The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 4, 2008, Pages 1364-1368

  Rodríguez Menchaca, Aldo A ^a   Navarro Polanco, Ricardo A ^a   Ferrer Villada, Tania ^b   Rupp, Jason ^b   Sachse, Frank B ^b,c   Tristani Firouzi, Martin ^b   Sánchez Chapula, José A ^a  

^a UNIVERSIDAD DE COLIMA   (Mexico)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

IK1; Ion channel; KCNJ2; Malaria; Polyamines

Indexed keywords

AROMATIC AMINO ACID; CHLOROQUINE; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; KIR2.1 CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

BINDING AFFINITY; BINDING SITE; BIOPHYSICS; CONDUCTANCE; CONFERENCE PAPER; CYTOPLASM; DRUG BINDING; DRUG MECHANISM; EMBRYO; HUMAN; HUMAN CELL; ION CONDUCTANCE; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; ARTICLE; CELL LINE; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATCH CLAMP; PROTEIN TERTIARY STRUCTURE; SURFACE PROPERTY; SYNTHESIS;

ANTIMALARIALS; BINDING SITES; CELL LINE; CHLOROQUINE; CYTOPLASM; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN STRUCTURE, TERTIARY; SURFACE PROPERTIES; TRANSFECTION;

EID: 39549090639     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0708153105     Document Type: Article

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