Roles of G-protein-coupled receptor dimerization

EMBO Reports

Volumn 5, Issue 1, 2004, Pages 30-34

  Terrillon, Sonia ^a   Bouvier, Michel ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

G protein coupled receptor function; Heterodimerization; Homodimerization; Oligomerization; Regulation

Indexed keywords

G PROTEIN COUPLED RECEPTOR;

ARTICLE; DIMERIZATION; DOWNSTREAM PROCESSING; ENDOCYTOSIS; GENE TARGETING; LIGAND BINDING; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

DIMERIZATION; MODELS, MOLECULAR; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 1242276192     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.7400052     Document Type: Article

References (65)

1. AbdAlla S, Lother H, Quitterer U (2000) AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. Nature 407: 94-98
2. 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci USA 97: 3684-3689
3. Angers S, Salahpour A, Bouvier M (2002) Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Annu Rev Pharmacol Toxicol 42: 409-435
4. Ayoub MA, Couturier C, Lucas-Meunier E, Angers S, Fossier P, Bouvier M, Jockers R (2002) Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J Biol Chem 277: 21522-21528
5. Babcock GJ, Farzan M, Sodroski J (2003) Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor. J Biol Chem 278: 3378-3385
6. Baneres JL, Parello J (2003) Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein. J Mol Biol 329: 815-829
7. Barki-Harrington L, Luttrell LM, Rockman HA (2003) Dual inhibition of β-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo. Circulation 108: 1611-1618
8. Benkirane M, Jin DY, Chun RF, Koup RA, Jeang KT (1997) Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by Ccr5δ32. J Biol Chem 272: 30603-30606
9. 2 receptor-receptor heteromerization. Qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J Biol Chem 278: 46741-46749
10. Charles AC, Mostovskaya N, Asas K, Evans CJ, Dankovich ML, Hales TG (2003) Coexpression of δ-opioid receptors with μ receptors in GH3 cells changes the functional response to μ agonists from inhibitory to excitation. Mol Pharmacol 63: 89-95
11. Cheng ZJ, Miller LJ (2001) Agonist-dependent dissociation of oligomeric complexes of G protein-coupled cholecystokinin receptors demonstrated in living cells using bioluminescence resonance energy transfer. J Biol Chem 276: 48040-48047
12. 1 receptors assemble into functionally interacting complexes. J Biol Chem 276: 18345-18351
13. Colley NJ, Cassill JA, Baker EK, Zuker CS (1995) Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration. Proc Natl Acad Sci USA 92: 3070-3074
14. Cornea A, Janovick JA, Maya-Nunez G, Conn PM (2001) Gonadotropin-releasing hormone receptor microaggregation. rate monitored by fluorescence resonance energy transfer. J Biol Chem 276: 2153-2158
15. Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ (2001) Insights into Wnt binding and signalling from the structures of two frizzled cysteine-rich domains. Nature 412: 86-90
16. Dinger MC, Bader JE, Kobor AD, Kretzschmar AK, Beck-Sickinger AG (2003) Homodimerization of neuropeptide Y receptors investigated by fluorescence resonance energy transfer in living cells. J Biol Chem 278: 10562-10571
17. Floyd DH, Geva A, Bruinsma SP, Overton MC, Blumer KJ, Baranski TJ (2003) C5a receptor oligomerization. II. Fluorescence resonance energy transfer studies of a human G protein-coupled receptor expressed in yeast. J Biol Chem 278: 35354-35361
18. Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K (2003) Atomic-force microscopy: rhodopsin dimers in native disc membranes. Nature 421: 127-128
19. Franco R et al (2000) Evidence for adenosine/dopamine receptor interactions: indications for heteromerization. Neuropsychopharmacology 23:S50-S59
20. B receptor function. EMBO J 20:2152-2159
21. George SR, Fan T, Xie Z, Tse R, Tam V, Varghese G, O'Dowd BF (2000) Oligomerization of μ- and δ-opioid receptors. Generation of novel functional properties. J Biol Chem 275: 26128-26135
22. George SR, O'Dowd BF, Lee SP (2002) G-protein-coupled receptor oligomerization and its potential for drug discovery. Nature Rev Drug Discov 1:808-820
23. 1 receptors form functionally interacting heteromeric complexes. Proc Natl Acad Sci USA 97:8606-8611
24. Gomes I, Jordan BA, Gupta A, Trapaidze N, Nagy V, Devi LA (2000) Heterodimerization of μ and δ opioid receptors: a role in opiate synergy. J Neurosci 20:RC110
25. Grosse R, Schoneberg T, Schultz G, Gudermann T (1997) Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. Mol Endocrinol 11: 1305-1318
26. 2 receptor homodimer. J Biol Chem 278: 4385-4388
27. Hamm HE (2001) How activated receptors couple to G proteins. Proc Natl Acad Sci USA 98: 4819-4821
28. 2 receptors. J Biol Chem 277: 18091-18097
29. Horvat RD, Roess DA, Nelson SE, Barisas BG, Clay CM (2001) Binding of agonist but not antagonist leads to fluorescence resonance energy transfer between intrinsically fluorescent gonadotropin-releasing hormone receptors. Mol Endocrinol 15: 695-703
