Molecular regulation of the chondrocyte phenotype

Journal of Musculoskeletal Neuronal Interactions

Volumn 2, Issue 6, 2002, Pages 517-520

  Goldring, M B ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Cartilage; Collagen; Cytokines; Gene regulation; Osteoarthritis

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AGGRECAN; COLLAGEN TYPE 1; COLLAGEN TYPE 10; COLLAGEN TYPE 11; COLLAGEN TYPE 2; COLLAGEN TYPE 3; COLLAGEN TYPE 4; COLLAGEN TYPE 9; COLLAGENASE; COLLAGENASE 3; CYCLOOXYGENASE 2; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 1BETA; MATRIX PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN E2; PROTEINASE; SERUM RESPONSE FACTOR; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CARTILAGE MATRIX; CELL PROLIFERATION; CHONDROGENESIS; EXTRACELLULAR MATRIX; GENE CONTROL; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MESENCHYME CELL; MONONUCLEAR CELL; OSSIFICATION; OSTEOARTHRITIS; PHENOTYPE; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIUM; TRANSCRIPTION INITIATION;

EID: 0036976214     PISSN: 11087161     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (55)

1. Goldring MB. The role of the chondrocyte in osteoarthritis. Arthritis Rheum 2000; 4:1916-1926.
2. Sandell LJ, Aigner T. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res 2001; 3:107-113.
3. Dinarello CA, Moldawer LL (eds). Proinflammatory and antiinflammatory cytokines in rheumatoid arthritis: A primer for clinicians. 2nd Edition. Amgen, Inc., Thousand Oaks, CA; 2000.
4. Goldring MB. The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connec Tiss Res 1999; 40:1-11.
5. Tetlow LC, Adlam DJ, Woolley DE. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage. Arthritis Rheum 2001; 44:585-594.
6. Tyler JA. Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules. Biochem J 1985; 227:869-878.
7. Tyler JA, Benton HP. Synthesis of type II collagen is decreased in cartilage cultured with interleukin 1 while the rate of intracellular degradation remains unchanged. Coll Relat Res 1988; 8:393-405.
8. Goldring MB, Birkhead J, Sandell LJ, Kimura T, Krane SM. Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. J Clin Invest 1988; 82:2026-2037.
9. van den Berg WB. Arguments for interleukin 1 as a target in chronic arthritis. Ann Rheum Dis 2000; 59(Suppl. 1):i81-84.
10. Goldring MB, Krane SM. Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells. J Biol Chem 1987; 262:16724-16729.
11. Riquet RB, Lai W-FT, Birkhead JR, Suen L-F, Karsenty G, Goldring MB. Suppression of type I collagen gene expression by prostaglandins in fibroblasts is mediated at the transcriptional level. Molec Med 2000; 6:705-719.
12. Goldring MB, Fukuo K, Birkhead JR, Dudek E, Sandell LJ. Transcriptional suppression by interleukin-1 and interferon-γ of type II collagen gene expression in human chondrocytes. J Cell Biochem 1994; 54:85-99.
13. Thomas B, Thirion S, Humbert L, Tan L, Goldring MB, Béréziat G, Berenbaum F. Differentiation regulates interleukin-1β-induced cyclo-oxygenase-2 in human articular chondrocytes: role of p38 mitogen-activated kinase. Biochem J 2002; 362:367-373.
14. Bordji K, Grillasca JP, Gouze JN, Magdalou J, Schohn H, Keller JM, Bianchi A, Dauca M, Netter P, Terlain B. Evidence for the presence of peroxisome proliferator-activated receptor (PPAR) α and γ and retinoid Z receptor in cartilage. PPARγ activation modulates the effects of interleukin-1β on rat chondrocytes. J Biol Chem 2000, 275:12243-12250.
15. Saklatvala J, Dean J, Finch A. Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor. Biochem Soc Symp 1999; 64:63-77.
16. Geng Y, Valbracht J, Lotz M. Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes. J Clin Invest 1996; 98:2425-2430.
17. Badger AM, Cook MN, Lark MW, Newman-Tarr TM, Swift BA, Nelson AH, Barone FC, Kumar S. SB203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes. J Immunol 1998; 161:467-473.
18. Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor κB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 2000; 43:801-811.
