Lactate elicits vascular endothelial growth factor from macrophages: A possible alternative to hypoxia

Wound Repair and Regeneration

Volumn 8, Issue 5, 2000, Pages 353-360

  Constant, James S ^a,b   Feng, John J ^a,b   Zabel, David D ^a,b   Yuan, Hui ^a,b   Suh, David Y ^a,b   Scheuenstuhl, Heinz ^a,b   Hunt, Thomas K ^a,b   Zamirul Hussain, M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; ANTIBODY; BASIC FIBROBLAST GROWTH FACTOR; LACTIC ACID; MATRIGEL; NICOTINAMIDE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL CULTURE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; HYPOXIA; IMMUNOASSAY; MACROPHAGE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RABBIT; RECEPTOR DOWN REGULATION;

ANIMALS; ANOXIA; ANTIBODIES; BIOCOMPATIBLE MATERIALS; BLOTTING, NORTHERN; CELLS, CULTURED; COLLAGEN; CORNEA; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; ENDOTHELIAL GROWTH FACTORS; IMMUNOASSAY; LACTIC ACID; LAMININ; LYMPHOKINES; MACROPHAGES; NEOVASCULARIZATION, PHYSIOLOGIC; NIACINAMIDE; OXIDATION-REDUCTION; POLY ADENOSINE DIPHOSPHATE RIBOSE; PROTEOGLYCANS; RABBITS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; WOUND HEALING;

EID: 0033667481     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.2000.00353.x     Document Type: Article

References (45)

1. Determination of endogenous cytokines in chronic wounds
2. Growth factors. Local and systemic
3. Therapeutic angiogenesis
4. Macrophages and angiogenesis
5. Lactate stimulation of macrophage-derived angiogenic activity is associated with inhibition of poly (ADP-ribose) synthesis
6. Isolation of a nonmitogenic angiogenesis factor from wound fluid
7. Oxygen tension regulates the expression of angiogenesis factor by macrophages
8. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
9. The biology of vascular endothelial growth factor
10. The role of oxygen in wound repair and wound infection
11. The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis
12. Basic principles of wound healing
13. Direct measurement of wound and tissue oxygen tension in postoperative patients
14. Tissue oxygen tension and other indicators of blood loss or organ perfusion during graded hemorrhage
15. Tissue oxygenation, anemia, and perfusion in relation to wound healing in surgical patients
16. The importance of fuel metabolism to macrophage function
17. Anaerobic metabolism and wound healing: An hypothesis for the initiation and cessation of collagen synthesis in wounds
18. Transcutaneous oxygen and carbon dioxide measurements for determination of skin graft 'take'
19. Comparison of clark electrode and optode for measurement of tissue oxygen tension
20. The incubation of laminin, collagen IV and heparan sulfate proteoglycan at 35 degrees C yields basement membrane-like structures
21. Basement membrane complexes with biological activity
22. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor
23. Inhibition of prolyl hydroxylase by poly (ADP-ribose) and phosphoribosyl-AMP. Possible role of ADP-ribosylation in intracellular prolyl hydroxylase regulation
24. Effect of lactate, pyruvate and pH on secretion of angiogenesis and mitogenesis factors by macrophages
25. Chemical identification of a tumor-derived angiogenic factor
26. The effect of nicotinamide on microvascular density and thermal injury in rats
27. ADP-ribosylation of proteins. Enzymology and biological significance
28. Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo
29. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
30. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
31. Poly (ADP-ribose) may signal changing metabolic conditions to the chromatin of mammalian cells
32. DNA strand breakage, activation of poly (ADP-ribose) synthetase and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite
33. Hypoxia upregulates the synthesis of TGF-beta 1 by human dermal fibroblasts
34. 13C NMR study of IGF-I- and insulin-effects on mitochondrial function in cultured brain cells
35. Cellular injury by oxidents
36. Lipopolysaccharide-induced change of ADP-ribosylation of a cytosolic protein in bone-marrow-derived macrophages
37. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
38. Macrophage activation by culture in an anoxic environment
39. Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implications for tumor angiogenesis
40. Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor
41. Molecular adaptation of vascular endothelial cells to oxidative stress
42. Hypoxia regulatory elements of the human vascular endothelial growth factor gene
43. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation
44. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia