITORY FACTOR; NERVE GROWTH FACTOR; NEUROMODULIN; NEURONAL CALCIUM SENSOR; NEUROTROPHIN 3; NEUROTROPHIN 3 RECEPTOR; NEUROTROPHIN 4; PARVOVIRUS VECTOR; RETINOIC ACID RECEPTOR BETA; SEMAPHORIN 3A; SOMATOMEDIN; STAT3 PROTEIN;

EID: 84859893578     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.01.015     Document Type: Review
Times cited : (40)

References (159)
  • 1
    • 70449473470 scopus 로고    scopus 로고
    • A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth
    • Alfa R.W., Tuszynski M.H., Blesch A. A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth. J. Neurosci. Res. 2009, 87:2624-2631.
    • (2009) J. Neurosci. Res. , vol.87 , pp. 2624-2631
    • Alfa, R.W.1    Tuszynski, M.H.2    Blesch, A.3
  • 2
    • 69449094846 scopus 로고    scopus 로고
    • Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury
    • Alto L.T., Havton L.A., Conner J.M., Hollis Ii E.R., Blesch A., Tuszynski M.H. Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nat. Neurosci. 2009, 12:1106-1113.
    • (2009) Nat. Neurosci. , vol.12 , pp. 1106-1113
    • Alto, L.T.1    Havton, L.A.2    Conner, J.M.3    Hollis Ii, E.R.4    Blesch, A.5    Tuszynski, M.H.6
  • 3
    • 5044220530 scopus 로고    scopus 로고
    • Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats
    • Ankeny D.P., McTigue D.M., Jakeman L.B. Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats. Exp. Neurol. 2004, 190:17-31.
    • (2004) Exp. Neurol. , vol.190 , pp. 17-31
    • Ankeny, D.P.1    McTigue, D.M.2    Jakeman, L.B.3
  • 5
    • 33645967159 scopus 로고    scopus 로고
    • Spontaneous locomotor recovery in spinal cord injured rats is accompanied by anatomical plasticity of reticulospinal fibers
    • Ballermann M., Fouad K. Spontaneous locomotor recovery in spinal cord injured rats is accompanied by anatomical plasticity of reticulospinal fibers. Eur. J. Neurosci. 2006, 23:1988-1996.
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 1988-1996
    • Ballermann, M.1    Fouad, K.2
  • 6
    • 0035122596 scopus 로고    scopus 로고
    • Neurotrophins BDNF and NT-3 promote axonal re-entry into the distal host spinal cord through Schwann cell-seeded mini-channels
    • Bamber N.I., Li H., Lu X., Oudega M., Aebischer P., Xu X.M. Neurotrophins BDNF and NT-3 promote axonal re-entry into the distal host spinal cord through Schwann cell-seeded mini-channels. Eur. J. Neurosci. 2001, 13:257-268.
    • (2001) Eur. J. Neurosci. , vol.13 , pp. 257-268
    • Bamber, N.I.1    Li, H.2    Lu, X.3    Oudega, M.4    Aebischer, P.5    Xu, X.M.6
  • 8
    • 0036264280 scopus 로고    scopus 로고
    • Targeting the host inflammatory response in traumatic spinal cord injury
    • Bethea J.R., Dietrich W.D. Targeting the host inflammatory response in traumatic spinal cord injury. Curr. Opin. Neurol. 2002, 15:355-360.
    • (2002) Curr. Opin. Neurol. , vol.15 , pp. 355-360
    • Bethea, J.R.1    Dietrich, W.D.2
  • 10
    • 0242497104 scopus 로고    scopus 로고
    • Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transection and induces remyelination
    • Blesch A., Tuszynski M.H. Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transection and induces remyelination. J. Comp. Neurol. 2003, 467:403-417.
    • (2003) J. Comp. Neurol. , vol.467 , pp. 403-417
    • Blesch, A.1    Tuszynski, M.H.2
  • 11
    • 34848866015 scopus 로고    scopus 로고
    • Transient growth factor delivery sustains regenerated axons after spinal cord injury
    • Blesch A., Tuszynski M.H. Transient growth factor delivery sustains regenerated axons after spinal cord injury. J. Neurosci. 2007, 27:10535-10545.
    • (2007) J. Neurosci. , vol.27 , pp. 10535-10545
    • Blesch, A.1    Tuszynski, M.H.2
  • 12
    • 0033135389 scopus 로고    scopus 로고
    • Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury
    • Blesch A., Uy H.S., Grill R.J., Cheng J.G., Patterson P.H., Tuszynski M.H. Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury. J. Neurosci. 1999, 19:3556-3566.
    • (1999) J. Neurosci. , vol.19 , pp. 3556-3566
    • Blesch, A.1    Uy, H.S.2    Grill, R.J.3    Cheng, J.G.4    Patterson, P.H.5    Tuszynski, M.H.6
  • 13
    • 5644264890 scopus 로고    scopus 로고
    • Axonal responses to cellularly delivered NT-4/5 after spinal cord injury
    • Blesch A., Yang H., Weidner N., Hoang A., Otero D. Axonal responses to cellularly delivered NT-4/5 after spinal cord injury. Mol. Cell. Neurosci. 2004, 27:190-201.
    • (2004) Mol. Cell. Neurosci. , vol.27 , pp. 190-201
    • Blesch, A.1    Yang, H.2    Weidner, N.3    Hoang, A.4    Otero, D.5
  • 14
    • 72249104303 scopus 로고    scopus 로고
    • Adeno-associated viral vector (AAV)-mediated gene transfer in the red nucleus of the adult rat brain: comparative analysis of the transduction properties of seven AAV serotypes and lentiviral vectors
    • Blits B., Derks S., Twisk J., Ehlert E., Prins J., Verhaagen J. Adeno-associated viral vector (AAV)-mediated gene transfer in the red nucleus of the adult rat brain: comparative analysis of the transduction properties of seven AAV serotypes and lentiviral vectors. J. Neurosci. Meth. 2010, 185:257-263.
    • (2010) J. Neurosci. Meth. , vol.185 , pp. 257-263
    • Blits, B.1    Derks, S.2    Twisk, J.3    Ehlert, E.4    Prins, J.5    Verhaagen, J.6
  • 15
    • 0033942954 scopus 로고    scopus 로고
    • Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function
    • Blits B., Dijkhuizen P.A., Boer G.J., Verhaagen J. Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function. Exp. Neurol. 2000, 164:25-37.
    • (2000) Exp. Neurol. , vol.164 , pp. 25-37
    • Blits, B.1    Dijkhuizen, P.A.2    Boer, G.J.3    Verhaagen, J.4
  • 16
    • 52649176389 scopus 로고    scopus 로고
    • Axonal guidance molecules and the failure of axonal regeneration in the adult mammalian spinal cord
    • Bolsover S., Fabes J., Anderson P.N. Axonal guidance molecules and the failure of axonal regeneration in the adult mammalian spinal cord. Restor. Neurol. Neurosci. 2008, 26:117-130.
