Comprehensive plasma thiol redox status determination for metabolomics

Journal of Proteome Research

Volumn 10, Issue 2, 2011, Pages 592-603

  D'Agostino, Lisa A ^a   Lam, Karen P ^a   Lee, Richard ^a   Britz McKibbin, Philip ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

CE MS; Chemical derivatization; Electrospray ionization; Metabolomics; Oxidative stress; Plasma thiols

Indexed keywords

MALEIMIDE; THIOL;

ARTICLE; CAPILLARY ELECTROPHORESIS; ELECTROSPRAY; IONIZATION; MASS SPECTROMETRY; METABOLOMICS; OXIDATIVE STRESS; PREDICTION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SPECIES DIFFERENTIATION;

BLOOD PROTEINS; ELECTROPHORESIS, CAPILLARY; HUMANS; MALEIMIDES; METABOLOMICS; MULTIVARIATE ANALYSIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFHYDRYL COMPOUNDS;

EID: 79955461502     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100771g     Document Type: Article

References (60)

1. Jones, D. P. Redefining oxidative stress. Antioxid. Redox Signal. 2006, 8, 1865-1879. (Pubitemid 44726359)
2. Wu, G.; Fang, Y.-Z.; Yang, S.; Lupton, J. R.; Turner, N. D. Glutathione metabolism and its implications for health. J. Nutr. 2004, 134, 489-492. (Pubitemid 38298485)
3. Dalle-Donne, I.; Rossi, R.; Giustarini, D.; Colombo, R.; Mizani, A. S-glutationylation in protein redox regulation. Free Radic. Biol. Med. 2007, 43, 883-898.
4. Dalle-Donne, I.; Rossi, R.; Colombo, R.; Giustarini, D.; Milzani, A. Biomarkers of oxidative damage in human disease. Clin. Chem. 2006, 52, 601-623.
5. Ueland, P. M.; Mansoor, M. A.; Guttormsen, A. B.; Muller, F.; Aukrust, P.; Refsum, H.; Svardal, A. M. Reduced, oxidized and protein-bound forms of homocysteine and other aminothiols in plasma comprise the redox thiol status - A possible element of the extracellular antioxidant system. J. Nutr. 1996, 126, 1281S-1284S. (Pubitemid 26105673)
6. Jones, D. P.; Liang, Y. Measuring the poise of thiol/disulfide couples in vivo. Free Radic. Biol. Med. 2009, 47, 1329-1338.
7. Droge, W. Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants. Exp. Gerontol. 2002, 37, 1333-1345.
8. Jones, D. P.; Mody, V. C. J.; Carlson, J. L.; Lynn, M. J.; Sternberg, P. J. Redox analysis of human plasma allows separation of prooxidant events of aging from decline in antioxidant defenses. Free Radic. Biol. Med. 2002, 33, 1290-1300. (Pubitemid 35246597)
9. Giustarini, D.; Dalle-Donne, I.; Lorenzini, S.; Milzani, A.; Rossi, R. Age-related influence on thiol, disulfide, and protein-mixed disulfide levels in human plasma. J. Gerontol. A: Biol. Sci. Med. Sci. 2006, 61, 1030-1038. (Pubitemid 44727210)
10. Ashfaq, S.; Abramson, J. L.; Jones, D. P.; Rhodes, S. D.; Weintraub, W. S.; Hooper, W. C.; Vaccarino, V.; Harrison, D. G.; Quyyumi, A. A. The relationship between plasma levels of oxidized and reduced thiols and early atherosclerosis in healthy adults. J. Am. College Cardiol. 2006, 47, 1005-1011.
11. Wlodek, P. J.; Smolenski, O. B.; Chwatko, G.; Iciek, M. B.; Milkowski, A.; Bald, E.; Wlodek, L. Disruption of thiol homeostasis in plasma of terminal renal failure patients. Clin. Chim. Acta 2006, 366, 137-145. (Pubitemid 43330974)
12. Raijmakers, M. T. M.; Peters, W. H. M.; Steegers, E. A. P.; Poston, L. Amino thiols, detoxiication and oxidative stress in pre-eclampsia and other disorders of pregnancy. Curr. Pharma. Design 2005, 11 , 711-734. (Pubitemid 40347976)
13. Andersson, A.; Lindgren, A; Hultberg, B. Effect of thiol oxidation and thiol export from erythrocytes on determination of redox status of homocysteine and other thiols in plasma from healthy subjects and patients with cerebral infarction. Clin. Chem. 1995, 41, 361-366.
