Catalytic mechanism of aromatic prenylation by NphB

Biochemistry

Volumn 51, Issue 12, 2012, Pages 2606-2618

  Yang, Yue ^a   Miao, Yipu ^a   Wang, Bing ^a   Cui, Guanglei ^a   Merz, Kenneth M ^a  

^a University of Florida ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE POCKET; AROMATIC SUBSTRATES; BINDING POCKETS; CARBOCATIONS; CATALYTIC MECHANISMS; COMPUTATIONAL STUDIES; DISSOCIATIVE MECHANISMS; FARNESYLTRANSFERASE; HIGH YIELD; HYDROGEN BOND INTERACTION; HYDROXYL GROUPS; PRENYLATION; PRENYLATION REACTIONS; PRENYLTRANSFERASE; PRODUCT FORMATION; PRODUCT RELEASE; PROTON ELIMINATION; PROTON LOSS; REACTION MECHANISM; REACTION PATHWAYS; RELEASE MECHANISM; RESTING STATE; SIDE-CHAINS; SUBSTRATE SELECTIVITY; TYR-288; WATER MOLECULE;

AROMATIZATION; CATALYSIS; ENERGY BARRIERS; FREE ENERGY; HYDROGEN BONDS; PROTON TRANSFER; REACTION INTERMEDIATES; REGIOSELECTIVITY; SUBSTRATES;

AROMATIC COMPOUNDS;

AROMATIC COMPOUND; DIMETHYLALLYLTRANSFERASE; HYDROXYL GROUP; NPHB PROTEIN; PROTON; UNCLASSIFIED DRUG; WATER;

ARTICLE; BINDING AFFINITY; CARBOCATION; CATALYSIS; CHEMICAL PARAMETERS; CHEMICAL REACTION; CRYSTALLOGRAPHY; DISSOCIATION; ELIMINATION REACTION; ENERGY; ENZYME ACTIVE SITE; HYDROGEN BOND; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN PRENYLATION; PROTEIN STRUCTURE; PROTON TRANSPORT; REGIOSELECTIVITY;

BIOCATALYSIS; DIMETHYLALLYLTRANSTRANSFERASE; DIPHOSPHATES; DITERPENES; FARNESYLTRANSTRANSFERASE; KINETICS; MOLECULAR DYNAMICS SIMULATION; NAPHTHOLS; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN PRENYLATION; PROTONS; QUANTUM THEORY; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 84859186669     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201800m     Document Type: Article

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