19. Robbins JR, Thomas B, Tan L, Choy B, Arbiser JL, Berenbaum F, Goldring MB. Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1β. Arthritis Rheum 2000; 43:2189-2201.
20. Goldring MB, Birkhead JR, Suen L-F, Yamin R, Mizuno S, Glowacki J, Arbiser JL, Apperley JF. Interleukin-1β-modulated gene expression in immortalized human chondrocytes. J Clin Invest 1994; 94:2307-2316.
21. Reginato AM, Sanz-Rodriguez C, Diaz A, Dharmavaram RM, Jimenez SA. Transcriptional modulation of cartilage-specific collagen gene expression by interferon γ and tumour necrosis factor α in cultured human chondrocytes. Biochem J 1993; 294:761-769.
22. Goldring MB, Sandell LJ, Stephenson ML, Krane SM. Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes. J Biol Chem 1986; 261:9049-9056.
23. Osaki M, Tan L, Choy BK, Yoshida Y, Auron PE, Cheah KSE, Goldring MB. The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-γ-mediated inhibition in human chondrocytes: requirement for Stat1α, Jak1, and Jak2. Biochem J 2002; 10:1042/BJ20020928.
24. Thomas B, Berenbaum F, Humbert L, Bian H, Béréziat G, Crofford L, Olivier JL. Critical role of C/EBPβ and C/EBPβ factors in the stimulation of cyclooxygenase-2 gene transcription by interleukin-1β in articular chondrocytes. Eur J Biochem 2000, 267:1-13.
25. Greenwel P, Tanaka S, Penkov D, Zhang W, Olive M, Moll J, Vinson C, Di Liberto M, Ramirez F. Tumor necrosis factor α inhibits type I collagen synthesis through repressive CCAAT/enhancer-binding proteins. Mol Cell Biol 2000; 20:912-918.
26. Okazaki K, Li J, Yu H, Fukui N, Sandell LJ. CCAAT/Enhancer-binding proteins β and δ mediate the repression of gene transcription of cartilage-derived retinoic acid-sensitive protein induced by interleukin-1β. J Biol Chem 2002; 277:31526-31533.
27. Ryan MC, Sieraski M, Sandell LJ. The human type II procollagen gene: Identification of an additional protein-coding domain and location of potential regulatory sequences in the promoter and first intron. Genomics 1990; 8:41-48.
28. Sandell LJ, Morris N, Robbins JR, Goldring MB. Alternatively spliced type II procollagen mRNAs define a distinct population of cells during vertebral development: differential expression of the amino-propeptide. J Cell Biol 1991; 114:1307-1319.
29. Sandell LJ, Goldring MB, Zamparo O, Wu J, Yamin R. Molecular, biology of type II collagen. New information in the gene. Kuettner K, Schleyerback R, Peyron JG, Hascall VC (eds) Articular cartilage and osteoarthritis. Raven Press, New York 1992:81-94.
30. Dharmavaram RM, Liu G, Mowers SD, Jimenez SA. Detection and characterization of Sp1 binding activity in human chondrocytes and its alterations during chondrocyte dedifferentiation. J Biol Chem 1997; 272:26918-26925.
31. Ghayor C, Chadjichristos C, Herrouin J-F, Ala-Kokko L, Suske G, Pujol J-P, Galéra P. Sp3 represses the Sp1-mediated transactivation of the human COL2A1 gene in primary and de-differentiated chondrocytes. J Biol Chem 2001; 276:36881-36895.
32. Murray D, Precht P, Balakir R, Horton WEJ. The transcription factor δEF1 is inversely expressed with type II collagen mRNA and can repress Col2a1 promoter activity in transfected chondrocytes. J Biol Chem 2001; 275:3610-3618.
33. Ghayor C, Herrouin J-F, Chadjichristos C, Ala-Kokko L, Takigawa M, Pujol J-P, Galéra P. Regulation of human COL2A1 gene expression in chondrocytes. Identification of C-Krox-responsive elements and modulation by phenotype alteration. J Biol Chem 2000; 275:27421-27438.
34. Lefebvre V, de Crombrugghe B. Toward understanding SOX9 function in chondrocyte differentiation. Matrix Biol 1998; 16:529-540.
35. Murakami S, Lefebvre V, de Crombrugghe B. Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-α. J Biol Chem 2000; 275:3687-3692.
36. Murakami S, Kan M, McKeehan WL, de Crombrugghe B. Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 2000; 97:1113-1118.
37. Xu SC, Harris MA, Rubenstein JLR, Mundy GR, Harris SE. Bone morphogenetic protein-2 (BMP-2) signaling to the Col2a1 gene in chondroblasts requires the homeobox gene Dlx-2. DNA Cell Biol 2001; 20:359-365.