    • (2008) Restor. Neurol. Neurosci. , vol.26 , pp. 117-130
    • Bolsover, S.1    Fabes, J.2    Anderson, P.N.3
  • 17
    • 77951565691 scopus 로고    scopus 로고
    • Promoting directional axon growth from neural progenitors grafted into the injured spinal cord
    • Bonner J.F., Blesch A., Neuhuber B., Fischer I. Promoting directional axon growth from neural progenitors grafted into the injured spinal cord. J. Neurosci. Res. 2010, 88:1182-1192.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 1182-1192
    • Bonner, J.F.1    Blesch, A.2    Neuhuber, B.3    Fischer, I.4
  • 19
    • 0032722126 scopus 로고    scopus 로고
    • NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord
    • Bradbury E.J., Khemani S., Von R., King Priestley J.V., McMahon S.B. NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord. Eur. J. Neurosci. 1999, 11:3873-3883.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 3873-3883
    • Bradbury, E.J.1    Khemani, S.2    Von, R.3    King Priestley, J.V.4    McMahon, S.B.5
  • 20
    • 0027504205 scopus 로고
    • Recovery of function after spinal cord injury: mechanisms underlying transplant-mediated recovery of function differ after spinal cord injury in newborn and adult rats
    • Bregman B.S., Kunkel-Bagden E., Reier P.J., Dai H.N., McAtee M., Gao D. Recovery of function after spinal cord injury: mechanisms underlying transplant-mediated recovery of function differ after spinal cord injury in newborn and adult rats. Exp. Neurol. 1993, 123:3-16.
    • (1993) Exp. Neurol. , vol.123 , pp. 3-16
    • Bregman, B.S.1    Kunkel-Bagden, E.2    Reier, P.J.3    Dai, H.N.4    McAtee, M.5    Gao, D.6
  • 22
    • 4344566457 scopus 로고    scopus 로고
    • Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system
    • Burger C., Gorbatyuk O.S., Velardo M.J., Peden C.S., Williams P., Zolotukhin S., Reier P.J., Mandel R.J., Muzyczka N. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol. Ther. 2004, 10:302-317.
    • (2004) Mol. Ther. , vol.10 , pp. 302-317
    • Burger, C.1    Gorbatyuk, O.S.2    Velardo, M.J.3    Peden, C.S.4    Williams, P.5    Zolotukhin, S.6    Reier, P.J.7    Mandel, R.J.8    Muzyczka, N.9
  • 23
    • 2342493315 scopus 로고    scopus 로고
    • Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice
    • Cafferty W.B., Gardiner N.J., Das P., Qiu J., McMahon S.B., Thompson S.W. Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice. J. Neurosci. 2004, 24:4432-4443.
    • (2004) J. Neurosci. , vol.24 , pp. 4432-4443
    • Cafferty, W.B.1    Gardiner, N.J.2    Das, P.3    Qiu, J.4    McMahon, S.B.5    Thompson, S.W.6
  • 24
    • 0035399823 scopus 로고    scopus 로고
    • Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate
    • Cai D., Qiu J., Cao Z., McAtee M., Bregman B.S., Filbin M.T. Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J. Neurosci. 2001, 21:4731-4739.
    • (2001) J. Neurosci. , vol.21 , pp. 4731-4739
    • Cai, D.1    Qiu, J.2    Cao, Z.3    McAtee, M.4    Bregman, B.S.5    Filbin, M.T.6
  • 25
    • 1542375991 scopus 로고    scopus 로고
    • Olfactory ensheathing cells genetically modified to secrete GDNF to promote spinal cord repair
    • Cao L., Liu L., Chen Z.Y., Wang L.M., Ye J.L., Qiu H.Y., Lu C.L., He C. Olfactory ensheathing cells genetically modified to secrete GDNF to promote spinal cord repair. Brain 2004, 127:535-549.
    • (2004) Brain , vol.127 , pp. 535-549
    • Cao, L.1    Liu, L.2    Chen, Z.Y.3    Wang, L.M.4    Ye, J.L.5    Qiu, H.Y.6    Lu, C.L.7    He, C.8
  • 26
    • 23044446572 scopus 로고    scopus 로고
    • Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells
    • Cao Q., Xu X.M., Devries W.H., Enzmann G.U., Ping P., Tsoulfas P., Wood P.M., Bunge M.B., Whittemore S.R. Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. J. Neurosci. 2005, 25:6947-6957.
    • (2005) J. Neurosci. , vol.25 , pp. 6947-6957
    • Cao, Q.1    Xu, X.M.2    Devries, W.H.3    Enzmann, G.U.4    Ping, P.5    Tsoulfas, P.6    Wood, P.M.7    Bunge, M.B.8    Whittemore, S.R.9
  • 28
    • 33750139963 scopus 로고    scopus 로고
    • Expression of neurotrophin-3 promotes axonal plasticity in the acute but not chronic injured spinal cord
    • Chen Q., Zhou L., Shine H.D. Expression of neurotrophin-3 promotes axonal plasticity in the acute but not chronic injured spinal cord. J. Neurotrauma 2006, 23:1254-1260.
    • (2006) J. Neurotrauma , vol.23 , pp. 1254-1260
    • Chen, Q.1    Zhou, L.2    Shine, H.D.3
  • 31
    • 0019856865 scopus 로고
    • Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
    • David S., Aguayo A.J. Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats. Science 1981, 214:931-933.
    • (1981) Science , vol.214 , pp. 931-933
    • David, S.1    Aguayo, A.J.2
  • 32
    • 0032703535 scopus 로고    scopus 로고
    • Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: differential regulation of GAP-43, tubulins, and neurofilament-M
    • Fernandes K.J., Fan D.P., Tsui B.J., Cassar S.L., Tetzlaff W. Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: differential regulation of GAP-43, tubulins, and neurofilament-M. J. Comp. Neurol. 1999, 414:495-510.
    • (1999) J. Comp. Neurol. , vol.414 , pp. 495-510
    • Fernandes, K.J.1    Fan, D.P.2    Tsui, B.J.3    Cassar, S.L.4    Tetzlaff, W.5
  • 33
    • 0141499228 scopus 로고    scopus 로고
    • Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
    • Filbin M.T. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat. Rev. Neurosci. 2003, 4:703-713.
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 703-713
    • Filbin, M.T.1
  • 34
    • 38649112309 scopus 로고    scopus 로고
    • CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure
    • Fitch M.T., Silver J. CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure. Exp. Neurol. 2008, 209:294-301.
    • (2008) Exp. Neurol. , vol.209 , pp. 294-301
    • Fitch, M.T.1    Silver, J.2
  • 35
    • 69249124531 scopus 로고    scopus 로고
    • Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI
    • Fortun J., Puzis R., Pearse D.D., Gage F.H., Bunge M.B. Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI. J. Neurotrauma 2009, 26:941-953.
    • (2009) J. Neurotrauma , vol.26 , pp. 941-953
    • Fortun, J.1    Puzis, R.2    Pearse, D.D.3    Gage, F.H.4    Bunge, M.B.5
  • 37
    • 0347694856 scopus 로고    scopus 로고
    • Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase
    • Gao Y., Nikulina E., Mellado W., Filbin M.T. Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase. J. Neurosci. 2003, 23:11770-11777.
    • (2003) J. Neurosci. , vol.23 , pp. 11770-11777
    • Gao, Y.1    Nikulina, E.2    Mellado, W.3    Filbin, M.T.4
  • 39
    • 0029989784 scopus 로고    scopus 로고
    • BDNF and NT-3, but not NGF, prevent axotomy-induced death of rat corticospinal neurons in vivo
    • Giehl K.M., Tetzlaff W. BDNF and NT-3, but not NGF, prevent axotomy-induced death of rat corticospinal neurons in vivo. Eur. J. Neurosci. 1996, 8:1167-1175.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1167-1175
    • Giehl, K.M.1    Tetzlaff, W.2
  • 41
    • 0037036144 scopus 로고    scopus 로고
    • Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells
    • Goldberg J.L., Klassen M.P., Hua Y., Barres B.A. Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. Science 2002, 296:1860-1864.
    • (2002) Science , vol.296 , pp. 1860-1864
    • Goldberg, J.L.1    Klassen, M.P.2    Hua, Y.3    Barres, B.A.4
  • 42
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M., Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA 1992, 89:5547-5551.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 44
    • 77649273563 scopus 로고    scopus 로고
    • Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB)
    • Gray S.J., Blake B.L., Criswell H.E., Nicolson S.C., Samulski R.J., McCown T.J. Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB). Mol. Ther. 2010, 18:570-578.
    • (2010) Mol. Ther. , vol.18 , pp. 570-578
    • Gray, S.J.1    Blake, B.L.2    Criswell, H.E.3    Nicolson, S.C.4    Samulski, R.J.5    McCown, T.J.6
  • 45
    • 16944366150 scopus 로고    scopus 로고
    • Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury
    • Grill R., Murai K., Blesch A., Gage F.H., Tuszynski M.H. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J. Neurosci. 1997, 17:5560-5572.
    • (1997) J. Neurosci. , vol.17 , pp. 5560-5572
    • Grill, R.1    Murai, K.2    Blesch, A.3    Gage, F.H.4    Tuszynski, M.H.5
  • 46
    • 0031408944 scopus 로고    scopus 로고
    • Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells
    • Grill R.J., Blesch A., Tuszynski M.H. Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells. Exp. Neurol. 1997, 148:444-452.
    • (1997) Exp. Neurol. , vol.148 , pp. 444-452
    • Grill, R.J.1    Blesch, A.2    Tuszynski, M.H.3
  • 47
    • 1542369977 scopus 로고    scopus 로고
    • From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy
    • Grimm D., Kay M.A. From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy. Curr. Gene Ther. 2003, 3:281-304.
    • (2003) Curr. Gene Ther. , vol.3 , pp. 281-304
    • Grimm, D.1    Kay, M.A.2
  • 49
    • 0035885111 scopus 로고    scopus 로고
    • Transplants of cells genetically modified to express neurotrophin-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats
    • Himes B.T., Liu Y., Solowska J.M., Snyder E.Y., Fischer I., Tessler A. Transplants of cells genetically modified to express neurotrophin-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats. J. Neurosci. Res. 2001, 65:549-564.
    • (2001) J. Neurosci. Res. , vol.65 , pp. 549-564
    • Himes, B.T.1    Liu, Y.2    Solowska, J.M.3    Snyder, E.Y.4    Fischer, I.5    Tessler, A.6
  • 53
    • 38649139370 scopus 로고    scopus 로고
    • Efficient retrograde neuronal transduction utilizing self-complementary AAV1
    • Hollis E.R., Kadoya K., Hirsch M., Samulski R.J., Tuszynski M.H. Efficient retrograde neuronal transduction utilizing self-complementary AAV1. Mol. Ther. 2008, 16:296-301.
    • (2008) Mol. Ther. , vol.16 , pp. 296-301
    • Hollis, E.R.1    Kadoya, K.2    Hirsch, M.3    Samulski, R.J.4    Tuszynski, M.H.5
  • 54
    • 57449092483 scopus 로고    scopus 로고
    • IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury
    • Hollis E.R., Lu P., Blesch A., Tuszynski M.H. IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury. Exp. Neurol. 2009, 215:53-59.
    • (2009) Exp. Neurol. , vol.215 , pp. 53-59
    • Hollis, E.R.1    Lu, P.2    Blesch, A.3    Tuszynski, M.H.4
  • 55
    • 0036434324 scopus 로고    scopus 로고
    • Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury
    • Jin Y., Fischer I., Tessler A., Houle J.D. Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. Exp. Neurol. 2002, 177:265-275.
    • (2002) Exp. Neurol. , vol.177 , pp. 265-275
    • Jin, Y.1    Fischer, I.2    Tessler, A.3    Houle, J.D.4
  • 56
    • 0034438394 scopus 로고    scopus 로고
    • Fibroblasts genetically modified to produce BDNF support regrowth of chronically injured serotonergic axons
    • Jin Y., Tessler A., Fischer I., Houle J.D. Fibroblasts genetically modified to produce BDNF support regrowth of chronically injured serotonergic axons. Neurorehabil. Neural Repair 2000, 14:311-317.
    • (2000) Neurorehabil. Neural Repair , vol.14 , pp. 311-317
    • Jin, Y.1    Tessler, A.2    Fischer, I.3    Houle, J.D.4
  • 57
    • 41149088114 scopus 로고    scopus 로고
    • Axon growth across a lesion site along a preformed guidance pathway in the brain
    • Jin Y., Ziemba K.S., Smith G.M. Axon growth across a lesion site along a preformed guidance pathway in the brain. Exp. Neurol. 2008, 210:521-530.
    • (2008) Exp. Neurol. , vol.210 , pp. 521-530
    • Jin, Y.1    Ziemba, K.S.2    Smith, G.M.3
  • 58
    • 70350203996 scopus 로고    scopus 로고
    • Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury
    • Kadoya K., Tsukada S., Lu P., Coppola G., Geschwind D., Filbin M., Blesch A., Tuszynski M.H. Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron 2009, 64:165-172.
    • (2009) Neuron , vol.64 , pp. 165-172
    • Kadoya, K.1    Tsukada, S.2    Lu, P.3    Coppola, G.4    Geschwind, D.5    Filbin, M.6    Blesch, A.7    Tuszynski, M.H.8
  • 60
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • Kaspar B.K., Llado J., Sherkat N., Rothstein J.D., Gage F.H. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 2003, 301:839-842.
    • (2003) Science , vol.301 , pp. 839-842
    • Kaspar, B.K.1    Llado, J.2    Sherkat, N.3    Rothstein, J.D.4    Gage, F.H.5
  • 61
    • 0029361836 scopus 로고
    • Targeting and gene expression in spinal cord motor neurons following intramuscular inoculation of an HSV-1 vector
    • Keir S.D., Mitchell W.J., Feldman L.T., Martin J.R. Targeting and gene expression in spinal cord motor neurons following intramuscular inoculation of an HSV-1 vector. J. Neurovirol. 1995, 1:259-267.
    • (1995) J. Neurovirol. , vol.1 , pp. 259-267
    • Keir, S.D.1    Mitchell, W.J.2    Feldman, L.T.3    Martin, J.R.4
  • 62
    • 33746190683 scopus 로고    scopus 로고
    • A common mechanism for cytoplasmic dynein-dependent microtubule binding shared among adeno-associated virus and adenovirus serotypes
    • Kelkar S., De B.P., Gao G., Wilson J.M., Crystal R.G., Leopold P.L. A common mechanism for cytoplasmic dynein-dependent microtubule binding shared among adeno-associated virus and adenovirus serotypes. J. Virol. 2006, 80:7781-7785.
    • (2006) J. Virol. , vol.80 , pp. 7781-7785
    • Kelkar, S.1    De, B.P.2    Gao, G.3    Wilson, J.M.4    Crystal, R.G.5    Leopold, P.L.6
  • 63
    • 0016774093 scopus 로고
    • Structural and functional evidence of plasticity in the central nervous system
    • Kerr F.W. Structural and functional evidence of plasticity in the central nervous system. Exp. Neurol. 1975, 48:16-31.
