-
1
-
-
1542316313
-
A molecular dissection of the glycoprotein hormone receptors
-
Vassart, G.; Pardo, L.; Costagliola, S. A molecular dissection of the glycoprotein hormone receptors. Trends Biochem. Sci. 2004, 29, 119-126.
-
(2004)
Trends Biochem. Sci
, vol.29
, pp. 119-126
-
-
Vassart, G.1
Pardo, L.2
Costagliola, S.3
-
2
-
-
0038182549
-
Glycoprotein hormone receptors: Determinants in leucine-rich repeats responsible for ligand specificity
-
Smits, G.; Campillo, M.; Govaerts, C.; Janssens, V.; Richter, C.; Vassart, G.; Pardo, L.; Costagliola, S. Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity. EMBO J. 2003, 22, 2692-2703.
-
(2003)
EMBO J
, vol.22
, pp. 2692-2703
-
-
Smits, G.1
Campillo, M.2
Govaerts, C.3
Janssens, V.4
Richter, C.5
Vassart, G.6
Pardo, L.7
Costagliola, S.8
-
3
-
-
0030317036
-
Clinical assessment of human gonadotrophins produced by recombinant DNA technology
-
Loumaye, E.; Martineau, I.; Piazzi, A.; O'Dea, L.; Ince, S.; Howles, C.; Decosterd, G.; Van Loon, K.; Galazka, A. Clinical assessment of human gonadotrophins produced by recombinant DNA technology. Hum. Reprod. 1996, 11 Suppl. 1, 95-107.
-
(1996)
Hum. Reprod
, vol.11
, Issue.SUPPL. 1
, pp. 95-107
-
-
Loumaye, E.1
Martineau, I.2
Piazzi, A.3
O'Dea, L.4
Ince, S.5
Howles, C.6
Decosterd, G.7
Van Loon, K.8
Galazka, A.9
-
4
-
-
61449108160
-
Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor
-
Van de Lagemaat, R.; Timmers, C. M.; Kelder, J.; Van Koppen, C.; Mosselman, S.; Hanssen, R. G. Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor. Hum. Reprod. 2009, 24 (3), 640-648.
-
(2009)
Hum. Reprod
, vol.24
, Issue.3
, pp. 640-648
-
-
Van de Lagemaat, R.1
Timmers, C.M.2
Kelder, J.3
Van Koppen, C.4
Mosselman, S.5
Hanssen, R.G.6
-
5
-
-
34547118332
-
Translational fusion of two -subunits of human chorionic gonadotropin results in production of a novel antagonist of the hormone
-
Roy, S.; Setlur, S.; Gadkari, R. A.; Krishnamurthy, H. N.; Dighe, R. R. Translational fusion of two -subunits of human chorionic gonadotropin results in production of a novel antagonist of the hormone. Endocrinology 2007, 148, 3977-3986.
-
(2007)
Endocrinology
, vol.148
, pp. 3977-3986
-
-
Roy, S.1
Setlur, S.2
Gadkari, R.A.3
Krishnamurthy, H.N.4
Dighe, R.R.5
-
6
-
-
57349185158
-
-
Heitman, L. H.; IJzerman, A. P. G protein-coupled receptors of the hypothalamic-pituitary-gonadal axis: A case for GnRH, LH, FSH, and GPR54 receptor ligands. Med. Res. Rev. 2008, 28, 975-1011.
-
Heitman, L. H.; IJzerman, A. P. G protein-coupled receptors of the hypothalamic-pituitary-gonadal axis: A case for GnRH, LH, FSH, and GPR54 receptor ligands. Med. Res. Rev. 2008, 28, 975-1011.
-
-
-
-
7
-
-
34250875316
-
Gonadotropins and ovarian cancer
-
Choi, J. H.; Wong, A. S.; Huang, H. F.; Leung, P. C. Gonadotropins and ovarian cancer. Endocr. Rev. 2007, 28, 440-461.]
