Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice

Radiation Research

Volumn 170, Issue 1, 2008, Pages 1-14

  Tyburski, John B ^a   Patterson, Andrew D ^a   Krausz, Kristopher W ^a   Slavík, Josef ^b   Fornace Jr , Albert J ^c   Gonzalez, Frank J ^a   Idle, Jeffrey R ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 2 METHYLBENZOIC ACID 3 O SULFATE; BENZOIC ACID DERIVATIVE; BIOLOGICAL MARKER; GLYCINE; N HEXANOYLGLYCINE; TAURINE; THYMIDINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSIMETRY; GAMMA RADIATION; LIQUID CHROMATOGRAPHY; MALE; METABOLOMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY;

ANIMALS; BIOLOGICAL MARKERS; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; PHENOTYPE; SULFURIC ACID ESTERS; TANDEM MASS SPECTROMETRY;

MUS;

EID: 46449100893     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1265.1     Document Type: Article

References (48)

1. E. J. Hall and A. J. Giaccia, Radiobiology for the Radiologist, 6th ed. Lippincott Williams & Wilkins, Philadelphia, 2006.
2. W. F. Blakely, C. A. Salter and P. G. Prasanna, Early-response biological dosimetry - recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism. Health Phys. 89, 494-504 (2005).
3. C. N. Coleman, W. F. Blakely, J. R. Fike, T. J. MacVittie, N. F. Metting, J. B. Mitchell, J. E. Moulder, R. J. Preston, T. M. Seed and R. S. L. Wong, Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: Report of a workshop at Bethesda, Maryland, December 17-18, 2001. Radiat. Res. 159, 812-834 (2003).
4. J. K. Waselenko, T. J. MacVittie, W. F. Blakely, N. Pesik, A. L.Wiley, W. E. Dickerson, H. Tsu, D. L. Confer, C. N. Coleman and N. Dainiak, Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann. Intern. Med. 140, 1037-1051 (2004).
5. V. Garaj-Vrhovac and N. Kopjar, The alkaline comet assay as biomarker in assessment of DNA damage in medical personnel occupationally exposed to ionizing radiation. Mutagenesis 18, 265-271 (2003).
6. U. G. Plappert, B. Stocker, H. Fender and T. M. Fliedner, Changes in the repair capacity of blood cells as a biomarker for chronic low-dose exposure to ionizing radiation. Environ. Mol. Mutagen. 30, 153-160 (1997).
7. W. F. Blakely, P. G. Prasanna, M. B. Grace and A. C. Miller, Radiation exposure assessment using cytological and molecular biomarkers. Radiat. Prot. Dosimetry 97, 17-23 (2001).
8. R. Budhwar, V. Bihari, N. Mathur, A. Srivastava and S. Kumar, DNA-protein crosslinks as a biomarker of exposure to solar radiation: a preliminary study in brick-kiln workers. Biomarkers 8, 162-166 (2003).
9. S. Porciani, A. Lanini, M. Balzi, P. Faraoni and A. Becciolini, Polyamines as biochemical indicators of radiation injury. Phys. Med. 17 (Suppl. 1), 187-188 (2001).
10. C. Menard, D. Johann, M. Lowenthal, T. Muanza, M. Sproull, S. Ross, J. Gulley, E. Petricoin, C. N. Coleman and K. Camphausen, Discovering clinical biomarkers of ionizing radiation exposure with serum proteomic analysis. Cancer Res. 66, 1844-1850 (2006).
11. S. A. Amundson, M. B. Grace, C. B. McLeland, M. W. Epperly, A. Yeager, Q. Zhan, J. S. Greenberger and A. J. Fornace, Jr., Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients. Cancer Res. 64, 6368-6371 (2004).
12. C. M. Kang, K. P. Park, J. E. Song, D. I. Jeoung, C. K. Cho, T. H. Kim, S. Bae, S. J. Lee and Y. S. Lee, Possible biomarkers for ionizing radiation exposure in human peripheral blood lymphocytes. Radiat. Res. 159, 312-319 (2003).
