A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics

Biochemical Pharmacology

Volumn 81, Issue 8, 2011, Pages 1043-1053

  Li, Fei ^a   Patterson, Andrew D ^a   Höfer, Constance C ^b   Krausz, Kristopher W ^a   Gonzalez, Frank J ^a   Idle, Jeffrey R ^a,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b DMPKORE   (Germany)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Metabolomics; Tandem mass spectrometry; ThioTEPA; Time of flight mass spectrometry; Ultraperformance liquid chromatography

Indexed keywords

1,2 DICHLOROTEPA; 1,2,3 TRICHLOROTEPA; CARBOCISTEINE; CHLOROACETALDEHYDE; DECHLOROETHYLTRICHLOROTEPA; DRUG METABOLITE; MONOCHLOROTEPA; TEPA; THIODIACETIC ACID; THIOTEPA; THIOTEPA CYSTEINATE; THIOTEPA MERCAPTURATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EXCRETION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; LIVER MICROSOME; MALE; METABOLOMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RING OPENING; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINARY EXCRETION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CARBOCYSTEINE; CHROMATOGRAPHY, LIQUID; MALE; METABOLOMICS; MICE; MICE, INBRED C57BL; MICROSOMES, LIVER; MULTIVARIATE ANALYSIS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THIOGLYCOLATES; THIOTEPA;

EID: 79952992201     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.01.024     Document Type: Article

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