TLR4 signaling in stromal cells is critical for the initiation of allergic Th2 responses to inhaled antigen

Journal of Immunology

Volumn 184, Issue 7, 2010, Pages 3535-3544

  Tan, Anna M ^a   Chen, Hui ^a,b   Pochard, Pierre ^a   Eisenbarth, Stephanie C ^a   Herrick, Christina A ^a   Bottomly, H Kim ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c WELLESLEY COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; JAGGED1; LIPOPOLYSACCHARIDE; OVALBUMIN; RNA; THYMIC STROMAL LYMPHOPOIETIN; TOLL LIKE RECEPTOR 4; TLR4 PROTEIN, MOUSE;

ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CD4+ T LYMPHOCYTE; CELL MIGRATION; CHIMERA; COCULTURE; DENDRITIC CELL; HEMATOPOIETIC CELL; HISTOLOGY; IMMUNE RESPONSE; LUNG LAVAGE; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENSITIZATION; STROMA CELL; TH1 CELL; TH2 CELL; ANIMAL; ASTHMA; BAGG ALBINO MOUSE; C57BL MOUSE; CELL DIFFERENTIATION; CYTOLOGY; FEMALE; GENE EXPRESSION; HISTOCOMPATIBILITY; HYPERSENSITIVITY; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; LUNG; LYMPHOCYTE ACTIVATION; MALE; NEUTROPHIL CHEMOTAXIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADMINISTRATION, INHALATION; ANIMALS; ANTIGENS; ASTHMA; CELL DIFFERENTIATION; CHEMOTAXIS, LEUKOCYTE; COCULTURE TECHNIQUES; DENDRITIC CELLS; FEMALE; GENE EXPRESSION; HYPERSENSITIVITY; LUNG; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; OVALBUMIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STROMAL CELLS; TH2 CELLS; TOLL-LIKE RECEPTOR 4; TRANSPLANTATION CHIMERA;

EID: 77951643500     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900340     Document Type: Article

References (37)