30. Hunzicker-Dunn M, Barisas G, Song J, Roess DA (2003) Membrane organization of luteinizing hormone receptors differs between actively signaling and desensitized receptors. J Biol Chem 278: 42744-42749
31. Issafras H, Angers S, Bulenger S, Blanpain C, Parmentier M, Labbe-Jullie C, Bouvier M, Marullo S (2002) Constitutive agonist-independent CCR5 oligomerization and antibody-mediated clustering occurring at physiological levels of receptors. J Biol Chem 277: 34666-34673
32. Jensen AA, Hansen JL, Sheikh SP, Brauner-Osborne (2002) Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy (BRET). Eur J Biochem 269: 5076-5087
33. Karpa KD, Lin R, Kabbani N, Levenson R (2000) The dopamine D3 receptor interacts with itself and the truncated D3 splice variant D3nf: D3-D3nf interaction causes mislocalization of D3 receptors. Mol Pharmacol 58: 677-683
34. Kroeger KM, Hanyaloglu AC, Seeber RM, Miles LE, Eidne KA (2001) Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer. J Biol Chem 276: 12736-12743
35. Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K (2000) Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407: 971-977
36. Latif R, Graves P, Davies TF (2002) Ligand-dependent inhibition of oligomerization at the human thyrotropin receptor. J Biol Chem 277: 45059-45067
37. Lavoie C et al (2002) β1/β2-adrenergic receptor heterodimerization regulates β-adrenergic receptor internalization and ERK signaling efficacy. J Biol Chem 277: 35402-35410
38. Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, Engel A (2003) Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem 278: 21655-21662
39. Maggio R, Barbier P, Colelli A, Salvadori F, Demontis G, Corsini GU (1999) G protein-linked receptors: pharmacological evidence for the formation of heterodimers. J Pharmacol Exp Ther 291: 251-257
40. B receptor heterodimerization. Neuron 27: 97-106
41. B receptors - the first 7TM heterodimers. Trends Pharmacol Sci 20: 396-399
42. Mellado M, Rodriguez-Frade JM, Vila-Coro AJ, Fernandez S, Martin de Ana A, Jones DR, Toran JL, Martinez A (2001) Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO J 20: 2497-2507
43. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS (2001) Mammalian sweet taste receptors. Cell 106: 381-390
44. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS (2002) An amino-acid taste receptor. Nature 416: 199-202
45. Overton MC, Blumer KJ (2000) G-protein-coupled receptors function as oligomers in vivo. Curr Biol 10: 341-344
46. Overton MC, Blumer KJ (2002) The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor. J Biol Chem 277: 41463-41472
47. Patel RC et al (2002) Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells. Proc Natl Acad Sci USA 99: 3294-3299
48. Petaja-Repo UE, Hogue M, Laperriere A, Walker P, Bouvier M (2000) Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human δ opioid receptor J Biol Chem 275: 13727-13736
49. Petaja-Repo UE, Hogue M, Laperriere A, Bhalla S, Walker P, Bouvier M (2001) Newly synthesized human δ opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome. J Biol Chem 276: 4416-4423
50. 2A. J Biol Chem 276: 14027-14036
51. Pfeiffer M, Koch T, Schroder H, Laugsch M, Hollt V, Schulz S (2002) Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization. J Biol Chem 277: 19762-19772
52. Ramsay D, Kellett E, McVey M, Rees S, Milligan G (2002) Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences. Biochem J 365: 429-440
53. Reddy PS, Corley RB (1998) Assembly, sorting, and exit of oligomeric proteins from the endoplasmic reticulum. BioEssays 20: 546-554
54. Rocheville M, Lange DC, Kumar U, Patel SC, Patel RC, Patel YC (200a) Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 288: 154-157
55. Rocheville M, Lange DC, Kumar U, Sasi R, Patel RC, Patel YC (200b) Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. J Biol Chem 275: 7862-7869
56. Rodriguez-Frade JM, Vila-Coro AJ, de Ana AM, Albar JP, Martinez A, Mellado M (1999) The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2. Proc Natl Acad Sci USA 96: 3628-3633
57. Roess DA, Smith SM (2003) Self-association and raft localization of functional luteinizing hormone receptors. Biol Reprod 69: 1765-1770
58. Shioda T, Nakayama EE, Tanaka Y, Xin X, Liu H, Kawana-Tachikawa A, Kato A, Sakai Y, Nagai Y, Iwamoto A (2001) Naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5. J Virol 75: 3462-3468
59. 1b -adrenergic receptor subtypes: potential implications in receptor internalization. J Biol Chem 278: 40239-40251
60. Terrillon S, Durroux T, Mouillac B, Breit A, Ayoub MA, Taulan M, Jockers R, Barberis C, Bouvier M (2003) Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis. Mol Endocrinol 17: 677-691
61. Trettel F, Di Bartolomeo S, Lauro C, Catalano M, Ciotti TM, Limatola C (2003) Ligand-independent CXCR2 dimerization. J Biol Chem 278: 40980-40988
62. 2 receptors by fusion to fluorescent proteins. FEBS Lett 507: 109-113
63. 1-adrenergic receptors. J Biol Chem 278: 10770-10777
64. Zhu CC, Cook LB, Hinkle PM (2002) Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. J Biol Chem 277: 28228-28237
65. Zhu X, Wess J (1998) Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function. Biochemistry 37: 15773-15784