The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9- hexahydrocycloocta[b]thiophenes as allosteric modulators of the A 1 adenosine receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 12, 2011, Pages 3704-3707

  Aurelio, Luigi ^a   Christopoulos, Arthur ^a   Flynn, Bernard L ^a   Scammells, Peter J ^a   Sexton, Patrick M ^a   Valant, Celine ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

2 Amino 3 benzoylthiophene; A 1 adenosine receptor (A 1 AR); Allosteric modulator; G protein coupled receptors (GPCRs)

Indexed keywords

2 AMINO 4,5,6,7,8,9 HEXAHYDROCYCLOOCTA[B]THIOPHENE DERIVATIVE; ADENOSINE A1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; THIOPHENE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG RESEARCH; DRUG SCREENING; ENZYME PHOSPHORYLATION; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ALLOSTERIC REGULATION; AMINES; ANIMALS; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIZATION; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; RECEPTOR, ADENOSINE A1; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 79957800958     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.080     Document Type: Article

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