1. Devereux, G. 2006. The increase in the prevalence of asthma and allergy: food for thought. Nat. Rev. Immunol. 6: 869-874.
2. Lambrecht, B. N. 2005. Dendritic cells and the regulation of the allergic immune response. Allergy 60: 271-282. (Pubitemid 40293342)
3. Vermaelen, K. Y., I. Carro-Muino, B. N. Lambrecht, and R. A. Pauwels. 2001. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193: 51-60.
4. Pasare, C., and R. Medzhitov. 2005. Toll-like receptors: linking innate and adaptive immunity. Adv. Exp. Med. Biol. 560: 11-18.
5. Iwasaki, A., and R. Medzhitov. 2004. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5: 987-995.
6. Reis e Sousa, C. 2004. Activation of dendritic cells: translating innate into adaptive immunity. Curr. Opin. Immunol. 16: 21-25.
7. Hoebe, K., E. Janssen, and B. Beutler. 2004. The interface between innate and adaptive immunity. Nat. Immunol. 5: 971-974.
8. Amsen, D., J. M. Blander, G. R. Lee, K. Tanigaki, T. Honjo, and R. A. Flavell. 2004. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117: 515-526. (Pubitemid 38610236)
9. Napolitani, G., A. Rinaldi, F. Bertoni, F. Sallusto, and A. Lanzavecchia. 2005. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat. Immunol. 6: 769-776.
10. Eisenbarth, S. C., D. A. Piggott, J. W. Huleatt, I. Visintin, C. A. Herrick, and K. Bottomly. 2002. Lipopolysaccharide-enhanced, Toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196: 1645-1651.
11. Kim, Y. K., S. Y. Oh, S. G. Jeon, H. W. Park, S. Y. Lee, E. Y. Chun, B. Bang, H. S. Lee, M. H. Oh, Y. S. Kim, et al. 2007. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J. Immunol. 178: 5375-5382.
12. Sha, Q., A. Q. Truong-Tran, J. R. Plitt, L. A. Beck, and R. P. Schleimer. 2004. Activation of airway epithelial cells by Toll-like receptor agonists. Am. J. Respir. Cell Mol. Biol. 31: 358-364.
13. Zhang, Z., J. P. Louboutin, D. J. Weiner, J. B. Goldberg, and J. M. Wilson. 2005. Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5. Infect. Immun. 73: 7151-7160.
14. Diamond, G., D. Legarda, and L. K. Ryan. 2000. The innate immune response of the respiratory epithelium. Immunol. Rev. 173: 27-38.
15. Monick, M. M., T. O. Yarovinsky, L. S. Powers, N. S. Butler, A. B. Carter, G. Gudmundsson, and G.W. Hunninghake. 2003. Respiratory syncytial virus upregulates TLR4 and sensitizes airway epithelial cells to endotoxin. J. Biol. Chem. 278: 53035-53044.
16. Bals, R., and P. S. Hiemstra. 2004. Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur. Respir. J. 23: 327-333.
17. Polito, A. J., and D. Proud. 1998. Epithelia cells as regulators of airway inflammation. J. Allergy Clin. Immunol. 102: 714-718.
18. Ritter, M., D. Mennerich, A. Weith, and P. Seither. 2005. Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response. J. Inflamm. (Lond.) 2: 16.
19. Saba, S., G. Soong, S. Greenberg, and A. Prince. 2002. Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways. Am. J. Respir. Cell Mol. Biol. 27: 561-567.
20. Khair, O. A., R. J. Davies, and J. L. Devalia. 1996. Bacterial-induced release of inflammatory mediators by bronchial epithelial cells. Eur. Respir. J. 9: 1913-1922.
21. Koyama, S., S. I. Rennard, G. D. Leikauf, and R. A. Robbins. 1991. Bronchial epithelial cells release monocyte chemotactic activity in response to smoke and endotoxin. J. Immunol. 147: 972-979.
22. Koyama, S., S. I. Rennard, G. D. Leikauf, S. Shoji, S. Von Essen, L. Claassen, and R. A. Robbins. 1991. Endotoxin stimulates bronchial epithelial cells to release chemotactic factors for neutrophils: a potential mechanism for neutrophil recruitment, cytotoxicity, and inhibition of proliferation in bronchial inflammation. J. Immunol. 147: 4293-4301.
23. Poynter, M. E., C. G. Irvin, and Y. M. Janssen-Heininger. 2003. A prominent role for airway epithelial NF-kB activation in lipopolysaccharide- induced airway inflammation. J. Immunol. 170: 6257-6265. (Pubitemid 36682611)
24. Luster, A. D., and A. M. Tager. 2004. T-cell trafficking in asthma: lipid mediators grease the way. Nat. Rev. Immunol. 4: 711-724.
25. Ying, S., B. O'Connor, J. Ratoff, Q. Meng, K. Mallett, D. Cousins, D. Robinson, G. Zhang, J. Zhao, T. H. Lee, and C. Corrigan. 2005. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J. Immunol. 174: 8183-8190.
26. Cohn, L., R. J. Homer, H. MacLeod, M. Mohrs, F. Brombacher, and K. Bottomly. 1999. Th2-induced airway mucus production is dependent on IL-4Rα, but not on eosinophils. J. Immunol. 162: 6178-6183. (Pubitemid 29314980)
27. Henegariu, O., N. A. Heerema, L. Lowe Wright, P. Bray-Ward, D. C. Ward, and G. H. Vance. 2001. Improvements in cytogenetic slide preparation: controlled chromosome spreading, chemical aging and gradual denaturing. Cytometry 43: 101-109. (Pubitemid 32115243)
28. Rudensky AYu, S. Rath, P. Preston-Hurlburt, D. B. Murphy, and C. A. Janeway, Jr. 1991. On the complexity of self. Nature 353: 660-662.
29. Voehringer, D., T. A. Reese, X. Huang, K. Shinkai, and R. M. Locksley. 2006. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic noneosinophil cells of the innate immune system. J. Exp. Med. 203: 1435-1446.
30. Schnare, M., G. M. Barton, A. C. Holt, K. Takeda, S. Akira, and R. Medzhitov. 2001. Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2: 947-950.
31. Nolte, M. A., S. Leibundgut-Landmann, O. Joffre, and C. Reis e Sousa. 2007. Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J. Exp. Med. 204: 1487-1501.
32. Iwasaki, A. 2007. Mucosal dendritic cells. Annu. Rev. Immunol. 25: 381-418.
33. Hammad, H., M. Chieppa, F. Perros, M. A. Willart, R. N. Germain, and B. N. Lambrecht. 2009. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat. Med. 15: 410-416.
34. Kheradmand, F., A. Kiss, J. Xu, S. H. Lee, P. E. Kolattukudy, and D. B. Corry. 2002. A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease. J. Immunol. 169: 5904-5911. (Pubitemid 35291696)
35. Trompette, A., S. Divanovic, A. Visintin, C. Blanchard, R. S. Hegde, R. Madan, P. S. Thorne, M. Wills-Karp, T. L. Gioannini, J. P. Weiss, and C. L. Karp. 2009. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 457: 585-588.
36. Zhou, B., M. R. Comeau, T. De Smedt, H. D. Liggitt, M. E. Dahl, D. B. Lewis, D. Gyarmati, T. Aye, D. J. Campbell, and S. F. Ziegler. 2005. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat. Immunol. 6: 1047-1053.
37. Sun, J., C. J. Krawczyk, and E. J. Pearce. 2008. Suppression of Th2 cell development by Notch ligands Delta1 and Delta4. J. Immunol. 180: 1655-1661.