Cellular networks controlling Th2 polarization in allergy and immunity

F1000 Biology Reports

Volumn 4, Issue 1, 2012, Pages

  Kool, Mirjam ^a,b   Hammad, Hamida ^a,c   Lambrecht, Bart N ^a,b,c  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CD40 LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 25; INTERLEUKIN 33; INTERLEUKIN 4; MONOCYTE CHEMOTACTIC PROTEIN 1; NOTCH RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; OSTEOPONTIN; OVALBUMIN; OX40 LIGAND; PARASITE ANTIGEN; PROTEIN TYROSINE KINASE; STAT5 PROTEIN; STAT6 PROTEIN; THYMIC STROMAL LYMPHOPOIETIN; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR GATA 3; XENOBIOTIC AGENT;

ADAPTIVE IMMUNITY; ALLERGIC ASTHMA; ALLERGY; BASOPHIL; CD8+ T LYMPHOCYTE; CELL COMMUNICATION; CELL FATE; CELL FUNCTION; CELL HYPOXIA; CELL INTERACTION; CELL MATURATION; CELLULAR IMMUNITY; COMPLEMENT SYSTEM; CYTOKINE PRODUCTION; DENDRITIC CELL; DERMATOPHAGOIDES; EOSINOPHIL; EPITHELIUM CELL; HELMINTH; HELMINTHIASIS; HOMEOSTASIS; HOUSE DUST ALLERGY; HUMAN; IN VIVO STUDY; INNATE IMMUNITY; LYMPHOCYTE DIFFERENTIATION; MAST CELL; MUCOSAL IMMUNITY; NONHUMAN; OXIDATIVE STRESS; PLASMACYTOID DENDRITIC CELL; POLARIZATION; PROTEIN EXPRESSION; RESPIRATORY TRACT INFLAMMATION; REVIEW; SIGNAL TRANSDUCTION; STROMA CELL; TH2 CELL; TISSUE INJURY; UPREGULATION;

VERMES;

EID: 84857872834     PISSN: 17404118     EISSN: 1757594X     Source Type: Journal    
DOI: 10.3410/B4-6     Document Type: Review

References (107)

1. Lambrecht BN, Kool M, Willart MAM, Hammad H: Mechanism of action of clinically approved adjuvants. Curr. Opin. Immunol 2009, 21:23-9.
2. O'Shea JJ, Paul WE: Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 2010, 327:1098-102. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
3. Paul WE, Zhu J: How are T(H)2-type immune responses initiated and amplified? Nat. Rev. Immunol 2010, 10:225-35. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
4. Pulendran B, Tang H, Manicassamy S: Programming dendritic cells to induce T(H)2 and tolerogenic responses. Nat. Immunol 2010, 11:647-55. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
5. Ohtani T, Nakagawa S, Kurosawa M, Mizuashi M, Ozawa M, Aiba S: Cellular basis of the role of diesel exhaust particles in inducing Th2-dominant response. J. Immunol 2005, 174:2412-9. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
6. Todd DJ, Lee A, Glimcher LH: The endoplasmic reticulum stress response in immunity and autoimmunity. Nat. Rev. Immunol 2008, 8:663-74. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
7. Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 1998, 392:245-52. (Pubitemid 28155090)
8. Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart MAM, Kool M, Muskens F, Lambrecht BN: Inflammatory dendritic cells-not basophils-are necessary and sufficient for induction ofTh2 immunity to inhaled house dust mite allergen. J. Exp. Med 2010, 207:2097-111. F1000 Factor 11 Evaluated by Achsah Keegan and Nicola Heller 21 Sep 2010, Minoru Fukuda and Xingfeng Bao 06 Dec 2010, Marc A Williams 17 Dec 2010
9. Lambrecht BN, Salomon B, Klatzmann D, Pauwels RA: Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice. J. Immunol 1998, 160:4090-7. (Pubitemid 28176120)
10. van Rijt LS, Jung S, Kleinjan A, VosN,WillartM,DuezC, HoogstedenHC, Lambrecht BN: In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J. Exp. Med 2005, 201:981-91. F1000 Factor 8 Evaluated by Giorgio Berton 21 Apr 2005
11. van Rijt LS, Vos N, Willart M, Muskens F, Tak PP, van der Horst C, Hoogsteden HC, Lambrecht BN: Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice. Am. J. Respir. Crit. Care Med 2011, 184:303-11.