    • (1975) Exp. Neurol. , vol.48 , pp. 16-31
    • Kerr, F.W.1
  • 64
    • 0031467240 scopus 로고    scopus 로고
    • BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration
    • Kobayashi N.R., Fan D.P., Giehl K.M., Bedard A.M., Wiegand S.J., Tetzlaff W. BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration. J. Neurosci. 1997, 17:9583-9595.
    • (1997) J. Neurosci. , vol.17 , pp. 9583-9595
    • Kobayashi, N.R.1    Fan, D.P.2    Giehl, K.M.3    Bedard, A.M.4    Wiegand, S.J.5    Tetzlaff, W.6
  • 65
    • 34248326047 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury
    • Kwon B.K., Liu J., Lam C., Plunet W., Oschipok L.W., Hauswirth W., Di Polo A., Blesch A., Tetzlaff W. Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury. Spine 2007, 32:1164-1173.
    • (2007) Spine , vol.32 , pp. 1164-1173
    • Kwon, B.K.1    Liu, J.2    Lam, C.3    Plunet, W.4    Oschipok, L.W.5    Hauswirth, W.6    Di Polo, A.7    Blesch, A.8    Tetzlaff, W.9
  • 67
    • 19344365362 scopus 로고    scopus 로고
    • Lineage-restricted neural precursors survive, migrate, and differentiate following transplantation into the injured adult spinal cord
    • Lepore A.C., Fischer I. Lineage-restricted neural precursors survive, migrate, and differentiate following transplantation into the injured adult spinal cord. Exp. Neurol. 2005, 194:230-242.
    • (2005) Exp. Neurol. , vol.194 , pp. 230-242
    • Lepore, A.C.1    Fischer, I.2
  • 68
    • 0030769193 scopus 로고    scopus 로고
    • Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells
    • Li Y., Field M., Raisman G. Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells. Science 1997, 277:2000-2002.
    • (1997) Science , vol.277 , pp. 2000-2002
    • Li, Y.1    Field, M.2    Raisman, G.3
  • 69
    • 0028246867 scopus 로고
    • Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord
    • Li Y., Raisman G. Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord. J. Neurosci. 1994, 14:4050-4063.
    • (1994) J. Neurosci. , vol.14 , pp. 4050-4063
    • Li, Y.1    Raisman, G.2
  • 71
    • 0033151593 scopus 로고    scopus 로고
    • Transplants of fibroblasts genetically modified to express brain-derived neurotrophic factor promote regeneration of adult rat rubrospinal axons and recovery of forelimb function
    • Liu Y., Kim D., Himes B.T., Chow S.Y., Schallert T., Murray M., Tessler A., Fischer I. Transplants of fibroblasts genetically modified to express brain-derived neurotrophic factor promote regeneration of adult rat rubrospinal axons and recovery of forelimb function. J. Neurosci. 1999, 19:4370-4387.
    • (1999) J. Neurosci. , vol.19 , pp. 4370-4387
    • Liu, Y.1    Kim, D.2    Himes, B.T.3    Chow, S.Y.4    Schallert, T.5    Murray, M.6    Tessler, A.7    Fischer, I.8
  • 72
    • 77952430179 scopus 로고    scopus 로고
    • A dual promoter lentiviral vector for the in vivo evaluation of gene therapeutic approaches to axon regeneration after spinal cord injury
    • Low K., Blesch A., Herrmann J., Tuszynski M.H. A dual promoter lentiviral vector for the in vivo evaluation of gene therapeutic approaches to axon regeneration after spinal cord injury. Gene Ther. 2010, 17:577-591.
    • (2010) Gene Ther. , vol.17 , pp. 577-591
    • Low, K.1    Blesch, A.2    Herrmann, J.3    Tuszynski, M.H.4
  • 74
    • 84859924050 scopus 로고    scopus 로고
    • Regeneration and bridging of long-descending motor axons after spinal cord injury. Abstract Viewer/Itinerary Planner. San Diego, CA: Society for Neuroscience, 2007. Online., Program No. 600.609.
    • Lu, P., Blesch, A., Graham, L., Yu, K., Culbertson, M., and Tuszynski, M. H., 2007. Regeneration and bridging of long-descending motor axons after spinal cord injury. Abstract Viewer/Itinerary Planner. San Diego, CA: Society for Neuroscience, 2007. Online., Program No. 600.609.
    • (2007)
    • Lu, P.1    Blesch, A.2    Graham, L.3    Yu, K.4    Culbertson, M.5    Tuszynski, M.H.6
  • 75
    • 0035817425 scopus 로고    scopus 로고
    • Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons
    • Lu P., Blesch A., Tuszynski M.H. Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons. J. Comp. Neurol. 2001, 436:456-470.
    • (2001) J. Comp. Neurol. , vol.436 , pp. 456-470
    • Lu, P.1    Blesch, A.2    Tuszynski, M.H.3
  • 76
    • 0038054469 scopus 로고    scopus 로고
    • Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury
    • Lu P., Jones L.L., Snyder E.Y., Tuszynski M.H. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp. Neurol. 2003, 181:115-129.
    • (2003) Exp. Neurol. , vol.181 , pp. 115-129
    • Lu, P.1    Jones, L.L.2    Snyder, E.Y.3    Tuszynski, M.H.4
  • 77
    • 11844273931 scopus 로고    scopus 로고
    • BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury
    • Lu P., Jones L.L., Tuszynski M.H. BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp. Neurol. 2005, 191:344-360.
    • (2005) Exp. Neurol. , vol.191 , pp. 344-360
    • Lu, P.1    Jones, L.L.2    Tuszynski, M.H.3
  • 78
    • 33751433363 scopus 로고    scopus 로고
    • Axon regeneration through scars and into sites of chronic spinal cord injury
    • Lu P., Jones L.L., Tuszynski M.H. Axon regeneration through scars and into sites of chronic spinal cord injury. Exp. Neurol. 2007, 203:8-21.
    • (2007) Exp. Neurol. , vol.203 , pp. 8-21
    • Lu, P.1    Jones, L.L.2    Tuszynski, M.H.3
  • 79
    • 33751102887 scopus 로고    scopus 로고
    • Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury
    • Lu P., Yang H., Culbertson M., Graham L., Roskams A.J., Tuszynski M.H. Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury. J. Neurosci. 2006, 26:11120-11130.
    • (2006) J. Neurosci. , vol.26 , pp. 11120-11130
    • Lu, P.1    Yang, H.2    Culbertson, M.3    Graham, L.4    Roskams, A.J.5    Tuszynski, M.H.6
  • 80
    • 3242711266 scopus 로고    scopus 로고
    • Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury
    • Lu P., Yang H., Jones L.L., Filbin M.T., Tuszynski M.H. Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J. Neurosci. 2004, 24:6402-6409.
    • (2004) J. Neurosci. , vol.24 , pp. 6402-6409
    • Lu, P.1    Yang, H.2    Jones, L.L.3    Filbin, M.T.4    Tuszynski, M.H.5
  • 81
    • 0037079079 scopus 로고    scopus 로고
    • Neurotrophin-3 is required for appropriate establishment of thalamocortical connections
    • Ma L., Harada T., Harada C., Romero M., Hebert J.M., McConnell S.K., Parada L.F. Neurotrophin-3 is required for appropriate establishment of thalamocortical connections. Neuron 2002, 36:623-634.
