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7
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9844254730
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note
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Compounds are referred to here by their standard names, but for simplicity in discussions of mechanisms, atoms are numbered according to their position in the acyclic isoprenoid diphosphate precursor.
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-
-
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11
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9844250434
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-
note
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12; the unit cell dimensions vary by a few angstroms between crystals, but on average a = 126 Å, c = 122 Å.
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-
-
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12
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84920325457
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-
2+ ions, and 270 water molecules; 95% of the residues are in the most favored regions of the Ramachandran plot, and none are in disallowed regions.
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Navaza, J.1
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13
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0000127585
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2+ ions, and 270 water molecules; 95% of the residues are in the most favored regions of the Ramachandran plot, and none are in disallowed regions.
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Lamzin, V.X.1
Wilson, K.S.2
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14
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0026572008
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M. Juy et al., Nature 357, 89 (1992).
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Juy, M.1
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17
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0030480263
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L. C. Tarshis, W. Yan, C. D. Poulter, J. C. Sacchettini, Biochemistry 33, 10871 (1994); L. C. Tarshis, P. J. Proteau, B. A. Kellogg, J. C. Sacchettini, C. D. Poulter, Proc. Natl. Acad. Sci. U.S.A. 93, 15018 (1996).
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Tarshis, L.C.1
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Poulter, C.D.5
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19
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9844241806
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-
note
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2+ ions, 150 water molecules, and one FHP molecule.
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-
-
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20
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9844265094
-
-
note
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3-FPP molecule.
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-
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23
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37049073877
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K. M. Biswas and A. H. Jackson, J. Chem. Soc. Perkin Trans. 1 11, 1981 (1989) and M. I. Abdullah, A. H. Jackson, P. P. Lynch, K. A. F. Record, Heterocycles 30, 317 (1990).
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Biswas, K.M.1
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24
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0000649630
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K. M. Biswas and A. H. Jackson, J. Chem. Soc. Perkin Trans. 1 11, 1981 (1989) and M. I. Abdullah, A. H. Jackson, P. P. Lynch, K. A. F. Record, Heterocycles 30, 317 (1990).
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Abdullah, M.I.1
Jackson, A.H.2
Lynch, P.P.3
Record, K.A.F.4
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26
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0029979356
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X. Lin, M. Hezari, A. E. Koepp, H. G. Floss, R. Croteau, Biochemistry 35, 2968 (1996).
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Lin, X.1
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27
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0001037624
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RIBBONS, M. Carson and C. E. Bugg, J. Mol. Graphics 4, 121 (1986); MOLSCRIPT, P. Kraulis, J. App. Crystallogr. 24, 946 (1991); RASTER3D, D. Bacon and W. F. Anderson, J. Mol. Graphics 6, 219 (1988); GRASP, A. Nicholls, K. A. Sharp, B. Honig, Proteins Struct. Funct. Genet. 11, 281 (1991).
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Carson, M.1
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0001037624
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RIBBONS, M. Carson and C. E. Bugg, J. Mol. Graphics 4, 121 (1986); MOLSCRIPT, P. Kraulis, J. App. Crystallogr. 24, 946 (1991); RASTER3D, D. Bacon and W. F. Anderson, J. Mol. Graphics 6, 219 (1988); GRASP, A. Nicholls, K. A. Sharp, B. Honig, Proteins Struct. Funct. Genet. 11, 281 (1991).
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Kraulis, P.1
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29
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0001037624
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RIBBONS, M. Carson and C. E. Bugg, J. Mol. Graphics 4, 121 (1986); MOLSCRIPT, P. Kraulis, J. App. Crystallogr. 24, 946 (1991); RASTER3D, D. Bacon and W. F. Anderson, J. Mol. Graphics 6, 219 (1988); GRASP, A. Nicholls, K. A. Sharp, B. Honig, Proteins Struct. Funct. Genet. 11, 281 (1991).
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Bacon, D.1
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0026319199
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Nicholls, A.1
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0002452464
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L. Sawyer, N. Isaacs, S. Bailey, Eds. CCP4 Study Weekend, SERC Daresbury Laboratory, Warrington, UK
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Z. Otwinowski, in Data Collection and Processing, L. Sawyer, N. Isaacs, S. Bailey, Eds. (CCP4 Study Weekend, SERC Daresbury Laboratory, Warrington, UK, 1993), pp. 56-62.
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Otwinowski, Z.1
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0343622575
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CCP4, SERC Daresbury Laboratory, Warrington, UK
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_, ML-PHARE (CCP4, SERC Daresbury Laboratory, Warrington, UK, 1991).
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(1991)
ML-PHARE
-
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-
34
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84889120137
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T. A. Jones, J. Y. Zou, S. W. Cowan, M. Kjeldgaard, Acta Crystallogr. A47, 110 (1991).
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Jones, T.A.1
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Kjeldgaard, M.4
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36
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9844236713
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note
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3-FPP; J. Kyte for discussion; M. Bowman, M. Harrington, and D. Wild for technical assistance; A. Bilwes, M. Bowman, R. Ranganathan, and S. Redford for assistance during data collection at beamline 7-1 at the Stanford Synchrotron Radiation Laboratory (SSRL); the staff at SSRL for assistance and advice. Supported in part by the Lucille P. Markey Charitable trust and NIH grant GM54029 (J.P.N.); NSF grant IBW-9408152 (J.C.); the Chapman Foundation and NIH training grant GM07240, administered through the University of California, San Diego (C.M.S.). Work performed at SSRL was supported by the NIH and DOE. Coordinates for uncomplexed TEAS have been deposited in the Brookhaven Protein Data Bank, code 5EAS.
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