A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells

Journal of Immunology

Volumn 182, Issue 8, 2009, Pages 5123-5130

  Zhang, Xun ^a   Lewkowich, Ian P ^a   Köhl, Gabriele ^a   Clark, Jennifer R ^a   Wills Karp, Marsha ^a   Köhl, Jörg ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; B7 DC ANTIGEN; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C3A RECEPTOR; COMPLEMENT COMPONENT C5A RECEPTOR; CYTOKINE; PROGRAMMED DEATH 1 LIGAND 1; UNCLASSIFIED DRUG; B7-DC ANTIGEN; COMPLEMENT C3A RECEPTOR; COMPLEMENT COMPONENT C5A; COMPLEMENT RECEPTOR; MEMBRANE PROTEIN; PDCD1LG1 PROTEIN, MOUSE; PEPTIDE;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; DERMATOPHAGOIDES; DISEASE COURSE; DISEASE MODEL; EX VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TH2 CELL; ANIMAL; ASTHMA; BAGG ALBINO MOUSE; IMMUNOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD80; ASTHMA; COMPLEMENT C5A; DENDRITIC CELLS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; PEPTIDES; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, COMPLEMENT; SIGNAL TRANSDUCTION; TH2 CELLS;

EID: 65249114882     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0804276     Document Type: Article

References (29)