12. Smith KA, Hochweller K, Hämmerling GJ, Boon L, MacDonald AS, Maizels RM: Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells. J. Immunol 2011, 186:7098-109.
13. Kool M, Soullié T, van Nimwegen M, Willart MAM, Muskens F, Jung S, Hoogsteden HC, Hammad H, Lambrecht BN: Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J. Exp. Med 2008, 205:869-82. F1000 Factor 8 Evaluated by Eric Denkers 28 Mar 2008
14. Kool M, Willart MAM, van Nimwegen M, Bergen I, Pouliot P, Virchow JC, Rogers N, Osorio F, Reis E, Sousa C, Hammad H, Lambrecht BN: An unexpected role for uric acid as an inducer of Thelper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity 2011, 34:527-40. F1000 Factor 6 Evaluated by Booki Min 10 Jun 2011
15. Jung S, Unutmaz D, Wong P, Sano G, de los Santos K, Sparwasser T, Wu S, Vuthoori S, Ko K, Zavala F, Pamer EG, Littman DR, Lang RA: In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 2002, 17:211-20. F1000 Factor 7 Evaluated by Peter Jensen 13 Sep 2002, John Cambier 04 Dec 2002
16. Lambrecht BN, Veerman M de, Coyle AJ, Gutierrez-Ramos JC, Thielemans K, Pauwels RA: Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J. Clin. Invest 2000, 106:551-9. (Pubitemid 30666388)
17. Plantinga M, Hammad H, Lambrecht BN: Origin and functional specializations of DC subsets in the lung. Eur. J. Immunol 2010, 40:2112-8.
18. Furuhashi K, Suda T, Hasegawa H, Suzuki Y, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Shibata K, Nakamura H, Chida K: Mouse Lung CD103+ and CD11bhigh dendritic cells preferentially induce distinct CD4+ T cell responses. Am. J. Respir. Cell Mol. Biol 2011.
19. Heer HJ de, Hammad H, Soullié T, Hijdra D, Vos N, Willart MAM, Hoogsteden HC, Lambrecht BN: Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J. Exp. Med 2004, 200:89-98. F1000 Factor 11 Evaluated by Ann Hill 13 Aug 2004, Marsha Wills-Karp 23 Sep 2004
20. Kool M, van Nimwegen M, Willart MAM, Muskens F, Boon L, Smit JJ, Coyle A, Clausen BE, Hoogsteden HC, Lambrecht BN, Hammad H: An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation. J. Immunol 2009, 183:1074-82.
21. Smit JJ, Lindell DM, Boon L, Kool M, Lambrecht BN, Lukacs NW: The balance between plasmacytoid DC versus conventional DC determines pulmonary immunity to virus infections. PLoS ONE 2008, 3:e1720.
22. Farkas L, Kvale EO, Johansen F, Jahnsen FL, Lund-Johansen F: Plasmacytoid dendritic cells activate allergen-specific TH2 memory cells: modulation by CpG oligodeoxynucleotides. J. Allergy Clin. Immunol 2004, 114:436-43. (Pubitemid 39119049)
23. Zhang X, Lewkowich IP, Köhl G, Clark JR, Wills-Karp M, Köhl J: A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells. J. Immunol 2009, 182:5123-30.
