HILIC-UPLC-MS for exploratory urinary metabolic profiling in toxicological studies

Analytical Chemistry

Volumn 83, Issue 1, 2011, Pages 382-390

  Spagou, Konstantina ^a,b   Wilson, Ian D ^c   Masson, Perrine ^a   Theodoridis, Georgios ^d   Raikos, Nikolaos ^b   Coen, Muireann ^a   Holmes, Elaine ^a   Lindon, John C ^a   Plumb, Robert S ^e   Nicholson, Jeremy K ^a   Want, Elizabeth J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c Department of Clinical Pharmacology Drug Metabolism and Pharmacokinetics ^*  (United Kingdom)

^d ASTRAZENECA   (United Kingdom)

^e WATERS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2-OXOGLUTARATE; AMINO ACID METABOLISM; ANALYTES; BIO-MARKER DISCOVERY; GALACTOSAMINE; HEPATOTOXICITY; HYDROPHILIC INTERACTION; METABOLIC PROFILES; METABOLIC PROFILING; METABOLOMES; N-ACETYLGLUCOSAMINE; POLAR METABOLITE; PROTECTIVE EFFECTS; RAT URINE; REPEAT ANALYSIS; REPRODUCIBILITIES; RETENTION TIME; REVERSED PHASE; RUNTIMES; SIGNAL INTENSITIES; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPLC-TOF-MS; UROCANIC ACID;

AMINO ACIDS; BIOMOLECULES; HYDROPHILICITY; LIQUID CHROMATOGRAPHY; METABOLITES; QUALITY CONTROL;

METABOLISM;

GALACTOSAMINE;

ANIMAL; ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METABOLISM; METABOLOMICS; METHODOLOGY; PRINCIPAL COMPONENT ANALYSIS; RAT; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; TOXICOLOGY; URINALYSIS; URINE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GALACTOSAMINE; MALE; MASS SPECTROMETRY; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TOXICOLOGY; URINALYSIS;

EID: 78650769334     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac102523q     Document Type: Article

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