14. Ueland, P. M. Importance of chemical reduction in plasma and serum homocysteine analysis. Clin. Chem. 2008, 54, 1085-1086. (Pubitemid 351793418)
15. Toyo'oka, T. Recent advances in separation and detection methods for thiol compounds in biological samples. J. Chromatogr., B 2009, 877, 3318-3330.
16. McMenamin, M. E.; Himmelfarb, J.; Nolin, T. D. Simultaneous analysis of multiple aminothiols in human plasma by high performance liquid chromatography with fluorescence detection. J. Chromatogr., B 2009, 877, 3274-3281.
17. Rafii, M.; Elango, R.; House, J. D.; Courtney-Martin, G.; Darling, P.; Fisher, L.; Pencharz, P. B. Measurement of homocysteine and related metabolites in human plasma and urine by liquid chromatography electrospray tandem mass spectrometry. J. Chromatogr., B 2009, 877, 3282-3291.
18. Suh, J. H.; Kim, R.; Yavuz, B.; Lee, D.; Lal, A.; Ames, B. N.; Shigenaga, M. K. Clinical assay of four thiol amino acid redox couples by LC-MS/MS: utility in thalassemia. J. Chromatogr., B 2009, 877, 3418-3427.
19. Zhu, P.; Oe, T.; Blain, I. A. Determination of cellular redox status by stable isotope dilution liquid chromatography/mass spectrometry analysis of glutathione and glutathione disulfide. Rapid Comm. Mass Spectrom. 2008, 22, 432-440. (Pubitemid 351300575)
20. Seiwert, B.; Karst, U. Simultaneous LC/MS/MS determination of thiols and disulfides in urine samples based on differential labeling with ferrocene-based maleimides. Anal. Chem. 2007, 79, 7131-7138. (Pubitemid 47438694)
21. Bouligand, J.; Deroussent, A.; Paci, A.; Morizet, J.; Vassal, G. Liquid chromatography-tandem mass spectrometry assay of reduced and oxidized glutathione and main precursors in mice liver. J. Chromatogr., B 2006, 832, 67-74. (Pubitemid 43213011)
22. Rellan-Alvarez, R.; Hernandez, L. E.; Abadia, J.; Alvarez-Fernandez, A. Direct and simultaneous determination of reduced and oxidized glutathione and homoglutathione by liquid chromatography-electrospray/mass spectrometry in plant tissue extracts. Anal. Biochem. 2006, 356, 254-264. (Pubitemid 44291655)
23. Guan, X.; Hoffman, B.; Dwivedi, C.; Matthees, D. P. A simultaneous liquid chromatography/mass spectrometric assay of glutathione, cysteine, homocysteine and thier disulfides in biological samples. J. Pharma. Biomed. Anal. 2003, 31, 251-261. (Pubitemid 36254807)
24. Steghens, J.-P.; Fluorie, F.; Arab, K.; Collombel, C. Fast liquid chromatography-mass spectrometry glutathione measurements in whole blood: micromolar GSSG is a sample preparation artifact. J. Chromatogr., B 2003, 798, 343-349. (Pubitemid 37487735)
25. Iwasaki, Y.; Hoshi, M.; Saito, K.; Nakazawa, H. Analysis of glutathione and glutathione disulfide in human saliva using hydrophilic interaction chromatography with mass spectrometry. J. Chromatogr., B 2003, 839, 74-79.
26. Johnson, J. M.; Strobel, F. H.; Reed, M.; Pohl, J.; Jones, D. P. A rapid LC-FTMS method for the analysis of cysteine, cystine and cysteine/cystine steady-state redox potential in human plasma. Clin. Chim. Acta 2008, 396, 43-48.
27. Sreekumar, A.; Poisson, L. M.; Rajendiran, T. M.; Khan, A. P.; Cao, Q.; Yu, J.; Laxman, B.; Mehra, R.; Lonigro, R. J.; Li, Y.; Nyati, M. K.; Ahsan, A.; Kalyana-Sundaram, S.; Han, B.; Cao, X.; Byun, J.; Omenn, G. S.; Ghosh, D.; Pennathur, S.; Alexander, D. C.; Berger, A.; Shuster, J. R.; Wei, J. T.; Varambally, S.; Beecher, C.; Chinnaiyan, A. M. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 2009, 457, 910-914.
