Synaptic multiprotein complexes associated with 5-HT2C receptors: A proteomic approach

EMBO Journal

Volumn 21, Issue 10, 2002, Pages 2332-2342

  Bécamel, Carine ^a   Alonso, Gérard ^a   Galéotti, Nathalie ^a   Demey, Emmanuelle ^b   Jouin, Patrick ^c   Ullmer, Christoph ^d   Dumuis, Aline ^e   Bockaert, Joël ^e   Marin, Philippe ^f  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c RESEARCH AND DEVELOPMENT   (Australia)

^d College of Chemistry and Molecular Engineering ^*  (China)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

^f CCIPE   (France)

Author keywords

5 HT2C receptor; PDZ domain; Proteomic analysis; Scaffold protein

Indexed keywords

ACTIN; G PROTEIN COUPLED RECEPTOR; IONOTROPIC RECEPTOR; PROTEIN TYROSINE KINASE; SEROTONIN 2C RECEPTOR; SPECTRIN;

AFFINITY CHROMATOGRAPHY; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOSKELETON; ELECTRON MICROSCOPY; IMMUNOBLOTTING; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEOMICS; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SYNAPSE;

AMINO ACID SEQUENCE; ANIMALS; CHOROID PLEXUS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GTP-BINDING PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; PROTEOME; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SYNAPSES; TRANSFECTION;

ANIMALIA;

EID: 0037093469     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.10.2332     Document Type: Article

References (52)

1. Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera
2. Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPPI
3. Mints as adaptors. Direct binding to neurexins and recruitment of Munc18
4. Cask and protein 4.1 support F-actin nucleation on neurexins
5. Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting
6. Molecular analysis of the X11-mLin-2/CASK complex in brain
7. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains
8. Signaling at zero G: G-protein-independent functions for 7-TM receptors
9. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain
10. Functional coupling of the 5-HT2C serotonin receptor to G proteins in Xenopus oocytes
11. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain
12. Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS
13. Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells
14. Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton
15. Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition
16. Regulation of mglu(7) receptors by proteins that interact with the intracellular C-terminus
17. Role of 5-HT(2C) receptors in the control of central dopamine function
18. Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments
19. Effect of chronic m-CPP on locomotion, hypophagia, plasma corticosterone and 5-HT2C receptor levels in the rat
20. The phagosome proteome: Insight into phagosome functions
21. The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
22. Heptahelical receptor signaling: Beyond the G protein paradigm
23. G proteins
24. The genetics of the protein 4.1 family: Organizers of the membrane and cytoskeleton
25. Proteomics of the nervous system
26. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
27. Characterization of MALS/Velis-1, -2, and -3: A family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex
28. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C.elegans EGF receptor LET-23 in vulval epithelial cells
29. Molecular cloning and characterization of Pals, proteins associated with mLin-7
30. Serotonin 5-HT2C receptor stimulates cyclic GMP formation in choroid plexus
31. Functional annotation of a full-length mouse cDNA collection
32. Proteomic and functional evidence for a P2X(7) receptor signalling complex
33. cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus
34. Role of striatal serotonin2A and serotonin2C receptor subtypes in the control of in vivo dopamine outflow in the rat striatum
35. Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifiuoromethylphenyl)piperazine on locomotor activity
36. Protein-protein interactions at G-protein-coupled receptors
37. Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice
38. Mints, Munc18-interacting proteins in synaptic vesicle exocytosis
39. Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses
40. Regulation of AMPA receptor GluR1 subunit surface expression by a 4.1 N-linked actin cytoskeletal association
41. PDZ domains and the organization of supramolecular complexes
42. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels
43. LET-23 receptor localization by the cell junction protein LIN-7 during C.elegans vulval induction
44. Protein 4.1, a multifunctional protein of the erythrocyte membrane skeleton: Structure and functions in erythrocytes and nonerythroid cells
45. Formation of nNOS/PSD-95 PDZ dimer requires a preformed β-finger structure from the nNOS PDZ domain
46. Cloning and characterization of MUPP1, a novel PDZ domain protein
47. Synaptic assembly of the brain in the absence of neurotransmitter secretion
48. A novel neuron-enriched homolog of the erythrocyte membrane cytoskeletal protein 4.1
49. Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-κB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain
50. Effect of capping protein, CapZ, on the length of actin filaments and mechanical properties of actin filament networks
51. Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1
52. Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain