Voltage-dependent gating at the KcsA selectivity filter

Nature Structural and Molecular Biology

Volumn 13, Issue 4, 2006, Pages 319-322

  Cordero Morales, Julio F ^a   Cuello, Luis G ^a,b   Perozo, Eduardo ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b THE UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCSA; PROTON; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; BACTERIAL PROTEIN; PROKARYOTIC POTASSIUM CHANNEL; RECOMBINANT PROTEIN;

ARTICLE; CHANNEL GATING; FILTER; MEMBRANE POTENTIAL; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; STEADY STATE; STRUCTURE ANALYSIS; AMINO ACID SUBSTITUTION; CELL MEMBRANE POTENTIAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; PH; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; STREPTOMYCES LIVIDANS;

PROKARYOTA;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POTASSIUM CHANNELS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STREPTOMYCES LIVIDANS;

EID: 33745055845     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb1070     Document Type: Article

References (32)

1. Hille, B. Ion channels of excitable membranes (Sinauer, Sunderland, Massachusetts, 2001).
2. Armstrong, C.M. Voltage-gated K channels. Sci. STKE 2003, re10 (2003).
3. Bezanilla, F. The voltage sensor in voltage-dependent ion channels. Physiol. Rev. 80, 555-592 (2000).
4. Yellen, G. The voltage-gated potassium channels and their relatives. Nature 419, 35-42 (2002).
5. Murata, Y., Iwasaki, H., Sasaki, M., Inaba, K. & Okamura, Y. Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature 435, 1239-1243 (2005).
6. Hodgkin, A. & Huxley, A. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond.) 117, 500-544 (1952).
7. + channel. Neuron 16, 1169-1177 (1996).
8. + channel. Neuron 16, 1159-1167 (1996).
9. + channel. Nature 423, 33-41 (2003).
10. + channel in a lipid bilayer. Science 306, 491-495 (2004).
11. Long, S.B., Campbell, E.B. & Mackinnon, R. Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science 309, 897-903 (2005).
12. Long, S.B., Campbell, E.B. & Mackinnon, R. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science 309, 903-908 (2005).
13. Bezanilla, F. The voltage-sensor structure in a voltage-gated channel. Trends Biochem. Sci. 30, 166-168 (2005).
14. Ahern, C.A. & Horn, R. Stirring up controversy with a voltage sensor paddle. Trends Neurosci. 27, 303-307 (2004).
15. Cohen, B.E., Grabe, M. & Jan, L.Y. Answers and questions from the KvAP structures. Neuron 39, 395-400 (2003).
16. Pusch, M., Ludewig, U., Rehfeldt, A. & Jentsch, T.J. Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion. Nature 373, 527-531 (1995).
17. + conduction and selectivity. Science 280, 69-77 (1998).
18. + channel. Biochemistry 37, 3229-3236 (1998).
19. + channels: functional asymmetries and sidedness of proton activation. J. Gen. Physiol. 114, 551-560 (1999).
20. Schoppa, N.E., McCormack, K., Tanouye, M.A. & Sigworth, F.J. The size of gating charge in wild-type and mutant Shaker potassium channels. Science 255, 1712-1715 (1992).
21. Cordero-Morales, J.F. et al. Molecular determinants of gating at the potassium channel selectivity filter. Nat. Struct. Mol. Biol., advance online publication 12 March 2006 (doi:10.1038/nsmb1069).
22. McLaughlin, S. The electrostatic properties of membranes. Annu. Rev. Biophys. Biophys. Chem. 18, 113-136 (1989).
23. Cortes, D.M., Cuello, L.G. & Perozo, E. Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating. J. Gen. Physiol. 117, 165-180 (2001).
24. + channel-Fab complex at 2.0 A resolution. Nature 414, 43-48 (2001).
25. Berneche, S. & Roux, B. Molecular dynamics of the KcsA K(+) channel in a bilayer membrane. Biophys. J. 78, 2900-2917 (2000).
26. Berneche, S. & Roux, B. The ionization state and the conformation of Glu-71 in the KcsA K+ channel. Biophys. J. 82, 772-780 (2002).
27. Guidoni, L., Torre, V. & Carloni, P. Potassium and sodium binding to the outer mouth of the K+ channel. Biochemistry 38, 8599-8604 (1999).
28. Ranatunga, K.M., Shrivastava, I.H., Smith, G.R. & Sansom, M.S. Side-chain ionization states in a potassium channel. Biophys. J. 80, 1210-1219 (2001).
29. Choi, H. & Heginbotham, L. Functional influence of the pore helix glutamate in the KcsA K+ channel. Biophys. J. 86, 2137-2144 (2004).
30. + channel (SKC1): oligomeric stoichiometry and stability. Biochemistry 36, 10343-10352 (1997).
31. + channel studied by EPR spectroscopy. Nat. Struct. Biol. 5, 459-469 (1998).
32. Delcour, A.H., Martinac, B., Adler, J. & Kung, C. Modified reconstitution method used in patch-clamp studies of Escherichia coli ion channels. Biophys. J. 56, 631-636 (1989).