G-protein coupled receptors as allosteric machines

Receptors and Channels

Volumn 10, Issue 2, 2004, Pages 51-60

  Kenakin, Terry ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

CCR5; HIV therapy; Receptor antagonism; Receptor theory

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); 3 METHYLSPIPERONE; ADRENERGIC RECEPTOR BLOCKING AGENT; ALCURONIUM; ALPHA 2A ADRENERGIC RECEPTOR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIVIRUS AGENT; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CHEMOKINE; CHEMOKINE RECEPTOR CCR5; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; CYANOPINDOLOL I 125; DIPRENORPHINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR ANTAGONIST; GALLAMINE; GLUTAMATE RECEPTOR ANTAGONIST; KAPPA OPIATE RECEPTOR; LIGAND; METHYLSCOPOLAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; N (2,3 DIPHENYL 1,2,4 THIADIAZOL 5(2H) YLIDENE)METHANAMINE; RECEPTOR BLOCKING AGENT; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; YOHIMBINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALLOSTERISM; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ALCURONIUM; ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANTI-HIV AGENTS; GALLAMINE TRIETHIODIDE; HIV INFECTIONS; HUMANS; LIGANDS; MODELS, MOLECULAR; RECEPTOR, MUSCARINIC M2; RECEPTORS, CCR5; RECEPTORS, CXCR4; RECEPTORS, G-PROTEIN-COUPLED;

EID: 3543061611     PISSN: 10606823     EISSN: None     Source Type: Journal    
DOI: 10.1080/10606820490464316     Document Type: Article

References (53)

