Overlapping binding sites of structurally different antiarrhythmics flecainide and propafenone in the subunit interface of potassium channel Kv2.1

Journal of Biological Chemistry

Volumn 285, Issue 44, 2010, Pages 33898-33905

  Madeja, Michael ^a,b   Steffen, Wibke ^a   Mesic, Ivana ^c   Garic, Bojan ^d   Zhorov, Boris S ^d  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^d MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO GROUP; AMMONIUM GROUPS; BENZAMIDES; CARBONYL GROUPS; DRUG DESIGN; ENERGY MINIMIZATION; HOMOLOGY MODELS; MONTE CARLO; OPEN CHANNELS; POTASSIUM CHANNELS; PROPYL GROUPS; SELECTIVITY FILTER; STRUCTURAL DETERMINANTS; SUBUNIT INTERFACES; TIME-DEPENDENT; XENOPUS LAEVIS OOCYTES;

AMIDES; AMMONIUM COMPOUNDS; BINDING SITES; BIOCHEMISTRY; LIGANDS; POTASSIUM;

BINDING ENERGY;

AMINO ACID DERIVATIVE; AMMONIUM DERIVATIVE; ANTIARRHYTHMIC AGENT; BENZAMIDE; CARBONYL DERIVATIVE; FLECAINIDE; HYDROGEN; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.2; POTASSIUM CHANNEL KV2.1; POTASSIUM ION; PROPAFENONE; PROPANE; SHAB POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; HYDROGEN BOND; ION CONDUCTANCE; ION CURRENT; MONTE CARLO METHOD; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; STRUCTURAL HOMOLOGY; XENOPUS LAEVIS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BINDING SITES; FLECAINIDE; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN BONDING; MONTE CARLO METHOD; OOCYTES; PROPAFENONE; PROTEIN BINDING; RATS; SHAB POTASSIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 77958580339     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.159897     Document Type: Article

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