Differential modulation of beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Kleinau, Gunnar ^a   Pratzka, Juliane ^a   Nürnberg, Daniela ^a   Grüters, Annette ^a   Führer Sakel, Dagmar ^b   Krude, Heiko ^a   Köhrle, Josef ^a   Schöneberg, Torsten ^c   Biebermann, Heike ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; DOPAMINE RECEPTOR; G PROTEIN COUPLED RECEPTOR; OCTOPAMINE; PHENETHYLAMINE; TRACE AMINE ASSOCIATED RECEPTOR 1; TRACE AMINE ASSOCIATED RECEPTOR 1 AGONIST; TYRAMINE; UNCLASSIFIED DRUG; ADRB1 PROTEIN, HUMAN; ADRB2 PROTEIN, HUMAN; ADRENERGIC RECEPTOR AFFECTING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; PHENETHYLAMINE DERIVATIVE; TRACE AMINE-ASSOCIATED RECEPTOR 1;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN HEK293; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PROTEIN STRUCTURE; RECEPTOR MODULATION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; CELL CULTURE; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; KIDNEY; METABOLISM;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC UPTAKE INHIBITORS; ALLOSTERIC REGULATION; BINDING SITES; CELLS, CULTURED; HUMANS; KIDNEY; OCTOPAMINE; PHENETHYLAMINES; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TYRAMINE;

EID: 80055113306     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027073     Document Type: Article

References (90)

1. Maguire JJ, Parker WAE, Foord SM, Bonner TI, Neubig RR, et al. (2009) International Union of Pharmacology. LXXII. Recommendations for Trace Amine Receptor Nomenclature. Pharmacological Reviews 61: 1-8.
2. Grandy DK, (2007) Trace amine-associated receptor 1--Family archetype or iconoclast? Pharmacology & Therapeutics 116: 355-390.
3. Lewin A, (2006) Receptors of mammalian trace amines. The AAPS Journal 8: E138-E145.
4. Lindemann L, Hoener MC, (2005) A renaissance in trace amines inspired by a novel GPCR family. Trends in Pharmacological Sciences 26: 274-281.
5. Zucchi R, Chiellini G, Scanlan TS, Grandy DK, (2006) Trace amine-associated receptors and their ligands. Br J Pharmacol 149: 967-978.
6. Burchett SA, Hicks TP, (2006) The mysterious trace amines: Protean neuromodulators of synaptic transmission in mammalian brain. Progress in Neurobiology 79: 223-246.
7. Pae CU, Drago A, Mandelli L, De Ronchi D, Serretti A, (2009) TAAR 6 and HSP-70 variations associated with bipolar disorder. Neurosci Lett 465: 257-261.
8. Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, et al. (2003) Novel human G-protein-coupled receptors. Biochem Biophys Res Commun 305: 67-71.
9. Duan J, Martinez M, Sanders AR, Hou C, Saitou N, et al. (2004) Polymorphisms in the Trace Amine Receptor 4 (TRAR4) Gene on Chromosome 6q23.2 Are Associated with Susceptibility to Schizophrenia. The American Journal of Human Genetics 75: 624-638.
10. Bly M, (2005) Examination of the trace amine-associated receptor 2 (TAAR2). Schizophrenia Research 80: 367-368.
11. D'Andrea G, Nordera G, Pizzolato G, Bolner A, Colavito D, et al. (2010) Trace amine metabolism in Parkinson's disease: Low circulating levels of octopamine in early disease stages. Neuroscience Letters 469: 348-351.
12. Pae CU, Drago A, Kim JJ, Patkar AA, Jun TY, et al. (2010) TAAR6 variations possibly associated with antidepressant response and suicidal behavior. Psychiatry Res 180: 20-24.
13. Branchek TA, Blackburn TP, (2003) Trace amine receptors as targets for novel therapeutics: legend, myth and fact. Current Opinion in Pharmacology 3: 90-97.
14. Sotnikova TD, Caron MG, Gainetdinov RR, (2009) Trace amine-associated receptors as emerging therapeutic targets. Mol Pharmacol 76: 229-235.
15. Liu IS, Kusumi I, Ulpian C, Tallerico T, Seeman P, (1998) A serotonin-4 receptor-like pseudogene in humans. Brain Res Mol Brain Res 53: 98-103.
16. Zeng Z, Fan P, Rand E, Kyaw H, Su K, et al. (1998) Cloning of a Putative Human Neurotransmitter Receptor Expressed in Skeletal Muscle and Brain. Biochemical and Biophysical Research Communications 242: 575-578.
17. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, et al. (2001) Trace amines: Identification of a family of mammalian G protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America 98: 8966-8971.
18. Stäubert C, Böselt I, Bohnekamp J, Römpler H, Enard W, et al. (2010) Structural and Functional Evolution of the Trace Amine-Associated Receptors TAAR3, TAAR4 and TAAR5 in Primates. PLoS ONE 5: e11133.
19. Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, et al. (2001) Amphetamine, 3,4-Methylenedioxymethamphetamine, Lysergic Acid Diethylamide, and Metabolites of the Catecholamine Neurotransmitters Are Agonists of a Rat Trace Amine Receptor. Molecular Pharmacology 60: 1181-1188.
20. Piehl S, Hoefig CS, Scanlan TS, Kohrle J, (2010) Thyronamines--Past, Present, and Future. Endocr Rev pp. er.2009-0040.
21. Ghelardoni S, Suffredini S, Frascarelli S, Brogioni S, Chiellini G, et al. (2009) Modulation of cardiac ionic homeostasis by 3-iodothyronamine. Journal of Cellular and Molecular Medicine 13: 3082-3090.
22. Gompf HS, Greenberg JH, Aston-Jones G, Ianculescu AG, Scanlan TS, et al. (2010) 3-Monoiodothyronamine: the rationale for its action as an endogenous adrenergic-blocking neuromodulator. Brain Res 1351: 130-140.
23. Ianculescu AG, Scanlan TS, (2010) 3-Iodothyronamine (T(1)AM): a new chapter of thyroid hormone endocrinology? Mol Biosyst 6: 1338-1344.
24. Panas HN, Lynch LJ, Vallender EJ, Xie Z, Chen GL, et al. (2010) Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. J Neurosci Res 88: 1962-1969.
25. Piehl S, Heberer T, Balizs G, Scanlan TS, Kohrle J, (2008) Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates. Rapid Commun Mass Spectrom 22: 3286-3296.
26. Pietsch CA, Scanlan TS, Anderson RJ, (2007) Thyronamines are substrates for human liver sulfotransferases. Endocrinology 148: 1921-1927.
27. Saba A, Chiellini G, Frascarelli S, Marchini M, Ghelardoni S, et al. (2010) Tissue Distribution and Cardiac Metabolism of 3-Iodothyronamine. Endocrinology 151: 5063-5073.
28. Scanlan TS, (2009) Minireview: 3-Iodothyronamine (T1AM): a new player on the thyroid endocrine team? Endocrinology 150: 1108-1111.
29. Zucchi R, Ghelardoni S, Chiellini G, (2010) Cardiac effects of thyronamines. Heart Failure Reviews 15: 171-176.
30. Wainscott DB, Little SP, Yin T, Tu Y, Rocco VP, et al. (2007) Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1. J Pharmacol Exp Ther 320: 475-485.
31. Wolinsky TD, Swanson CJ, Smith KE, Zhong H, Borowsky B, et al. (2007) The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia. Genes, Brain and Behavior 6: 628-639.
32. Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, et al. (2005) Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Genomics 85: 372-385.
33. Liberles SD, Buck LB, (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature 442: 645-650.
34. Fleischer J, Breer H, Strotmann J, (2009) Mammalian olfactory receptors. Front Cell Neurosci 3: 9.
35. Krautwurst D, (2008) Human Olfactory Receptor Families and Their Odorants. Chemistry & Biodiversity 5: 842-852.
36. Liberles SD, (2009) Trace Amine-associated Receptors Are Olfactory Receptors in Vertebrates. Annals of the New York Academy of Sciences 1170: 168-172.
37. Wallach JV, (2009) Endogenous hallucinogens as ligands of the trace amine receptors: a possible role in sensory perception. Med Hypotheses 72: 91-94.
38. Gloriam DEI, Bjarnadóttir TK, Yan Y-L, Postlethwait JH, Schiöth HB, et al. (2005) The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish. Molecular Phylogenetics and Evolution 35: 470-482.
39. Hussain A, Saraiva LR, Korsching SI, (2009) Positive Darwinian selection and the birth of an olfactory receptor clade in teleosts. Proceedings of the National Academy of Sciences 106: 4313-4318.
40. Vallender EJ, Xie Z, Westmoreland SV, Miller GM, (2010) Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs. BMC Evol Biol 10: 51.