38. Kokenyesi R, Tan L, Robbins JR, Goldring MB. Proteoglycan production by immortalized human chondrocyte cell lines cultured under conditions that promote expression of the differentiated phenotype. Arch Biochem Biophys 2000; 383:79-90.
39. Matsumoto T, Tsurumoto T, Goldring MB, Shindo H. Differential effects of IGF-binding proteins, IGFBP-3 and IGFBP-5, on IGF-I action and binding to cell membranes of immortalized human chondrocytes. J Endocrinol 2000; 166:29-37.
40. Loeser RF, Sadiev S, Tan L, Goldring MB. Integrin expression by primary and immortalized human chondrocytes: evidence of a differential role for α1β1 and α2β1 integrins in mediating chondrocyte adhesion to types II and VI collagen. Osteoarthritis Cartilage 2000; 8:96-105.
41. Loeser RF, Varnum BC, Carlson CS, Goldring MB, Liu E, Sadiev S, Kute TE, Wallin R. Chondrocyte expression of growth arrest specific gene-6 and the tyrosine kinase receptor axl: potential role in autocrine signaling to promote cell survival. Arthritis Rheum 1997; 40:1455-1465.
42. Moulton PJ, Hiran TS, Goldring MB, Hancock JT. Detection of protein and mRNA of various components of the NADPH oxidase complex in an immortalized human chondrocyte line. Br J Rheumatol 1997; 36:522-529.
43. Cawston TE, Curry VA, Summers CA, Clark IM, Riley GP, Life PF, Spaull JR, Goldring MB, Koshy PJT, Rowan AD, Shingleton WD. The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint. Arthritis Rheum 1998; 41:1760-1771.
44. Kaarniranta K, Elo M, Sironen R, Lammi MJ, Goldring MB, Eriksson E, Sistonen L, Helminen HJ. Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation. Proc Natl Acad Sci USA 1998; 95:2319-2324.
45. Terkeltaub R, Lotz M, Johnson K, Deng D, Hashimoto S, Goldring MB, Burton D, Deftos LJ. Parathyroid hormone related protein (PTHrP) is abundant in osteoarthritic cartilage, and the PTHrP 1-173 isoform is selectively induced by TGFβ in articular chondrocytes and suppresses extracellular inorganic pyrophosphate generation. Arthritis Rheum 1998; 41:2152-2164.
46. Ding GJ, Fischer PA, Boltz RC, Schmidt JA, Colaianne JJ, Gough A, Rubin RA, Miller DK. Characterization and quantitation of NF-κB nuclear translocation induced by interleukin-1 and tumor necrosis factor-α. Development and use of a high capacity fluorescence cytometric system. J Biol Chem 1998; 273:28897-28905.
47. Labelle Y, Bussieres J, Courjal F, Goldring MB. The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator. Oncogene 1999; 18:3303-3308.
48. Nuttall ME, Nadeau DP, Fisher PW, Wang F, Keller PM, DeWolf WE Jr, Goldring MB, Badger AM, Lee D, Levy MA, Gowen M, Lark MW. Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro. J Orthop Res 2000; 18:356-363.
49. Lee D, Long SA, Adams JL, Chan G, Vaidya KS, Francis TA, Kikly K, Winkler JD, Sung CM, Debouck C, et al. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. J Biol Chem 2000; 275:16007-16014.
50. Westacott CI, Urban JP, Goldring MB, Elson CJ. The effects of pressure on chondrocyte tumour necrosis factor receptor expression. Biorheology 2002; 39:125-132.
51. Attur MG, Dave M, Cipolletta C, Kang P, Goldring MB, Patel IR, Abramson SB, Amin AR. Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention. J Biol Chem 2000; 275:40307-40315.
52. Johnson K, Vaingankar S, Chen Y, Moffa A, Goldring MB, Sano K, Jin-Hua P, Sali A, Goding J, Terkeltaub R. Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Arthritis Rheum 1999; 42:1986-1997.
53. Palmer G, Guerne PA, Mezin F, Maret M, Guicheux J, Goldring MB, Gabay C. Production of interleukin-1 receptor antagonist by human articular chondrocytes. Arthritis Res 2002; 4:226-231.
54. Ulrich-Vinther M, Maloney MD, Goater JJ, Søballe K, Goldring MB, O'Keefe RJ, Schwarz EM. Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes. Arthritis Rheum 2002; 46:2095-2104.
55. Zwicky R, Muntener K, Goldring MB, Baici A. Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes. Biochem J 2002; 367:209-217.