    • (2002) Neuron , vol.36 , pp. 623-634
    • Ma, L.1    Harada, T.2    Harada, C.3    Romero, M.4    Hebert, J.M.5    McConnell, S.K.6    Parada, L.F.7
  • 82
    • 77950838482 scopus 로고    scopus 로고
    • CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease
    • Mandel R.J. CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease. Curr. Opin. Mol. Ther. 2010, 12:240-247.
    • (2010) Curr. Opin. Mol. Ther. , vol.12 , pp. 240-247
    • Mandel, R.J.1
  • 83
    • 41949110690 scopus 로고    scopus 로고
    • Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
    • Marks W.J., Ostrem J.L., Verhagen L., Starr P.A., Larson P.S., Bakay R.A., Taylor R., Cahn-Weiner D.A., Stoessl A.J., Olanow C.W., Bartus R.T. Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial. Lancet Neurol. 2008, 7:400-408.
    • (2008) Lancet Neurol. , vol.7 , pp. 400-408
    • Marks, W.J.1    Ostrem, J.L.2    Verhagen, L.3    Starr, P.A.4    Larson, P.S.5    Bakay, R.A.6    Taylor, R.7    Cahn-Weiner, D.A.8    Stoessl, A.J.9    Olanow, C.W.10    Bartus, R.T.11
  • 85
    • 3843149566 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is expressed in a gradient in the superior colliculus during development of the retinocollicular projection
    • Marotte L.R., Vidovic M., Wheeler E., Jhaveri S. Brain-derived neurotrophic factor is expressed in a gradient in the superior colliculus during development of the retinocollicular projection. Eur. J. Neurosci. 2004, 20:843-847.
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 843-847
    • Marotte, L.R.1    Vidovic, M.2    Wheeler, E.3    Jhaveri, S.4
  • 87
    • 0346777307 scopus 로고    scopus 로고
    • Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo
    • McCarty D.M., Fu H., Monahan P.E., Toulson C.E., Naik P., Samulski R.J. Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo. Gene Ther. 2003, 10:2112-2118.
    • (2003) Gene Ther. , vol.10 , pp. 2112-2118
    • McCarty, D.M.1    Fu, H.2    Monahan, P.E.3    Toulson, C.E.4    Naik, P.5    Samulski, R.J.6
  • 88
    • 0034882826 scopus 로고    scopus 로고
    • Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis
    • McCarty D.M., Monahan P.E., Samulski R.J. Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Ther. 2001, 8:1248-1254.
    • (2001) Gene Ther. , vol.8 , pp. 1248-1254
    • McCarty, D.M.1    Monahan, P.E.2    Samulski, R.J.3
  • 89
    • 0032528159 scopus 로고    scopus 로고
    • Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord
    • McTigue D.M., Horner P.J., Stokes B.T., Gage F.H. Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J. Neurosci. 1998, 18:5354-5365.
    • (1998) J. Neurosci. , vol.18 , pp. 5354-5365
    • McTigue, D.M.1    Horner, P.J.2    Stokes, B.T.3    Gage, F.H.4
  • 90
    • 0031814388 scopus 로고    scopus 로고
    • Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord
    • Menei P., Montero-Menei C., Whittemore S.R., Bunge R.P., Bunge M.B. Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord. Eur. J. Neurosci. 1998, 10:607-621.
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 607-621
    • Menei, P.1    Montero-Menei, C.2    Whittemore, S.R.3    Bunge, R.P.4    Bunge, M.B.5
  • 92
    • 22044438251 scopus 로고    scopus 로고
    • Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats
    • Mitsui T., Fischer I., Shumsky J.S., Murray M. Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats. Exp. Neurol. 2005, 194:410-431.
    • (2005) Exp. Neurol. , vol.194 , pp. 410-431
    • Mitsui, T.1    Fischer, I.2    Shumsky, J.S.3    Murray, M.4
  • 94
    • 0031036301 scopus 로고    scopus 로고
    • Fetal spinal cord transplants rescue some axotomized rubrospinal neurons from retrograde cell death in adult rats
    • Mori F., Himes B.T., Kowada M., Murray M., Tessler A. Fetal spinal cord transplants rescue some axotomized rubrospinal neurons from retrograde cell death in adult rats. Exp. Neurol. 1997, 143:45-60.
    • (1997) Exp. Neurol. , vol.143 , pp. 45-60
    • Mori, F.1    Himes, B.T.2    Kowada, M.3    Murray, M.4    Tessler, A.5
  • 95
    • 0037071890 scopus 로고    scopus 로고
    • Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation
    • Neumann S., Bradke F., Tessier-Lavigne M., Basbaum A.I. Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation. Neuron 2002, 34:885-893.
    • (2002) Neuron , vol.34 , pp. 885-893
    • Neumann, S.1    Bradke, F.2    Tessier-Lavigne, M.3    Basbaum, A.I.4
  • 97
    • 33750492639 scopus 로고    scopus 로고
    • IGF-I specifically enhances axon outgrowth of corticospinal motor neurons
    • Ozdinler P.H., Macklis J.D. IGF-I specifically enhances axon outgrowth of corticospinal motor neurons. Nat. Neurosci. 2006, 9:1371-1381.
    • (2006) Nat. Neurosci. , vol.9 , pp. 1371-1381
    • Ozdinler, P.H.1    Macklis, J.D.2
  • 99
    • 8144225167 scopus 로고    scopus 로고
    • Adult neural progenitor cells provide a permissive guiding substrate for corticospinal axon growth following spinal cord injury
    • Pfeifer K., Vroemen M., Blesch A., Weidner N. Adult neural progenitor cells provide a permissive guiding substrate for corticospinal axon growth following spinal cord injury. Eur. J. Neurosci. 2004, 20:1695-1704.
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 1695-1704
    • Pfeifer, K.1    Vroemen, M.2    Blesch, A.3    Weidner, N.4
  • 100
    • 0036218099 scopus 로고    scopus 로고
    • Promoting axonal regeneration in the central nervous system by enhancing the cell body response to axotomy
    • Plunet W., Kwon B.K., Tetzlaff W. Promoting axonal regeneration in the central nervous system by enhancing the cell body response to axotomy. J. Neurosci. Res. 2002, 68:1-6.
    • (2002) J. Neurosci. Res. , vol.68 , pp. 1-6
    • Plunet, W.1    Kwon, B.K.2    Tetzlaff, W.3
  • 101
    • 67650497872 scopus 로고    scopus 로고
    • Damage control in the nervous system: beware the immune system in spinal cord injury
    • Popovich P., McTigue D. Damage control in the nervous system: beware the immune system in spinal cord injury. Nat. Med. 2009, 15:736-737.
    • (2009) Nat. Med. , vol.15 , pp. 736-737
    • Popovich, P.1    McTigue, D.2
  • 102
    • 14044250276 scopus 로고    scopus 로고
    • Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation
    • Qiu J., Cafferty W.B., McMahon S.B., Thompson S.W. Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation. J. Neurosci. 2005, 25:1645-1653.
    • (2005) J. Neurosci. , vol.25 , pp. 1645-1653
    • Qiu, J.1    Cafferty, W.B.2    McMahon, S.B.3    Thompson, S.W.4
  • 104
    • 0015937791 scopus 로고
    • A quantitative investigation of the development of collateral reinnervation after partial deafferentation of the septal nuclei
    • Raisman G., Field P.M. A quantitative investigation of the development of collateral reinnervation after partial deafferentation of the septal nuclei. Brain Res. 1973, 50:241-264.
