A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 378, Issue 5, 2008, Pages 503-514

  Van Koppen, Chris J ^a   Zaman, Guido J R ^a   Timmers, C Marco ^a   Kelder, Jan ^a   Mosselman, Sietse ^a   Van De Lagemaat, Ruud ^a   Smit, Martin J ^a   Hanssen, Rob G J M ^a  

^a NV ORGANON   (Netherlands)

Author keywords

Allosterism; GPCR; LH; Luteinizing hormone; Ovary

Indexed keywords

ADENYLATE CYCLASE; CHORIONIC GONADOTROPIN; CYCLIC AMP; HORMONE RECEPTOR STIMULATING AGENT; IODINE 125; LUCIFERASE; LUTEINIZING HORMONE RECEPTOR; ORG 43553; PHOSPHOLIPASE C; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING ASSAY; CHO CELL; CONTROLLED STUDY; DISSOCIATION; DRUG STRUCTURE; ENZYME INHIBITION; GENE CONSTRUCT; HUMAN; HUMAN CELL; IC 50; MOLECULAR WEIGHT; NONHUMAN; OVULATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ALLOSTERIC REGULATION; ANIMALS; CELL LINE; CHO CELLS; CHORIONIC GONADOTROPIN; CRICETINAE; CRICETULUS; CYCLIC AMP; HUMANS; INHIBITORY CONCENTRATION 50; LUTEINIZING HORMONE; PYRIMIDINES; RECEPTORS, LH; SIGNAL TRANSDUCTION; THIOPHENES; TYPE C PHOSPHOLIPASES;

EID: 54249130252     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0318-3     Document Type: Article

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