Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells

Journal of Natural Products

Volumn 68, Issue 6, 2005, Pages 947-950

  Zhou, Yu Dong ^a   Kim, Yong Pil ^a   Mohammed, Kaleem Asjad ^a   Jones, Deborah K ^a   Muhammad, Ilias ^a   Dunbar, D Chuck ^a   Nagle, Dale G ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID DERIVATIVE; EMETINE; HYPOXIA INDUCIBLE FACTOR 1; IRON CHELATE; ISOCEPHAELINE; KLUGINE; TERPENOID DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; GENE ACTIVATION; HUMAN; HUMAN CELL; HYPOXIA; IC 50; TUMOR CELL;

ALKALOIDS; BREAST NEOPLASMS; DNA-BINDING PROTEINS; EMETINE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; QUINAZOLINES; RUBIACEAE; TERPENES; TETRAHYDROISOQUINOLINES; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 20744449495     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np050029m     Document Type: Article

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