28. Lanza, I. R.; Zhang, S. C.; Ward, L. E.; Karakelides, H.; Rafferty, D.; Nair, K. S. Quantitative metabolomics by H-1-NMR and LC-MS/ MS confirms altered metabolic pathways in diabetes. PLoS ONE 2010, 5, e10538.
29. Chalcraft, K. R.; Lee, R.; Mills, C.; Britz-McKibbin, P. Virtual quantification of metabolites by capillary electrophoresis-electro- spray ionization-mass spectrometry: Predicting ionization efficiency without chemical standards. Anal. Chem. 2009, 81, 2506-2515.
30. Yang, W.-C.; Adamec, J.; Regnier, F. E. Enhancement of the LC/ MS analysis of fatty acids through derivatization and stable isotope coding. Anal. Chem. 2007, 70, 5150-5157. (Pubitemid 47121024)
31. Williams, D. K.; Meadows, C. W.; Bori, I. D.; Hawkridge, A. M.; Comins, D. L.; Muddiman, D. C. Synthesis, characterization and application of iodoacetamide derivatives utilized for the ALIPHAT strategy. J. Am. Soc. Chem. 2008, 130, 2122-2123. (Pubitemid 351287965)
32. Carlson, E. E.; Cravatt, B. F. Chemoselective probes for metabolite enrichment and profiling. Nat. Met. 2007, 4, 429-435. (Pubitemid 46901277)
33. Carlucci, F.; Tabucchi, A. Capillary electrophoresis in the evaluation of aminothiols in body fluids. J. Chromatogr., B 2009, 877, 3347-3357.
34. Zinellu, A.; Sotgia, S.; Scanu, B.; Usai, M. F.; Fois, A. G.; Spada, V.; Deledda, A.; Deiana, L.; Pirina, P.; Carru, C. Simultaneous detection of N-acetyl-L-cysteine and physiological low molecular mass thiols in plasma by capillary electrophoresis. Amino Acids 2009, 37, 395-400.
35. Carru, C.; Delana, L.; Sotgia, S.; Pes, G. M.; Zinellu, A. Plasma thiols redox status by laser-induced fluorescence capillary electrophoresis. Electrophoresis 2004, 25, 882-889. (Pubitemid 38401379)
36. Lee, R.; Britz-McKibbin, P. Differential rates of glutathione oxidation for assessment of cellular redox status and antioxdiant capacity by capillary electrophoresis-mass spectrometry: An elusive biomarker of oxidative stress. Anal. Chem. 2009, 81, 7047-7056.
37. Lee, R.; Britz-McKibbin, P. Metabolomic studies of radiation- induced apoptosis of human leukocytes by capillary electrophoresis-mass spectrometry and flow cytometry: Adaptive cellular responses to ionizing radiation. Electrophoresis 2010, 31, 2328-2337.
38. Chalcraft, K. R.; Britz-McKibbin, P. Newborn screening of inborn errors of metabolism by capillary electrophoresis-electrospray ionization-mass spectrometry: A second-tier method with improved specificity and sensitivity. Anal. Chem. 2009, 81, 307-314.
39. Mansoor, M. A.; Svandal, A. M.; Ueland, P. M. Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine and glutathione in human plasma. Anal. Biochem. 1992, 200, 218-229.
40. Lee, R.; Ptolemy, A. S.; Niewzcas, L.; Britz-McKibbin, P. Integrative metabolomics for characterizing unknown low-abundance metabolites by capillary electrophoresis-mass spectrometry with computer simulations. Anal. Chem. 2007, 79, 403-415. (Pubitemid 46106104)
41. Bokman, C. F.; Bylund, D.; Markides, K. E.; Sjoberg, P. J. R. Relating chromatographic retention and electrophoretic mobility to the ion distribution within electrosprayed droplets. J. Am. Soc. Mass Spectrom. 2006, 17, 318-324. (Pubitemid 43290191)
42. Oss, M.; Kruve, A.; Herodes, K.; Leito, I. Electrospray ionization efficiency scale of organic compounds. Anal. Chem. 2010, 82, 2865-2872.
43. Lee, R.; West, D.; Phillips, S. M.; Britz-McKibbin, P. Differential metabolomics for quantitative assessment of oxidative stress with strenuous exercise and nutritional intervention: Thiol-specific regulation of cellular metabolism with N-acetyl-L-cysteine pretreatment. Anal. Chem. 2010, 82, 2959-2968.