1. Atchison, R. E., Gosling, J., Monteclaro, F. S., Franci, C., Digilio, L., Charo, I. F., and Goldsmith, M. 1996. Science 274:1924-1926.
2. Baba, M., Nishimura, O., Kanzaki, N., Okamoto, M., Sawada, H., Iizawa, Y., Shiraishi, M., Aramaki, Y., Okonogi, K., Ogawa, Y., Meguro, K., and Fujino, M. 1999. Proc. Natl. Acad. Sci. USA 96:5698-5703.
3. Bieniassz, P. D., Fridell, R. A., Aramori, I., Ferguson, S. S., Caron, M. G., and Cullen, B. R. 1997. EMBO J. 16:2599-2609.
4. Blanpain, C., Vanderwinden, J.-M., Cihak, J., Wittamer, V., Le Poul, E., Issafras, H., Stangassinger, M., Vassart, G., Marullo, S., Schlondorff, D., Parmentier, M., and Mack, M. 2002. Mol. Biol. Cell 13:723-737.
5. Bursavich, M. G., and Rich, D. H. 2001. J. Med. Chem. 45:541-558.
6. Christopolous, A., and Kenakin, T. P. 2002. Pharmacol. Rev. 54:323-374.
7. Doms, R. W., and Peiper, S. C. 1997. Virol. 235:179-190.
8. Doranz, B. J., Lu, Z.-H., Rucker, J., Zhang, T.-Y, Sharron, M., Cen, Y.-H., Wang, Z.-X., Guo, H.-H., Du, J.-D., Accavitti, M. A., Doms, R. W., and Peiper, S. C. 1997. J. Virol. 71:6305-6314.
9. Ehlert, F. J. 1988. Mol. Pharmacol. 33:187-194.
10. Fawazi, A. B., MacDonald, D., Benbow, L. L., Smith-Torhan, A., Zhang, H., Weig, B. C., Ho, G., Tulshian, D., Linder, M. E., Graziano, M. P. 2001. Mol. Pharmacol. 59:30-37.
11. Finke, G., Oates, B., Mills, S. G., MacCoss, M., Malkowitz L., Springer, M. S., Gould, S. L., DeMartino, A., Carella, A., Carver, G., et al. 2001. Bioorg. Med. Chem. Lett. 11:2475-2479.
12. Frauenfelder, H., Parak, F., and Young, R. D. 1988. Ann. Rev. Biophys. Biophys. Chem. 17:451-479.
13. Frauenfelder, H., Sligar, S. G., and Wolynes, P. G. 1991. Science 254:1598-1603.
14. Ghanouni, P., Grycynski, Z., Steenhuis, J.J., Lee, T.W., Farrens, D.L., Lakowicz, J.R., and Kobilka, B. K. 2001. J. Biol. Chem. 276: 24433-24436.
15. Hall, D. A. 2000. Mol. Pharmacol. 58:1412-1423.
16. Hejnova, L., Tucek, S., and El-Fakahany, E. E. 1995. Eur. J. Pharmacol. 291:427-430.
17. Heveker, N., Montes, M., Germeroth, L., Amara, A., Trautmann, A., Alizon, M., and Schneider-Mergener, J. 1998. Current Biology 8:369-376.
18. Hilser, V. J., and Freire, E. 1996. J Mol. Biol. 262:756-772.
19. Hilser, V. J., and Freire, E. 1997. Protein Struct. Funct. Genet. 27:171-183.
20. Hilser, V. J., Townsend, B. D., and Freire, E. 1997. Biophys. Chem. 64:69-79.
21. Hilser, V. J., Dowdy, D., Oas, T. G., and Freire, E. 1998. Proc. Natl. Acad. Sci. USA 95:9903-9908.
22. Jakubic, J., Bacakova, L., Lisa, V., El-Fakahany, E. E., and Tucek, S. 1996. Proc. Natl. Acad. Sci USA 93:8705-8709.
23. Jakubic, J., Bacakova, L., Lisa, V., El-Fakahany, E. E., and Tucek, S. 1997. Mol. Pharmacol. 52:172-179.
24. Kazmierski, W. M., Boone, L., Lawrence, W., Watson, C., and Kenakin, T. 2002. Current Drug Targets - Infectious Disorders 2:265-278.
25. Kenakin, T. P. 2002a. Ann. Rev. Pharmacol. Toxicol. 42:349-379.
26. Kenakin, T. P. 2002b. Nature Reviews (Drug Discovery) 1:103-109.
27. Kenakin, T. P. 2003. Trends Pharmacol. Sci. 24:346-354.
28. Kenakin, T. P., and Onaran, O. 2002. Trends Pharmacol. Sci. 23:275-280.
29. Kumar, S., Ma, B., Tsai, C. J., Wolfson, H., and Nussinov, R. 1999. Cell Biochem. Biophys. 31: 141-164.
30. Kwong, P. D., Wyatt, R., Robinson, J., Sweet, R. W., Sodroski, J., and Hendricks, W. A. 1998. Nature 393: 648-659.
31. Lee, B., Sharron, M., Blanpain, C., Doranz, B. J., Vakili, J., Setoh, P., Berg, E., Liu, G., Guy, H. R., Durell, S. R., Parmentier, M., Chang, C. N., Price, K., Tsang, M., and Doms, R. W. 1999a. J. Biol. Chem. 274:9617-9626.
32. Litschig, S., Gasparini, F., Rueegg, D. F., Stoehr, N., Flor, P. J., Vranesic, I., Prézeau, L., Pin, J. P., Thomsen, C., and Kuhn, R. 1999. Mol. Pharmacol. 55:453-461.
33. Ma, B., Kumar, S., Tsai, C. J., and Nussinov, R. 1999. Protein Eng. 12:713-720.
34. Moore, J. P., Trkola, A., and Dragic, T. 1997. Curr. Opin. Immunol. 9:551-562.
35. Nagasaw, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S., Kitamura, Y., Yoshida, N., Kikutani, H., and Kishimoto, T. 1996. Nature 382: 635-638.
36. Onaran, H. O., and Costa, T. 1997. Ann. N. Y. Acad. Sci. 812:98-115.
37. Onaran, H. O., Scheer, A., Cotecchia, S., and Costa, T. 2000. In The Pharmacology of Functional, Biochemical, and Recombinant Systems Handbook of Experimental Pharmacology, vol. 148. Eds. T. P. Kenakin and J. A. Angus. Germany: Springer, Heidelberg. pp. 217-80.
38. Picard, L., Simmons, G., Power, C. A., Meyer, A., Wiess, R. A., and Clapham, P. R. 1997. J. Virol. 71:5003-5011.
39. Rees, S., Morrow, D., and Kenakin, T. 2002. Receptors and Channels 8:261-268.
40. Rizzuto, C. D., Wyatt, R., Hernández-Ramos, N., Sun, Y., Kwong, P. D., Hendrickson, W. A., and Sodroski, J. 1998. Science 280:1949-1953.
41. Roettger, B. F., Ghanekar, D., Rao, R., Toledo, C., Yingling, J., Pinon, D., and Miller, L. J. 1997. Mol. Pharmacol. 51:357-362.
42. Ross, T., Bieniasz, P. D., and Cullen, B. R. 1999. Adv. Virus Res. 52:233-267.
43. Rucker, J., Edinger, A. L., Sharron, M., Samson, M., Lee, B., Berson, J. F. Y., Collman, R. G., Doranz, B. J., Domes, R. W., and Parmentier, M. 1997. J. Virol. 71:8999-9007.
44. Sachpatzidis, A., Benton, B. K., Manfredis, J. P., Wang, H., Hamilton, A., Dohlman, H. G., and Lolis, E. 2003. J. Biol. Chem. 278:896-907.
45. Smyth, R. J., Yi, Y., Singh, A., and Collman, R. G. 1998. J. Virol. 72:4478-4484.
46. Stephenson, R. P. 1956. Br. J. Pharmacol. 11:379-393.
47. Straub, F. B. 1964. Adv. Enzymology 26:89-114.
48. Strizki, J. M., Xu, S., Wagner, N. E., Wojcik, L., Jia Liu, J., Hou, Y., Endres, M., Palani, A., Shapiro, S., Clader, J. W., Greenlee, W. J., Tagat, J. R., et al. 2001. Proc. Natl. Acad. Sci. USA. 98:12718-12723.
49. Tachibana, K., Hirota, S., Iizasa, H., Yoshida, H., Kawabata, K., Kataoka, Y., Kitamura, Y., Matsushima, K., Yoshida, N., Nishikawa, S., Kishimoto, T., and Nagasawa, T. 1998. Nature 393:591-594.
50. Tsai, C. J., Kumar, S., Ma, B., and Nussinov, R. 1999. Protein Sci. 8:1181-1190.
51. Tucek, S., and Proska, J. 1995. Trends Pharmacol. Sci. 16:205-212.
52. Venter, J. C., Adams, M. D., Myers, E. M., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. 2001. Science 291:1304-1351.
53. Zou, Y. R., Kottmann, A. H., Kuroda, M., Taniuchi, I., and Littman, D. R. 1998. Nature 393:595-599.