-
(2007)
Endocr. Rev
, vol.28
, pp. 440-461
-
-
Choi, J.H.1
Wong, A.S.2
Huang, H.F.3
Leung, P.C.4
-
8
-
-
38549139769
-
3H]Org 43553, the First Low-Molecular-Weight Agonistic and Allosteric Radioligand for the Human Luteinizing Hormone Receptor
-
3H]Org 43553, the First Low-Molecular-Weight Agonistic and Allosteric Radioligand for the Human Luteinizing Hormone Receptor. Mol. Pharmacol. 2008, 73, 518-524.
-
(2008)
Mol. Pharmacol
, vol.73
, pp. 518-524
-
-
Heitman, L.H.1
Oosterom, J.2
Bonger, K.M.3
Timmers, C.M.4
Wiegerinck, P.H.G.5
IJzerman, A.P.6
-
9
-
-
0030218059
-
Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation
-
Kostenis, E.; Mohr, K. Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation. Trends Pharmacol. Sci. 1996, 17, 280-283.
-
(1996)
Trends Pharmacol. Sci
, vol.17
, pp. 280-283
-
-
Kostenis, E.1
Mohr, K.2
-
10
-
-
2042507954
-
Palladium-catalyzed cross-coupling reactions of organoboron compounds
-
Miyaura, N.; Suzuki, A. Palladium-catalyzed cross-coupling reactions of organoboron compounds. Chem. Rev. 1995, 95, 2457-2483.
-
(1995)
Chem. Rev
, vol.95
, pp. 2457-2483
-
-
Miyaura, N.1
Suzuki, A.2
-
11
-
-
0001528697
-
Improvements in the synthesis of phenylacetylene monodendrons including a solid-phase convergent method
-
Bharathi, P.; Patel, U.; Kawaguchi, T.; Pesak, D. J.; Moore, J. S. Improvements in the synthesis of phenylacetylene monodendrons including a solid-phase convergent method. Macromolecules 1995, 28, 5955-5963.
-
(1995)
Macromolecules
, vol.28
, pp. 5955-5963
-
-
Bharathi, P.1
Patel, U.2
Kawaguchi, T.3
Pesak, D.J.4
Moore, J.S.5
-
12
-
-
10644241871
-
2,4,6-Trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists
-
Chang, L. C. W.; Spanjersberg, R. F.; von Frijtag Drabbe Kunzel, J. K.; Mulder-Krieger, T.; van den Hout, G.; Beukers, M. W.; Brussee, J.; IJzerman, A. P. 2,4,6-Trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J. Med. Chem. 2004, 47, 6529-6540.
-
(2004)
J. Med. Chem
, vol.47
, pp. 6529-6540
-
-
Chang, L.C.W.1
Spanjersberg, R.F.2
von Frijtag Drabbe Kunzel, J.K.3
Mulder-Krieger, T.4
van den Hout, G.5
Beukers, M.W.6
Brussee, J.7
IJzerman, A.P.8
-
13
-
-
33847366159
-
2,6,8- Trisubstituted 1-deazapurines as adenosine receptor antagonists
-
Chang, L. C. W.; von Frijtag Drabbe Kunzel, J. K.; Mulder-Krieger, T.; Westerhout, J.; Spangenberg, T.; Brussee, J.; IJzerman, A. P. 2,6,8- Trisubstituted 1-deazapurines as adenosine receptor antagonists. J. Med. Chem. 2007, 50, 828-834.
-
(2007)
J. Med. Chem
, vol.50
, pp. 828-834
-
-
Chang, L.C.W.1
von Frijtag Drabbe Kunzel, J.K.2
Mulder-Krieger, T.3
Westerhout, J.4
Spangenberg, T.5
Brussee, J.6
IJzerman, A.P.7
-
14
-
-
49449100234
-
2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists
-
Mantri, M.; de Graaf, O.; van Veldhoven, J.; Göblyos, A.; von Frijtag Drabbe Kunzel, J. K.; Mulder-Krieger, T.; Link, R.; de Vries, H.; Beukers, M. W.; Brussee, J.; IJzerman, A. P. 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J. Med. Chem. 2008, 51, 4449-4455.
