Allosteric block of KCa2 channels by apamin

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 27067-27077

  Lamy, Cédric ^b   Goodchild, Samuel J ^a   Weatherall, Kate L ^a   Jane, David E ^a   Liégeois, Jean François ^b   Seutin, Vincent ^b   Marrion, Neil V ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MECHANISMS; BEE VENOM; BINDING AFFINITIES; CALCIUM-ACTIVATED POTASSIUM; CELL LINES; CHANNEL INTERACTIONS; CHANNEL PORE; HIGH AFFINITY; HIGH SENSITIVITY; HISTIDINE RESIDUES; MECHANISM OF ACTION; MULTI-DISCIPLINARY APPROACH; NEURONAL FIRINGS; PATCH CLAMP; PORE BLOCKER; STRUCTURAL MODELING; SYNAPTIC PLASTICITY; TETRAETHYLAMMONIUM;

AMMONIUM COMPOUNDS; BINDING ENERGY; CELL CULTURE; PHOSPHATASES; TOXIC MATERIALS;

CALCIUM;

APAMIN; HISTIDINE; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; TETRYLAMMONIUM; KCNN2 PROTEIN, RAT; POTASSIUM CHANNEL BLOCKING AGENT;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CELL LINE; CONTROLLED STUDY; MOLECULAR MODEL; MUTAGENESIS; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL PLASTICITY; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN BINDING; ANIMAL; BEE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; RAT;

APOIDEA;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANIMALS; APAMIN; BEES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PROTEIN BINDING; RATS; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; TETRAETHYLAMMONIUM;

EID: 77956248845     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.110072     Document Type: Article

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