Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: An 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients

Clinical Therapeutics

Volumn 31, Issue 12, 2009, Pages 2860-2872

  Kim, Jinhyun ^a   Lee, Eun Young ^a   Koh, Eun Mi ^b   Cha, Hoon Suk ^b   Yoo, Bin ^c   Lee, Chang Keun ^c   Lee, Yun Jong ^d   Ryu, Heejung ^d   Lee, Ki Hoon ^e   Song, Yeong Wook ^a  

^a Seoul National University Hospital   (South Korea)

^b Samsung Medical Center   (South Korea)

^c Asan Medical Center   (South Korea)

^d Seoul National University Bundang Hospital   (South Korea)

^e Jeonju University   (South Korea)

Author keywords

knee; nabumetone; osteoarthritis; S adenosylmethionine

Indexed keywords

NABUMETONE; PARACETAMOL; S ADENOSYLMETHIONINE; SAYME; UNCLASSIFIED DRUG;

ABDOMINAL DISCOMFORT; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTHRALGIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BACKACHE; CIRCUMORAL PARESTHESIA; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG ERUPTION; DRUG RESPONSE; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPNEA; EDEMA; EPIGASTRIC PAIN; EVENING DOSAGE; FATIGUE; FEMALE; HEART PALPITATION; HUMAN; KNEE OSTEOARTHRITIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PAIN ASSESSMENT; PARESTHESIA; PATIENT COMPLIANCE; PHASE 4 CLINICAL TRIAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SOUTH KOREA; URINARY FREQUENCY; VISUAL ANALOG SCALE;

AGED; ANALGESICS; ANTI-INFLAMMATORY AGENTS; ASIAN CONTINENTAL ANCESTRY GROUP; BUTANONES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KOREA; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PAIN; PAIN MEASUREMENT; S-ADENOSYLMETHIONINE; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME;

EID: 74549116052     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2009.12.016     Document Type: Article

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