    • (1973) Brain Res. , vol.50 , pp. 241-264
    • Raisman, G.1    Field, P.M.2
  • 105
    • 0033757632 scopus 로고    scopus 로고
    • Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia
    • Ramon-Cueto A., Cordero M.I., Santos-Benito F.F., Avila J. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron 2000, 25:425-435.
    • (2000) Neuron , vol.25 , pp. 425-435
    • Ramon-Cueto, A.1    Cordero, M.I.2    Santos-Benito, F.F.3    Avila, J.4
  • 106
    • 0028108704 scopus 로고
    • Regeneration into the spinal cord of transected dorsal root axons is promoted by ensheathing glia transplants
    • Ramon-Cueto A., Nieto-Sampedro M. Regeneration into the spinal cord of transected dorsal root axons is promoted by ensheathing glia transplants. Exp. Neurol. 1994, 127:232-244.
    • (1994) Exp. Neurol. , vol.127 , pp. 232-244
    • Ramon-Cueto, A.1    Nieto-Sampedro, M.2
  • 107
    • 0018908523 scopus 로고
    • Axons from CNS neurons regenerate into PNS grafts
    • Richardson P.M., McGuinness U.M., Aguayo A.J. Axons from CNS neurons regenerate into PNS grafts. Nature 1980, 284:264-265.
    • (1980) Nature , vol.284 , pp. 264-265
    • Richardson, P.M.1    McGuinness, U.M.2    Aguayo, A.J.3
  • 108
    • 38649092415 scopus 로고    scopus 로고
    • Olfactory ensheathing cell transplantation following spinal cord injury: hype or hope?
    • Richter M.W., Roskams A.J. Olfactory ensheathing cell transplantation following spinal cord injury: hype or hope?. Exp. Neurol. 2008, 209:353-367.
    • (2008) Exp. Neurol. , vol.209 , pp. 353-367
    • Richter, M.W.1    Roskams, A.J.2
  • 109
    • 0035503328 scopus 로고    scopus 로고
    • Functional regeneration of chronically injured sensory afferents into adult spinal cord after neurotrophin gene therapy
    • Romero M.I., Rangappa N., Garry M.G., Smith G.M. Functional regeneration of chronically injured sensory afferents into adult spinal cord after neurotrophin gene therapy. J. Neurosci. 2001, 21:8408-8416.
    • (2001) J. Neurosci. , vol.21 , pp. 8408-8416
    • Romero, M.I.1    Rangappa, N.2    Garry, M.G.3    Smith, G.M.4
  • 110
    • 12144288408 scopus 로고    scopus 로고
    • Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury
    • Ruitenberg M.J., Blits B., Dijkhuizen P.A., te Beek E.T., Bakker A., van Heerikhuize J.J., Pool C.W., Hermens W.T., Boer G.J., Verhaagen J. Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury. Neurobiol. Dis. 2004, 15:394-406.
    • (2004) Neurobiol. Dis. , vol.15 , pp. 394-406
    • Ruitenberg, M.J.1    Blits, B.2    Dijkhuizen, P.A.3    te Beek, E.T.4    Bakker, A.5    van Heerikhuize, J.J.6    Pool, C.W.7    Hermens, W.T.8    Boer, G.J.9    Verhaagen, J.10
  • 111
    • 16844384738 scopus 로고    scopus 로고
    • NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration
    • Ruitenberg M.J., Levison D.B., Lee S.V., Verhaagen J., Harvey A.R., Plant G.W. NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration. Brain 2005, 128:839-853.
    • (2005) Brain , vol.128 , pp. 839-853
    • Ruitenberg, M.J.1    Levison, D.B.2    Lee, S.V.3    Verhaagen, J.4    Harvey, A.R.5    Plant, G.W.6
  • 112
    • 0043127466 scopus 로고    scopus 로고
    • Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: effects on rubrospinal tract regeneration, lesion size, and functional recovery after implantation in the injured rat spinal cord
    • Ruitenberg M.J., Plant G.W., Hamers F.P., Wortel J., Blits B., Dijkhuizen P.A., Gispen W.H., Boer G.J., Verhaagen J. Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: effects on rubrospinal tract regeneration, lesion size, and functional recovery after implantation in the injured rat spinal cord. J. Neurosci. 2003, 23:7045-7058.
    • (2003) J. Neurosci. , vol.23 , pp. 7045-7058
    • Ruitenberg, M.J.1    Plant, G.W.2    Hamers, F.P.3    Wortel, J.4    Blits, B.5    Dijkhuizen, P.A.6    Gispen, W.H.7    Boer, G.J.8    Verhaagen, J.9
  • 113
    • 0028115777 scopus 로고
    • Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion
    • Schnell L., Schneider R., Kolbeck R., Barde Y.A., Schwab M.E. Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature 1994, 367:170-173.
    • (1994) Nature , vol.367 , pp. 170-173
    • Schnell, L.1    Schneider, R.2    Kolbeck, R.3    Barde, Y.A.4    Schwab, M.E.5
  • 114
    • 33745001188 scopus 로고    scopus 로고
    • The transcription factor ATF-3 promotes neurite outgrowth
    • Seijffers R., Allchorne A.J., Woolf C.J. The transcription factor ATF-3 promotes neurite outgrowth. Mol. Cell. Neurosci. 2006, 32:143-154.
    • (2006) Mol. Cell. Neurosci. , vol.32 , pp. 143-154
    • Seijffers, R.1    Allchorne, A.J.2    Woolf, C.J.3
  • 115
    • 34547484768 scopus 로고    scopus 로고
    • ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration
    • Seijffers R., Mills C.D., Woolf C.J. ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration. J. Neurosci. 2007, 27:7911-7920.
    • (2007) J. Neurosci. , vol.27 , pp. 7911-7920
    • Seijffers, R.1    Mills, C.D.2    Woolf, C.J.3
  • 116
    • 0742288565 scopus 로고    scopus 로고
    • Regeneration beyond the glial scar
    • Silver J., Miller J.H. Regeneration beyond the glial scar. Nat. Rev. Neurosci. 2004, 5:146-156.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 146-156
    • Silver, J.1    Miller, J.H.2
  • 117
    • 0031029782 scopus 로고    scopus 로고
    • A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth
    • Smith D.S., Skene J.H. A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth. J. Neurosci. 1997, 17:646-658.
    • (1997) J. Neurosci. , vol.17 , pp. 646-658
    • Smith, D.S.1    Skene, J.H.2
  • 119
    • 0026719173 scopus 로고
    • Fetal grafts alter chronic behavioral outcome after contusion damage to the adult rat spinal cord
    • Stokes B.T., Reier P.J. Fetal grafts alter chronic behavioral outcome after contusion damage to the adult rat spinal cord. Exp. Neurol. 1992, 116:1-12.
    • (1992) Exp. Neurol. , vol.116 , pp. 1-12
    • Stokes, B.T.1    Reier, P.J.2
  • 122
    • 34249828947 scopus 로고    scopus 로고
    • Targeting sensory axon regeneration in adult spinal cord
    • Tang X.Q., Heron P., Mashburn C., Smith G.M. Targeting sensory axon regeneration in adult spinal cord. J. Neurosci. 2007, 27:6068-6078.