41. Berry MD, (2004) Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators. J Neurochem 90: 257-271.
42. Zucchi R, Chiellini G, Scanlan TS, Grandy DK, (2006) Trace amine-associated receptors and their ligands. British Journal of Pharmacology 149: 967-978.
43. David JC, Coulon JF, (1985) Octopamine in invertebrates and vertebrates. A review. Prog Neurobiol 24: 141-185.
44. Roeder T, (2005) Tyramine and octopamine: ruling behavior and metabolism. Annu Rev Entomol 50: 447-477.
45. Arakawa S, Gocayne JD, McCombie WR, Urquhart DA, Hall LM, et al. (1990) Cloning, localization, and permanent expression of a Drosophila octopamine receptor. Neuron 4: 343-354.
46. Cazzamali G, Klaerke DA, Grimmelikhuijzen CJ, (2005) A new family of insect tyramine receptors. Biochem Biophys Res Commun 338: 1189-1196.
47. Saudou F, Amlaiky N, Plassat JL, Borrelli E, Hen R, (1990) Cloning and characterization of a Drosophila tyramine receptor. EMBO J 9: 3611-3617.
48. Gerhardt CC, Bakker RA, Piek GJ, Planta RJ, Vreugdenhil E, et al. (1997) Molecular cloning and pharmacological characterization of a molluscan octopamine receptor. Mol Pharmacol 51: 293-300.
49. Massarsky A, Trudeau VL, Moon TW, (2011) beta-blockers as endocrine disruptors: the potential effects of human beta-blockers on aquatic organisms. J Exp Zool A Ecol Genet Physiol 315: 251-265.
50. Airriess CN, Rudling JE, Midgley JM, Evans PD, (1997) Selective inhibition of adenylyl cyclase by octopamine via a human cloned alpha 2A-adrenoceptor. Br J Pharmacol 122: 191-198.
51. Brown CM, McGrath JC, Midgley JM, Muir AG, O'Brien JW, et al. (1988) Activities of octopamine and synephrine stereoisomers on alpha-adrenoceptors. Br J Pharmacol 93: 417-429.
52. Carpene C, Galitzky J, Fontana E, Atgie C, Lafontan M, et al. (1999) Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn Schmiedebergs Arch Pharmacol 359: 310-321.
53. Ma G, Bavadekar SA, Schaneberg BT, Khan IA, Feller DR, (2010) Effects of synephrine and beta-phenethylamine on human alpha-adrenoceptor subtypes. Planta Med 76: 981-986.
54. Lindemann L, Meyer CA, Jeanneau K, Bradaia A, Ozmen L, et al. (2008) Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity. Journal of Pharmacology and Experimental Therapeutics 324: 948-956.
55. Miller GM, Verrico CD, Jassen A, Konar M, Yang H, et al. (2005) Primate Trace Amine Receptor 1 Modulation by the Dopamine Transporter. Journal of Pharmacology and Experimental Therapeutics 313: 983-994.
56. Xie Z, Miller GM, (2007) Trace amine-associated receptor 1 is a modulator of the dopamine transporter. J Pharmacol Exp Ther 321: 128-136.
57. Xie Z, Westmoreland SV, Bahn ME, Chen GL, Yang H, et al. (2007) Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther 321: 116-127.
58. Xie Z, Westmoreland SV, Miller GM, (2008) Modulation of monoamine transporters by common biogenic amines via trace amine-associated receptor 1 and monoamine autoreceptors in human embryonic kidney 293 cells and brain synaptosomes. J Pharmacol Exp Ther 325: 629-640.
59. Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, et al. (2011) TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A. 108 (20): 8485-90.
60. Bradaia A, Trube G, Stalder H, Norcross RD, Ozmen L, et al. (2009) The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc Natl Acad Sci U S A 106: 20081-20086.
61. Stalder H, Hoener MC, Norcross RD, (2011) Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): discovery of EPPTB (RO5212773). Bioorg Med Chem Lett 21: 1227-1231.
62. Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, et al. (2007) High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318: 1258-1265.
63. Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, et al. (2007) Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature 450: 383-387.
64. Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, et al. (2011) Structure and function of an irreversible agonist-beta(2) adrenoceptor complex. Nature 469: 236-240.
65. Chien EY, Liu W, Zhao Q, Katritch V, Han GW, et al. (2010) Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science 330: 1091-1095.
66. Ballesteros JA, Weinstein H, Stuart CS, (1995) [19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors. Methods in Neurosciences Academic Press pp. 366-428.