13. Z. Deanovic, Z. Supek and M. Randic, Relationship between the dose of whole-body x-irradiation and the urinary excretion of 5-hydroxyindoleacetic acid in rats. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 7, 1-9 (1963).
14. M. Randic and Z. Supek, Urinary excretion of 5-hydroxyindolacetic acid after a single whole-body x-irradiation in normal and adrenal-ectomized rats. Int. J. Radiat. Biol. 4, 151-153 (1961).
15. H. Smith and A. O. Langlands, Alterations in tryptophan metabolism in man after irradiation. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 11, 487-494 (1966).
16. C. W. Scarantino, R. D. Ornitz, L. G. Hoffman and R. F. Anderson, Jr., On the mechanism of radiation-induced emesis: the role of serotonin. Int. J. Radiat. Oncol. Biol. Phys. 30, 825-830 (1994).
17. D. Pericic and Z. Deanovic, The metabolites of catecholamines in urine of patients irradiated therapeutically. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 29, 367-376 (1976).
18. D. Pericic, Z. Deanovic and S. Pavicic, Excretion of metabolites of biogenic amines in patients with irradiated brain tumours. Acta Radiol. Ther. Phys. Biol. 15, 81-90 (1976).
19. R. Cathcart, E. Schwiers, R. L. Saul and B. N. Ames, Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage. Proc. Natl. Acad. Sci. USA 81, 5633-5637 (1984).
20. D. S. Bergtold, C. D. Berg and M. G. Simic, Urinary biomarkers in radiation therapy of cancer. Adv. Exp. Med. Biol. 264, 311-316 (1990).
21. M. J. Schneidkraut, P. A. Kot, P. W. Ramwell and J. C. Rose, Regional release of cyclooxygenase products after radiation exposure of the rat. J. Appl. Physiol. 61, 1264-1269 (1986).
22. R. M. Wolfram, A. C. Budinsky, B. Palumbo, R. Palumbo and H. Sinzinger, Radioiodine therapy induces dose-dependent in vivo oxidation injury: evidence by increased isoprostane 8-epi-PGF(2 alpha). J. Nucl. Med. 43, 1254-1258 (2002).
23. K. Camphausen, C. Menard, M. Sproull, E. Goley, S. Basu and C. N. Coleman, Isoprostane levels in the urine of patients with prostate cancer receiving radiotherapy are not elevated. Int. J. Radiat. Oncol. Biol. Phys. 58, 1536-1539 (2004).
24. 31P NMR of human urine. Magn. Reson. Med. 31, 48-52 (1994).
25. D. S. Michaud, R. P. Troiano, A. F. Subar, S. Runswick, S. Bingham, V. Kipnis and A. Schatzkin, Comparison of estimated renal net acid excretion from dietary intake and body size with urine pH. J. Am. Diet Assoc. 103, 1001-1007; discussion 1007 (2003).
26. A. R. Fernie, R. N. Trethewey, A. J. Krotzky and L. Willmitzer, Metabolite profiling: from diagnostics to systems biology. Nat. Rev. Mol. Cell Biol. 5, 763-769 (2004).
27. J. L. Griffin, The Cinderella story of metabolic profiling: does metabolomics get to go to the functional genomics ball? Philos. Trans. R. Soc. Lond. B Biol. Sci. 361, 147-161 (2006).
28. J. K. Nicholson and I. D. Wilson, Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2, 668-676 (2003).
29. B. A. Osikowska, J. R. Idle, F. J. Swinbourne and P. S. Sever, Unequivocal synthesis and characterisation of dopamine 3- and 4-O-sulphates. Biochem. Pharmacol. 31, 2279-2284 (1982).
30. E. L. Green, Biology of the Laboratory Mouse, 2nd ed. McGraw-Hill, New York, 1966.
31. M. C. Hollander, M. S. Sheikh, D. V. Bulavin, K. Lundgren, L. Augeri-Henmueller, R. Shehee, T. A. Molinaro, K. E. Kim, E. Tolosa and A. J. Fornace, Jr., Genomic instability in Gadd45a-deficient mice. Nat. Genet. 23, 176-184 (1999).
32. R. S. Plumb, J. H. Granger, C. L. Stumpf, K. A. Johnson, B. W. Smith, S. Gaulitz, I. D. Wilson and J. Castro-Perez, A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice. Analyst 130, 844-849 (2005).
33. C. M. Slupsky, K. N. Rankin, J. Wagner, H. Fu, D. Chang, A. M. Weljie, E. J. Saude, B. Lix, D. J. Adamko and T. J. Marrie, Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles. Anal. Chem. 79, 6995-7004 (2007).
34. G. S. Eichler, S. Huang and D. E. Ingber, Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics 19, 2321-2322 (2003).
35. Y. Guo, G. S. Eichler, Y. Feng, D. E. Ingber and S. Huang, Towards a holistic, yet gene-centered analysis of gene expression profiles: a case study of human lung cancers. J. Biomed. Biotechnol. 2006, 69141 (2006).
36. E. Leete, L. Marion and I. D. Spenser, The biogenesis of alkaloids. XIII. The role of ornithine in the biosynthesis of stachydrine. J. Biol. Chem. 214, 71-77 (1955).
37. H. X. Chen, S. L. Shen, F. M. Han and Y. Chen, HPLC-ESI/MS analysis of stachydrine and its metabolites in rat urine. Yao Xue Xue Bao 41, 467-470 (2006).
38. H. G. Sammons and R. T. Williams, Studies in detoxication: The metabolism of vanillin and vanillic acid in the rabbit. The identification of glucurovanillin and the structure of glucurovanillic acid. Biochem. J. 35, 1175-1189 (1941).
39. L. P. Strand and R. R. Scheline, The metabolism of vanillin and isovanillin in the rat. Xenobiotica 5, 49-63 (1975).
40. L. Gros, A. A. Ishchenko, H. Ide, R. H. Elder and M. K. Saparbaev, The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway. Nucleic Acids Res. 32, 73-81 (2004).
41. H. G. Claycamp and S. T. Smith, Absence of pyrimidine salvage and prevention of thymineless radiosensitization in Escherichia coli thyA cells fed dihydrothymine or thymine glycol. Radiat. Res. 115, 617-623 (1988).
42. M. J. Straus, S. E. Straus, L. Battiste and S. Krezoski, The uptake, excretion, and radiation hazards of tritiated thymidine in humans. Cancer Res. 37, 610-618 (1977).
43. N. Gregersen, S. Kolvraa, K. Rasmussen, P. B. Mortensen, P. Divry, M. David and N. Hobolth, General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases. Clin. Chim. Acta 132, 181-191 (1983).
44. Y. Zhen, K. W. Krausz, C. Chen, J. R. Idle and F. J. Gonzalez, Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation. Mol. Endocrinol. 21, 2136-2151 (2007).
45. W. Zhao, S. Iskandar, M. Kooshki, J. G. Sharpe, V. Payne and M. E. Robbins, Knocking out peroxisome proliferator-activated receptor (PPAR) alpha inhibits radiation-induced apoptosis in the mouse kidney through activation of NF-κB and increased expression of IAPs. Radiat. Res. 167, 581-591 (2007).
46. C. J. Waterfield, J. A. Turton, M. D. Scales and J. A. Timbrell, Taurine, a possible urinary marker of liver damage: a study of taurine excretion in carbon tetrachloride-treated rats. Arch. Toxicol. 65, 548-555 (1991).
47. B. M. Beckwith-Hall, J. K. Nicholson, A. W. Nicholls, P. J. Foxall, J. C. Lindon, S. C. Connor, M. Abdi, J. Connelly and E. Holmes, Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chem. Res. Toxicol. 11, 260-272 (1998).
48. T. A. Clayton, J. C. Lindon, J. R. Everett, C. Charuel, G. Hanton, J. L. Le Net, J. P. Provost and J. K. Nicholson, An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria. Arch. Toxicol. 77, 208-217 (2003).