Insights into the mechanistic dichotomy of the protein farnesyltransferase peptide substrates CVIM and CVLS

Journal of the American Chemical Society

Volumn 134, Issue 2, 2012, Pages 820-823

  Yang, Yue ^a   Wang, Bing ^a   Ucisik, Melek N ^a   Cui, Guanglei ^a   Fierke, Carol A ^b   Merz, Kenneth M ^a  

^a University of Florida ^*  (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; FARNESYLATION; ISOTOPE EFFECT; KINETIC ISOTOPE EFFECTS; PEPTIDE SUBSTRATES; POTENTIAL OF MEAN FORCE; PROTEIN FARNESYLTRANSFERASE; QUANTUM MECHANICAL/MOLECULAR MECHANICAL STUDIES; RATE LIMITING; TRANSITION STATE; TRANSITION STATE STRUCTURE; UMBRELLA SAMPLING;

CARRIER MOBILITY; CATALYSIS; ISOTOPES; MOLECULAR MODELING; PEPTIDES;

SUBSTRATES;

ARGININE; HISTIDINE; LYSINE; PEPTIDE DERIVATIVE; PEPTIDE SUBSTRATE CVIM; PEPTIDE SUBSTRATE CVLS; PROTEIN FARNESYLTRANSFERASE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; DISSOCIATION; ENERGY; FARNESYLATION; HYDROGEN BOND; PHASE TRANSITION; PROTEIN CONFORMATION; PROTEIN MOTIF; QUANTUM MECHANICS; SIMULATION;

ALKYL AND ARYL TRANSFERASES; CATALYTIC DOMAIN; KINETICS; MODELS, MOLECULAR; OLIGOPEPTIDES; PRENYLATION; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 84862908683     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja209650h     Document Type: Article

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