67. Worth CL, Kleinau G, Krause G, (2009) Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PLoS One 4: e7011.
68. Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, et al. (2008) The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322: 1211-1217.
69. Peeters MC, van Westen GJ, Guo D, Wisse LE, Muller CE, et al. (2011) GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor. FASEB J 25: 632-643.
70. Peeters MC, van Westen GJ, Li Q, AP IJ, (2011) Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. Trends Pharmacol Sci 32: 35-42.
71. Kratochwil NA, Malherbe P, Lindemann L, Ebeling M, Hoener MC, et al. (2005) An Automated System for the Analysis of G Protein-Coupled Receptor Transmembrane Binding Pockets:  Alignment, Receptor-Based Pharmacophores, and Their Application. Journal of Chemical Information and Modeling 45: 1324-1336.
72. Wichard JD, Ter Laak A, Krause G, Heinrich N, Kuhne R, et al. (2011) Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling. PLoS One 6: e16811.
73. Strader CD, Fong TM, Tota MR, Underwood D, Dixon RA, (1994) Structure and function of G protein-coupled receptors. Annu Rev Biochem 63: 101-132.
74. Vilar S, Karpiak J, Berk B, Costanzi S, (2011) In silico analysis of the binding of agonists and blockers to the beta2-adrenergic receptor. J Mol Graph Model 29: 809-817.
75. Hu LA, Zhou T, Ahn J, Wang S, Zhou J, et al. (2009) Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands. Biochemical Journal 424: 39-45.
76. Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, et al. (2011) TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A 108: 8485-8490.
77. Huang ES, (2003) Construction of a sequence motif characteristic of aminergic G protein-coupled receptors. Protein Sci 12: 1360-1367.
78. Tan ES, Groban ES, Jacobson MP, Scanlan TS, (2008) Toward deciphering the code to aminergic G protein-coupled receptor drug design. Chem Biol 15: 343-353.
79. Huang J, Hamasaki T, Ozoe F, Ohta H, Enomoto K, et al. (2007) Identification of critical structural determinants responsible for octopamine binding to the alpha-adrenergic-like Bombyx mori octopamine receptor. Biochemistry 46: 5896-5903.
80. Warne T, Moukhametzianov R, Baker JG, Nehme R, Edwards PC, et al. (2011) The structural basis for agonist and partial agonist action on a beta(1)-adrenergic receptor. Nature 469: 241-244.
81. Huang J, Hamasaki T, Ozoe F, Ozoe Y, (2008) Single amino acid of an octopamine receptor as a molecular switch for distinct G protein couplings. Biochem Biophys Res Commun 371: 610-614.
82. Rosenkilde MM, Benned-Jensen T, Frimurer TM, Schwartz TW, (2010) The minor binding pocket: a major player in 7TM receptor activation. Trends Pharmacol Sci 31: 567-574.
83. Cody V, Meyer T, Dohler KD, Hesch RD, Rokos H, et al. (1984) Molecular structure and biochemical activity of 3,5,3′-triiodothyronamine. Endocr Res 10: 91-99.
84. Meyer T, Hesch RD, (1983) Triiodothyronamine--a beta-adrenergic metabolite of triiodothyronine? Horm Metab Res 15: 602-606.
85. Hart ME, Suchland KL, Miyakawa M, Bunzow JR, Grandy DK, et al. (2006) Trace Amine-Associated Receptor Agonists: Synthesis and Evaluation of Thyronamines and Related Analogues. Journal of Medicinal Chemistry 49: 1101-1112.
86. Lewin AH, Navarro HA, Gilmour BP, (2009) Amiodarone and its putative metabolites fail to activate wild type hTAAR1. Bioorganic & Medicinal Chemistry Letters 19: 5913-5914.
87. Snead AN, Miyakawa M, Tan ES, Scanlan TS, (2008) Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites. Bioorg Med Chem Lett 18: 5920-5922.
88. Stalder H, Hoener MC, Norcross RD, (2011) Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): Discovery of EPPTB (RO5212773). Bioorganic & Medicinal Chemistry Letters In Press, Corrected Proof.
89. Tan ES, Miyakawa M, Bunzow JR, Grandy DK, Scanlan TS, (2007) Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1. J Med Chem 50: 2787-2798.
90. Tan ES, Naylor JC, Groban ES, Bunzow JR, Jacobson MP, et al. (2009) The Molecular Basis of Species-Specific Ligand Activation of Trace Amine-Associated Receptor 1 (TAAR1). ACS Chemical Biology 4: 209-220.