Determination of different putative allosteric binding pockets at the lutropin receptor by using diverse drug-like low molecular weight ligands

Molecular and Cellular Endocrinology

Volumn 351, Issue 2, 2012, Pages 326-336

  Heitman, Laura H ^a   Kleinau, Gunnar ^b,c   Brussee, Johannes ^a   Krause, Gerd ^c   Ijzerman, Adriaan P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

Allosteric modulation; G protein coupled receptors; Glycoprotein hormone receptors; Low molecular weight ligands; Luteinizing hormone receptor; Lutropin receptor

Indexed keywords

CHORIONIC GONADOTROPIN RECEPTOR; LUTEINIZING HORMONE RECEPTOR; RADIOLIGAND; TRITIUM;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING COMPETITION; BINDING SITE; CONTROLLED STUDY; DISSOCIATION; ISOTOPE LABELING; LIGAND BINDING; MOLECULAR LIBRARY; MOLECULAR MODEL; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN DOMAIN; RADIOASSAY; STRUCTURAL HOMOLOGY;

ALLOSTERIC SITE; ANIMALS; BENZAMIDES; BINDING SITES; CARBAMATES; CHO CELLS; CRICETINAE; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PYRIMIDINES; RECEPTORS, LH; TERPHENYL COMPOUNDS; THIAZOLES; THIOPHENES;

EID: 84857141510     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.01.010     Document Type: Article

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