Promoting directional axon growth from neural progenitors grafted into the injured spinal cord

Journal of Neuroscience Research

Volumn 88, Issue 6, 2010, Pages 1182-1192

  Bonner, Joseph F ^a   Blesch, Armin ^b   Neuhuber, Birgit ^a   Fischer, Itzhak ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Brain derived neurotrophic factor; Cell transplantation; Dorsal columns; Neural stem cells; Neurotrophin gradients

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ALKALINE PHOSPHATASE; BRAIN DERIVED NEUROTROPHIC FACTOR; LENTIVIRUS VECTOR; NEUROTROPHIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL TRANSPLANTATION; CONTROLLED STUDY; FEMALE; IMMUNOHISTOCHEMISTRY; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; NERVE FIBER GROWTH; NEURAL STEM CELL; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; SPINAL GANGLION; SPINE;

AGING; ANIMALS; AXONS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL ENLARGEMENT; FEMALE; GAMMA-AMINOBUTYRIC ACID; GENETIC VECTORS; GLUTAMIC ACID; LENTIVIRUS; NERVE REGENERATION; NEUROGLIA; NEURONS; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 77951565691     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22288     Document Type: Article

References (39)

1. Belegu V, Oudega M, Gary DS, McDonald JW. 2007. Restoring function after spinal cord injury: promoting spontaneous regeneration with stem cells and activity-based therapies. Neurosurg Clin North Am 18:143-168, xi.
2. Blesch A. 2004. Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer. Methods 33:164-172. (Pubitemid 38569661)
3. Bolsover S, Fabes J, Anderson PN. 2008. Axonal guidance molecules and the failure of axonal regeneration in the adult mammalian spinal cord. Restor Neurol Neurosci 26:117-130.
4. Charron F, Tessier-Lavigne M. 2005. Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance. Development 132:2251-2262. (Pubitemid 40872796)
5. Darian-Smith C. 2009. Synaptic plasticity, neurogenesis, and functional recovery after spinal cord injury. Neuroscientist 15:149-165.
6. Davies SJ, Goucher DR, Doller C, Silver J. 1999. Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci 19:5810-5822. (Pubitemid 29327918)
7. Eaton MJ, Pearse DD, McBroom JS, Berrocal YA. 2008. The combination of human neuronal serotonergic cell implants and environmental enrichment after contusive SCI improves motor recovery over each individual strategy. Behav Brain Res 194:236-241.
8. Gallo G, Letourneau PC. 2004. Regulation of growth cone actin filaments by guidance cues. J Neurobiol 58:92-102. (Pubitemid 37543341)
9. Han SS, Kang DY, Mujtaba T, Rao MS, Fischer I. 2002. Grafted lineage-restricted precursors differentiate exclusively into neurons in the adult spinal cord. Exp Neurol 177:360-375. (Pubitemid 35366126)
10. Han SS, Liu Y, Tyler-Polsz C, Rao MS, Fischer I. 2004. Transplantation of glial-restricted precursor cells into the adult spinal cord: survival, glial-specific differentiation, and preferential migration in white matter. Glia 45:1-16. (Pubitemid 38076223)
11. Harper JM, Krishnan C, Darman JS, Deshpande DM, Peck S, Shats I, Backovic S, Rothstein JD, Kerr DA. 2004. Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuroninjured adult rats. Proc Natl Acad Sci U S A 101:7123-7128. (Pubitemid 38596453)
12. Himes BT, Liu Y, Solowska JM, Snyder EY, Fischer I, Tessler A. 2001. Transplants of cells genetically modified to express neurotrophin-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats. J Neurosci Res 65:549-564. (Pubitemid 32847148)
13. Jin Y, Ziemba KS, Smith GM. 2008. Axon growth across a lesion site along a preformed guidance pathway in the brain. Exp Neurol 210: 521-530.
14. Jones LL, Tuszynski MH. 2001. Chronic intrathecal infusions after spinal cord injury cause scarring and compression. Microsc Res Techniq 54:317-324.
15. Kalyani AJ, Piper D, Mujtaba T, Lucero MT, Rao MS. 1998. Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. J Neurosci 18:7856-7868. (Pubitemid 28441025)
16. Kamei N, Tanaka N, Oishi Y, Hamasaki T, Nakanishi K, Sakai N, Ochi M. 2007. BDNF, NT-3, and NGF released from transplanted neural progenitor cells promote corticospinal axon growth in organotypic co-cultures. Spine 32:1272-1278. (Pubitemid 46791444)
