Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor

Cellular and Molecular Life Sciences

Volumn 68, Issue 1, 2011, Pages 159-167

  Haas, Ann Karin ^a   Kleinau, Gunnar ^a   Hoyer, Inna ^a   Neumann, Susanne ^b   Furkert, Jens ^a   Rutz, Claudia ^a   Schülein, Ralf ^a   Gershengorn, Marvin C ^b   Krause, Gerd ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Allosteric binding pocket; Antagonist; G protein coupled receptor (GPCR); Signal transduction; Silencing mutations; Thyrotropin receptor

Indexed keywords

CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; INOSITOL 1,4,5 TRISPHOSPHATE; THYROTROPIN; THYROTROPIN RECEPTOR;

ALLOSTERISM; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN CELL; LIGAND BINDING; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY;

BINDING SITES; CYCLIC AMP; HEK293 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, THYROTROPIN; SIGNAL TRANSDUCTION;

EID: 78650984744     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0451-2     Document Type: Article

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