-
(2008)
J. Med. Chem
, vol.51
, pp. 4449-4455
-
-
Mantri, M.1
de Graaf, O.2
van Veldhoven, J.3
Göblyos, A.4
von Frijtag Drabbe Kunzel, J.K.5
Mulder-Krieger, T.6
Link, R.7
de Vries, H.8
Beukers, M.W.9
Brussee, J.10
IJzerman, A.P.11
-
15
-
-
44249086389
-
Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor
-
Heitman, L. H.; Ye, K.; Oosterom, J.; Ijzerman, A. P. Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor. Mol. Pharmacol. 2008, 73, 1808-1815.
-
(2008)
Mol. Pharmacol
, vol.73
, pp. 1808-1815
-
-
Heitman, L.H.1
Ye, K.2
Oosterom, J.3
Ijzerman, A.P.4
-
16
-
-
0033539111
-
Allosteric modulation of the adenosine A1 receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding
-
Van der Klein, P. A.; Kourounakis, A. P.; IJzerman, A. P. Allosteric modulation of the adenosine A1 receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding. J. Med. Chem. 1999, 42, 3629-3635.
-
(1999)
J. Med. Chem
, vol.42
, pp. 3629-3635
-
-
Van der Klein, P.A.1
Kourounakis, A.P.2
IJzerman, A.P.3
-
17
-
-
33744807197
-
Structure-activity relationships of new 1Himidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor
-
Göblyös, A.; Gao, Z. G.; Brussee, J.; Connestari, R.; Santiago, S. N.; Ye, K.; IJzerman, A. P.; Jacobson, K. A. Structure-activity relationships of new 1Himidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor. J. Med. Chem. 2006, 49, 3354-3361.
-
(2006)
J. Med. Chem
, vol.49
, pp. 3354-3361
-
-
Göblyös, A.1
Gao, Z.G.2
Brussee, J.3
Connestari, R.4
Santiago, S.N.5
Ye, K.6
IJzerman, A.P.7
Jacobson, K.A.8
-
18
-
-
24044539957
-
Allosteric modulation of the cannabinoid CB1 receptor
-
Price, M. R.; Baillie, G. L.; Thomas, A.; Stevenson, L. A.; Easson, M.; Goodwin, R.; McLean, A.; McIntosh, L.; Goodwin, G.; Walker, G.; Westwood, P.; Marrs, J.; Thomson, F.; Cowley, P.; Christopoulos, A.; Pertwee, R. G.; Ross, R. A. Allosteric modulation of the cannabinoid CB1 receptor. Mol. Pharmacol. 2005, 68, 1484-1495.
-
(2005)
Mol. Pharmacol
, vol.68
, pp. 1484-1495
-
-
Price, M.R.1
Baillie, G.L.2
Thomas, A.3
Stevenson, L.A.4
Easson, M.5
Goodwin, R.6
McLean, A.7
McIntosh, L.8
Goodwin, G.9
Walker, G.10
Westwood, P.11
Marrs, J.12
Thomson, F.13
Cowley, P.14
Christopoulos, A.15
Pertwee, R.G.16
Ross, R.A.17
-
19
-
-
54249130252
-
A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor
-
Van Koppen, C.; Zaman, G.; Timmers, C.; Kelder, J.; Mosselman, S.; van de Lagemaat, R.; Smit, M. J.; Hanssen, R. A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor. Naunyn Schmiedeberg's Arch. Pharmacol. 2008, 378, 503-514.
-
(2008)
Naunyn Schmiedeberg's Arch. Pharmacol
, vol.378
, pp. 503-514
-
-
Van Koppen, C.1
Zaman, G.2
Timmers, C.3
Kelder, J.4
Mosselman, S.5
van de Lagemaat, R.6
Smit, M.J.7
Hanssen, R.8
-
20
-
-
33847122495
-
Allosteric modulation of G protein-coupled receptors
-
May, L. T.; Leach, K.; Sexton, P. M.; Christopoulos, A. Allosteric modulation of G protein-coupled receptors. Annu. Rev. Pharmacol. Toxicol. 2007, 47, 1-51.