24. Xanthou G, Alissafi T, Semitekolou M, Simoes DCM, Economidou E, Gaga M, Lambrecht BN, Lloyd CM, Panoutsakopoulou V: Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Nat. Med 2007, 13:570-8. (Pubitemid 46828486)
25. Köhl J, Baelder R, Lewkowich IP, Pandey MK, Hawlisch H, Wang L, Best J, Herman NS, Sproles AA, Zwirner J, Whitsett JA, Gerard C, Sfyroera G, Lambris JD, Wills-Karp M: A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J. Clin. Invest 2006, 116:783-96. (Pubitemid 43326888)
26. Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D: MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat. Immunol 2009, 10:697-705. F1000 Factor 20 Evaluated by Dale Umetsu 01 Jun 2009, Eric Denkers 03 Jun 2009, Richard Grencis 17 Jun 2009, Caetano Reis e Sousa 02 Jul 2009, Thomas Wynn 23 Jul 2009, Jonathan Lamb 09 Sep 2009, Mark Bix 6 Nov 2009
27. Sokol CL, Chu N, Yu S, Nish SA, Laufer TM, Medzhitov R: Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat. Immunol 2009, 10:713-20. F1000 Factor 20 Evaluated by Eric Denkers 03 Jun 2009, Shinsuke Taki 04 Jun 2009, Kiyoshi Takeda 12 Jun 2009, Richard Grencis 17 Jun 2009, Caetano Reis e Sousa 02 Jul 2009, Thomas Wynn 23 Jul 2009, Mark Bix 26 Nov 2009
28. Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, Battaile JT, Alevy Y, Le Yan, Agapov E, Kim EY, Holtzman MJ: Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J. Exp. Med 2007, 204:2759-69. F1000 Factor 6 Evaluated by Marc Rothenberg 03 Dec 2007
29. Ohnmacht C, Schwartz C, Panzer M, Schiedewitz I, Naumann R, Voehringer D: Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 2010, 33:364-74. F1000 Factor 13 Evaluated by Hilde Cheroutre and Daniel Mucida 16 Sep 2010, Richard L Stevens 04 Oct 2010, Rick Maizels and James Hewitson 14 Oct 2010, Troy Randall, Luz Garcia-Hernandez and Javier Rangel- Moreno 10 Feb 2011, Avinash Bhandoola 18 Feb 2011
30. Sullivan BM, Liang H, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CDC, Locksley RM: Genetic analysis of basophil function in vivo. Nat. Immunol 2011, 12:527-35. F1000 Factor 10 Evaluated by Shinsuke Taki 16 May 2011, Richard Grencis 18 May 2011
31. Tang H, Cao W, Kasturi SP, Ravindran R, Nakaya HI, Kundu K, Murthy N, Kepler TB, Malissen B, Pulendran B: The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat. Immunol 2010, 11:608-17. F1000 Factor 11 Evaluated by Shinsuke Taki 27 May 2010, Juan Rivera and Nicolas Charles 16 Jul 2010, Bart Lambrecht 17 Feb 2012
32. Kuipers H, Heirman C, Hijdra D, Muskens F, Willart M, van Meirvenne S, Thielemans K, Hoogsteden HC, Lambrecht BN: Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization. J. Leukoc. Biol 2004, 76:1028-38. (Pubitemid 39458714)
33. Dodge IL, Carr MW, Cernadas M, Brenner MB: IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J. Immunol 2003, 170:4457-64. (Pubitemid 36519950)
34. Krishnamoorthy N, Oriss TB, Paglia M, Fei M, Yarlagadda M, Vanhaesebroeck B, Ray A, Ray P: Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma. Nat. Med 2008, 14:565-73. (Pubitemid 351655220)
35. Rincón M, Anguita J, Nakamura T, Fikrig E, Flavell RA: Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J. Exp. Med 1997, 185:461-9. (Pubitemid 27078364)
36. Brewer JM, Conacher M, Hunter CA, Mohrs M, Brombacher F, Alexander J: Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL- 13-mediated signaling. J. Immunol 1999, 163:6448-54.
37. Okahashi N, Yamamoto M, Vancott JL, Chatfield SN, Roberts M, Bluethmann H, Hiroi T, Kiyono H, McGhee JR: Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses. Infect. Immun 1996, 64:1516-25.