44. Maxwell, E. J.; Chen, D. D. Y. Twenty years of interface development for capillary electrophoresis-electrospray ionization-mass spectrometry. Anal. Chim. Acta 2008, 627, 25-33.
45. Chang, C.-W.; Tseng, W.-L. Gold nanoparticle extraction followed by capillary electrophoresis to determine the total, free, and protein-bound aminothiols in plasma. Anal. Chem. 2010, 82, 2696-2702.
46. Schaefer, F. Q.; Buettner, G. R. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic. Biol. Med. 2001, 30, 1191-1212. (Pubitemid 32463931)
47. Blanco, R. A.; Ziegler, T. R.; Carlson, B. A.; Cheng, P. Y; Park, Y; Cotsonis, G. A.; Accardi, C. J.; Jones, D. P. Diurnal variation in glutathione and cysteine redox states in human plasma. Am. J. Clin. Nutr. 2007, 86, 1016-1023. (Pubitemid 47538304)
48. Garg, U. C.; Zheng, Z.-J.; Folsom, A. R.; Moyer, Y. S.; Tsai, M. Y.; McGovern, P.; Eckfeldt, J. H. Short-term and long-term variability of plasma homocysteine measurement. Clin. Chem. 1997, 43, 141-145. (Pubitemid 27024404)
49. Ashfaq, S.; Abramson, J. L.; Jones, D. P.; Rhodes, S. D.; Weintraub, W. S.; Hooper, W. C.; Vaccarino, V.; Alexander, R. W.; Harrison, D. G.; Quyyumi, A. A. Endothelial function and aminothiol biomarkers of oxidative stress in healthy adults. Hypertension 2008, 52, 80-85.
50. Struys, E. A.; Jansen, E. E. W.; Meer, K. d.; Jakobs, C. Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution mass spectrometry. Clin. Chem. 2000, 46, 1650-1656.
51. Desiderio, C.; Rossetti, D. V.; Messana, I.; Giardina, B.; Castagnola, M. Analysis of arginine and methylated metabolites in human plasma by field amplified sample injection capillary electrophoresis tandem mass spectrometry. Electrophoresis 2010, 31, 1894-1902.
52. Elshorbagy, A. K.; Nurk, E.; Gjesdal, C. G.; Tell, G. S.; Ueland, P. M.; Nygard, O.; Tverdal, A.; Vollset, S. E.; Refsum, H. Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: Does cysteine link amino acid and lipid metabolism? Am. J. Clin. Nutr. 2008, 88, 738-746.
53. Refsum, H.; Nurk, E.; Smith, A. D.; Ueland, P. M.; Gjesdal, C. G.; Bjelland, I.; Tverdal, A.; Tell, G. S.; Nygard, O.; Vollset, S. E. The Hordaland Homocysteine Study: A community-based study of homocysteine, its determinants and associations with disease. J. Nutr. 2006, 136, 1731S-1740S. (Pubitemid 43765389)
54. The Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease. N. Engl. J. Med. 2006, 354, 1567-1577.
55. Steenge, G. R.; Verhoef, P.; Katan, M. B. Betaine supplementation lowers plasma homocysteine in healthy men and women. J. Nutr. 2003, 133, 1291-1295. (Pubitemid 36548696)
56. Dangour, A. D.; Breeze, E.; Clarke, R.; Shetty, P. S.; Uauy, R.; Fletcher, A. E. Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom. J Nutr. 2008, 138, 1121-1128. (Pubitemid 351769139)
57. Ohashi, Y.; Hirayama, A.; Ishikawa, T.; Nakamura, S.; Shimizu, K.; Ueno, Y.; Tomita, M.; Soga, T. Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS. Mol. Biosys. 2008, 4, 135-147.
58. Atkuri, K. R.; Mantovani, J. J.; Herzenberg, L. A.; Herzenberg, L. A. N-acetylcysteine-A safe antidote for cysteine/glutathione deficiency. Curr. Opin. Pharmacol. 2007, 7, 1-5.
59. Brattstrom, L.; Wilcken, D. E. L. Homocysteine and cardiovascular disease: Cause or effect? Am. J. Clin. Nutr. 2000, 72, 315-323. (Pubitemid 30620632)
60. Selhub, J. The many facets of hyperhomocysteinemia: Studies from Framingham cohorts. J. Nutr. 2006, 136, 1726S-1730S. (Pubitemid 43765388)