Free energy study of the catalytic mechanism of Trypanosoma cruzi trans -sialidase. from the Michaelis complex to the covalent intermediate

Biochemistry

Volumn 50, Issue 46, 2011, Pages 10150-10158

  Pierdominici Sottile, Gustavo ^a,b   Horenstein, Nicole A ^b   Roitberg, Adrian E ^b,c  

^a UNIVERSIDAD NACIONAL DE QUILMES   (Argentina)

^b University of Florida ^*  (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATES; CARBOXYLIC ACIDS; CATALYSIS; FREE ENERGY; ISOTOPES; REACTION INTERMEDIATES;

2-DEOXY-2; CARBOCATIONS; CATALYTIC MECHANISMS; CHAGAS' DISEASE; COMPUTATIONAL TOOLS; ENERGY DECOMPOSITION; ENERGY STUDIES; GLYCOCONJUGATES; INHIBITOR DESIGN; KINETIC ISOTOPE EFFECTS; MECHANISTIC PATHWAYS; MICHAELIS COMPLEX; PARASITE-; SIALIC ACIDS; SIALIDASES; TRANS-SIALIDASES; TRANSITION STATE; TRYPANOSOMA CRUZI;

QUANTUM CHEMISTRY;

NUCLEOPHILE; SIALIDASE;

ARTICLE; CATALYSIS; COVALENT BOND; DECOMPOSITION; ENERGY; ENZYME MECHANISM; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; SOLVOLYSIS; TRYPANOSOMA CRUZI;

PROTOZOA; TRYPANOSOMA CRUZI;

EID: 84961980629     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2009618     Document Type: Article

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