38. Zheng W, Flavell RA: The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997, 89:587-96. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
39. Zhu J, Guo L, Min B, Watson CJ, Hu-Li J, Young HA, Tsichlis PN, Paul WE: Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity 2002, 16:733-44. F1000 Factor 10 Evaluated by Dan Conrad 14 Jun 2002
40. Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, Busslinger M, McCright B, Gridley T, Flavell RA: Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 2007, 27:89-99. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
41. Seki N, Miyazaki M, Suzuki W, Hayashi K, Arima K, Myburgh E, Izuhara K, Brombacher F, Kubo M: IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation. J. Immunol 2004, 172:6158-66. F1000 Factor 6 Evaluated by Mark Bix 17 May 2004
42. Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA: Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 2004, 117:515-26. F1000 Factor 18 Evaluated by David Chaplin 24 May 2004, Chen Dong 03 Jun 2004, Warren Pear 16 Jul 2004, Raphael Kopan 23 Jul 2004, Alan Houghton 27 Jul 2004
43. Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WS: Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 2007, 27:100-10. (Pubitemid 47096803)
44. Ong C, Sedy JR, Murphy KM, Kopan R: Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS ONE 2008, 3: e2823.
45. Kashyap M, Rochman Y, Spolski R, Samsel L, Leonard WJ: Thymic stromal lymphopoietin is produced by dendritic cells. J. Immunol 2011, 187:1207-11. F1000 Factor 6 Evaluated by Elizabeth Kelly and Jim Stahl 06 Dec 2011
46. Jong EC de, Vieira PL, Kalinski P, Schuitemaker JHN, Tanaka Y, Wierenga EA, Yazdanbakhsh M, Kapsenberg ML: Microbial compounds selectively induce Th1 cell-promoting or Th2 cellpromoting dendritic cells in vitro with diverse th cell-polarizing signals. J. Immunol 2002, 168:1704-9. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
47. Jenkins SJ, Perona-Wright G, Worsley AGF, Ishii N, MacDonald AS: Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. J. Immunol 2007, 179:3515-23. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
48. Wang Y, Liu Y: Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses. Clin. Exp. Allergy 2009, 39:798-806. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
49. Kashiwakura J, Yokoi H, Saito H, Okayama Y: T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: comparison of gene expression profiles between human tonsillar and lung-cultured mast cells. J. Immunol 2004, 173:5247-57. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
50. MacDonald AS, Straw AD, Dalton NM, Pearce EJ: Cutting edge: Th2 response induction by dendritic cells: a role for CD40. J. Immunol 2002, 168:537-40. F1000 Factor 8 Evaluated by Thomas Wynn 30 Jan 2002
51. MacDonald AS, Patton EA, La Flamme AC, Araujo MI, Huxtable CR, Bauman B, Pearce EJ: Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction. J. Immunol 2002, 168:4643-9. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
52. MacDonald AS, Straw AD, Bauman B, Pearce EJ: CD8- dendritic cell activation status plays an integral role in influencing Th2 response development. J. Immunol 2001, 167:1982-8. F1000 Factor 8 Evaluated by Thomas Wynn 30 Nov 2001
53. Jankovic D, Kullberg MC, Caspar P, Sher A: Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling. J. Immunol 2004, 173:2419-27. F1000 Factor6 Evaluated by Bart Lambrecht 17 Feb 2012
54. Everts B, Perona-Wright G, Smits HH, Hokke CH, van der Ham AJ, Fitzsimmons CM, Doenhoff MJ, van der Bosch J, Mohrs K, Haas H, Mohrs M, Yazdanbakhsh M, Schramm G: Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. J. Exp. Med 2009, 206:1673-80. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
55. Chieppa M, Rescigno M, Huang AYC, Germain RN: Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J. Exp. Med 2006, 203:2841-52. F1000 Factor 8 Evaluated by David Alpers 12 Apr 2007
56. Hammad H, Lambrecht BN: Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses. Allergy 2011, 66:579-87.
57. Lambrecht BN, Hammad H: The role of dendritic and epithelial cells as master regulators of allergic airway inflammation. Lancet 2010, 376:835-43.
58. Nolte MA, Leibundgut-Landmann S, Joffre O, Reis E, Sousa C: Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J. Exp. Med 2007, 204:1487-501. (Pubitemid 46919885)
59. Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN: House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat. Med 2009, 15:410-6. F1000 Factor 10 Evaluated by John Kyriakis 14 Apr 2009, Achsah Keegan 05 Jun 2009
60. Nathan AT, Peterson EA, Chakir J, Wills-Karp M: Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J. Allergy Clin. Immunol 2009, 123:612-8. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
61. Pichavant M, Charbonnier A, Taront S, Brichet A, Wallaert B, Pestel J, Tonnel A, Gosset P: Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment. J. Allergy Clin. Immunol 2005, 115:771-8. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
62. Wada K, Matsuwaki Y, Moriyama H, Kita H: Cockroach induces inflammatory responses through protease-dependent pathways. Int. Arch. Allergy Immunol 2011, 155(Suppl 1):135-41. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
63. Eiwegger T, Akdis CA: IL-33 links tissue cells, dendritic cells and Th2 cell development in a mouse model of asthma. Eur. J. Immunol 2011, 41:1535-8. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
64. Stämpfli MR, Wiley RE, Neigh GS, Gajewska BU, Lei XF, Snider DP, Xing Z, Jordana M: GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice. J. Clin. Invest 1998, 102:1704-14. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
65. Cates EC, Fattouh R, Wattie J, Inman MD, Goncharova S, Coyle AJ, Gutierrez-Ramos J, Jordana M: Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GMCSF- mediated mechanism. J. Immunol 2004, 173:6384-92. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
66. Cates EC, Gajewska BU, Goncharova S, Alvarez D, Fattouh R, Coyle AJ, Gutierrez-Ramos J, Jordana M: Effect of GM-CSF on immune, inflammatory, and clinical responses to ragweed in a novel mouse model of mucosal sensitization. J. Allergy Clin. Immunol 2003, 111:1076-86. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
67. Fattouh R, Pouladi MA, Alvarez D, Johnson JR, Walker TD, Goncharova S, Inman MD, Jordana M: House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation. Am. J. Respir. Crit. Care Med 2005, 172:314-21. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
68. Yamashita N, Tashimo H, Ishida H, Kaneko F, Nakano J, Kato H, Hirai K, Horiuchi T, Ohta K: Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte-macrophage colony-stimulating factor (GMCSF). Cell. Immunol 2002, 219:92-7. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
69. Moon P, Kim H: Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-kB pathway in mast cells. Cytokine 2011, 54:239-43. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
70. Ito T, Wang Y, Duramad O, Hori T, Delespesse GJ, Watanabe N, Qin FX, Yao Z, Cao W, Liu Y: TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J. Exp. Med 2005, 202:1213-23. F1000 Factor 8 Evaluated by Mark Bix 08 Mar 2011
71. Liu Y: Thymic stromal lymphopoietin: master switch for allergic inflammation. J. Exp. Med 2006, 203:269-73. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
72. Wang Y, Angkasekwinai P, Lu N, Voo KS, Arima K, Hanabuchi S, Hippe A, Corrigan CJ, Dong C, Homey B, Yao Z, Ying S, Huston DP, Liu Y: IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J. Exp. Med 2007, 204:1837-47. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
73. Wong CK, Hu S, Cheung PFY, Lam CWK: Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils: implications in allergic inflammation. Am. J. Respir. Cell Mol. Biol 2010, 43:305-15. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
74. Zhang F, Huang G, Hu B, Song Y, Shi Y: A soluble thymic stromal lymphopoietin (TSLP) antagonist, TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cells. Clin. Exp. Immunol 2011, 164:256-64. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
75. Allakhverdi Z, Comeau MR, Jessup HK, Yoon BP, Brewer A, Chartier S, Paquette N, Ziegler SF, Sarfati M, Delespesse G: Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J. Exp. Med 2007, 204:253-8. F1000 Factor 8 Evaluated by P'ng Loke 23 Feb 2007, Marc Rothenberg 08 Mar 2007, Dale Umetsu 11 Apr 2007
76. Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry EJ, Jessup HK, Siegel LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegler SF, Comeau MR, Artis D: TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature 2011, 477:229-33. F1000 Factor 16 Evaluated by Booki Min 31 Aug 2011, Richard Grencis 09 Sep 2011, David Voehringer 18 Nov 2011, Marc A Williams 20 Dec 2011
77. Massacand JC, Stettler RC, Meier R, Humphreys NE, Grencis RK, Marsland BJ, Harris NL: Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function. Proc. Natl. Acad. Sci. U.S.A 2009, 106:13968-73.