    • (2007) J. Neurosci. , vol.27 , pp. 6068-6078
    • Tang, X.Q.1    Heron, P.2    Mashburn, C.3    Smith, G.M.4
  • 123
    • 0742287916 scopus 로고    scopus 로고
    • Semaphorin3A inhibits nerve growth factor-induced sprouting of nociceptive afferents in adult rat spinal cord
    • Tang X.Q., Tanelian D.L., Smith G.M. Semaphorin3A inhibits nerve growth factor-induced sprouting of nociceptive afferents in adult rat spinal cord. J. Neurosci. 2004, 24:819-827.
    • (2004) J. Neurosci. , vol.24 , pp. 819-827
    • Tang, X.Q.1    Tanelian, D.L.2    Smith, G.M.3
  • 124
    • 33748887028 scopus 로고    scopus 로고
    • Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord
    • Taylor L., Jones L., Tuszynski M.H., Blesch A. Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord. J. Neurosci. 2006, 26:9713-9721.
    • (2006) J. Neurosci. , vol.26 , pp. 9713-9721
    • Taylor, L.1    Jones, L.2    Tuszynski, M.H.3    Blesch, A.4
  • 126
    • 0029959555 scopus 로고    scopus 로고
    • The molecular biology of axon guidance
    • Tessier-Lavigne M., Goodman C.S. The molecular biology of axon guidance. Science 1996, 274:1123-1133.
    • (1996) Science , vol.274 , pp. 1123-1133
    • Tessier-Lavigne, M.1    Goodman, C.S.2
  • 127
    • 0025977479 scopus 로고
    • Intraspinal transplants
    • Tessler A. Intraspinal transplants. Ann. Neurol. 1991, 29:115-123.
    • (1991) Ann. Neurol. , vol.29 , pp. 115-123
    • Tessler, A.1
  • 128
    • 0030635613 scopus 로고    scopus 로고
    • Embryonic spinal cord transplants enhance locomotor performance in spinalized newborn rats
    • Tessler A., Fischer I., Giszter S., Himes B.T., Miya D., Mori F., Murray M. Embryonic spinal cord transplants enhance locomotor performance in spinalized newborn rats. Adv. Neurol. 1997, 72:291-303.
    • (1997) Adv. Neurol. , vol.72 , pp. 291-303
    • Tessler, A.1    Fischer, I.2    Giszter, S.3    Himes, B.T.4    Miya, D.5    Mori, F.6    Murray, M.7
  • 129
    • 0345227300 scopus 로고    scopus 로고
    • Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration
    • Tobias C.A., Shumsky J.S., Shibata M., Tuszynski M.H., Fischer I., Tessler A., Murray M. Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration. Exp. Neurol. 2003, 184:97-113.
    • (2003) Exp. Neurol. , vol.184 , pp. 97-113
    • Tobias, C.A.1    Shumsky, J.S.2    Shibata, M.3    Tuszynski, M.H.4    Fischer, I.5    Tessler, A.6    Murray, M.7
  • 130
    • 74349088517 scopus 로고    scopus 로고
    • Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6
    • Towne C., Schneider B.L., Kieran D., Redmond D.E., Aebischer P. Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6. Gene Ther. 2010, 17:141-146.
    • (2010) Gene Ther. , vol.17 , pp. 141-146
    • Towne, C.1    Schneider, B.L.2    Kieran, D.3    Redmond, D.E.4    Aebischer, P.5
  • 131
    • 0035152814 scopus 로고    scopus 로고
    • Neurotrophins are required for nerve growth during development
    • Tucker K.L., Meyer M., Barde Y.A. Neurotrophins are required for nerve growth during development. Nat. Neurosci. 2001, 4:29-37.
    • (2001) Nat. Neurosci. , vol.4 , pp. 29-37
    • Tucker, K.L.1    Meyer, M.2    Barde, Y.A.3
  • 132
    • 0030054303 scopus 로고    scopus 로고
    • Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury
    • Tuszynski M.H., Gabriel K., Gage F.H., Suhr S., Meyer S., Rosetti A. Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury. Exp. Neurol. 1996, 137:157-173.
    • (1996) Exp. Neurol. , vol.137 , pp. 157-173
    • Tuszynski, M.H.1    Gabriel, K.2    Gage, F.H.3    Suhr, S.4    Meyer, S.5    Rosetti, A.6
  • 133
    • 0037403572 scopus 로고    scopus 로고
    • NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection
    • Tuszynski M.H., Grill R., Jones L.L., Brant A., Blesch A., Low K., Lacroix S., Lu P. NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection. Exp. Neurol. 2003, 181:47-56.
    • (2003) Exp. Neurol. , vol.181 , pp. 47-56
    • Tuszynski, M.H.1    Grill, R.2    Jones, L.L.3    Brant, A.4    Blesch, A.5    Low, K.6    Lacroix, S.7    Lu, P.8
  • 134
    • 84882458528 scopus 로고    scopus 로고
    • Axonal plasticity and regeneraton in the injured spinal cord
    • Academic Press, London, J.H. Kordower, M.H. Tuszynski (Eds.)
    • Tuszynski M.H., Lu P. Axonal plasticity and regeneraton in the injured spinal cord. CNS regeneration: basic science and clinical advances 2008, 319-337. Academic Press, London. J.H. Kordower, M.H. Tuszynski (Eds.).
    • (2008) CNS regeneration: basic science and clinical advances , pp. 319-337
    • Tuszynski, M.H.1    Lu, P.2
  • 135
    • 0028218083 scopus 로고
    • Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord
    • Tuszynski M.H., Peterson D.A., Ray J., Baird A., Nakahara Y., Gage F.H. Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Exp. Neurol. 1994, 126:1-14.
    • (1994) Exp. Neurol. , vol.126 , pp. 1-14
    • Tuszynski, M.H.1    Peterson, D.A.2    Ray, J.3    Baird, A.4    Nakahara, Y.5    Gage, F.H.6
  • 137
    • 0031919140 scopus 로고    scopus 로고
    • Grafts of genetically modified Schwann cells to the spinal cord: survival, axon growth, and myelination
    • Tuszynski M.H., Weidner N., McCormack M., Miller I., Powell H., Conner J. Grafts of genetically modified Schwann cells to the spinal cord: survival, axon growth, and myelination. Cell Transplant. 1998, 7:187-196.
    • (1998) Cell Transplant. , vol.7 , pp. 187-196
    • Tuszynski, M.H.1    Weidner, N.2    McCormack, M.3    Miller, I.4    Powell, H.5    Conner, J.6
  • 138
    • 33745112188 scopus 로고    scopus 로고
    • BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats
    • Vavrek R., Girgis J., Tetzlaff W., Hiebert G.W., Fouad K. BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats. Brain 2006, 129:1534-1545.
    • (2006) Brain , vol.129 , pp. 1534-1545
    • Vavrek, R.1    Girgis, J.2    Tetzlaff, W.3    Hiebert, G.W.4    Fouad, K.5
  • 139
    • 0025968252 scopus 로고
    • Plasticity of spinal systems after unilateral lumbosacral dorsal rhizotomy in the adult rat
    • Wang S.D., Goldberger M.E., Murray M. Plasticity of spinal systems after unilateral lumbosacral dorsal rhizotomy in the adult rat. J. Comp. Neurol. 1991, 304:555-568.
    • (1991) J. Comp. Neurol. , vol.304 , pp. 555-568
    • Wang, S.D.1    Goldberger, M.E.2    Murray, M.3
  • 140
    • 0033232045 scopus 로고    scopus 로고
    • Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1
    • Weidner N., Blesch A., Grill R.J., Tuszynski M.H. Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1. J. Comp. Neurol. 1999, 413:495-506.