17. Kishino A, Katayama N, Ishige Y, Yamamoto Y, Ogo H, Tatsuno T, Mine T, Noguchi H, Nakayama C. 2001. Analysis of effects and pharmacokinetics of subcutaneously administered BDNF. Neuroreport 12:1067-1072. (Pubitemid 32281476)
18. Kwon BK, Liu J, Lam C, Plunet W, Oschipok LW, Hauswirth W, Di Polo A, Blesch A, Tetzlaff W. 2007. Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury. Spine 32:1164-1173. (Pubitemid 46743016)
19. Lepore AC, Fischer I. 2005. Lineage-restricted neural precursors survive, migrate, and differentiate following transplantation into the injured adult spinal cord. Exp Neurol 194:230-242. (Pubitemid 40719758)
20. Lepore AC, Han SS, Tyler-Polsz CJ, Cai J, Rao MS, Fischer I. 2004. Differential fate of multipotent and lineage-restricted neural precursors following transplantation into the adult CNS. Neuron Glia Biol 1:113-126.
21. Lepore AC, Neuhuber B, Connors TM, Han SS, Liu Y, Daniels MP, Rao MS, Fischer I. 2006. Long-term fate of neural precursor cells following transplantation into developing and adult CNS. Neuroscience 142:287-304.
22. Lu P, Tuszynski MH. 2008. Growth factors and combinatorial therapies for CNS regeneration. Exp Neurol 209:313-320. (Pubitemid 351174138)
23. Mai J, Fok L, Gao H, Zhang X, Poo MM. 2009. Axon initiation and growth cone turning on bound protein gradients. J Neurosci 29:7450-7458.
24. Mayer-Proschel M, Kalyani AJ, Mujtaba T, Rao MS. 1997. Isolation of lineage-restricted neuronal precursors from multipotent neuroepithelial stem cells. Neuron 19:773-785. (Pubitemid 27471383)
25. Ming G, Song H, Berninger B, Inagaki N, Tessier-Lavigne M, Poo M. 1999. Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Neuron 23:139-148. (Pubitemid 29262471)
26. Panter SS, Yum SW, Faden AI. 1990. Alteration in extracellular amino acids after traumatic spinal cord injury. Ann Neurol 27:96-99. (Pubitemid 20031364)
27. Paves H, Saarma M. 1997. Neurotrophins as in vitro growth cone guidance molecules for embryonic sensory neurons. Cell Tissue Res 290:285-297. (Pubitemid 27470061)
28. Piantino J, Burdick JA, Goldberg D, Langer R, Benowitz LI. 2006. An injectable, biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injury. Exp Neurol 201:359-367. (Pubitemid 44344229)
29. Pineau I, Lacroix S. 2007. Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved. J Comp Neurol 500:267-285. (Pubitemid 44937122)
30. Ramer MS, Priestley JV, McMahon SB. 2000. Functional regeneration of sensory axons into the adult spinal cord. Nature 403:312-316.
31. Ruediger T, Bolz J. 2007. Neurotransmitters and the development of neuronal circuits. Adv Exp Med Biol 621:104-115.
32. Taylor L, Jones L, Tuszynski MH, Blesch A. 2006. Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord. J Neurosci 26:9713-9721. (Pubitemid 44427710)
33. Tripathi RB, McTigue DM. 2008. Chronically increased ciliary neurotrophic factor and fibroblast growth factor-2 expression after spinal contusion in rats. J Comp Neurol 510:129-144.
34. Tuszynski MH, Grill R, Jones LL, Brant A, Blesch A, Low K, Lacroix S, Lu P. 2003. NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection. Exp Neurol 181:47-56. (Pubitemid 36438675)
35. Wang L, Hu B, Wong WM, Lu P, Wu W, Xu XM. 2008. Glial and axonal responses in areas of Wallerian degeneration of the corticospinal and dorsal ascending tracts after spinal cord dorsal funiculotomy. Neuropathology (in press).
36. Wright DE, White FA, Gerfen RW, Silos-Santiago I, Snider WD. 1995. The guidance molecule semaphorin III is expressed in regions of spinal cord and periphery avoided by growing sensory axons. J Comp Neurol 361:321-333.
37. Yang H, Mujtaba T, Venkatraman G, Wu YY, Rao MS, Luskin MB. 2000. Region-specific differentiation of neural tube-derived neuronal restricted progenitor cells after heterotopic transplantation. Proc Natl Acad Sci U S A 97:13366-13371.
38. 2+-dependent growth cone guidance. Nat Neurosci 9:1265-1273.
39. Ziemba KS, Chaudhry N, Rabchevsky AG, Jin Y, Smith GM. 2008. Targeting axon growth from neuronal transplants along preformed guidance pathways in the adult CNS. J Neurosci 28:340-348.