78. Angkasekwinai P, Park H, Wang Y, Wang Y, Chang SH, Corry DB, Liu Y, Zhu Z, Dong C: Interleukin 25 promotes the initiation of proallergic type 2 responses. J. Exp. Med 2007, 204:1509-17. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
79. Corrigan CJ, Wang W, Meng Q, Fang C, Wu H, Reay V, Lv Z, Fan Y, An Y, Wang Y, Liu Y, Lee TH, Ying S: T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma. Proc. Natl. Acad. Sci. U.S.A 2011, 108:1579-84. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
80. Kaiko GE, Phipps S, Angkasekwinai P, Dong C, Foster PS: NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25. J. Immunol 2010, 185:4681-90. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
81. Dinarello CA: A signal for the caspase-1 inflammasome free of TLR. Immunity 2007, 26:383-5. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
82. Dinarello CA: Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol 2009, 27:519-50.
83. Dinarello CA: Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011, 117:3720-32. F1000 Factor 8 Evaluated by Ulf Mueller-Ladner 28 Feb 2011
84. Lee H, Ziegler SF: Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB. Proc. Natl. Acad. Sci. U.S.A 2007, 104:914-9. (Pubitemid 46154711)
85. Rusznak C, Sapsford RJ, Devalia JL, Shah SS, Hewitt EL, Lamont AG, Davies RJ, Lozewicz S: Interaction of cigarette smoke and house dust mite allergens on inflammatory mediator release from primary cultures of human bronchial epithelial cells. Clin. Exp. Allergy 2001, 31:226-38. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
86. Phipps S, Lam CE, Kaiko GE, Foo SY, Collison A, Mattes J, Barry J, Davidson S, Oreo K, Smith L, Mansell A, Matthaei KI, Foster PS: Toll/ IL-1 signaling is critical for house dust mite-specific Th1 and Th2 responses. Am. J. Respir. Crit. Care Med 2009, 179:883-93. F1000 Factor 7 Evaluated by Patricia Finn and Kenneth Liu 14 Jul 2009, Bart Lambrecht 17 Feb 2012
87. Layland LE, Wagner H, da Costa CUP: Lack of antigen-specific Th1 response alters granuloma formation and composition in Schistosoma mansoni-infected MyD88-/- mice. Eur. J. Immunol 2005, 35:3248-57. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
88. Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H,Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S: IL-33 is a crucial amplifier of innate rather than acquired immunity. Proc. Natl. Acad. Sci. U.S.A 2010, 107:18581-6. F1000 Factor 6 Evaluated by Richard L Stevens 16 Dec 2010
89. Besnard A, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B: IL- 33-activated dendritic cells are critical for allergic airway inflammation. Eur. J. Immunol 2011, 41:1675-86. F1000 Factor 6 Evaluated by Joerg Koehl and Yves Laumonnier 09 Aug 2011
90. Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA: IL-33, an interleukin-1- like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005, 23:479-90. F1000 Factor 8 Evaluated by Richard Grencis 04 Jan 2006
91. Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, Furusawa J, Ohtani M, Fujii H, Koyasu S: Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 2010, 463:540-4. F1000 Factor 22 valuated by Richard Locksley 14 Jan 2010, James Disanto 19 Jan 2010, Flavius Martin and Dhaya Seshasayee 01 Feb 2010, Dale Umetsu 11 Feb 2010, Troy Randall 24 Feb 2010, Steve Ward and John Gordon Foster 25 Feb 2010, Avinash Bhandoola 10 Jan 2011, Bart Lambrecht 17 Feb 2012
92. Fallon PG, Ballantyne SJ, Mangan NE, Barlow JL, Dasvarma A, Hewett DR, McIlgorm A, Jolin HE, McKenzie ANJ: Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J. Exp. Med 2006, 203:1105-16. F1000 Factor 10 Evaluated by Thomas Nutman 21 Apr 2006, Thomas Wynn 28 Apr 2006
93. Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TKA, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie ANJ: Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 2010, 464:1367-70. F1000 Factor 18 Evaluated by Torben Lund 30 Mar 2010, Lieping Chen 01 Apr 2010, Rick Maizels and James Hewitson 11 May 2010, Dan Conrad 14 May 2010, Bart Lambrecht 17 Feb 2012
94. Tan AM, Chen H, Pochard P, Eisenbarth SC, Herrick CA, Bottomly HK: TLR4 signaling in stromal cells is critical for the initiation of allergic Th2 responses to inhaled antigen. J. Immunol 2010, 184:3535-44. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
95. Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde RS, Madan R, Thorne PS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL: Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 2009, 457:585-8. F1000 Factor 14 Evaluated by Rene Toes and Leendert Trouw 14 Jan 2009, Philipp M Lepper and Kathy Triantafilou 16 Feb 2009, Torben Sigsgaard and Vivi Schlunssen 29 May 2009, Michael Fessler 28 Jun 2011
96. Vanhoutte F, Breuilh L, Fontaine J, Zouain CS, Mallevaey T, Vasseur V, Capron M, Goriely S, Faveeuw C, Ryffel B, Trottein F: Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology. Microbes Infect 9:1606-13. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
97. Magalhaes JG, Rubino SJ, Travassos LH, Le Bourhis L, Duan W, Sellge G, Geddes K, Reardon C, Lechmann M, Carneiro LA, Selvanantham T, Fritz JH, Taylor BC, Artis D, Mak TW, Comeau MR, Croft M, Girardin SE, Philpott DJ: Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc. Natl. Acad. Sci. U.S.A 2011, 108:14896-901. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
98. Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA: Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 2008, 453:1122-6. F1000 Factor 12 Evaluated by Drusilla Burns 28 May 2008, David Chaplin 14 Jul 2008, Dale Umetsu 28 Jul 2008, Shizuo Akira 09 Sep 2008
99. Kuroda E, Ishii KJ, Uematsu S, Ohata K, Coban C, Akira S, Aritake K, Urade Y, Morimoto Y: Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms. Immunity 2011, 34:514-26. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
100. Marrack P, McKee AS, Munks MW: Towards an understanding of the adjuvant action of aluminium. Nat. Rev. Immunol 2009, 9:287-93. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
101. Schmitz N, Kurrer M, Kopf M: The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model. Eur. J. Immunol 2003, 33:991-1000. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
102. Li H, Willingham SB, Ting JP, Re F: Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J. Immunol 2008, 181:17-21. F1000 Factor 8 Evaluated by Denise M Monack 23 Jul 2008
103. McKee AS, Munks MW, MacLeod MKL, Fleenor CJ, van Rooijen N, Kappler JW, Marrack P: Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J. Immunol 2009, 183:4403-14. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012
104. Franchi L, Núñez G: The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur. J. Immunol 2008, 38:2085-9. F1000 Factor 7 Evaluated by Moriya Tsuji 03 Sep 2008, Bart Lambrecht 17 Feb 2012
105. Kool M, Pétrilli V, Smedt T de, Rolaz A, Hammad H, van Nimwegen M, Bergen IM, Castillo R, Lambrecht BN, Tschopp J: Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J. Immunol 2008, 181:3755-9.
106. Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, Hashimoto K: Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes. J. Allergy Clin. Immunol 2011, 127:806-14.e1-4.
107. Barrett NA, Rahman OM, Fernandez JM, Parsons MW, Xing W, Austen KF, Kanaoka Y: Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. J. Exp. Med 2011, 208:593-604. F1000 Factor 6 Evaluated by Bart Lambrecht 17 Feb 2012