Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: Structure-activity relationships and selective binding patterns

Journal of Medicinal Chemistry

Volumn 49, Issue 13, 2006, Pages 3888-3896

  Moore, Susanna ^a   Jaeschke, Holger ^a,b   Kleinau, Gunnar ^a,c   Neumann, Susanne ^a   Costanzi, Stefano ^a   Jiang, Jian Kang ^a   Childress, John ^a   Raaka, Bruce M ^a   Colson, Anny ^a   Paschke, Ralf ^b   Krause, Gerd ^c   Thomas, Craig J ^a   Gershengorn, Marvin C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN RECEPTOR; LUTEINIZING HORMONE RECEPTOR; N TERT BUTYL 5 AMINO 4 (3 METHOXYPHENYL) 2 (METHYLTHIO)THIENO[2,3 D]PYRIMIDINE 6 CARBOXAMIDE; ORG 41841; PARTIAL AGONIST; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; THYROTROPIN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; HUMAN; HUMAN CELL; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CHORIONIC GONADOTROPIN; HYDROGEN BONDING; LIGANDS; LUTEINIZING HORMONE; MODELS, MOLECULAR; PYRIMIDINES; RECEPTORS, THYROTROPIN; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 33745670600     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060247s     Document Type: Article

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