1. Barnes, P. J. 2008. Immunology of asthma and chronic obstructive pulmonary disease. Nat. Rev. Immunol. 8: 183-192. (Pubitemid 351323287)
2. Köhl, J., R. Baelder, I. P. Lewkowich, M. K. Pandey, H. Hawlisch, L. Wang, J. Best, N. S. Herman, A. A. Sproles, J. Zwirner, et al. 2006. A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J. Clin. Invest. 116: 783-796. (Pubitemid 43326888)
3. Köhl, J., and M. Wills-Karp. 2007. A dual role for complement in allergic asthma. Curr. Opin. Pharmacol. 7: 283-289. (Pubitemid 46731203)
4. Karp, C. L., A. Grupe, E. Schadt, S. L. Ewart, M. Keane-Moore, P. J. Cuomo, J. Köhl, L. Wahl, D. Kuperman, S. Germer, et al. 2000. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat. Immunol. 1: 221-226.
5. Drouin, S. M., M. Sinha, G. Sfyroera, J. D. Lambris, and R. A. Wetsel. 2006. A protective role for the fifth complement component (c5) in allergic airway disease. Am. J. Respir. Crit. Care Med. 173: 852-857.
6. McKinley, L., J. Kim, G. L. Bolgos, J. Siddiqui, and D. G. Remick. 2006. Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Respir. Res. 7: 129. (Pubitemid 44734065)
7. Bautsch, W., H. G. Hoymann, Q. Zhang, I. Meier-Wiedenbach, U. Raschke, R. S. Ames, B. Sohns, N. Flemme, A. Meyer zu Vilsendorf, M. Grove, A. Klos, and J. Köhl. 2000. Cutting edge: guinea pigs with a natural C3a-receptor defect exhibit decreased bronchoconstriction in allergic airway disease: evidence for an involvement of the C3a anaphylatoxin in the pathogenesis of asthma. J. Immunol. 165: 5401-5405.
8. Humbles, A. A., B. Lu, C. A. Nilsson, C. Lilly, E. Israel, Y. Fujiwara, N. P. Gerard, and C. Gerard. 2000. A role for the C3a anaphylatoxin receptor in the effector phase of asthma. Nature 406: 998-1001.
9. Drouin, S. M., D. B. Corry, T. J. Hollman, J. Kildsgaard, and R. A. Wetsel. 2002. Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. J. Immunol. 169: 5926-5933.
10. Milian, E., and A. M. Diaz. 2004. Allergy to house dust mites and asthma. P. R. Health Sci. J. 23: 47-57.
11. Cates, E. C., R. Fattouh, J. Wattie, M. D. Inman, S. Goncharova, A. J. Coyle, J. C. Gutierrez-Ramos, and M. Jordana. 2004. Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism. J. Immunol. 173: 6384-6392. (Pubitemid 39487798)
12. Wills-Karp, M., J. Luyimbazi, X. Xu, B. Schofield, T. Y. Neben, C. L. Karp, and D. D. Donaldson. 1998. Interleukin-13: central mediator of allergic asthma. Science 282: 2258-2261. (Pubitemid 29004074)
13. Hawlisch, H., Y. Belkaid, R. Baelder, D. Hildeman, C. Gerard, and J. Köhl. 2005. C5a negatively regulates Toll-like receptor 4-induced immune responses. Immunity 22: 415-426. (Pubitemid 40545108)
14. Soruri, A., S. Kim, Z. Kiafard, and J. Zwirner. 2003. Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody. Immunol. Lett. 88: 47-52. (Pubitemid 36835849)
15. Godau, J., T. Heller, H. Hawlisch, M. Trappe, E. Howells, J. Best, J. Zwirner, J. S. Verbeek, P. M. Hogarth, C. Gerard, et al. 2004. C5a initiates the inflammatory cascade in immune complex peritonitis. J. Immunol. 173: 3437-3445. (Pubitemid 39142055)
16. Baelder, R., B. Fuchs, W. Bautsch, J. Zwirner, J. Köhl, H. G. Hoymann, T. Glaab, V. Erpenbeck, N. Krug, and A. Braun. 2005. Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation. J. Immunol. 174: 783-789. (Pubitemid 40094273)
17. Köhl, J., and M. Wills-Karp. 2007. Complement regulates inhalation tolerance at the dendritic cell/T cell interface. Mol. Immunol. 44: 44-56. (Pubitemid 44647103)
18. Kozel, T. R., M. A. Wilson, T. P. Farrell, and S. M. Levitz. 1989. Activation of C3 and binding to Aspergillus fumigatus conidia and hyphae. Infect. Immun. 57: 3412-3417.
19. Maruo, K., T. Akaike, T. Ono, T. Okamoto, and H. Maeda. 1997. Generation of anaphylatoxins through proteolytic processing of C3 and C5 by house dust mite protease. J. Allergy Clin. Immunol. 100: 253-260. (Pubitemid 27349869)
20. Hammad, H., and B. N. Lambrecht. 2008. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat. Rev. Immunol. 8: 193-204. (Pubitemid 351323293)
21. Zhou, W., Q. Peng, K. Li, and S. H. Sacks. 2007. Role of dendritic cell synthesis of complement in the allospecific T cell response. Mol. Immunol. 44: 57-63. (Pubitemid 44647110)
22. Werfel, T., K. Kirchhoff, M. Wittmann, G. Begemann, A. Kapp, F. Heidenreich, O. Götze, and J. Zwirner. 2000. Activated human T lymphocytes express a functional C3a receptor. J. Immunol. 165: 6599-6605.
23. Kawamoto, S., A. Yalcindag, D. Laouini, S. Brodeur, P. Bryce, B. Lu, A. A. Humbles, H. Oettgen, C. Gerard, and R. S. Geha. 2004. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. J. Clin. Invest. 114: 399-407. (Pubitemid 39071612)
24. Settmacher, B., D. Bock, H. Saad, S. Gartner, C. Rheinheimer, J. Köhl, W. Bautsch, and A. Klos. 1999. Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a. J. Immunol. 162: 7409-7416. (Pubitemid 29277719)
25. De Heer, H. J., H. Hammad, T. Soullie, D. Hijdra, N. Vos, M. A. Willart, H. C. Hoogsteden, and B. N. Lambrecht. 2004. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J. Exp. Med. 200: 89-98.
26. + T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J. Exp. Med. 202: 1549-1561.
27. Keane-Myers, A. M., W. C. Gause, F. D. Finkelman, X. D. Xhou, and M. Wills-Karp. 1998. Development of murine allergic asthma is dependent upon B7-2 costimulation. J. Immunol. 160: 1036-1043.
28. Matsumoto, K., H. Inoue, T. Nakano, M. Tsuda, Y. Yoshiura, S. Fukuyama, F. Tsushima, T. Hoshino, H. Aizawa, H. Akiba, et al. 2004. B7-DC regulates asthmatic response by an IFN-γ-dependent mechanism. J. Immunol. 172: 2530-2541. (Pubitemid 38182404)
29. Keir, M. E., M. J. Butte, G. J. Freeman, and A. H. Sharpe. 2008. PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26: 677-704. (Pubitemid 351600389)