    • (1999) J. Comp. Neurol. , vol.413 , pp. 495-506
    • Weidner, N.1    Blesch, A.2    Grill, R.J.3    Tuszynski, M.H.4
  • 141
    • 0035853114 scopus 로고    scopus 로고
    • Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury
    • Weidner N., Ner A., Salimi N., Tuszynski M.H. Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc. Natl Acad. Sci. USA 2001, 98:3513-3518.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 3513-3518
    • Weidner, N.1    Ner, A.2    Salimi, N.3    Tuszynski, M.H.4
  • 142
    • 0035873540 scopus 로고    scopus 로고
    • Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid
    • Widenfalk J., Lundströmer K., Jubran M., Brene S., Olson L. Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid. J. Neurosci. 2001, 21:3457-3475.
    • (2001) J. Neurosci. , vol.21 , pp. 3457-3475
    • Widenfalk, J.1    Lundströmer, K.2    Jubran, M.3    Brene, S.4    Olson, L.5
  • 146
    • 33746874152 scopus 로고    scopus 로고
    • Adeno-associated virus serotypes: vector toolkit for human gene therapy
    • Wu Z., Asokan A., Samulski R.J. Adeno-associated virus serotypes: vector toolkit for human gene therapy. Mol. Ther. 2006, 14:316-327.
    • (2006) Mol. Ther. , vol.14 , pp. 316-327
    • Wu, Z.1    Asokan, A.2    Samulski, R.J.3
  • 148
    • 38649122410 scopus 로고    scopus 로고
    • White matter inhibitors in CNS axon regeneration failure
    • Xie F., Zheng B. White matter inhibitors in CNS axon regeneration failure. Exp. Neurol. 2008, 209:302-312.
    • (2008) Exp. Neurol. , vol.209 , pp. 302-312
    • Xie, F.1    Zheng, B.2
  • 149
    • 0030989043 scopus 로고    scopus 로고
    • Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord
    • Xu X.M., Chen A., Guenard V., Kleitman N., Bunge M.B. Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord. J. Neurocytol. 1997, 26:1-16.
    • (1997) J. Neurocytol. , vol.26 , pp. 1-16
    • Xu, X.M.1    Chen, A.2    Guenard, V.3    Kleitman, N.4    Bunge, M.B.5
  • 150
    • 0028874907 scopus 로고
    • A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord
    • Xu X.M., Guenard V., Kleitman N., Aebischer P., Bunge M.B. A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord. Exp. Neurol. 1995, 134:261-272.
    • (1995) Exp. Neurol. , vol.134 , pp. 261-272
    • Xu, X.M.1    Guenard, V.2    Kleitman, N.3    Aebischer, P.4    Bunge, M.B.5
  • 151
    • 0028870347 scopus 로고
    • Axonal regeneration into Schwann cell-seeded guidance channels grafted into transected adult rat spinal cord
    • Xu X.M., Guenard V., Kleitman N., Bunge M.B. Axonal regeneration into Schwann cell-seeded guidance channels grafted into transected adult rat spinal cord. J. Comp. Neurol. 1994, 351:145-160.
    • (1994) J. Comp. Neurol. , vol.351 , pp. 145-160
    • Xu, X.M.1    Guenard, V.2    Kleitman, N.3    Bunge, M.B.4
  • 152
    • 0031013730 scopus 로고    scopus 로고
    • Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons
    • Ye J.H., Houle J.D. Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons. Exp. Neurol. 1997, 143:70-81.
    • (1997) Exp. Neurol. , vol.143 , pp. 70-81
    • Ye, J.H.1    Houle, J.D.2
  • 153
    • 33750213134 scopus 로고    scopus 로고
    • Lentiviral vector expressing retinoic acid receptor beta2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord
    • Yip P.K., Wong L.F., Pattinson D., Battaglia A., Grist J., Bradbury E.J., Maden M., McMahon S.B., Mazarakis N.D. Lentiviral vector expressing retinoic acid receptor beta2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord. Hum. Mol. Genet. 2006, 15:3107-3118.
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 3107-3118
    • Yip, P.K.1    Wong, L.F.2    Pattinson, D.3    Battaglia, A.4    Grist, J.5    Bradbury, E.J.6    Maden, M.7    McMahon, S.B.8    Mazarakis, N.D.9
  • 154
    • 77954733569 scopus 로고    scopus 로고
    • Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat
    • Yip P.K., Wong L.F., Sears T.A., Yanez-Munoz R.J., McMahon S.B. Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat. PLoS Biol. 2010, 8:e1000399.
    • (2010) PLoS Biol. , vol.8
    • Yip, P.K.1    Wong, L.F.2    Sears, T.A.3    Yanez-Munoz, R.J.4    McMahon, S.B.5
  • 155
    • 0034281370 scopus 로고    scopus 로고
    • Compensatory sprouting and impulse rerouting after unilateral pyramidal tract lesion in neonatal rats
    • Z'Graggen W.J., Fouad K., Raineteau O., Metz G.A., Schwab M.E., Kartje G.L. Compensatory sprouting and impulse rerouting after unilateral pyramidal tract lesion in neonatal rats. J. Neurosci. 2000, 20:6561-6569.
    • (2000) J. Neurosci. , vol.20 , pp. 6561-6569
    • Z'Graggen, W.J.1    Fouad, K.2    Raineteau, O.3    Metz, G.A.4    Schwab, M.E.5    Kartje, G.L.6
  • 156
    • 34548731859 scopus 로고    scopus 로고
    • Lentiviral-mediated expression of polysialic acid in spinal cord and conditioning lesion promote regeneration of sensory axons into spinal cord
    • Zhang Y., Zhang X., Wu D., Verhaagen J., Richardson P.M., Yeh J., Bo X. Lentiviral-mediated expression of polysialic acid in spinal cord and conditioning lesion promote regeneration of sensory axons into spinal cord. Mol. Ther. 2007, 15:1796-1804.
    • (2007) Mol. Ther. , vol.15 , pp. 1796-1804
    • Zhang, Y.1    Zhang, X.2    Wu, D.3    Verhaagen, J.4    Richardson, P.M.5    Yeh, J.6    Bo, X.7
  • 158
    • 0037442795 scopus 로고    scopus 로고
    • Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord
    • Zhou L., Baumgartner B.J., Hill-Felberg S.J., McGowen L.R., Shine H.D. Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord. J. Neurosci. 2003, 23:1424-1431.
    • (2003) J. Neurosci. , vol.23 , pp. 1424-1431
    • Zhou, L.1    Baumgartner, B.J.2    Hill-Felberg, S.J.3    McGowen, L.R.4    Shine, H.D.5
  • 159
    • 38349065415 scopus 로고    scopus 로고
    • Targeting axon growth from neuronal transplants along preformed guidance pathways in the adult CNS
    • Ziemba K.S., Chaudhry N., Rabchevsky A.G., Jin Y., Smith G.M. Targeting axon growth from neuronal transplants along preformed guidance pathways in the adult CNS. J. Neurosci. 2008, 28:340-348.
    • (2008) J. Neurosci. , vol.28 , pp. 340-348
    • Ziemba, K.S.1    Chaudhry, N.2    Rabchevsky, A.G.3    Jin, Y.4    Smith, G.M.5


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