-
(2007)
Annu. Rev. Pharmacol. Toxicol
, vol.47
, pp. 1-51
-
-
May, L.T.1
Leach, K.2
Sexton, P.M.3
Christopoulos, A.4
-
21
-
-
0346996805
-
Allosteric enhancers of A1 adenosine receptors increase receptor-G protein coupling and counteract guanine nucleotide effects on agonist binding
-
Figler, H.; Olsson, R. A.; Linden, J. Allosteric enhancers of A1 adenosine receptors increase receptor-G protein coupling and counteract guanine nucleotide effects on agonist binding. Mol. Pharmacol. 2003, 64, 1557-1564.
-
(2003)
Mol. Pharmacol
, vol.64
, pp. 1557-1564
-
-
Figler, H.1
Olsson, R.A.2
Linden, J.3
-
22
-
-
3142685557
-
The heptahelical domain of GABAB2 is activated directly by CGP7930, a positive allosteric modulator of the GABAB receptor
-
Binet, V.; Brajon, C.; Le Corre, L.; Acher, F.; Pin, J.-P.; Prezeau, L. The heptahelical domain of GABAB2 is activated directly by CGP7930, a positive allosteric modulator of the GABAB receptor. J. Biol. Chem. 2004, 279, 29085-29091.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 29085-29091
-
-
Binet, V.1
Brajon, C.2
Le Corre, L.3
Acher, F.4
Pin, J.-P.5
Prezeau, L.6
-
23
-
-
30044435787
-
Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)- 4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M1 receptor: Direct pharmacological evidence that AC-42 is an allosteric agonist
-
Langmead, C. J.; Fry, V. A. H.; Forbes, I. T.; Branch, C. L.; Christopoulos, A.; Wood, M. D.; Herdon, H. J. Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)- 4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M1 receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol. Pharmacol. 2006, 69, 236-246.
-
(2006)
Mol. Pharmacol
, vol.69
, pp. 236-246
-
-
Langmead, C.J.1
Fry, V.A.H.2
Forbes, I.T.3
Branch, C.L.4
Christopoulos, A.5
Wood, M.D.6
Herdon, H.J.7
-
24
-
-
33645796458
-
Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors
-
Schwartz, T. W.; Holst, B. Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors. J. Recept. Signal Transduction 2006, 26, 107-128.
-
(2006)
J. Recept. Signal Transduction
, vol.26
, pp. 107-128
-
-
Schwartz, T.W.1
Holst, B.2
-
25
-
-
34447638166
-
Allosteric enhancers, allosteric agonists and ago-allosteric modulators: Where do they bind and how do they act?
-
Schwartz, T. W.; Holst, B. Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act? Trends Pharmacol. Sci. 2007, 28, 366-373.
-
(2007)
Trends Pharmacol. Sci
, vol.28
, pp. 366-373
-
-
Schwartz, T.W.1
Holst, B.2
-
26
-
-
54249140783
-
Preparation of thieno[2,3-d]- pyrimidines with combined LH and FSH agonistic activity
-
WO 2003020726
-
Hanssen, R. G. J. M.; Timmers, C. M. Preparation of thieno[2,3-d]- pyrimidines with combined LH and FSH agonistic activity. WO 2003020726, 2003.
-
(2003)
-
-
Hanssen, R.G.J.M.1
Timmers, C.M.2
-
27
-
-
0035913059
-
ElogD(oct): A tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds
-
Lombardo, F.; Shalaeva, M. Y.; Tupper, K. A.; Gao, F. ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. J. Med. Chem. 2001, 44, 2490-2497.
-
(2001)
J. Med. Chem
, vol.44
, pp. 2490-2497
-
-
Lombardo, F.1
Shalaeva, M.Y.2
Tupper, K.A.3
Gao, F.4
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